CY1118206T1 - Φαρμακευτικη συνθεση για δερματικη χρηση για να θεραπευεται ψωριαση που περιλαμβανει καλσιποτριολη και βηταμεθαζονη - Google Patents

Φαρμακευτικη συνθεση για δερματικη χρηση για να θεραπευεται ψωριαση που περιλαμβανει καλσιποτριολη και βηταμεθαζονη

Info

Publication number
CY1118206T1
CY1118206T1 CY20161101042T CY161101042T CY1118206T1 CY 1118206 T1 CY1118206 T1 CY 1118206T1 CY 20161101042 T CY20161101042 T CY 20161101042T CY 161101042 T CY161101042 T CY 161101042T CY 1118206 T1 CY1118206 T1 CY 1118206T1
Authority
CY
Cyprus
Prior art keywords
kalipipotriol
bethamethasone
medicinal composition
therapy containing
leather use
Prior art date
Application number
CY20161101042T
Other languages
English (en)
Inventor
Erik Didriksen
Gert Høy
Original Assignee
Leo Pharma A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8094933&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1118206(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Leo Pharma A/S filed Critical Leo Pharma A/S
Publication of CY1118206T1 publication Critical patent/CY1118206T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Η παρούσα εφεύρεση αφορά σε μία φαρμακευτική σύνθεση για δερματική χρήση, η εν λόγω δε σύνθεση περιλαμβάνει ένα πρώτο φαρμακολογικώς δραστικό συστατικό Α που συνίσταται από τουλάχιστον μία βιταμίνη D ή ανάλογο βιταμίνης D και ένα δεύτερο φαρμακολογικώς δραστικό συστατικό Β που συνίσταται από τουλάχιστον ένα κορτικοστεροειδές.
CY20161101042T 1999-04-23 2016-10-19 Φαρμακευτικη συνθεση για δερματικη χρηση για να θεραπευεται ψωριαση που περιλαμβανει καλσιποτριολη και βηταμεθαζονη CY1118206T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA199900561 1999-04-23
EP00901483.8A EP1178808B2 (en) 1999-04-23 2000-01-27 Non-aqueous pharmaceutical composition for dermal use to treat psoriasis comprising a vitamin d, a corticosteroid and a solvent component

Publications (1)

Publication Number Publication Date
CY1118206T1 true CY1118206T1 (el) 2017-06-28

Family

ID=8094933

Family Applications (5)

Application Number Title Priority Date Filing Date
CY20121100676T CY1113967T1 (el) 1999-04-23 2012-07-31 Μη-υδατικη φαρμακευτικη συνθεση για δερματικη χρηση για να θεραπευεται ψωριαση περιλαμβανουσα βιταμινη d, κορτικοστεροειδες και ενα συστατικο διαλυτη
CY20131100822T CY1114420T1 (el) 1999-04-23 2013-09-19 Φαρμακευτικη συνθεση για δερματικη χρηση που περιλαμβανει καλσιποτριολη και βηταμεθαζονη για την αγωγη της ψωριασης
CY20161101042T CY1118206T1 (el) 1999-04-23 2016-10-19 Φαρμακευτικη συνθεση για δερματικη χρηση για να θεραπευεται ψωριαση που περιλαμβανει καλσιποτριολη και βηταμεθαζονη
CY20181100600T CY1120313T1 (el) 1999-04-23 2018-06-08 Φαρμακευτικη συνθεση για δερματικη χρηση για να θεραπευεται ψωριαση που περιλαμβανει βιταμινη d και κορτικοστεοειδες
CY181100924T CY1120659T1 (el) 1999-04-23 2018-09-04 Αλοιφες για την τοπικη θεραπεια ψωριασης

Family Applications Before (2)

Application Number Title Priority Date Filing Date
CY20121100676T CY1113967T1 (el) 1999-04-23 2012-07-31 Μη-υδατικη φαρμακευτικη συνθεση για δερματικη χρηση για να θεραπευεται ψωριαση περιλαμβανουσα βιταμινη d, κορτικοστεροειδες και ενα συστατικο διαλυτη
CY20131100822T CY1114420T1 (el) 1999-04-23 2013-09-19 Φαρμακευτικη συνθεση για δερματικη χρηση που περιλαμβανει καλσιποτριολη και βηταμεθαζονη για την αγωγη της ψωριασης

Family Applications After (2)

