ATE195527T1 - Neue steroidester zur behandlung von hauterkrankungen - Google Patents
Neue steroidester zur behandlung von hauterkrankungenInfo
- Publication number
- ATE195527T1 ATE195527T1 AT96930714T AT96930714T ATE195527T1 AT E195527 T1 ATE195527 T1 AT E195527T1 AT 96930714 T AT96930714 T AT 96930714T AT 96930714 T AT96930714 T AT 96930714T AT E195527 T1 ATE195527 T1 AT E195527T1
- Authority
- AT
- Austria
- Prior art keywords
- treatment
- skin diseases
- steroid esters
- new steroid
- esters
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/007—Preparations for dry skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/006—Antidandruff preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Cosmetics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/527,145 US5736537A (en) | 1995-09-12 | 1995-09-12 | Dehydroep:androsterone sailcylate useful against skin atrophy |
PCT/US1996/014247 WO1997010255A1 (en) | 1995-09-12 | 1996-09-05 | Novel steroid esters useful against skin disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE195527T1 true ATE195527T1 (de) | 2000-09-15 |
Family
ID=24100286
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT96930714T ATE195527T1 (de) | 1995-09-12 | 1996-09-05 | Neue steroidester zur behandlung von hauterkrankungen |
Country Status (13)
Country | Link |
---|---|
US (3) | US5736537A (de) |
EP (1) | EP0876391B1 (de) |
AR (1) | AR004683A1 (de) |
AT (1) | ATE195527T1 (de) |
AU (1) | AU712977B2 (de) |
CA (1) | CA2231781C (de) |
CO (1) | CO4770981A1 (de) |
DE (1) | DE69609868T2 (de) |
ES (1) | ES2151180T3 (de) |
HK (1) | HK1015794A1 (de) |
IL (1) | IL123637A (de) |
WO (1) | WO1997010255A1 (de) |
ZA (1) | ZA967704B (de) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5736537A (en) | 1995-09-12 | 1998-04-07 | Estee Lauder, Inc. | Dehydroep:androsterone sailcylate useful against skin atrophy |
EP0908183A1 (de) * | 1997-10-08 | 1999-04-14 | Institute For Advanced Skin Research Inc. | Dehydroepiandrosterone oder ihre Derivate zur Erhöhung des Hyaluronische Saüre-Gehalts der Haut |
US6962904B1 (en) * | 1998-03-13 | 2005-11-08 | Connective Tissue Imagineering | Elastin peptide analogs and uses thereof |
US6809075B1 (en) | 2000-05-30 | 2004-10-26 | Connective Tissue Imagineering Llc | Elastin peptide analogs and uses of same incombination with skin enhancing agents |
KR100302372B1 (ko) * | 1998-07-24 | 2001-12-05 | 박상철 | 골다공증예방및치료제로서의디히드로에피안드로스테론유도체 |
US6777389B1 (en) | 1998-11-19 | 2004-08-17 | Connective Tissue Imagineering Llc | Cosmetic or dermatological use of 7-hydroxylated steroids in combination with elastin derived peptides |
EP1054677B1 (de) * | 1998-11-19 | 2008-10-22 | Connective Tissue Imagineering LLC | Kosmetische oder dermatologische verwendung von 7-hydroxylierten steroiden aleine oder zusammen mit von elastin abgeleiteten peptiden |
EP2322182A1 (de) | 1999-09-30 | 2011-05-18 | Harbor BioSciences, Inc. | Androstenolderivate als Androgenrezeptormodulator |
FR2803514B1 (fr) * | 1999-10-13 | 2004-05-21 | Oreal | Compostion, notamment cosmetique, renfermant un steroide et un filtre uv liposoluble |
FR2799645B1 (fr) * | 1999-10-13 | 2004-04-30 | Oreal | Utilisation de la dhea ou de ses precurseurs ou derives metaboliques comme depigmentant |
FR2803513B1 (fr) * | 2000-01-12 | 2003-12-19 | Oreal | Utilisation de la dhea et/ou de ses precurseurs ou derives pour ameliorer l'aspect papyrace de la peau |
FR2803750B1 (fr) * | 2000-01-17 | 2004-04-02 | Assist Publ Hopitaux De Paris | Utilisation par voie orale de la dehydroepiandrosterone, de ses precurseurs biologiques et de ses derives metaboliques comme anti-atrophiant |
