CL2007001597A1 - Compuestos derivados de 2-oxo-piridin-1(2h)-il-tiazol, imidazol o tiofen-carboxamida; composicion farmaceutica; y uso para el tratamiento de una enfermedad mediada por la estearoil-coa-desaturasa, tal como sindrome metabolico, hipertension y diabetes - Google Patents
Compuestos derivados de 2-oxo-piridin-1(2h)-il-tiazol, imidazol o tiofen-carboxamida; composicion farmaceutica; y uso para el tratamiento de una enfermedad mediada por la estearoil-coa-desaturasa, tal como sindrome metabolico, hipertension y diabetesInfo
- Publication number
- CL2007001597A1 CL2007001597A1 CL200701597A CL2007001597A CL2007001597A1 CL 2007001597 A1 CL2007001597 A1 CL 2007001597A1 CL 200701597 A CL200701597 A CL 200701597A CL 2007001597 A CL2007001597 A CL 2007001597A CL 2007001597 A1 CL2007001597 A1 CL 2007001597A1
- Authority
- CL
- Chile
- Prior art keywords
- desaturasa
- estearoil
- thiofen
- tiazol
- piridin
- Prior art date
Links
- RAXXELZNTBOGNW-UHFFFAOYSA-N 1H-imidazole Chemical compound C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 title 1
- 206010020772 Hypertension Diseases 0.000 title 1
- 208000001145 Metabolic Syndrome Diseases 0.000 title 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 206010012601 diabetes mellitus Diseases 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 230000001404 mediated effect Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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- A—HUMAN NECESSITIES
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C07—ORGANIC CHEMISTRY
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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- C07—ORGANIC CHEMISTRY
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0834—Compounds having one or more O-Si linkage
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US81091506P | 2006-06-05 | 2006-06-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2007001597A1 true CL2007001597A1 (es) | 2008-05-16 |
Family
ID=38802273
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL200701597A CL2007001597A1 (es) | 2006-06-05 | 2007-06-04 | Compuestos derivados de 2-oxo-piridin-1(2h)-il-tiazol, imidazol o tiofen-carboxamida; composicion farmaceutica; y uso para el tratamiento de una enfermedad mediada por la estearoil-coa-desaturasa, tal como sindrome metabolico, hipertension y diabetes |
Country Status (20)
Country | Link |
---|---|
US (2) | US8501746B2 (es) |
EP (1) | EP2029572B1 (es) |
JP (1) | JP5043105B2 (es) |
KR (1) | KR101124070B1 (es) |
CN (1) | CN101460476B (es) |
AR (1) | AR061222A1 (es) |
AT (1) | ATE486862T1 (es) |
AU (1) | AU2007256708B2 (es) |
BR (1) | BRPI0712902A2 (es) |
CA (1) | CA2653655A1 (es) |
CL (1) | CL2007001597A1 (es) |
DE (1) | DE602007010287D1 (es) |
ES (1) | ES2358297T3 (es) |
MX (1) | MX2008015229A (es) |
PE (1) | PE20080714A1 (es) |
PL (1) | PL2029572T3 (es) |
PT (1) | PT2029572E (es) |
RU (1) | RU2491285C2 (es) |
TW (1) | TW200815420A (es) |
WO (1) | WO2007143597A2 (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2597453T3 (es) * | 2006-08-15 | 2017-01-18 | Xenon Pharmaceuticals Inc. | Compuestos heterocíclicos adecuados para el tratamiento de enfermedades relacionadas con un elevado nivel de lípidos |
CN101595105B (zh) | 2006-12-20 | 2013-01-23 | 诺瓦提斯公司 | 作为scd抑制剂的2-取代的5元杂环化合物 |
JP2010524861A (ja) * | 2007-04-20 | 2010-07-22 | メルク フロスト カナダ リミテツド | ステアロイル−補酵素aデルタ−9デサチュラーゼの阻害剤としての新規な複素環式芳香族化合物 |
UA105758C2 (uk) | 2007-07-19 | 2014-06-25 | Х. Луннбек А/С | 5-членні гетероциклічні аміди та споріднені сполуки |
BRPI0907826A2 (pt) * | 2008-02-20 | 2019-12-10 | Novartis Ag | inibidores heterocíclicos de estearoil-coa desaturase |
CN102762551A (zh) | 2009-12-21 | 2012-10-31 | 拜尔农作物科学股份公司 | 噻吩基吡(嘧)啶基吡唑及其用于防治植物致病菌的用途 |
US9296719B2 (en) * | 2011-07-08 | 2016-03-29 | Indiana University Research And Technology Corporation | Compositions and methods for the treatment of norovirus infection |