Application Number Title Priority Date Filing Date
CY20181100600T CY1120313T1 (el) 1999-04-23 2018-06-08 Φαρμακευτικη συνθεση για δερματικη χρηση για να θεραπευεται ψωριαση που περιλαμβανει βιταμινη d και κορτικοστεοειδες
CY181100924T CY1120659T1 (el) 1999-04-23 2018-09-04 Αλοιφες για την τοπικη θεραπεια ψωριασης

Country Status (30)

Country Link
US (1) US6753013B1 (el)
EP (5) EP1178808B2 (el)
JP (4) JP4426729B2 (el)
KR (1) KR100694526B1 (el)
CN (1) CN1173703C (el)
AU (1) AU774600B2 (el)
BG (1) BG65115B1 (el)
BR (3) BRPI0009956B8 (el)
CA (1) CA2370565C (el)
CY (5) CY1113967T1 (el)
CZ (1) CZ303142B6 (el)
DK (5) DK2455083T3 (el)
ES (5) ES2432691T3 (el)
HK (1) HK1045650B (el)
HR (1) HRP20010779B1 (el)
HU (1) HU230045B1 (el)
IL (2) IL145983A0 (el)
IS (1) IS6120A (el)
LT (2) LT2915534T (el)
ME (1) ME00298B (el)
MX (1) MXPA01010676A (el)
NO (1) NO329486B1 (el)
NZ (1) NZ515142A (el)
PL (1) PL199123B1 (el)
PT (5) PT2450043T (el)
RS (1) RS52182B (el)
RU (1) RU2238734C2 (el)
SI (3) SI3146969T1 (el)
SK (1) SK287653B6 (el)
WO (1) WO2000064450A1 (el)

