ATE475718T1 - Stearoyl-coa-desaturase zur identifizierung von triglyceridreduktionstherapeutika - Google Patents

Stearoyl-coa-desaturase zur identifizierung von triglyceridreduktionstherapeutika

Info

Publication number
ATE475718T1
ATE475718T1 AT01920143T AT01920143T ATE475718T1 AT E475718 T1 ATE475718 T1 AT E475718T1 AT 01920143 T AT01920143 T AT 01920143T AT 01920143 T AT01920143 T AT 01920143T AT E475718 T1 ATE475718 T1 AT E475718T1
Authority
AT
Austria
Prior art keywords
stearoyl
coa desaturase
therapeutics
identifying
triglyceride reduction
Prior art date
Application number
AT01920143T
Other languages
English (en)
Inventor
Alison Brownlie
Michael Hayden
Alan Attie
James Ntambi
Mark Gray-Keller
Makoto Miyazaki
Original Assignee
Xenon Pharmaceuticals Inc
Wisconsin Alumni Res Found
Univ British Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenon Pharmaceuticals Inc, Wisconsin Alumni Res Found, Univ British Columbia filed Critical Xenon Pharmaceuticals Inc
Application granted granted Critical
Publication of ATE475718T1 publication Critical patent/ATE475718T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0083—Miscellaneous (1.14.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/902—Oxidoreductases (1.)
    • G01N2333/90245—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Analytical Chemistry (AREA)
  • Dermatology (AREA)
  • Plant Pathology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Virology (AREA)
  • Cardiology (AREA)
AT01920143T 2000-02-24 2001-02-23 Stearoyl-coa-desaturase zur identifizierung von triglyceridreduktionstherapeutika ATE475718T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US18452600P 2000-02-24 2000-02-24
US22169700P 2000-07-31 2000-07-31
US25577100P 2000-12-15 2000-12-15
PCT/US2001/005855 WO2001062954A2 (en) 2000-02-24 2001-02-23 Stearoyl-coa desaturase to identify triglyceride reducing therapeutic agents

Publications (1)

Publication Number Publication Date
ATE475718T1 true ATE475718T1 (de) 2010-08-15

Family

ID=27391846

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01920143T ATE475718T1 (de) 2000-02-24 2001-02-23 Stearoyl-coa-desaturase zur identifizierung von triglyceridreduktionstherapeutika

Country Status (9)