JP6042896B2 (ja) | 2011-10-06 | 2016-12-14 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングBayer Intellectual Property GmbH | 殺菌剤としての複素環ピリ(ミ)ジニルピラゾール |
WO2013056148A2 (en) | 2011-10-15 | 2013-04-18 | Genentech, Inc. | Methods of using scd1 antagonists |
WO2013175474A2 (en) | 2012-05-22 | 2013-11-28 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Selective inhibitors of undifferentiated cells |
BR112016016348B1 (pt) * | 2014-01-14 | 2022-10-18 | Connexios Life Sciences Pvt. Ltd | Compostos de heteroarila bicíclica substituída como antagonistas de rxr, composição farmacêutica e uso de um composto |
US11970486B2 (en) | 2016-10-24 | 2024-04-30 | Janssen Pharmaceutica Nv | Compounds and uses thereof |
EP3566055A4 (en) | 2017-01-06 | 2020-12-02 | Yumanity Therapeutics, Inc. | TREATMENT METHODS FOR NEUROLOGICAL DISORDERS |
EP3700934A4 (en) | 2017-10-24 | 2021-10-27 | Yumanity Therapeutics, Inc. | COMPOUNDS AND USES OF THESE COMPOUNDS |
WO2022167457A1 (en) * | 2021-02-02 | 2022-08-11 | Liminal Biosciences Limited | Gpr84 antagonists and uses thereof |
JP2024506858A (ja) * | 2021-02-02 | 2024-02-15 | リミナル・バイオサイエンシーズ・リミテッド | Gpr84アンタゴニストおよびその使用 |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3575991A (en) * | 1969-03-11 | 1971-04-20 | American Home Prod | 1-(4-aryl - 5 - carboxymethyl-2-thiazolyl)-1,6-dihydro -6 - oxonicotinic acids and esters thereof |
US5716632A (en) * | 1989-11-22 | 1998-02-10 | Margolin; Solomon B. | Compositions and methods for reparation and prevention of fibrotic lesions |
EP0702551B1 (en) * | 1993-05-07 | 2002-09-25 | MARGOLIN, Solomon B. | Compositions and methods for reparation and prevention of fibrotic lesions |
WO1996027374A1 (en) * | 1995-03-03 | 1996-09-12 | Margolin Solomon B | Treatment of cytokine growth factor caused disorders |
US6114353A (en) * | 1995-03-03 | 2000-09-05 | Margolin; Solomon B. | Compositions and method for treatment of lymphomas, leukemias, and leiomyomas |
BR9610480A (pt) * | 1995-09-19 | 1999-03-16 | Solomon Begelfor Margolin | Inibição do fator alfa de necrose tumoral |
FR2754262B1 (fr) * | 1996-10-08 | 1998-10-30 | Synthelabo | Derives de 1h-pyrido[3,4-b]indole-4-carboxamide, leur preparation et leur application en therapeutique |
EP1254904B1 (en) * | 2000-01-20 | 2006-05-24 | Eisai Co., Ltd. | Novel piperidine compounds and drugs containing the same |
CA2400491A1 (en) * | 2000-02-21 | 2001-08-30 | Solomon B. Margolin | Compositions and methods for treatment of epilepsy |
ATE475718T1 (de) | 2000-02-24 | 2010-08-15 | Xenon Pharmaceuticals Inc | Stearoyl-coa-desaturase zur identifizierung von triglyceridreduktionstherapeutika |
CA2430987A1 (en) | 2000-09-26 | 2002-04-04 | Xenon Genetics, Inc. | Methods and compositions employing a novel stearoyl-coa desaturase-hscd5 |
CA2476012C (en) * | 2002-02-14 | 2011-04-19 | Pharmacia Corporation | Substituted pyridinones as modulators of p38 map kinase |
PL372427A1 (en) * | 2002-03-14 | 2005-07-25 | Bayer Healthcare Ag | Monocyclic aroylpyridinones as antiinflammatory agents |
CA2533898A1 (en) | 2003-07-29 | 2005-02-10 | Xenon Pharmaceuticals Inc. | Pyridyl derivatives and their use as therapeutic agents |
KR20060037409A (ko) | 2003-07-30 | 2006-05-03 | 제논 파마슈티칼스 인크. | 피페라진 유도체 및 그의 치료제로서의 용도 |
SG145699A1 (en) | 2003-07-30 | 2008-09-29 | Xenon Pharmaceuticals Inc | Pyridazine derivatives and their use as therapeutic agents |
ES2375134T3 (es) | 2003-07-30 | 2012-02-27 | Xenon Pharmaceuticals Inc. | Derivados de piperazina y su uso como agentes terapéuticos. |
CA2533900A1 (en) | 2003-07-30 | 2005-02-10 | Xenon Pharmaceuticals Inc. | Pyridyl derivatives and their use as therapeutic agents |
CL2004002050A1 (es) * | 2003-08-13 | 2005-06-03 | Pharmacia Corp Sa Organizada B | Compuestos derivados de piridinonas sustituidas; su uso en el tratamiento de afecciones causadas o exacerbadas por actividad p38 map kinasa y/o tnf no regulada, tales como inflamaciones, tumores, sida y otros. |
ES2380020T3 (es) | 2004-07-06 | 2012-05-07 | Xenon Pharmaceuticals Inc. | Derivados de nicotinamida y su uso como agentes terapéuticos |