Families Citing this family (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8263580B2 (en) * 1998-09-11 2012-09-11 Stiefel Research Australia Pty Ltd Vitamin formulation
BRPI0009956B8 (pt) 1999-04-23 2021-07-06 Leo Pharm Prod Ltd Composição farmacêutica não aquosa para uso dermatológico compreendendo calcipotriol e betametasona, e, uso da mesma
US20090098065A1 (en) * 2000-01-11 2009-04-16 Avikam Harel Composition and methods for the treatment of skin disorders
PT1330468E (pt) * 2000-09-18 2007-09-13 Serono Lab Análogos de enxofre de 21-hidroxi-6, 19-oxidoprogesterona ( 21oh-60p) para tratar excesso de glucocorticóides.
DK1331927T3 (da) 2000-10-27 2008-05-05 Leo Pharma As Topisk komposition der indeholder mindst et D-vitamin eller en D-vitamin analog og mindst et kosttikosteroid
US20090143328A1 (en) * 2001-08-13 2009-06-04 Mcdonald George Method of Treating Cancer by Administration of Topical Active Corticosteroids
US20030175314A1 (en) * 2001-11-19 2003-09-18 Didriksen Erik Johannes Pharmaceutical composition for dermal application
IL152486A0 (en) 2002-10-25 2003-05-29 Meir Eini Alcohol-free cosmetic and pharmaceutical foam carrier
US7704518B2 (en) 2003-08-04 2010-04-27 Foamix, Ltd. Foamable vehicle and pharmaceutical compositions thereof
US7700076B2 (en) 2002-10-25 2010-04-20 Foamix, Ltd. Penetrating pharmaceutical foam
US8900554B2 (en) 2002-10-25 2014-12-02 Foamix Pharmaceuticals Ltd. Foamable composition and uses thereof
US20080138296A1 (en) 2002-10-25 2008-06-12 Foamix Ltd. Foam prepared from nanoemulsions and uses
NZ540166A (en) 2002-10-25 2007-06-29 Foamix Ltd Cosmetic and pharmaceutical foam
US9265725B2 (en) 2002-10-25 2016-02-23 Foamix Pharmaceuticals Ltd. Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof
US7820145B2 (en) 2003-08-04 2010-10-26 Foamix Ltd. Oleaginous pharmaceutical and cosmetic foam
US20080031907A1 (en) * 2002-10-25 2008-02-07 Foamix Ltd. Cosmetic and pharmaceutical foam
US9668972B2 (en) 2002-10-25 2017-06-06 Foamix Pharmaceuticals Ltd. Nonsteroidal immunomodulating kit and composition and uses thereof
US10117812B2 (en) * 2002-10-25 2018-11-06 Foamix Pharmaceuticals Ltd. Foamable composition combining a polar solvent and a hydrophobic carrier
US20050101576A1 (en) * 2003-11-06 2005-05-12 Novacea, Inc. Methods of using vitamin D compounds in the treatment of myelodysplastic syndromes
US7351869B2 (en) * 2002-11-18 2008-04-01 Teva Pharmaceutical Industries Ltd Crystallization method for purification of calcipotriene
FR2848454B1 (fr) * 2002-12-17 2007-03-30 Galderma Res & Dev Composition pharmaceutique comprenant une association de calcitriol et d'un corticosteroide
EP1875916A3 (en) * 2002-12-17 2008-01-23 Galderma S.A. Pharmaceutical composition comprising a combination of calcitriol and clobetasol propionate
RU2361594C2 (ru) * 2002-12-17 2009-07-20 Галдерма Са Фармацевтические композиции, включающие комбинацию кальцитриола и клобетазола пропионат
JP2004359585A (ja) * 2003-06-03 2004-12-24 Medorekkusu:Kk 被膜形成型の副腎皮質ステロイド薬含有外用製剤
FR2856301B1 (fr) 2003-06-23 2007-08-03 Galderma Res & Dev Composition sous forme de spray comprenant un actif pharmaceutique, au moins un silicone volatile et une phase non polaire non volatile
US8795693B2 (en) 2003-08-04 2014-08-05 Foamix Ltd. Compositions with modulating agents
AR045241A1 (es) * 2003-08-12 2005-10-19 Novartis Consumer Health Sa Composicion topica que comprende terbinafina e hidrocortisona
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
US8404667B2 (en) * 2006-12-29 2013-03-26 Wisconsin Alumni Research Foundation Compounds, compositions, kits and methods of use to orally and topically treat acne and other skin conditions by 19-Nor vitamin D analog
EP1748784A4 (en) * 2004-05-26 2008-02-13 Cedars Sinai Medical Center INDUCTION OF IMMUNITY IN VITAMIN D3 AND ITS ANALOGUES
FR2871694B1 (fr) * 2004-06-17 2008-07-04 Galderma Sa Composition pharmaceutique comprenant un onguent oleagineux et deux principes actifs solubilises
FR2871698B1 (fr) * 2004-06-17 2008-07-04 Galderma Sa Composition sous forme de spray comprenant une association d'actifs pharmaceutiques et une phase huileuse