Country Link
US (5) US6987001B2 (de)
EP (2) EP1315831B8 (de)
JP (2) JP2003533978A (de)
AT (1) ATE475718T1 (de)
AU (4) AU4722801A (de)
CA (1) CA2398940C (de)
DE (2) DE60142692D1 (de)
PT (1) PT1315831E (de)
WO (1) WO2001062954A2 (de)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6579974B1 (en) * 1998-06-23 2003-06-17 The Regents Of The University Of California Acyl CoA:cholesterol acyltransferase (ACAT-2)
CA2398940C (en) * 2000-02-24 2012-02-21 Xenon Genetics, Inc. Methods and compositions using stearoyl-coa desaturase to identify triglyceride reducing therapeutic agents
US20030064950A1 (en) * 2001-02-23 2003-04-03 Ntambi James M. Methods for reducing body fat and increasing lean body mass by reducing stearoyl-CoA desaturase 1 activity
DE60134995D1 (de) 2000-09-26 2008-09-04 Xenon Pharmaceuticals Inc Verfahren und zusammensetzungen, die eine stearoyl-coa desuturase-hscd5 verwenden
US20020151018A1 (en) * 2000-10-31 2002-10-17 Prouty Stephen M. Stearoyl-CoA desaturase gene promoter
AU2002218091A1 (en) * 2000-11-17 2002-05-27 Xenon Genetics Inc Fat regulated genes, uses thereof, and compounds for modulating same
US20050256068A1 (en) * 2001-05-18 2005-11-17 Sirna Therapeutics, Inc. RNA interference mediated inhibition of stearoyl-CoA desaturase (SCD) gene expression using short interfering nucleic acid (siNA)
EP2266558B1 (de) 2001-06-07 2017-04-19 Analgesic Neuropharmaceuticals, LLC Behandlung neuropathischen Schmerzes mit dem N-Methyl-D-Aspartat (NMDA) -Rezeptorantagonist Dextromethorphan
WO2003004692A2 (en) * 2001-07-03 2003-01-16 Xenon Genetics, Inc. Screening processes for agents modulating cholesterol levels
US20050043256A1 (en) * 2001-07-30 2005-02-24 Isis Pharmaceuticals, Inc. Antisense modulation of stearoyl-CoA desaturase expression
US6759208B2 (en) 2001-08-29 2004-07-06 Xenon Genetics Inc. High throughput screening assays using fatty acid synthetic enzymes
US20050119251A1 (en) * 2001-12-21 2005-06-02 Jian-Min Fu Nicotinamide derivatives and their use as therapeutic agents
US7390813B1 (en) 2001-12-21 2008-06-24 Xenon Pharmaceuticals Inc. Pyridylpiperazines and aminonicotinamides and their use as therapeutic agents
EP1499628A4 (de) * 2002-02-20 2005-06-15 Sirna Therapeutics Inc Rna-interferenz-vermittelte hemmung der expression des stearoyl-coa-desaturase (scd)-gens unter verwendung von sina (short interfering nucleic acid)
AU2003224638A1 (en) * 2002-03-01 2003-09-16 Exelixis, Inc. PDPK1s AS MODIFIERS OF THE p53 PATHWAY AND METHODS OF USE
CA2493584A1 (en) * 2002-07-25 2004-02-05 Wisconsin Alumni Research Foundation Inhibition of stearoyl-coa desaturase 1 (scd1) increases insulin sensitivity and treats diabetes
EP1431399A1 (de) * 2002-12-20 2004-06-23 Clinigenetics Verfahren und Zusammen setzung zur Identifizierung von therapeutischen Mitteln gegen atheriosklerotische Plaques
US7763618B2 (en) * 2003-07-29 2010-07-27 Xenon Pharmaceuticals Inc. Pyridyl derivatives and their use as therapeutic agents
RU2326118C2 (ru) * 2003-07-30 2008-06-10 Зинон Фармасьютиклз Инк. Производные пиридазина и их применение в качестве терапевтических агентов
TW201038270A (en) * 2003-07-30 2010-11-01 Xenon Pharmaceuticals Inc Pyridazine derivatives and their use in the inhibition of stearoyl-CoA desaturase
WO2005011656A2 (en) 2003-07-30 2005-02-10 Xenon Pharmaceuticals Inc. Pyridyl derivatives and their use as therapeutic agents
US7514436B2 (en) * 2003-07-30 2009-04-07 Xenon Pharmaceuticals Inc. Pyridazine derivatives and their use as therapeutic agents
SG145701A1 (en) * 2003-07-30 2008-09-29 Xenon Pharmaceuticals Inc Piperazine derivatives and their use as therapeutic agents
US7759348B2 (en) 2003-07-30 2010-07-20 Xenon Pharmaceuticals Inc. Pyridazine derivatives and their use as therapeutic agents
US7754711B2 (en) 2003-07-30 2010-07-13 Xenon Pharmaceuticals Inc. Pyridazine derivatives and their use as therapeutic agents
US7285395B2 (en) * 2004-06-09 2007-10-23 Wisconsin Alumni Research Foundation Stearoyl-CoA desaturase 4 gene
BRPI0418939A (pt) * 2004-07-06 2008-04-08 Xenon Pharmaceuticals Inc derivados de nicotinamida e sua utilização como agentes terapêuticos
MX2007003318A (es) 2004-09-20 2007-05-18 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como agentes terapeuticos.
CN101090724A (zh) * 2004-09-20 2007-12-19 泽农医药公司 用于抑制人硬脂酰CoA去饱和酶的吡啶衍生物
TW200626138A (en) 2004-09-20 2006-08-01 Xenon Pharmaceuticals Inc Heterocyclic derivatives and their use as therapeutic agents
CA2580857A1 (en) 2004-09-20 2006-09-28 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
CN101084212A (zh) * 2004-09-20 2007-12-05 泽农医药公司 杂环衍生物及其作为硬脂酰CoA去饱和酶介导剂的用途
MX2007003319A (es) * 2004-09-20 2007-06-05 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como agentes terapeuticos.