JP5094398B2 (ja) * | 2004-09-20 | 2012-12-12 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | 複素環式誘導体およびステアロイル−CoAデサチュラーゼのメディエータとしてのそれらの使用 |
US7829712B2 (en) | 2004-09-20 | 2010-11-09 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives for inhibiting human stearoyl-CoA-desaturase |
EP2289510A1 (en) * | 2004-09-20 | 2011-03-02 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes |
MX2007003321A (es) | 2004-09-20 | 2007-06-05 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como agentes terapeuticos. |
DE602005025924D1 (en) | 2004-09-20 | 2011-02-24 | Xenon Pharmaceuticals Inc | Royl-coa-desaturase |
US7547698B2 (en) | 2004-09-20 | 2009-06-16 | Xenon Pharmaceuticals Inc. | Bicyclic heterocyclic derivatives and their use as inhibitors of stearoyl-coadesaturase (SCD) |
CN101084207A (zh) | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 杂环衍生物及其作为硬脂酰CoA去饱和酶抑制剂的用途 |
EP1807085B1 (en) | 2004-09-20 | 2013-08-21 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
US20090099200A1 (en) | 2005-06-09 | 2009-04-16 | Chun Sing Li | Azacyclohexane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase |
EP1910352A1 (en) | 2005-07-20 | 2008-04-16 | Merck Frosst Canada Ltd. | Heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase |
JP5112082B2 (ja) * | 2006-02-02 | 2013-01-09 | クミアイ化学工業株式会社 | ピリドン誘導体及び除草剤 |
-
2007
- 2007-06-04 WO PCT/US2007/070293 patent/WO2007143597A2/en active Application Filing
- 2007-06-04 ES ES07798049T patent/ES2358297T3/es active Active
- 2007-06-04 PL PL07798049T patent/PL2029572T3/pl unknown
- 2007-06-04 KR KR1020087029648A patent/KR101124070B1/ko not_active IP Right Cessation
- 2007-06-04 EP EP07798049A patent/EP2029572B1/en not_active Not-in-force
- 2007-06-04 MX MX2008015229A patent/MX2008015229A/es active IP Right Grant
- 2007-06-04 CN CN2007800204238A patent/CN101460476B/zh not_active Expired - Fee Related
- 2007-06-04 TW TW096119972A patent/TW200815420A/zh unknown
- 2007-06-04 AU AU2007256708A patent/AU2007256708B2/en not_active Ceased
- 2007-06-04 DE DE602007010287T patent/DE602007010287D1/de active Active
- 2007-06-04 US US12/303,490 patent/US8501746B2/en not_active Expired - Fee Related
- 2007-06-04 BR BRPI0712902A patent/BRPI0712902A2/pt not_active IP Right Cessation
- 2007-06-04 AT AT07798049T patent/ATE486862T1/de active
- 2007-06-04 AR ARP070102401A patent/AR061222A1/es unknown
- 2007-06-04 CA CA002653655A patent/CA2653655A1/en not_active Abandoned
- 2007-06-04 JP JP2009514484A patent/JP5043105B2/ja not_active Expired - Fee Related
- 2007-06-04 RU RU2008151051/04A patent/RU2491285C2/ru not_active IP Right Cessation
- 2007-06-04 PE PE2007000690A patent/PE20080714A1/es not_active Application Discontinuation
- 2007-06-04 CL CL200701597A patent/CL2007001597A1/es unknown
- 2007-06-04 PT PT07798049T patent/PT2029572E/pt unknown
-
2013
- 2013-07-15 US US13/942,404 patent/US20140024583A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
BRPI0712902A2 (pt) | 2018-10-30 |
ES2358297T3 (es) | 2011-05-09 |
RU2491285C2 (ru) | 2013-08-27 |
AU2007256708B2 (en) | 2011-12-15 |
WO2007143597A9 (en) | 2010-11-11 |
EP2029572B1 (en) | 2010-11-03 |
CN101460476A (zh) | 2009-06-17 |
WO2007143597A3 (en) | 2008-04-10 |
CN101460476B (zh) | 2013-12-04 |
US8501746B2 (en) | 2013-08-06 |
AR061222A1 (es) | 2008-08-13 |
WO2007143597A2 (en) | 2007-12-13 |
PE20080714A1 (es) | 2008-07-31 |
PL2029572T3 (pl) | 2011-05-31 |
US20090156615A1 (en) | 2009-06-18 |
JP2009539868A (ja) | 2009-11-19 |
KR20090015107A (ko) | 2009-02-11 |
JP5043105B2 (ja) | 2012-10-10 |
US20140024583A1 (en) | 2014-01-23 |
CA2653655A1 (en) | 2007-12-13 |
DE602007010287D1 (de) | 2010-12-16 |
EP2029572A2 (en) | 2009-03-04 |
RU2008151051A (ru) | 2010-07-20 |
KR101124070B1 (ko) | 2012-04-12 |
MX2008015229A (es) | 2008-12-12 |
PT2029572E (pt) | 2011-02-09 |
TW200815420A (en) | 2008-04-01 |
ATE486862T1 (de) | 2010-11-15 |
AU2007256708A1 (en) | 2007-12-13 |
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