SK1222003A3 - Non-peptide CCR1 receptor antagonists in combination with cyclosporin A for the treatment of heart transplant rejection - Google Patents
Non-peptide CCR1 receptor antagonists in combination with cyclosporin A for the treatment of heart transplant rejection Download PDFInfo
- Publication number
- SK1222003A3 SK1222003A3 SK122-2003A SK1222003A SK1222003A3 SK 1222003 A3 SK1222003 A3 SK 1222003A3 SK 1222003 A SK1222003 A SK 1222003A SK 1222003 A3 SK1222003 A3 SK 1222003A3
- Authority
- SK
- Slovakia
- Prior art keywords
- methyl
- ccr1 receptor
- piperazine
- fluorobenzyl
- phenoxy
- Prior art date
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- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- 230000009871 nonspecific binding Effects 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- KHIWWQKSHDUIBK-UHFFFAOYSA-N periodic acid Chemical compound OI(=O)(=O)=O KHIWWQKSHDUIBK-UHFFFAOYSA-N 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
- 239000002953 phosphate buffered saline Substances 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 150000004885 piperazines Chemical class 0.000 description 1
- MXXWOMGUGJBKIW-YPCIICBESA-N piperine Chemical compound C=1C=C2OCOC2=CC=1/C=C/C=C/C(=O)N1CCCCC1 MXXWOMGUGJBKIW-YPCIICBESA-N 0.000 description 1
- 229940075559 piperine Drugs 0.000 description 1
- WVWHRXVVAYXKDE-UHFFFAOYSA-N piperine Natural products O=C(C=CC=Cc1ccc2OCOc2c1)C3CCCCN3 WVWHRXVVAYXKDE-UHFFFAOYSA-N 0.000 description 1
- 235000019100 piperine Nutrition 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920002523 polyethylene Glycol 1000 Polymers 0.000 description 1
- 229940113116 polyethylene glycol 1000 Drugs 0.000 description 1
- 229940057838 polyethylene glycol 4000 Drugs 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 238000011533 pre-incubation Methods 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 150000003141 primary amines Chemical class 0.000 description 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
- 229960004919 procaine Drugs 0.000 description 1
- AAEVYOVXGOFMJO-UHFFFAOYSA-N prometryn Chemical compound CSC1=NC(NC(C)C)=NC(NC(C)C)=N1 AAEVYOVXGOFMJO-UHFFFAOYSA-N 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
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- 229940107700 pyruvic acid Drugs 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 238000003127 radioimmunoassay Methods 0.000 description 1
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- 229960004889 salicylic acid Drugs 0.000 description 1
- 229940063122 sandimmune Drugs 0.000 description 1
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- 239000008299 semisolid dosage form Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000013207 serial dilution Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 229940035044 sorbitan monolaurate Drugs 0.000 description 1
- 210000000278 spinal cord Anatomy 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 125000000547 substituted alkyl group Chemical group 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 229940066771 systemic antihistamines piperazine derivative Drugs 0.000 description 1
- 239000000454 talc Chemical class 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
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- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 229960004418 trolamine Drugs 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Transplantation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22205300P | 2000-07-31 | 2000-07-31 | |
