RU2009107917A - Аминоизохинолиновый ингибитор тромбина с улучшенной биодоступностью - Google Patents
Аминоизохинолиновый ингибитор тромбина с улучшенной биодоступностью Download PDFInfo
- Publication number
- RU2009107917A RU2009107917A RU2009107917/04A RU2009107917A RU2009107917A RU 2009107917 A RU2009107917 A RU 2009107917A RU 2009107917/04 A RU2009107917/04 A RU 2009107917/04A RU 2009107917 A RU2009107917 A RU 2009107917A RU 2009107917 A RU2009107917 A RU 2009107917A
- Authority
- RU
- Russia
- Prior art keywords
- amino
- compound according
- pharmaceutically acceptable
- isochinoline
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
1. Соединение, представляющее собой N-(2-оксо-2-пропоксиэтил)-β-фенил-D-фенилаланил-N-[(1-амино-6-изохинолинил)метил]-L-пролинамид, или его фармацевтически приемлемая соль. ! 2. Соединение по п.1 в виде дигидрохлорида. ! 3. Фармацевтическая композиция, содержащая соединение по п.1 и фармацевтически приемлемые вспомогательные вещества. ! 4. Соединение по п.1 для применения в терапии. ! 5. Применение соединения по п.1 для производства лекарственного средства для лечения или профилактики заболеваний, опосредованных тромбином. ! 6. Соединение, представляющее собой N-(карбоксиметил)-β-фенил-D-фенилаланил-N-[(1-амино-6-изохинолинил)метил]-L-пролинамид, или его фармацевтически приемлемая соль.
Claims (6)
1. Соединение, представляющее собой N-(2-оксо-2-пропоксиэтил)-β-фенил-D-фенилаланил-N-[(1-амино-6-изохинолинил)метил]-L-пролинамид, или его фармацевтически приемлемая соль.
2. Соединение по п.1 в виде дигидрохлорида.
3. Фармацевтическая композиция, содержащая соединение по п.1 и фармацевтически приемлемые вспомогательные вещества.
4. Соединение по п.1 для применения в терапии.
5. Применение соединения по п.1 для производства лекарственного средства для лечения или профилактики заболеваний, опосредованных тромбином.
6. Соединение, представляющее собой N-(карбоксиметил)-β-фенил-D-фенилаланил-N-[(1-амино-6-изохинолинил)метил]-L-пролинамид, или его фармацевтически приемлемая соль.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06118608 | 2006-08-08 | ||
| EP06118608.6 | 2006-08-08 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2009107917A true RU2009107917A (ru) | 2010-09-20 |
| RU2437879C2 RU2437879C2 (ru) | 2011-12-27 |
Family
ID=37561257
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2009107917/04A RU2437879C2 (ru) | 2006-08-08 | 2007-08-06 | Аминоизохинолиновый ингибитор тромбина с улучшенной биодоступностью |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US8299091B2 (ru) |
| EP (1) | EP2054402B1 (ru) |
| JP (1) | JP5271904B2 (ru) |
| KR (1) | KR20090048496A (ru) |
| CN (1) | CN101511816B (ru) |
| AR (1) | AR062215A1 (ru) |
| AU (1) | AU2007283596B2 (ru) |
| BR (1) | BRPI0715384A2 (ru) |
| CA (1) | CA2659154A1 (ru) |
| CL (1) | CL2007002294A1 (ru) |
| CO (1) | CO6150148A2 (ru) |
| IL (1) | IL196783A (ru) |
| MX (1) | MX2009001384A (ru) |
| MY (1) | MY143949A (ru) |
| NO (1) | NO20090448L (ru) |
| NZ (1) | NZ574550A (ru) |
| PE (1) | PE20080526A1 (ru) |
| RU (1) | RU2437879C2 (ru) |
| TW (1) | TWI389899B (ru) |
| WO (1) | WO2008017650A1 (ru) |
| ZA (1) | ZA200900903B (ru) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20150047597A (ko) * | 2012-08-27 | 2015-05-04 | 어레이 바이오파마 인크. | 과증식성 질환의 치료를 위한 세린/트레오닌 키나아제 억제제 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4115468A1 (de) * | 1991-05-11 | 1992-11-12 | Behringwerke Ag | Amidinophenylalaninderivate, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel als antikoagulantien |
| GB9322976D0 (en) * | 1993-11-08 | 1994-01-05 | Pfizer Ltd | Therapeutic agents |