BRPI0515477A (pt) 2004-09-20 2008-07-22 Xenon Pharmaceuticals Inc derivados heterocìclicos bicìclicos e o uso dos mesmos como inibidores de estaroil-coa-desaturase (scd)
CA2580855A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
US8071603B2 (en) 2004-09-20 2011-12-06 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
WO2007046868A2 (en) * 2005-05-19 2007-04-26 Xenon Pharmaceuticals Inc. Thiazolidine derivatives and their uses as therapeutic agents
EP2029138A1 (de) 2005-06-03 2009-03-04 Xenon Pharmaceuticals Inc. Aminothiazolderivate als humane stearoyl-coa desaturasehemmer
US20060281071A1 (en) * 2005-06-08 2006-12-14 Ntambi James M Stearoyl-CoA desaturase assay
US20070231335A1 (en) * 2005-07-20 2007-10-04 Bruce Beutler Compositions and methods for treating Gram positive bacterial infection in a mammalian subject
PL2029572T3 (pl) 2006-06-05 2011-05-31 Novartis Ag Związki organiczne
TWI404718B (zh) 2006-08-15 2013-08-11 Novartis Ag 調節硬脂醯CoA去飽和酶活性之化合物及其用途
MX2009002019A (es) 2006-08-24 2009-03-09 Novartis Ag Derivados de 2-(pirazin-2-il)-tiazol y 2-(1h-pirazol-3-il)-tiazol asi como compuestos relacionados como inhibidores de la estearoil-coa-desaturasa (scd) para el tratamiento de trastornos metabolicos, cardiovasculares, y otros.
US20080182249A1 (en) * 2006-09-01 2008-07-31 Fox Brian G Expression systems for mammalian and mycobacterial desaturases
EP1932921A1 (de) * 2006-12-13 2008-06-18 Novartis AG Einfaches, auf Mutanten basierendes, differentielles Screening-Verfahren für ein spezifisches Ziel modulierende Zusammensetzungen
US8153392B2 (en) * 2007-05-10 2012-04-10 Undurti N Das Method(s) of preventing, arresting, reversing and treatment of atherosclerosis
WO2008157844A1 (en) * 2007-06-21 2008-12-24 Forest Laboratories Holdings Limited Novel piperazine derivatives as inhibitors of stearoyl-coa desaturase
EP2197873B1 (de) 2007-09-20 2014-07-16 Irm Llc Verbindungen und zusammensetzungen als modulatoren der gpr119-aktivität
GB0722077D0 (en) 2007-11-09 2007-12-19 Smithkline Beecham Corp Compounds
MX2010010242A (es) 2008-03-20 2010-12-06 Forest Lab Holdings Ltd Derivados novedosos de piperazina como inhibidores de la estearoil-coa desaturasa.
RU2010142937A (ru) 2008-03-20 2012-04-27 Форест Лабораториес Холдингс Лимитед (Bm) НОВЫЕ ПРОИЗВОДНЫЕ ПИПЕРИДИНА В КАЧЕСТВЕ ИНГИБИТОРОВ СТЕАРОИЛ-КоА ДЕСАТУРАЗЫ
MX2010014572A (es) 2008-06-27 2011-03-24 Novartis Ag Compuestos organicos.
EP2161580A1 (de) * 2008-09-02 2010-03-10 Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO Biomarker zur Identifizierung von prädispositionierten Patienten zur Entwicklung einer Insulinresistenz und Bestimmung des Insulinresistenzstatus
US20110184027A1 (en) * 2008-09-25 2011-07-28 Glenmark Pharmaceuticals S.A. Tissue selective stearoyl-coa desaturase 1 inhibitors and cell based screening assay for their identification
WO2010075356A1 (en) * 2008-12-23 2010-07-01 Forest Laboratories Holdings Limited Novel piperazine derivatives as inhibitors of stearoyl-coa desaturase
US20120010135A1 (en) 2009-04-01 2012-01-12 Xenon Pharmaceuticals Inc. Spiro derivatives for the modulation of stearoyl-coa desaturase
EP2475367A1 (de) 2009-09-10 2012-07-18 Centre National De La Recherche Scientifique Neuartige stearoyl-coa-desaturase-1-hemmer und ihre verwendung
AU2010302577A1 (en) 2009-10-01 2012-03-15 Novartis Ag Pyrazole derivatives which modulate stearoyl-CoA desaturase
WO2011163560A1 (en) * 2010-06-25 2011-12-29 The U.S.A., As Represented By The Secretary, Department Of Health And Human Services Methods of treatment using sterculic acid
EP2766000A2 (de) * 2011-10-15 2014-08-20 F.Hoffmann-La Roche Ag Scd1-antagonisten zur behandlung von krebs
DE102014005771A1 (de) 2014-04-23 2015-10-29 Clariant International Ltd. Verwendung von wässrigen driftreduzierenden Zusammensetzungen
US11970486B2 (en) 2016-10-24 2024-04-30 Janssen Pharmaceutica Nv Compounds and uses thereof
JP2020514293A (ja) 2017-01-06 2020-05-21 ユマニティ セラピューティクス，インコーポレーテッド 神経障害を治療する方法
CA3083000A1 (en) 2017-10-24 2019-05-02 Yumanity Therapeutics, Inc. Compounds and uses thereof
EP3768269B1 (de) 2018-03-23 2025-08-20 Janssen Pharmaceutica NV Verbindungen und verwendungen davon
MX2021008903A (es) 2019-01-24 2021-11-04 Yumanity Therapeutics Inc Compuestos y usos de los mismos.
EA202192047A1 (ru) 2019-11-13 2021-12-08 Юманити Терапьютикс, Инк. Соединения и их применение
WO2023023227A1 (en) 2021-08-20 2023-02-23 Alexion Pharmaceuticals, Inc. Methods for treating sickle cell disease or beta thalassemia using complement alternative pathway inhibitors
WO2023023220A1 (en) 2021-08-20 2023-02-23 Alexion Pharmaceuticals, Inc. Methods for treating sickle cell disease or beta thalassemia using a complement alternative pathway inhibitor