FR2803751B1 (fr) * | 2000-01-17 | 2004-03-12 | Assist Publ Hopitaux De Paris | Utilisation par voie orale de la dehydroepiandrosterone,de ses precurseurs et de ses derives comme agents hydratants a action directe |
DE10007277A1 (de) * | 2000-02-17 | 2001-10-11 | Juergen Thudium | Kajal-Eye-Liner zur Warzenentfernung |
FR2807323A1 (fr) * | 2000-04-10 | 2001-10-12 | Oreal | Composition, notamment cosmetique, renfermant un steroide et un 2-alkyl alcanol ou un ester |
FR2808683B1 (fr) * | 2000-05-15 | 2003-05-23 | Oreal | Utilisation de la dhea et/ou ses precurseurs et derives chimiques et/ou biologiques, dans une composition notamment cosmetique, pour prevenir ou traiter l'atrophie de l'epiderme |
US6794362B1 (en) * | 2000-05-30 | 2004-09-21 | Connective Tissue Imagineering Llc | Asparagine containing elastin peptide analogs |
FR2811567B1 (fr) * | 2000-07-13 | 2003-01-17 | Oreal | Composition, notamment cosmetique, comprenant la dhea et/ou un precurseur ou derive de celle-ci, en association avec au moins un inhibiteur de no-synthase |
FR2811561B1 (fr) * | 2000-07-13 | 2003-03-21 | Oreal | Composition, notamment cosmetique, renfermant la dhea et/ou un precurseur ou derive chimique ou biologique de celle-ci, et un inhibiteur de metalloproteinase |
US6399084B1 (en) * | 2001-03-05 | 2002-06-04 | Humanetics Corporation | Method for diminishing wrinkles and fine lines of the skin by the topical application of Δ5-androstene-3β-ol-7, 17 dione and metabolizable precursors thereof |
US6399085B1 (en) * | 2001-03-05 | 2002-06-04 | Humanetics Corporation | Method of moisturizing the skin by the topical application of Δ5-androstene-3β-ol-7,17 dione and metabolizable precursors thereof |
WO2002096374A2 (en) * | 2001-05-31 | 2002-12-05 | Upsher-Smith Laboratories, Inc. | Dermatological compositions and methods comprising alpha-hydroxy acids or derivatives |
ES2320103T3 (es) * | 2001-06-26 | 2009-05-19 | L'oreal | Composiciones que comprenden un compuesto de baja solubilidad y un derivado lipofilo de acido aminado, utilizaciones y procedimientos correspondientes. |
FR2826272B1 (fr) * | 2001-06-26 | 2005-02-18 | Oreal | Composition contenant de la dhea ou un derive de la dhea et un derive lipophile d'acide amine |
WO2003013548A1 (fr) * | 2001-08-09 | 2003-02-20 | Sekisui Chemical Co., Ltd. | Composition medicale a usage externe destinee au traitement des dermatoses |
FR2832928B1 (fr) * | 2001-11-30 | 2004-02-06 | Dermo Cosmologie Lab De | Composition a base d'ester de diosgenine applicable par voie topique |
US6962940B2 (en) | 2002-03-20 | 2005-11-08 | Celgene Corporation | (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof |
FR2847467B1 (fr) * | 2002-11-25 | 2006-05-26 | Oreal | UTILISATION D'UN AGENT MODULATEUR DE L'ACTIVITE DE L'OXYSTEROL 7alpha-HYDROXYLASE POUR LE TRAITEMENT COSMETIQUE DE DESORDRES CUTANES |
FR2853318A1 (fr) * | 2003-04-07 | 2004-10-08 | Mayoly Spindler | Nouveaux procedes de preparation de derives de la dhea |
TW200522932A (en) * | 2003-09-15 | 2005-07-16 | Combinatorx Inc | Methods and reagents for the treatment of diseases and disorders associated with increased levels of proinflammatory cytokines |
RS20070185A (en) * | 2004-11-01 | 2008-09-29 | Endorecherche Inc., | Use of androgens to reduce the likelihood of acquiring or to treat skin aging |
CN100415709C (zh) * | 2006-05-15 | 2008-09-03 | 西北大学 | β-(3,4-二羟基苯基)-α-羟基丙酸冰片酯、其合成方法和用途 |
JP2011516585A (ja) * | 2008-04-15 | 2011-05-26 | イマネンス・インテグラル・デルモ・コレクション・インコーポレーテッド | スキンケア組成物およびその使用方法 |