FR2871699A1 (fr) * 2004-06-17 2005-12-23 Galderma Sa Composition de type emulsion inverse contenant du calcitrol et du 17-propionate de clobetasol, et ses utilisations en cosmetiques et en dermatologie
ATE376834T1 (de) 2004-06-17 2007-11-15 Galderma Sa Zusammensetzung in sprayform mit einer kombination aus clobetasolpropionat und calcitriol, einer alkoholphase und ölphase
JP2008502645A (ja) * 2004-06-17 2008-01-31 ガルデルマ・ソシエテ・アノニム 油性相中にコルチコイドとビタミンｄ誘導体との組み合わせを含むスプレー形態の組成物
FR2871696B1 (fr) * 2004-06-17 2006-11-10 Galderma Sa Composition topique pour le traitement du psoriasis
AU2005253735A1 (en) * 2004-06-17 2005-12-29 Galderma S.A. Composition for the treatment of psoriasis comprising a silicone agent, a corticosteroid and vitamin D or a derivative thereof
FR2871693B1 (fr) * 2004-06-17 2006-08-25 Galderma Sa Utilisation d'une composition pharmaceutique comprenant du calcitriol et du propionate de clobetasol pour le traitement du psoriasis
FR2871695B1 (fr) * 2004-06-17 2008-07-04 Galderma Sa Composition pharmaceutique comprenant un agent silicone et deux principes actifs solubilises
FR2871700B1 (fr) * 2004-06-17 2006-11-17 Galderma Sa Composition sous forme de spray comprenant une association d'actifs pharmaceutiques, une phase alcoolique, et une phase huileuse
FR2871697B1 (fr) * 2004-06-17 2007-06-29 Galderma Sa Composition sous forme de spray comprenant une association d'actifs pharmaceutiques, une phase alcoolique, au moins un silicone volatile et une phase huileuse non volatile
JP2006131544A (ja) * 2004-11-05 2006-05-25 Medorekkusu:Kk 皮膚疾患治療用外用剤
NZ555281A (en) * 2004-11-22 2011-01-28 Wisconsin Alumni Res Found 2-methylene-19,26,27-trinor-(20s)-1alpha-alpha-hydroxyvitamin D3 and its uses
EP1874320A1 (en) * 2005-04-19 2008-01-09 Galderma S.A. Composition of film-forming solution type, comprising vitamin d or a derivative thereof and a corticosteroid, and use thereof in dermatology
FR2884419B1 (fr) * 2005-04-19 2007-06-22 Galderma Sa Composition de type solution filmogene comprenant de la vitamine d ou un de ses derives et un corticosteroide, et son utilisation en dermatologie
CN101193641B (zh) * 2005-05-10 2013-05-29 德米普瑟尔有限公司 用于治疗表皮过度增殖疾病的组合物和方法
CN101217868A (zh) * 2005-05-10 2008-07-09 德米普瑟尔有限公司 用于皮肤护理的组合物和方法
NZ563560A (en) * 2005-06-01 2009-11-27 Stiefel Res Australia Pty Ltd Vitamin formulation for treating a dermatological skin disorder
US20080152596A1 (en) * 2005-07-19 2008-06-26 Foamix Ltd. Polypropylene glycol foamable vehicle and pharmaceutical compositions thereof
DE06722936T8 (de) 2006-03-17 2008-06-05 Leo Pharma A/S Isomerisation pharmazeutischer zwischenprodukte
MX2009002337A (es) * 2006-08-29 2009-03-20 Teva Pharma Composiciones farmacologicamente estables que incluyen compuestos que contienen vitamina d y corticosteroides con compatibilidad con bajo ph.
NZ575159A (en) * 2006-09-28 2012-04-27 Wisconsin Alumni Res Found 2-methylene-(20s,25s)-19,27-dinor-(22e)-vitamin d analogs
CA2662992A1 (en) * 2006-09-28 2008-04-03 Wisconsin Alumni Research Foundation 2-methylene-(20r,25s)-19,27-dinor-(22e)-vitamin d analogs
US20080260655A1 (en) 2006-11-14 2008-10-23 Dov Tamarkin Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses
FR2909284B1 (fr) * 2006-11-30 2012-09-21 Galderma Sa Nouvelles compositions sous forme d'onguent sans vaseline comprenant un derive de vitamine d et eventuellement un anti-inflammatoire steroidien
ES2272198B1 (es) * 2006-12-28 2008-06-01 Laboratorios Viñas S.A. Procedimiento para la obtencion de hidrato de calcipotriol.
EP1970048A1 (en) * 2007-03-15 2008-09-17 Drug Delivery Solutions Limited Polyaphron topical composition with vitamin D
US10265265B2 (en) 2007-03-15 2019-04-23 Drug Delivery Solutions Limited Topical composition
EP1970049A1 (en) * 2007-03-15 2008-09-17 Drug Delivery Solutions Limited Polyaphron topical composition with vitamin D and corticosteroid
EP2008651A1 (en) 2007-06-26 2008-12-31 Drug Delivery Solutions Limited A bioerodible patch
HU227970B1 (en) 2007-07-10 2012-07-30 Egis Gyogyszergyar Nyrt Pharmaceutical compositions containing silicones of high volatility
US8636982B2 (en) 2007-08-07 2014-01-28 Foamix Ltd. Wax foamable vehicle and pharmaceutical compositions thereof