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3274330D1 (en) * 1982-08-02 1987-01-08 Unitika Ltd An intravenous nutrient
IN164555B (de) 1986-02-14 1989-04-08 Adly Habib Nagy
JP3070611B2 (ja) 1989-03-07 2000-07-31 サントリー株式会社 △▲上５▼―不飽和化酵素阻害剤
US5162179A (en) 1990-04-17 1992-11-10 Armstrong World Industries, Inc. Electrographic structure and process
AU659087B2 (en) * 1990-05-25 1995-05-11 E.I. Du Pont De Nemours And Company Nucleotide sequence of soybean stearoyl-ACP desaturase gene
US5336974A (en) * 1991-12-23 1994-08-09 U.S. Philips Corporation High-pressure discharge lamp
US5554646A (en) 1992-04-29 1996-09-10 Wisconsin Alumni Research Foundation Method for reducing body fat in animals
US5861485A (en) 1994-08-23 1999-01-19 Millennium Pharmaceuticals, Inc. Polypeptides involved in body weight disorders, including obesity
US6162455A (en) 1997-01-22 2000-12-19 American Cyanamid Company Method for increasing lean meat, improving the lean meat to fat ratio and improving amino acid utilization in warm-blooded animals
EP1100489B2 (de) 1997-06-23 2010-08-04 Cornell Research Foundation, Inc. Methode zur änderung der nährmittelzusammenstellung der milch die durch milchspendende tiere abgesonderd wird
EP1100511A2 (de) 1998-06-08 2001-05-23 Sambasiva R. Chavali Inhibierung der delta-9-desaturase wirkung mit saponinen
WO2000009754A2 (en) 1998-08-14 2000-02-24 Johnson & Johnson Consumer Companies, Inc. HUMAN STEAROYL-CoA DESATURASE-RELATED COMPOSITIONS AND METHODS FOR TREATING SKIN DISORDERS
US20030064950A1 (en) 2001-02-23 2003-04-03 Ntambi James M. Methods for reducing body fat and increasing lean body mass by reducing stearoyl-CoA desaturase 1 activity
CA2398940C (en) 2000-02-24 2012-02-21 Xenon Genetics, Inc. Methods and compositions using stearoyl-coa desaturase to identify triglyceride reducing therapeutic agents
EP1966183A4 (de) * 2005-12-20 2010-12-29 Merck Frosst Canada Ltd Heteroaromatische verbindungen als inhibitoren von stearoyl-coenzym a-delta-9-desaturase
TW200826936A (en) * 2006-12-01 2008-07-01 Merck Frosst Canada Ltd Azacycloalkane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase

