DE60025189D1 - Cyanopyrrole als progesteronrezeptoragonisten - Google Patents
Cyanopyrrole als progesteronrezeptoragonistenInfo
- Publication number
- DE60025189D1 DE60025189D1 DE60025189T DE60025189T DE60025189D1 DE 60025189 D1 DE60025189 D1 DE 60025189D1 DE 60025189 T DE60025189 T DE 60025189T DE 60025189 T DE60025189 T DE 60025189T DE 60025189 D1 DE60025189 D1 DE 60025189D1
- Authority
- DE
- Germany
- Prior art keywords
- alkyl
- substituted
- hydrogen
- aminoalkyl
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/34—Gestagens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Gynecology & Obstetrics (AREA)
- Diabetes (AREA)
- Pregnancy & Childbirth (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18305099P | 1999-05-04 | 1999-05-04 | |
US304550 | 1999-05-04 | ||
US09/552,544 US6407101B1 (en) | 1999-05-04 | 2000-04-19 | Cyanopyrroles |
US552544 | 2000-04-19 | ||
PCT/US2000/011844 WO2000066581A1 (en) | 1999-05-04 | 2000-05-01 | Cyanopyrroles as progesterone receptor agonists |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60025189D1 true DE60025189D1 (de) | 2006-02-02 |
DE60025189T2 DE60025189T2 (de) | 2006-09-07 |
Family
ID=26878699
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60025189T Expired - Lifetime DE60025189T2 (de) | 1999-05-04 | 2000-05-01 | Cyanopyrrole als progesteronrezeptoragonisten |
Country Status (15)
Country | Link |
---|---|
US (5) | US6407101B1 (de) |
EP (1) | EP1173433B1 (de) |
JP (2) | JP4836331B2 (de) |
CN (1) | CN1133635C (de) |
AT (1) | ATE314365T1 (de) |
AU (1) | AU4980000A (de) |
CA (1) | CA2372560C (de) |
CY (1) | CY1105688T1 (de) |
DE (1) | DE60025189T2 (de) |
DK (1) | DK1173433T3 (de) |
ES (1) | ES2256008T3 (de) |
HK (1) | HK1043990B (de) |
MX (1) | MXPA01011295A (de) |
SI (1) | SI1173433T1 (de) |
WO (1) | WO2000066581A1 (de) |
Families Citing this family (48)
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---|---|---|---|---|
US6462032B1 (en) | 1999-05-04 | 2002-10-08 | Wyeth | Cyclic regimens utilizing indoline derivatives |
US6391907B1 (en) * | 1999-05-04 | 2002-05-21 | American Home Products Corporation | Indoline derivatives |
US6509334B1 (en) | 1999-05-04 | 2003-01-21 | American Home Products Corporation | Cyclocarbamate derivatives as progesterone receptor modulators |
US6407101B1 (en) * | 1999-05-04 | 2002-06-18 | American Home Products Corporation | Cyanopyrroles |
US6355648B1 (en) * | 1999-05-04 | 2002-03-12 | American Home Products Corporation | Thio-oxindole derivatives |
US6444668B1 (en) | 1999-05-04 | 2002-09-03 | Wyeth | Combination regimens using progesterone receptor modulators |
US6566372B1 (en) | 1999-08-27 | 2003-05-20 | Ligand Pharmaceuticals Incorporated | Bicyclic androgen and progesterone receptor modulator compounds and methods |
UA73119C2 (en) | 2000-04-19 | 2005-06-15 | American Home Products Corpoir | Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors |
KR20050012831A (ko) * | 2002-06-25 | 2005-02-02 | 와이어쓰 | 피부 질환을 치료하는 데 있어서의 티오-옥스인돌유도체의 용도 |
WO2004000230A2 (en) * | 2002-06-25 | 2003-12-31 | Wyeth | Cyclothiocarbamative derivatives as pr modulators and use thereof for treatment of skin disorders |
AU2003247608A1 (en) * | 2002-06-25 | 2004-01-06 | Wyeth | Use of cyclothiocarbamate derivatives in treatment of hormone-related conditions |
TW200407124A (en) * | 2002-06-25 | 2004-05-16 | Wyeth Corp | Use of thio-oxindole derivatives in treatment of hormone-related conditions |
AU2003258047A1 (en) * | 2002-10-11 | 2004-05-04 | Ligand Pharmaceuticals Incorporated | 5-(1',1'-CYCLOALKYL/ALKENYL)METHYLIDENE 1,2-DIHYDRO-5H-CHROMENO(3,4-f)QUINOLINES AS SELECTIVE PROGESTERONE RECEPTOR MODULATOR COMPOUNDS |
MXPA05003721A (es) * | 2002-10-11 | 2005-06-17 | Ligand Pharm Inc | Derivados de 5-cicloalquenilo-5h-cromeno[3,4-f]quinolina como compuestos moduladores, selectivos de receptores de progesterona. |
US7247625B2 (en) * | 2003-10-09 | 2007-07-24 | Wyeth | 6-amino-1,4-dihydro-benzo[d][1,3] oxazin-2-ones and analogs useful as progesterone receptor modulators |
US7323455B2 (en) * | 2004-03-24 | 2008-01-29 | Wyeth | 7-aryl 1,5-dihydro-4,1-benzoxazepin-2(3H)-one derivatives and their use as progesterone receptor modulators |
AU2005233648B2 (en) | 2004-04-08 | 2011-06-23 | Wyeth | Methods for minimizing thioamide impurities |
ES2317223T3 (es) * | 2004-04-08 | 2009-04-16 | Wyeth | Derivados de tioamida como moduladores del receptor de progesterona. |