US9439857B2 (en) * 2007-11-30 2016-09-13 Foamix Pharmaceuticals Ltd. Foam containing benzoyl peroxide
WO2009090495A2 (en) 2007-12-07 2009-07-23 Foamix Ltd. Oil and liquid silicone foamable carriers and formulations
US20090192228A1 (en) * 2008-01-28 2009-07-30 Actavis Group Ptc Ehf Controlled-Release Tolterodine Compositions and Methods
PE20110849A1 (es) * 2008-10-03 2011-12-02 Nexmed Holdings Inc Composicion estabilizada para el tratamiento de la psoriasis
CA2760186C (en) 2009-04-28 2019-10-29 Foamix Ltd. Foamable vehicle and pharmaceutical compositions comprising aprotic polar solvents and uses thereof
WO2010129062A1 (en) * 2009-05-07 2010-11-11 Jason Carbol Pharmaceutical composition including a corticosteroid and a vitamin d analog having improved stability
CA2769677A1 (en) 2009-07-29 2011-02-03 Foamix Ltd. Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses
WO2011013009A2 (en) 2009-07-29 2011-02-03 Foamix Ltd. Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses
US20110053898A1 (en) * 2009-08-26 2011-03-03 Glenmark Generics Ltd Topical composition comprising vitamin d analogue and corticosteroids
UA118087C2 (uk) 2009-10-01 2018-11-26 Адер Фармасьютікалз, Інк. Композиція кортикостероїду, застосована перорально
BR112012007473A2 (pt) 2009-10-02 2019-05-07 Foamix Ltd composições tópicas de tetraciclina e respectivo método de uso
US9849142B2 (en) 2009-10-02 2017-12-26 Foamix Pharmaceuticals Ltd. Methods for accelerated return of skin integrity and for the treatment of impetigo
EP2515866B1 (en) * 2009-12-22 2014-02-19 Leo Pharma A/S Pharmaceutical composition comprising solvent mixture and a vitamin d derivative or analogue
RS53809B1 (en) 2010-06-11 2015-06-30 Leo Pharma A/S PHARMACEUTICAL COMPOSITION SKIN SPRAY CONTAINING VITAMIN D ANALYSIS AND CORTICOSTEROID
US8968755B2 (en) 2010-10-23 2015-03-03 Joel Schlessinger Topical base and active agent-containing compositions, and methods for improving and treating skin
US8685381B2 (en) 2010-10-23 2014-04-01 Joel Schlessinger Topical base and active agent-containing compositions, and methods for improving and treating skin
SI2686017T1 (sl) 2011-03-14 2019-11-29 Drug Delivery Solutions Ltd Očesna sestava
US11154535B2 (en) 2012-07-31 2021-10-26 Egis Pharmaceuticals Plc Transdermal formulation containing COX inhibitors
US10045935B2 (en) 2012-07-31 2018-08-14 Egis Pharmaceuticals Plc Transdermal formulation containing COX inhibitors
CN103110648A (zh) * 2013-01-25 2013-05-22 江苏圣宝罗药业有限公司 钙泊三醇倍他米松软膏及其制备方法
CN110128370A (zh) 2013-01-29 2019-08-16 埃维克辛公司 抗炎症和抗肿瘤的2-氧代噻唑类和2-氧代噻吩类化合物
WO2015034678A2 (en) 2013-09-06 2015-03-12 Aptalis Pharmatech, Inc. Corticosteroid containing orally disintegrating tablet compositions for eosinophilic esophagitis
CN104666312B (zh) * 2015-02-12 2017-11-07 重庆华邦制药有限公司 含有卡泊三醇和二丙酸倍他米松的制剂
MA41818A (fr) * 2015-03-27 2018-01-30 Leo Pharma As Timbre à micro-aiguilles pour administration d'un principe actif à la peau
TW201636025A (zh) * 2015-04-15 2016-10-16 Maruho Kk 皮膚用之醫藥組成物
KR101641372B1 (ko) * 2015-05-08 2016-07-20 (주)동구바이오제약 안정성과 피부투과율이 향상된 약학 조성물
CN107157918B (zh) * 2016-03-08 2019-12-27 上海通用药业股份有限公司 一种用于银屑病治疗的半固体制剂的制备方法
CN107157920B (zh) * 2016-03-08 2019-12-27 上海通用药业股份有限公司 一种包含维生素d或其衍生物的半固体制剂的制备方法
CN107157917B (zh) * 2016-03-08 2019-12-27 上海通用药业股份有限公司 一种用于治疗银屑病的软膏的制备方法
CN107157919B (zh) * 2016-03-08 2019-12-27 上海通用药业股份有限公司 一种用于治疗银屑病的半固体制剂的制备方法
GB201604318D0 (en) 2016-03-14 2016-04-27 Avexxin As Combination therapy
TWI777515B (zh) 2016-08-18 2022-09-11 美商愛戴爾製藥股份有限公司 治療嗜伊紅性食道炎之方法
CA2978573A1 (en) 2016-09-08 2018-03-08 Foamix Pharmaceuticals Ltd. Compositions and methods for treating rosacea and acne
WO2019072353A1 (en) * 2017-10-11 2019-04-18 Elmasry Mohamed Zakria Ahmed Ali TOPICAL PHARMACEUTICAL PREPARATION OF BETAMETHASONE, CALCIPOTRIOL AND ROSE OIL FOR THE TREATMENT OF PSORIASIS
EP3542788A1 (en) 2018-03-19 2019-09-25 MC2 Therapeutics Limited Topical composition comprising calcipotriol and betamethasone dipropionate
FR3083701B1 (fr) 2018-07-13 2020-08-14 Gifrer Barbezat Liniment oleo-alcalin
JP7350985B2 (ja) 2020-03-19 2023-09-26 シオノギヘルスケア株式会社 ベタメタゾン吉草酸エステル含有組成物
CN115177586A (zh) * 2022-08-31 2022-10-14 江苏知原药业股份有限公司 一种卡泊三醇组合物