| US5523308A (en) * | 1995-06-07 | 1996-06-04 | Costanzo; Michael J. | Peptidyl heterocycles useful in the treatment of thrombin related disorders |
| NZ336046A (en) * | 1996-12-06 | 2000-10-27 | Cortech Inc | Serine protease inhibitors containing substituted oxadiazole, thiadiazole and triazole peptide derivatives |
| IL123986A (en) * | 1997-04-24 | 2011-10-31 | Organon Nv | Medicinal compounds |
| TW575567B (en) | 1998-10-23 | 2004-02-11 | Akzo Nobel Nv | Serine protease inhibitor |
| EP1303491A1 (en) * | 2000-07-12 | 2003-04-23 | Akzo Nobel N.V. | Thrombin inhibitors comprising an aminoisoquinoline group |
-
2007
- 2007-07-18 TW TW096126164A patent/TWI389899B/zh not_active IP Right Cessation
- 2007-08-06 JP JP2009523262A patent/JP5271904B2/ja not_active Expired - Fee Related
- 2007-08-06 EP EP07788235.5A patent/EP2054402B1/en active Active
- 2007-08-06 BR BRPI0715384-8A patent/BRPI0715384A2/pt not_active IP Right Cessation
- 2007-08-06 CN CN2007800328071A patent/CN101511816B/zh not_active Expired - Fee Related
- 2007-08-06 CA CA002659154A patent/CA2659154A1/en not_active Abandoned
- 2007-08-06 WO PCT/EP2007/058111 patent/WO2008017650A1/en active Application Filing
- 2007-08-06 NZ NZ574550A patent/NZ574550A/en not_active IP Right Cessation
- 2007-08-06 AR ARP070103455A patent/AR062215A1/es not_active Application Discontinuation
- 2007-08-06 MX MX2009001384A patent/MX2009001384A/es active IP Right Grant
- 2007-08-06 KR KR1020097004645A patent/KR20090048496A/ko not_active Application Discontinuation
- 2007-08-06 RU RU2009107917/04A patent/RU2437879C2/ru not_active IP Right Cessation
- 2007-08-06 US US12/376,529 patent/US8299091B2/en not_active Expired - Fee Related
- 2007-08-06 AU AU2007283596A patent/AU2007283596B2/en not_active Ceased
- 2007-08-07 CL CL200702294A patent/CL2007002294A1/es unknown
- 2007-08-07 PE PE2007001050A patent/PE20080526A1/es not_active Application Discontinuation
- 2007-08-07 MY MYPI20071301A patent/MY143949A/en unknown
-
2009
- 2009-01-29 NO NO20090448A patent/NO20090448L/no not_active Application Discontinuation
- 2009-01-29 IL IL196783A patent/IL196783A/en not_active IP Right Cessation
- 2009-02-06 ZA ZA200900903A patent/ZA200900903B/xx unknown
- 2009-03-06 CO CO09023453A patent/CO6150148A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2659154A1 (en) | 2008-02-14 |
| JP5271904B2 (ja) | 2013-08-21 |
| BRPI0715384A2 (pt) | 2013-06-18 |
| WO2008017650A1 (en) | 2008-02-14 |
| AU2007283596A1 (en) | 2008-02-14 |
| IL196783A (en) | 2013-03-24 |
| AR062215A1 (es) | 2008-10-22 |
| CL2007002294A1 (es) | 2008-04-18 |
| CN101511816B (zh) | 2013-01-02 |
| ZA200900903B (en) | 2010-06-30 |
| TWI389899B (zh) | 2013-03-21 |
| NO20090448L (no) | 2009-02-05 |
| KR20090048496A (ko) | 2009-05-13 |
| EP2054402A1 (en) | 2009-05-06 |
| US20100305153A1 (en) | 2010-12-02 |
| JP2010500321A (ja) | 2010-01-07 |
| PE20080526A1 (es) | 2008-06-13 |
| MX2009001384A (es) | 2009-04-30 |
| AU2007283596B2 (en) | 2012-07-05 |
| TW200821294A (en) | 2008-05-16 |
| NZ574550A (en) | 2010-09-30 |
| CO6150148A2 (es) | 2010-04-20 |
| RU2437879C2 (ru) | 2011-12-27 |
| EP2054402B1 (en) | 2013-11-27 |
| MY143949A (en) | 2011-07-29 |
| US8299091B2 (en) | 2012-10-30 |
| CN101511816A (zh) | 2009-08-19 |
| IL196783A0 (en) | 2009-11-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC43 | Official registration of the transfer of the exclusive right without contract for inventions |
Effective date: 20120326 |
|
| PC43 | Official registration of the transfer of the exclusive right without contract for inventions |
Effective date: 20130917 |
|
| PC43 | Official registration of the transfer of the exclusive right without contract for inventions |
Effective date: 20140402 |
|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20140807 |