| US23128200P | 2000-09-08 | 2000-09-08 | |
| US09/915,411 US6740636B2 (en) | 2000-07-31 | 2001-07-25 | Non-peptide CCR1 receptor antagonists in combination with cyclosporin A for the treatment of heart transplant rejection |
| PCT/US2001/023862 WO2002009762A2 (en) | 2000-07-31 | 2001-07-31 | Non-peptide ccr1 receptor antagonists in combination with cyclosporin a for the treatment of heart transplant rejection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK1222003A3 true SK1222003A3 (en) | 2003-09-11 |
Family
ID=27397025
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK122-2003A SK1222003A3 (en) | 2000-07-31 | 2001-07-31 | Non-peptide CCR1 receptor antagonists in combination with cyclosporin A for the treatment of heart transplant rejection |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US6740636B2 (el) |
| EP (1) | EP1305047B1 (el) |
| JP (1) | JP2004530630A (el) |
| KR (1) | KR20030048000A (el) |
| CN (1) | CN1655818A (el) |
| AT (1) | ATE330634T1 (el) |
| AU (2) | AU2001278073B2 (el) |
| BG (1) | BG107502A (el) |
| BR (1) | BR0113140A (el) |
| CA (1) | CA2417636A1 (el) |
| CY (1) | CY1105321T1 (el) |
| DE (1) | DE60120986T2 (el) |
| DK (1) | DK1305047T3 (el) |
| EE (1) | EE200300047A (el) |
| ES (1) | ES2261447T3 (el) |
| HR (1) | HRP20030121A2 (el) |
| HU (1) | HUP0300686A3 (el) |
| IL (1) | IL153933A0 (el) |
| LV (1) | LV13033B (el) |
| MX (1) | MXPA03000836A (el) |
| NO (1) | NO20030475L (el) |
| NZ (1) | NZ523688A (el) |
| PL (1) | PL364521A1 (el) |
| PT (1) | PT1305047E (el) |
| SI (1) | SI21123A (el) |
| SK (1) | SK1222003A3 (el) |
| WO (1) | WO2002009762A2 (el) |
| YU (1) | YU6703A (el) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0413846A (pt) * | 2003-08-22 | 2006-10-24 | Schering Aktiengellschaft | derivados de piperazina inibidores de quimiocina e seu uso para tratar miocardite |
| US7917195B2 (en) | 2004-03-05 | 2011-03-29 | Lifesciences Solutions LLC | Systems, methods and computer program products for heart monitoring |
| US10499828B2 (en) * | 2004-03-05 | 2019-12-10 | Lifescience Solutions, Llc | System and method for heart monitoring |
| US8103065B2 (en) * | 2006-01-05 | 2012-01-24 | Lifescience Solutions Llc | Assessment of medical conditions |
| US20110009758A1 (en) * | 2009-07-10 | 2011-01-13 | Lifescience Solutions Llc | System and method for heart monitoring |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6323206B1 (en) | 1996-07-12 | 2001-11-27 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| YU41399A (sh) | 1997-02-26 | 2001-09-28 | Pfizer Inc. | Derivati amida heteroaril-kapronske kiseline, njihovo dobijanje i njihova upotreba kao selektivnih inhibitora mip-1.alfa vezivanjem za njegov ccr1 receptor |
| US6207665B1 (en) | 1997-06-12 | 2001-03-27 | Schering Aktiengesellschaft | Piperazine derivatives and their use as anti-inflammatory agents |
| US6329385B1 (en) | 1998-01-21 | 2001-12-11 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| WO1999037619A1 (en) | 1998-01-21 | 1999-07-29 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| PL342817A1 (en) | 1998-02-05 | 2001-07-02 | Pfizer Prod Inc | Novel derivatives of dihydroxyhexanic acid |
| EP1000626A1 (en) | 1998-09-18 | 2000-05-17 | Applied Research Systems ARS Holding N.V. | Chemokine receptor antagonist and cyclosporin in combined therapy |