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB892127A (en) 1958-03-03 1962-03-21 Merck & Co Inc Therapeutic preparations comprising steroids and vitamin d
DK116528A (el) * 1966-09-30
US4083974A (en) * 1977-03-07 1978-04-11 The Upjohn Company Topical steroidal anti-inflammatory preparations containing polyoxypropylene 15 stearyl ether
JPS59139315A (ja) * 1983-01-31 1984-08-10 Taisho Pharmaceut Co Ltd クリ−ム剤
US4569935A (en) * 1983-03-17 1986-02-11 University Of Tennessee Research Corp. Topical treatment of psoriasis with imidazole antibiotics
US4610978A (en) * 1983-03-22 1986-09-09 Yissum Research Development Company Of The Hebrew University Of Jerusalem Compositions containing 1α-hydroxycholecalciferol for topical treatment of skin disorders and methods employing same
JP2522962B2 (ja) * 1986-09-19 1996-08-07 中外製薬株式会社 乾癬治療剤
US4847071A (en) 1987-10-22 1989-07-11 The Procter & Gamble Company Photoprotection compositions comprising tocopherol sorbate and an anti-inflammatory agent
GB8821129D0 (en) * 1988-09-09 1988-10-12 Unilever Plc Cosmetic composition
GB9004544D0 (en) * 1990-03-01 1990-04-25 Leo Pharm Prod Ltd Novel treatment ii
US5087620A (en) * 1990-05-17 1992-02-11 Bristol-Myers Squibb Co. Controlled dermal penetration enhancement using imidazoles
US5185150A (en) * 1990-08-24 1993-02-09 Wisconsin Alumni Research Fdn. Cosmetic compositions containing 19-nor-vitamin D compounds
IL99368A (en) 1991-09-02 1996-01-19 Teva Pharma Preparations for the treatment of psoriasis and atopic dermatitis, which contain the result of xanthine
GB9226860D0 (en) * 1992-12-23 1993-02-17 Leo Pharm Prod Ltd Novel treatment
GB9300763D0 (en) * 1993-01-15 1993-03-03 Leo Pharm Prod Ltd Chemical compound
GB9314400D0 (en) * 1993-07-12 1993-08-25 Leo Pharm Prod Ltd Produktionsaktieselskab) chemical compounds
JPH07173053A (ja) * 1993-12-20 1995-07-11 Otsuka Pharmaceut Co Ltd 抗微生物剤
JP3506474B2 (ja) * 1994-01-07 2004-03-15 帝人株式会社 安定性の向上した乾癬治療剤
TW460296B (en) * 1994-09-01 2001-10-21 Janssen Pharmaceutica Nv Topical ketoconazole emulsion compositions without sodium sulfite
US5840925A (en) * 1995-06-29 1998-11-24 Hauser, Inc. Trioxane dimer compounds having antiproliferative and antitumor activities
JPH11514999A (ja) * 1995-10-10 1999-12-21 ストルーブ，マリリン ビタミンｄおよびその誘導体による掻痒症治療
FR2740042B1 (fr) * 1995-10-23 1997-11-14 Oreal Support, et composition contenant ce support et un actif cosmetique ou dermatologique stabilise
SG70009A1 (en) * 1996-05-23 2000-01-25 Hoffmann La Roche Vitamin d3 analogs
JPH1067757A (ja) * 1996-06-21 1998-03-10 Ss Pharmaceut Co Ltd トリアゾール誘導体またはその塩
JPH10139669A (ja) * 1996-11-05 1998-05-26 Teijin Ltd 脂漏性角化症治療剤
EP0981523B1 (en) * 1997-05-16 2005-12-07 Woman & Infants Hospital Cyclic ether vitamin d3 compounds, 1alpha (oh) 3-epi-vitamin d3 compounds and uses thereof
AU744471B2 (en) * 1997-05-16 2002-02-21 Women & Infants Hospital 3-epi vitamin D2 compounds and uses thereof
KR20010032892A (ko) * 1997-12-09 2001-04-25 나가야마 오사무 비타민 ｄ３유도체를 함유하는 크림제
EP1051974A4 (en) * 1997-12-09 2001-09-12 Chugai Pharmaceutical Co Ltd LOTIONS CONTAINING VITAMIN D 3 DERIVATIVES
JPH11188054A (ja) * 1997-12-25 1999-07-13 Lion Corp 皮膚外用部材
JPH11246329A (ja) * 1998-02-27 1999-09-14 Shiseido Co Ltd 皮膚外用剤
ES2245511T3 (es) * 1998-03-04 2006-01-01 Teijin Limited Lociones de vitamina d3 activa en forma de emulsion.
US5990100A (en) * 1998-03-24 1999-11-23 Panda Pharmaceuticals, L.L.C. Composition and method for treatment of psoriasis
US5886038A (en) 1998-03-24 1999-03-23 Panda Pharmaceuticals, L.L.C. Composition and method for treatment of psoriasis
BRPI0009956B8 (pt) * 1999-04-23 2021-07-06 Leo Pharm Prod Ltd Composição farmacêutica não aquosa para uso dermatológico compreendendo calcipotriol e betametasona, e, uso da mesma