FR2931064B1 (fr) | 2008-05-14 | 2010-08-13 | Oreal | Composition cosmetique contenant un derive de dibenzoylmethane et un derive de pyrrolidinone; procede de photostabilisation du derive de dibenzoylmethane |
FR2939309B1 (fr) | 2008-12-08 | 2010-12-17 | Oreal | Utilisation d'un derive ester de 2-pyrrolidinone 4-carboxy comme solvant dans les compositions cosmetiques ; compositions cosmetiques les contenant |
FR2939799B1 (fr) | 2008-12-11 | 2011-03-11 | Sederma Sa | Composition cosmetique comprenant des oligoglucuronanes acetyles. |
WO2010082177A2 (en) | 2009-01-16 | 2010-07-22 | Sederma | New compounds, in particular peptides, compositions comprising them and cosmetic and dermopharmaceutical uses |
FR2941232B1 (fr) | 2009-01-16 | 2014-08-08 | Sederma Sa | Nouveaux peptides, compositions les comprenant et utilisations cosmetiques et dermo-pharmaceutiques. |
FR2941231B1 (fr) | 2009-01-16 | 2016-04-01 | Sederma Sa | Nouveaux peptides, compositions les comprenant et utilisations cosmetiques et dermo-pharmaceutiques. |
FR2944435B1 (fr) | 2009-04-17 | 2011-05-27 | Sederma Sa | Composition cosmetique comprenant de l'oridonine |
FR2945939B1 (fr) | 2009-05-26 | 2011-07-15 | Sederma Sa | Utilisation cosmetique du dipeptide tyr-arg pour lutter contre le relachement cutane. |
FR2972346B1 (fr) | 2011-03-09 | 2013-11-08 | Oreal | Utilisation d'un derive diester d'acide 2-methyl succinique comme solvant dans les compositions cosmetiques ; compositions cosmetiques les contenant |
WO2012134446A1 (en) * | 2011-03-29 | 2012-10-04 | SUTTER WEST BAY HOSPITALS doing business as CALIFORNIA PACIFIC MEDICAL CENTER | Epiandrosterone and/or androsterone derivatives and method of use thereof |
FR2996133B1 (fr) | 2012-10-02 | 2015-06-26 | Oreal | Nouvelles utilisations cosmetiques de polymeres dispersants en association avec au moins un actif |
US9879045B2 (en) | 2013-05-21 | 2018-01-30 | Dr. Reddy's Laboratories Limited | Processes for the preparation of dehydroepiandrosterone and its intermediates |
DE112014004733A5 (de) | 2013-10-15 | 2016-07-14 | Chelac Holding Gmbh | Steroid-Carbonsäureester, Zusammensetzungen, enthaltend Steroid-Carbonsäureester und Verwendung dieser bei lokal topischer Applikation für kosmetische oder dermatologische Zwecke |
US20160362442A1 (en) * | 2015-06-10 | 2016-12-15 | IronMag Labs | Method For DHEA Enanthate Processing |
GB202101299D0 (en) | 2020-06-09 | 2021-03-17 | Avacta Life Sciences Ltd | Diagnostic polypetides and methods |
Family Cites Families (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE788897A (fr) * | 1971-09-17 | 1973-03-15 | Schering Ag | Medicament a base d'esters de dehydroepiandrosterone |
US3879537A (en) * | 1973-09-04 | 1975-04-22 | Scott Eugene J Van | Treatment of ichthyosiform dermatoses |
US3988470A (en) * | 1974-02-25 | 1976-10-26 | Scott Eugene J Van | Treatment of palmar and plant disturbed keratosis |
US3984566A (en) * | 1974-02-25 | 1976-10-05 | Scott Eugene J Van | Method of alleviating the symptoms of dandruff |
US4105782A (en) * | 1975-03-07 | 1978-08-08 | Yu Ruey J | Treatment of acne and dandruff |
US4380549A (en) * | 1975-07-23 | 1983-04-19 | Scott Eugene J Van | Topical treatment of dry skin |
US4363815A (en) * | 1975-07-23 | 1982-12-14 | Yu Ruey J | Alpha hydroxyacids, alpha ketoacids and their use in treating skin conditions |
US4197316A (en) * | 1975-07-23 | 1980-04-08 | Scott Eugene J Van | Treatment of dry skin |
US4021572A (en) * | 1975-07-23 | 1977-05-03 | Scott Eugene J Van | Prophylactic and therapeutic treatment of acne vulgaris utilizing lactamides and quaternary ammonium lactates |
