NO20090448L - En aminoisoquinolin trombin inhibitor med forbedret biotilgjengelighet - Google Patents
En aminoisoquinolin trombin inhibitor med forbedret biotilgjengelighetInfo
- Publication number
- NO20090448L NO20090448L NO20090448A NO20090448A NO20090448L NO 20090448 L NO20090448 L NO 20090448L NO 20090448 A NO20090448 A NO 20090448A NO 20090448 A NO20090448 A NO 20090448A NO 20090448 L NO20090448 L NO 20090448L
- Authority
- NO
- Norway
- Prior art keywords
- aminoisoquinoline
- thrombin inhibitor
- improved bioavailability
- compound
- thrombin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
Oppfinnelsen angår forbindelsen N-(2-okso-2-propoksyetyl)-ß-fenyl-D-fenylalanyl-N-[(1-amino-6-isokinolinyl)metyl]-L-prolinamid eller et farmasøytisk akseptabelt salt derav, et farmasøytisk preparat omfattende nevnte forbindelse, så vel som til anvendelse av forbindelsen for fremstilling av et medikament for behandling av eller for forhindring av trombin medierte sykdommer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06118608 | 2006-08-08 | ||
PCT/EP2007/058111 WO2008017650A1 (en) | 2006-08-08 | 2007-08-06 | An aminoisoquinoline thrombin inhibitor with improved bioavailability |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20090448L true NO20090448L (no) | 2009-02-05 |
Family
ID=37561257
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20090448A NO20090448L (no) | 2006-08-08 | 2009-01-29 | En aminoisoquinolin trombin inhibitor med forbedret biotilgjengelighet |
Country Status (21)
Country | Link |
---|---|
US (1) | US8299091B2 (no) |
EP (1) | EP2054402B1 (no) |
JP (1) | JP5271904B2 (no) |
KR (1) | KR20090048496A (no) |
CN (1) | CN101511816B (no) |
AR (1) | AR062215A1 (no) |
AU (1) | AU2007283596B2 (no) |
BR (1) | BRPI0715384A2 (no) |
CA (1) | CA2659154A1 (no) |
CL (1) | CL2007002294A1 (no) |
CO (1) | CO6150148A2 (no) |
IL (1) | IL196783A (no) |
MX (1) | MX2009001384A (no) |
MY (1) | MY143949A (no) |
NO (1) | NO20090448L (no) |
NZ (1) | NZ574550A (no) |
PE (1) | PE20080526A1 (no) |
RU (1) | RU2437879C2 (no) |
TW (1) | TWI389899B (no) |
WO (1) | WO2008017650A1 (no) |
ZA (1) | ZA200900903B (no) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20150047597A (ko) * | 2012-08-27 | 2015-05-04 | 어레이 바이오파마 인크. | 과증식성 질환의 치료를 위한 세린/트레오닌 키나아제 억제제 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4115468A1 (de) * | 1991-05-11 | 1992-11-12 | Behringwerke Ag | Amidinophenylalaninderivate, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel als antikoagulantien |
GB9322976D0 (en) * | 1993-11-08 | 1994-01-05 | Pfizer Ltd | Therapeutic agents |
US5523308A (en) * | 1995-06-07 | 1996-06-04 | Costanzo; Michael J. | Peptidyl heterocycles useful in the treatment of thrombin related disorders |
NZ336046A (en) * | 1996-12-06 | 2000-10-27 | Cortech Inc | Serine protease inhibitors containing substituted oxadiazole, thiadiazole and triazole peptide derivatives |
IL123986A (en) * | 1997-04-24 | 2011-10-31 | Organon Nv | Medicinal compounds |
TW575567B (en) | 1998-10-23 | 2004-02-11 | Akzo Nobel Nv | Serine protease inhibitor |
EP1303491A1 (en) * | 2000-07-12 | 2003-04-23 | Akzo Nobel N.V. | Thrombin inhibitors comprising an aminoisoquinoline group |
-
2007
- 2007-07-18 TW TW096126164A patent/TWI389899B/zh not_active IP Right Cessation
- 2007-08-06 JP JP2009523262A patent/JP5271904B2/ja not_active Expired - Fee Related
- 2007-08-06 EP EP07788235.5A patent/EP2054402B1/en active Active
- 2007-08-06 BR BRPI0715384-8A patent/BRPI0715384A2/pt not_active IP Right Cessation
- 2007-08-06 CN CN2007800328071A patent/CN101511816B/zh not_active Expired - Fee Related
- 2007-08-06 CA CA002659154A patent/CA2659154A1/en not_active Abandoned
- 2007-08-06 WO PCT/EP2007/058111 patent/WO2008017650A1/en active Application Filing
- 2007-08-06 NZ NZ574550A patent/NZ574550A/en not_active IP Right Cessation
- 2007-08-06 AR ARP070103455A patent/AR062215A1/es not_active Application Discontinuation
- 2007-08-06 MX MX2009001384A patent/MX2009001384A/es active IP Right Grant
- 2007-08-06 KR KR1020097004645A patent/KR20090048496A/ko not_active Application Discontinuation
- 2007-08-06 RU RU2009107917/04A patent/RU2437879C2/ru not_active IP Right Cessation
- 2007-08-06 US US12/376,529 patent/US8299091B2/en not_active Expired - Fee Related
- 2007-08-06 AU AU2007283596A patent/AU2007283596B2/en not_active Ceased
- 2007-08-07 CL CL200702294A patent/CL2007002294A1/es unknown
- 2007-08-07 PE PE2007001050A patent/PE20080526A1/es not_active Application Discontinuation
- 2007-08-07 MY MYPI20071301A patent/MY143949A/en unknown
-
2009
- 2009-01-29 NO NO20090448A patent/NO20090448L/no not_active Application Discontinuation
- 2009-01-29 IL IL196783A patent/IL196783A/en not_active IP Right Cessation
- 2009-02-06 ZA ZA200900903A patent/ZA200900903B/xx unknown
- 2009-03-06 CO CO09023453A patent/CO6150148A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
CA2659154A1 (en) | 2008-02-14 |
JP5271904B2 (ja) | 2013-08-21 |
BRPI0715384A2 (pt) | 2013-06-18 |
WO2008017650A1 (en) | 2008-02-14 |
RU2009107917A (ru) | 2010-09-20 |
AU2007283596A1 (en) | 2008-02-14 |
IL196783A (en) | 2013-03-24 |
AR062215A1 (es) | 2008-10-22 |
CL2007002294A1 (es) | 2008-04-18 |
CN101511816B (zh) | 2013-01-02 |
ZA200900903B (en) | 2010-06-30 |
TWI389899B (zh) | 2013-03-21 |
KR20090048496A (ko) | 2009-05-13 |
EP2054402A1 (en) | 2009-05-06 |
US20100305153A1 (en) | 2010-12-02 |
JP2010500321A (ja) | 2010-01-07 |
PE20080526A1 (es) | 2008-06-13 |
MX2009001384A (es) | 2009-04-30 |
AU2007283596B2 (en) | 2012-07-05 |
TW200821294A (en) | 2008-05-16 |
NZ574550A (en) | 2010-09-30 |
CO6150148A2 (es) | 2010-04-20 |
RU2437879C2 (ru) | 2011-12-27 |
EP2054402B1 (en) | 2013-11-27 |
MY143949A (en) | 2011-07-29 |
US8299091B2 (en) | 2012-10-30 |
CN101511816A (zh) | 2009-08-19 |
IL196783A0 (en) | 2009-11-18 |
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Legal Events
Date | Code | Title | Description |
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FC2A | Withdrawal, rejection or dismissal of laid open patent application |