Also Published As

Publication number Publication date
EP2172560A3 (de) 2010-09-29
US7816075B2 (en) 2010-10-19
AU4722801A (en) 2001-09-03
US7696151B2 (en) 2010-04-13
US20030157552A1 (en) 2003-08-21
US20110060014A1 (en) 2011-03-10
AU2007201711B2 (en) 2009-12-10
US20050256033A1 (en) 2005-11-17
PT1315831E (pt) 2010-11-04
AU2001247228B2 (en) 2007-01-18
US6987001B2 (en) 2006-01-17
CA2398940A1 (en) 2001-08-30
JP2008131939A (ja) 2008-06-12
US20050250160A1 (en) 2005-11-10
US7790408B1 (en) 2010-09-07
AU2010200879A1 (en) 2010-04-01
DE01920143T1 (de) 2004-05-19
AU2007201711A1 (en) 2007-05-10
WO2001062954A2 (en) 2001-08-30
DE60142692D1 (de) 2010-09-09
WO2001062954A3 (en) 2003-03-27
CA2398940C (en) 2012-02-21
EP2172560A2 (de) 2010-04-07
WO2001062954A8 (en) 2002-02-14
DE01920143T9 (de) 2005-04-28
JP2003533978A (ja) 2003-11-18
EP1315831B8 (de) 2010-09-01
AU2010200879B2 (en) 2012-01-19
EP1315831B1 (de) 2010-07-28
EP1315831A2 (de) 2003-06-04

Similar Documents

Publication Publication Date Title
ATE475718T1 (de) Stearoyl-coa-desaturase zur identifizierung von triglyceridreduktionstherapeutika
ATE195527T1 (de) Neue steroidester zur behandlung von hauterkrankungen
DK0606012T3 (da) Sammensætninger indeholdende cholesterylestere af umættede fedtsyrer
EP1360965A4 (de) Verfahren zur behandlung von krankheiten in zusammenhang mit einer abnahme der expression des aop-1-gens oder aop-1 und mittel zur behandlung der krankheiten
DE69625691D1 (de) Verabreichung von peptidylheterocyclen zur behandlung von thrombin in zusammenhang stehenden krankheiten
ATE356113T1 (de) Probucolbernsteinsäureester zur hemmung der expression von vcam-1
TW429145B (en) Pharmaceutical composition for treating schizophrenia, tardive dyskinesia, depression, and alzheimer's disease comprising EPA/SA
BR9905398A (pt) Derivados de fitoesteróis e/ou fitoestanóis
DE69620306D1 (de) 4-(.Alpha.-hydroxy-.alpha.-aryl-alkylcarbonylamino)-Piperidine zur Behandlung und Prophylaxe von Erkrankungen der Harnwege
ATE135208T1 (de) Verwendung von nervonsäure und langkettiger fettsäuren zur behandlung demyelinisierender erkrankungen
DK0774962T3 (da) Anvendelse af DHA i behandlingen af ordblindhed
NO950784D0 (no) Fettsyrederivater
EP1411916A4 (de) Verfahren und materialien für die behandlung des testosteron-mangels bei männern
DE69927147D1 (de) Verwendung von osteoprotegerin zur vorbeugung und behandlung cardiovaskulärer erkrankungen
DE69838509D1 (de) Verwendung von rekombinanten menschlichen uteroglobin zur behandlung von fibrotischen krankheitszuständen
DE69734838D1 (de) Verwendung von zinksalzen der konjugierten linoleinsäuren zur behandlung von hautkrankheiten
NO20030295L (no) Anvendelse av derivater av valproinsyre- og 2- valproensyreamider for behandling av manier ved bipolare lidelser
DE3851971D1 (de) Verwendung antigener Substanzen zur Prophylaxe oder Therapie von Störungen und Krankheiten im Verdauungstrakt von Tieren und Menschen.
ATE269705T1 (de) Verwendung von optisch reinem (r)-tofizopam zur behandlung und pravention von angststörungen
DE69317716D1 (de) Verwendung von Fettsäuren zur Behandlung von abnormalen Verkalkung des Gewebes
DE59900222D1 (de) Verwendung von hyperforin und hyperforinhaltigen extrakten zur behandlung und prophylaxe von demenzerkrankungen
ATE283347T1 (de) Verwendung des pilzes gliocadium catenulatun zur biologischen kontrolle von pflanzenkrankheiten
DE69501352D1 (de) Verfahren zur Herstellung von Essigsäureanhydrid und Essigsäure
DE60329588D1 (de) Verwendung von epa and dha zur sekundären prevention von schlaganfällen
DE60105734D1 (de) Verfahren zur Herstellung von 4-Cyano-4-Oxobuttersäureester und 4-Cyano-3-Hydroxybuttersäureester

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1315831

Country of ref document: EP