DE2656015A1 (de) * | 1976-12-10 | 1978-06-15 | Bbc Brown Boveri & Cie | Verfahren zum herstellen von halbleiterbauelementen |
US4194007A (en) * | 1978-01-13 | 1980-03-18 | Scott Eugene J Van | α-Hydroxyretinoic acid, α-ketoretinoic acid and mixtures and their use in treating skin conditions |
US4234599A (en) * | 1978-10-04 | 1980-11-18 | Scott Eugene J Van | Treatment of skin keratoses with α-hydroxy acids and related compounds |
US4246261A (en) * | 1979-08-09 | 1981-01-20 | Scott Eugene J Van | Additives enhancing topical corticosteroid action |
US4542129A (en) * | 1982-08-16 | 1985-09-17 | Norman Orentreich | DHEA Formulations and methods for treating dry skin |
US4496556A (en) * | 1982-08-16 | 1985-01-29 | Norman Orentreich | Topical applications for preventing dry skin |
DE3485647D1 (de) * | 1983-08-02 | 1992-05-21 | Research Corp | Steroide und diese enthaltende therapeutische zusammensetzungen. |
JPS60161912A (ja) * | 1984-02-01 | 1985-08-23 | Kanebo Ltd | 皮膚化粧料 |
US4628052A (en) * | 1985-05-28 | 1986-12-09 | Peat Raymond F | Pharmaceutical compositions containing dehydroepiandrosterone and other anesthetic steroids in the treatment of arthritis and other joint disabilities |
EP0210665B1 (de) * | 1985-08-02 | 1989-10-18 | Research Corporation | Steroide zur Verwendung als Mittel gegen Krebs, Fettsucht, Hyperglyzemie, autoimmune Krankheit und Hypercholesterolemie |
EP0230574A3 (de) * | 1986-01-31 | 1989-03-22 | Yale University | Pharmazeutische Zusammensetzungen gegen durch LAV/HTLV-III-Virus verursachte Infektionen und ihre Verwendung |
US5091171B2 (en) * | 1986-12-23 | 1997-07-15 | Tristrata Inc | Amphoteric compositions and polymeric forms of alpha hydroxyacids and their therapeutic use |
DE3862405D1 (de) * | 1987-03-09 | 1991-05-23 | Alza Corp | Zusammensetzung zur vorbeugung einer kontaktallergie durch gleichzeitiges verabreichen eines kortikosteroids mit einem sensiblisierenden arzneistoff. |
NL194728C (nl) * | 1987-04-16 | 2003-01-07 | Hollis Eden Pharmaceuticals | Farmaceutisch preparaat geschikt voor de profylaxe of therapie van een retrovirale infectie of een complicatie of gevolg daarvan. |
JPS6440428A (en) * | 1987-08-07 | 1989-02-10 | Daiichi Yakuhin Sangyo Kk | Antihyperlipemia |
US5232917A (en) * | 1987-08-25 | 1993-08-03 | University Of Southern California | Methods, compositions, and compounds for allosteric modulation of the GABA receptor by members of the androstane and pregnane series |
US4898694A (en) * | 1987-11-25 | 1990-02-06 | Schwartz Arthur G | 17-Hydroxy-steroids |
US5001119A (en) * | 1987-11-25 | 1991-03-19 | Schwartz Arthur G | 16-substituted androstanes and 16-substituted androstenes |
US5028631A (en) * | 1987-11-25 | 1991-07-02 | Schwartz Arthur G | Homoandrostan-17-one and homoandrosten-17-ones |
US5227907A (en) * | 1988-11-03 | 1993-07-13 | Ascom Tech Ag | Method and device for decentralized transmission of data on a transmission line |
US5262407A (en) * | 1988-12-16 | 1993-11-16 | L'oreal | Use of salicylic derivatives for the treatment of skin aging |
US4920115A (en) * | 1988-12-28 | 1990-04-24 | Virginia Commonwealth University | Method of lowering LDL cholesterol in blood |
US5077284A (en) * | 1988-12-30 | 1991-12-31 | Loria Roger M | Use of dehydroepiandrosterone to improve immune response |
US5407684A (en) * | 1988-12-30 | 1995-04-18 | Virginia Commonwealth University | Use of DHEA as a medicinal |
DK0494224T3 (da) * | 1989-09-25 | 2000-08-07 | Univ Utah Res Found | Anvendelse af steroidhormoner i sammensætninger til induktion af T-cellelymfokinproduktion |