| CA2360672A1 (en) | 1999-01-29 | 2000-08-03 | Wayne W. Hancock | Methods for preventing graft rejection and ischemia-reperfusion injury |
-
2001
- 2001-07-25 US US09/915,411 patent/US6740636B2/en not_active Expired - Fee Related
- 2001-07-31 MX MXPA03000836A patent/MXPA03000836A/es unknown
- 2001-07-31 PT PT01956035T patent/PT1305047E/pt unknown
- 2001-07-31 HU HU0300686A patent/HUP0300686A3/hu unknown
- 2001-07-31 AT AT01956035T patent/ATE330634T1/de not_active IP Right Cessation
- 2001-07-31 DE DE60120986T patent/DE60120986T2/de not_active Expired - Fee Related
- 2001-07-31 CA CA002417636A patent/CA2417636A1/en not_active Abandoned
- 2001-07-31 EE EEP200300047A patent/EE200300047A/xx unknown
- 2001-07-31 DK DK01956035T patent/DK1305047T3/da active
- 2001-07-31 YU YU6703A patent/YU6703A/sh unknown
- 2001-07-31 BR BR0113140-0A patent/BR0113140A/pt not_active IP Right Cessation
- 2001-07-31 EP EP01956035A patent/EP1305047B1/en not_active Expired - Lifetime
- 2001-07-31 JP JP2002515314A patent/JP2004530630A/ja not_active Withdrawn
- 2001-07-31 PL PL01364521A patent/PL364521A1/xx not_active Application Discontinuation
- 2001-07-31 KR KR10-2003-7001483A patent/KR20030048000A/ko not_active Application Discontinuation
- 2001-07-31 WO PCT/US2001/023862 patent/WO2002009762A2/en active IP Right Grant
- 2001-07-31 IL IL15393301A patent/IL153933A0/xx unknown
- 2001-07-31 AU AU2001278073A patent/AU2001278073B2/en not_active Expired - Fee Related
- 2001-07-31 ES ES01956035T patent/ES2261447T3/es not_active Expired - Lifetime
- 2001-07-31 AU AU7807301A patent/AU7807301A/xx active Pending
- 2001-07-31 SI SI200120045A patent/SI21123A/sl not_active IP Right Cessation
- 2001-07-31 NZ NZ523688A patent/NZ523688A/en unknown
- 2001-07-31 CN CNA018138004A patent/CN1655818A/zh active Pending
- 2001-07-31 SK SK122-2003A patent/SK1222003A3/sk unknown
-
2003
- 2003-01-27 BG BG107502A patent/BG107502A/xx unknown
- 2003-01-30 NO NO20030475A patent/NO20030475L/no not_active Application Discontinuation
- 2003-02-19 HR HR20030121A patent/HRP20030121A2/hr not_active Application Discontinuation
- 2003-02-28 LV LVP-03-25A patent/LV13033B/en unknown
-
2006
- 2006-09-05 CY CY20061101266T patent/CY1105321T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK1305047T3 (da) | 2006-10-23 |
| CN1655818A (zh) | 2005-08-17 |
| LV13033B (en) | 2004-02-20 |
| HUP0300686A3 (en) | 2005-03-29 |
| HUP0300686A2 (hu) | 2003-08-28 |
| DE60120986T2 (de) | 2006-11-23 |
| BG107502A (en) | 2003-07-31 |
| MXPA03000836A (es) | 2003-06-06 |
| CA2417636A1 (en) | 2002-02-07 |
| PL364521A1 (en) | 2004-12-13 |
| NO20030475L (no) | 2003-03-28 |
| NZ523688A (en) | 2005-04-29 |
| ES2261447T3 (es) | 2006-11-16 |
| AU2001278073B2 (en) | 2005-06-30 |
| WO2002009762A2 (en) | 2002-02-07 |
| HRP20030121A2 (en) | 2005-02-28 |
| KR20030048000A (ko) | 2003-06-18 |
| EE200300047A (et) | 2004-10-15 |
| EP1305047A2 (en) | 2003-05-02 |
| AU7807301A (en) | 2002-02-13 |
| DE60120986D1 (de) | 2006-08-03 |
| US6740636B2 (en) | 2004-05-25 |
| EP1305047B1 (en) | 2006-06-21 |
| CY1105321T1 (el) | 2010-03-03 |
| PT1305047E (pt) | 2006-11-30 |
| WO2002009762A3 (en) | 2003-01-09 |
| IL153933A0 (en) | 2003-07-31 |
| US20020039997A1 (en) | 2002-04-04 |
| SI21123A (sl) | 2003-08-31 |
| BR0113140A (pt) | 2003-06-24 |
| YU6703A (sh) | 2006-05-25 |
| NO20030475D0 (no) | 2003-01-30 |
| ATE330634T1 (de) | 2006-07-15 |
| JP2004530630A (ja) | 2004-10-07 |
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