Also Published As

Publication number Publication date
BG106030A (en) 2002-05-31
PT3146969T (pt) 2018-10-18
ES2388425T3 (es) 2012-10-15
CZ20013739A3 (cs) 2002-06-12
BRPI0009956A (pt) 2002-01-08
CA2370565A1 (en) 2000-11-02
PL351387A1 (en) 2003-04-07
CY1120659T1 (el) 2019-12-11
HK1045650B (zh) 2005-04-08
CY1113967T1 (el) 2016-07-27
PT2450043T (pt) 2016-10-12
NO20015175L (no) 2001-10-23
EP2450043A1 (en) 2012-05-09
RU2238734C2 (ru) 2004-10-27
EP1178808B2 (en) 2019-06-12
IL145983A (en) 2006-08-20
DK1178808T4 (da) 2019-09-02
HRP20010779A2 (en) 2002-12-31
BR122012030846B1 (pt) 2021-04-27
EP3146969B1 (en) 2018-06-20
HUP0200879A3 (en) 2004-04-28
DK3146969T3 (en) 2018-08-27
HUP0200879A2 (en) 2002-08-28
EP3146969A1 (en) 2017-03-29
KR100694526B1 (ko) 2007-03-13
SK15182001A3 (sk) 2002-06-04
WO2000064450A1 (en) 2000-11-02
CN1173703C (zh) 2004-11-03
RS52182B (sr) 2012-10-31
US6753013B1 (en) 2004-06-22
NZ515142A (en) 2004-01-30
HK1045650A1 (en) 2002-12-06
CA2370565C (en) 2008-11-25
KR20010110803A (ko) 2001-12-13
BG65115B1 (bg) 2007-03-30
BR122012030846B8 (pt) 2021-05-25
SI3146969T1 (en) 2018-08-31
PT2455083E (pt) 2013-10-09
JP5886999B2 (ja) 2016-03-16
JP2013075923A (ja) 2013-04-25
PL199123B1 (pl) 2008-08-29
BR122012030847B1 (pt) 2021-07-06
HU230045B1 (hu) 2015-06-29
AU2278300A (en) 2000-11-10
IS6120A (is) 2001-10-22
SI1178808T1 (sl) 2012-10-30
BRPI0009956B8 (pt) 2021-07-06
ES2602450T3 (es) 2017-02-21
EP2915534B1 (en) 2018-03-14
HRP20010779B1 (en) 2011-02-28
LT3146969T (lt) 2018-09-25
SI2915534T1 (sl) 2018-10-30
EP1178808A1 (en) 2002-02-13
EP2455083A1 (en) 2012-05-23
PT2915534T (pt) 2018-06-20
YU75701A (sh) 2005-07-19
JP5721926B2 (ja) 2015-05-20
MXPA01010676A (es) 2003-08-20
EP1178808B1 (en) 2012-05-30
JP2008297309A (ja) 2008-12-11
EP2455083B1 (en) 2013-09-18
CY1114420T1 (el) 2016-08-31
JP4426729B2 (ja) 2010-03-03
CY1120313T1 (el) 2019-07-10
IL145983A0 (en) 2002-07-25
DK2915534T3 (en) 2018-06-14
PT1178808E (pt) 2012-08-16
NO329486B1 (no) 2010-10-25
DK2455083T3 (da) 2013-09-30
EP2450043B1 (en) 2016-08-17
JP2015155451A (ja) 2015-08-27
EP2915534A1 (en) 2015-09-09
BRPI0009956B1 (pt) 2014-11-11
MEP39108A (en) 2011-02-10
SK287653B6 (sk) 2011-05-06
ES2671785T3 (es) 2018-06-08
CN1351499A (zh) 2002-05-29
ES2674563T3 (es) 2018-07-02
DK2450043T3 (en) 2016-09-12
ME00298B (me) 2011-05-10
LT2915534T (lt) 2018-06-25
CZ303142B6 (cs) 2012-05-02
JP2002542293A (ja) 2002-12-10
AU774600B2 (en) 2004-07-01
ES2432691T3 (es) 2013-12-04
DK1178808T3 (da) 2012-07-30
ES2388425T5 (es) 2020-02-12
NO20015175D0 (no) 2001-10-23