US5518725A (en) * | 1989-09-25 | 1996-05-21 | University Of Utah Research Foundation | Vaccine compositions and method for induction of mucosal immune response via systemic vaccination |
US5162198A (en) * | 1991-02-08 | 1992-11-10 | Virginia Commonwealth University | Method of using dehydroepiandrosterone and dehydroepiandrosterone-sulfate as inhibitors of thrombuxane production and platelet aggregation |
US5110810A (en) * | 1991-02-08 | 1992-05-05 | Virginia Commonwealth University | Method of using dehydroepiandrosterone and dehydroepiandrosterone-sulfate as inhibitors of platelet aggregation |
US5254343A (en) * | 1991-03-19 | 1993-10-19 | Bristol-Myers Squibb Company | Reduction of cutaneous atrophy |
US5206008A (en) * | 1991-04-15 | 1993-04-27 | Virginia Commonwealth University | Enhancement of immune response |
WO1993010756A1 (en) * | 1991-11-25 | 1993-06-10 | Richardson-Vicks, Inc. | Use of salicylic acid for regulating skin wrinkles and/or skin atrophy |
CA2134228A1 (en) * | 1992-05-01 | 1993-11-11 | Raymond A. Daynes | Compositions and methods for regulating il-6 production in vivo |
SK103195A3 (en) * | 1993-03-09 | 1996-12-04 | Univ Utah Res Found | Use of dehydroepiandrosterone derivative for pharmaceutical compositions production and pharmaceutical composition containing dehydroepiandrosterone derivative |
US5387583A (en) * | 1993-04-20 | 1995-02-07 | Loria; Roger M. | Compositions containing corticosteroids or analogues thereof and corticosteroid buffering effective amounts of 5-androstene 3B, 17B or 5-androstene 3B, 7B, 17B triol or analogues thereof |
US5736537A (en) | 1995-09-12 | 1998-04-07 | Estee Lauder, Inc. | Dehydroep:androsterone sailcylate useful against skin atrophy |
-
1995
- 1995-09-12 US US08/527,145 patent/US5736537A/en not_active Expired - Fee Related
-
1996
- 1996-09-05 ES ES96930714T patent/ES2151180T3/es not_active Expired - Lifetime
- 1996-09-05 DE DE69609868T patent/DE69609868T2/de not_active Expired - Fee Related
- 1996-09-05 WO PCT/US1996/014247 patent/WO1997010255A1/en active IP Right Grant
- 1996-09-05 AU AU69669/96A patent/AU712977B2/en not_active Ceased
- 1996-09-05 EP EP96930714A patent/EP0876391B1/de not_active Expired - Lifetime
- 1996-09-05 IL IL12363796A patent/IL123637A/xx not_active IP Right Cessation
- 1996-09-05 AT AT96930714T patent/ATE195527T1/de not_active IP Right Cessation
- 1996-09-05 CA CA002231781A patent/CA2231781C/en not_active Expired - Fee Related
- 1996-09-12 CO CO96048732A patent/CO4770981A1/es unknown
- 1996-09-12 ZA ZA967704A patent/ZA967704B/xx unknown
- 1996-09-12 AR ARP960104328A patent/AR004683A1/es unknown
-
1998
- 1998-01-16 US US09/008,444 patent/US6025347A/en not_active Expired - Fee Related
-
1999
- 1999-02-15 HK HK99100660A patent/HK1015794A1/xx not_active IP Right Cessation
-
2000
- 2000-01-26 US US09/491,710 patent/US6284750B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE69609868D1 (de) | 2000-09-21 |
US6025347A (en) | 2000-02-15 |
IL123637A0 (en) | 1998-10-30 |
AU6966996A (en) | 1997-04-01 |
CO4770981A1 (es) | 1999-04-30 |
EP0876391A4 (de) | 1998-12-30 |
ZA967704B (en) | 1997-05-27 |
HK1015794A1 (en) | 1999-10-22 |
ES2151180T3 (es) | 2000-12-16 |
IL123637A (en) | 2003-03-12 |
US6284750B1 (en) | 2001-09-04 |
CA2231781C (en) | 2005-07-12 |
CA2231781A1 (en) | 1997-03-20 |
EP0876391A1 (de) | 1998-11-11 |
AU712977B2 (en) | 1999-11-18 |
EP0876391B1 (de) | 2000-08-16 |
AR004683A1 (es) | 1999-03-10 |
DE69609868T2 (de) | 2001-03-15 |
WO1997010255A1 (en) | 1997-03-20 |
US5736537A (en) | 1998-04-07 |
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