Similar Documents

Publication Publication Date Title
CY1118206T1 (el) Φαρμακευτικη συνθεση για δερματικη χρηση για να θεραπευεται ψωριαση που περιλαμβανει καλσιποτριολη και βηταμεθαζονη
ECSP055701A (es) Nuevos derivados de pirimidinamida y el uso de los mismos
DE69736441D1 (de) Pharmazeutische zusammensetzung zur behandlung von neurologischen und neuropsychiatrischen erkrankungen
CY1124763T1 (el) Μεθοδος για την θεραπευτικη αντιμετωπιση της πρωτοπαθους αϋπνιας
BR9711805A (pt) Compostos e métodos para providenciar preparações farmacologicamente ativas e uso dos mesmos
PT754176E (pt) Novos carbamatos e ureias como modificadores da resistencia a multiplas drogas
MXPA03003960A (es) Combinaciones de farmacos (v.gr., clorpromazina y pentamidina) para el tratamiento de desordenes neoplasticos.
HUP0203590A2 (hu) Gyógyszerkészítmény a csonttömeg csökkenésével járó betegségek kezelésére
GT199700009AA (es) Terapia combinada para la osteoporosis
CY1112376T1 (el) Παραγωγα 2,3,4,9-τετραϋδρο-1η-καρβαζολης ως ανταγωνιστες του υποδοχεα crth2
DE60001974D1 (de) Derivate von flavonen, xanthonen und kumarinen
BRPI0410049A (pt) composto ou um sal ou estereoisÈmero farmaceuticamente aceitável do mesmo, uso de um composto, composição farmacêutica, e, kit farmacêutico
CY1113894T1 (el) Φαρμακευτικη συνθεση που περιλαμβανει ροφλουμιλαστη και λεβοκετιριζινη
BR9908510A (pt) Uso de um composto, composto, processo para a preparação de um composto, composição farmacêutica, e, processo de tratar um paciente que sofre de, ou em risco de, uma doença micobacteriana
DE69322251T2 (de) Medizinische zusammensetzung
NO994165L (no) Anvendelse av deskarboetoksyloratadin for fremstilling av et medikament for behandling av urininkontinens, reisesyke og svimmelhet
BR0014598A (pt) Combinações sinérgicas de um antagonista de receptor nk, e um análogo estrutural gaba
BR9812531A (pt) Combinação de componentes, preparação farmacêutica, produção desta, e, uso da combinação ou da preparação farmacêutica
TR200401810T4 (tr) Kısırlık tedavisinde fsh'ın kullanılması
DE69626544T2 (de) Arzneistoffe
BR0015781A (pt) Composição farmacêutica para tratamento de doenças associadas à diminuição de massa óssea
ES2144857T3 (es) Utilizacion de derivados benzonaftalenicos para la fabricacion de medicamentos destinados para el tratamiento de las enfermedades del sistema nervioso.
AR109456A2 (es) Uso de et743 para la preparación de un medicamento para el tratamiento de un paciente humano afectado por cáncer mediante terapia de combinación
ES2186909T3 (es) Agentes antipaludicos y antibabesiosis y composiciones farmaceuticas que los contienen.
PT942729E (pt) Utilizacao de antagonistas de receptores nk-1 para tratamento de doencas do stresse