MXPA06012402A (es) | 2004-04-27 | 2007-01-17 | Wyeth Corp | Carbamato y tiocarbamato biarilos ciclicos que contienen cianopirrol y metodos para preparar los mismos. |
BRPI0510260A (pt) | 2004-04-27 | 2007-10-23 | Wyeth Corp | método para purificar um composto, e, kit farmacêutico |
US7446211B2 (en) * | 2004-04-27 | 2008-11-04 | Wyeth | Coupling process for generating reactive boron-containing derivatives of N-substituted pyrrole-2-carbonitriles to produce biaryls |
GT200500186A (es) * | 2004-07-07 | 2006-03-02 | Regimenes anticonceptivos con antagonistas del receptor de progesterona y kits | |
CA2571377C (en) * | 2004-07-07 | 2014-03-25 | Wyeth | Cyclic progestin regimens and kits |
GT200500185A (es) * | 2004-08-09 | 2006-04-10 | Moduladores del receptor de progesterona que comprenden derivados de pirrol-oxindol y sus usos | |
GT200500183A (es) * | 2004-08-09 | 2006-04-10 | Moduladores del receptor de progesterona que comprenden derivados de pirrol-oxindol y sus usos | |
CN101027321A (zh) * | 2004-08-20 | 2007-08-29 | 惠氏公司 | 孕酮受体结构 |
AR053710A1 (es) | 2005-04-11 | 2007-05-16 | Xenon Pharmaceuticals Inc | Compuestos espiroheterociclicos y sus usos como agentes terapeuticos |
MY144968A (en) * | 2005-04-11 | 2011-11-30 | Xenon Pharmaceuticals Inc | Spiro-oxindole compounds and their uses as therapeutic agents |
AR056317A1 (es) * | 2005-04-20 | 2007-10-03 | Xenon Pharmaceuticals Inc | Compuestos de oxindol y composicion farmaceutica |
PE20070341A1 (es) * | 2005-07-29 | 2007-04-13 | Wyeth Corp | Derivados de pirrol como moduladores del receptor de progesterona |
PE20070182A1 (es) | 2005-07-29 | 2007-03-06 | Wyeth Corp | Derivados cianopirrol-fenil amida como moduladores del receptor de progesterona |
PE20070404A1 (es) * | 2005-07-29 | 2007-05-10 | Wyeth Corp | Compuestos derivados de cianopirrol-sulfonamida como moduladores del receptor de progesterona |
GEP20135796B (en) | 2006-03-07 | 2013-04-10 | Compositions comprising human embryonic stem cells and their derivatives, methods of use, and methods of preparation | |
US20070213526A1 (en) * | 2006-03-07 | 2007-09-13 | Wyeth | Purification of progesterone receptor modulators |
ATE545416T1 (de) * | 2006-10-12 | 2012-03-15 | Xenon Pharmaceuticals Inc | Verwendung von spiro-oxindol-verbindungen als therapeutika |
AU2007307638A1 (en) * | 2006-10-12 | 2008-04-17 | Xenon Pharmaceuticals Inc. | Spiro (furo [3, 2-C] pyridine-3-3 ' -indol) -2' (1'H)-one derivatives and related compounds for the treatment of sodium-channel mediated diseases, such as pain |
CA2666136A1 (en) * | 2006-10-12 | 2008-04-17 | Xenon Pharmaceuticals Inc. | Tricyclic spiro-oxindole derivatives and their uses as therapeutic agents |
US20080319204A1 (en) * | 2007-06-25 | 2008-12-25 | Wyeth | Process for the synthesis of progesterone receptor modulators |
US20090170823A1 (en) * | 2007-12-20 | 2009-07-02 | Duramed Pharmaceuticals, Inc. | Dosage Regimens and Pharmaceutical Compositions and Packages for Emergency Contraception |
US20090197878A1 (en) * | 2008-02-01 | 2009-08-06 | Wyeth | SUBSTITUTED BENZO[d][1,3]OXAZIN-2(4H)-ONES AND RELATED DERIVATIVES AND THEIR USES FOR MODULATING THE PROGESTERONE RECEPTOR |
CA2741029A1 (en) | 2008-10-17 | 2010-04-22 | Xenon Pharmaceuticals Inc. | Spiro-oxindole compounds and their use as therapeutic agents |
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AR077252A1 (es) | 2009-06-29 | 2011-08-10 | Xenon Pharmaceuticals Inc | Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos |
NZ712378A (en) | 2009-10-14 | 2017-05-26 | Xenon Pharmaceuticals Inc | Synthetic methods for spiro-oxindole compounds |
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EP2538919B1 (de) | 2010-02-26 | 2017-07-12 | Xenon Pharmaceuticals Inc. | Pharmazeutische zusammensetzungen einer spirooxindolverbindung für die topische verabreichung und ihre verwendung als therapeutika |
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TW201636017A (zh) | 2015-02-05 | 2016-10-16 | 梯瓦製藥國際有限責任公司 | 以螺吲哚酮化合物之局部調配物治療帶狀疱疹後遺神經痛之方法 |
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2000
- 2000-04-19 US US09/552,544 patent/US6407101B1/en not_active Expired - Lifetime
- 2000-05-01 EP EP00932005A patent/EP1173433B1/de not_active Expired - Lifetime
- 2000-05-01 ES ES00932005T patent/ES2256008T3/es not_active Expired - Lifetime
- 2000-05-01 DE DE60025189T patent/DE60025189T2/de not_active Expired - Lifetime
- 2000-05-01 CN CNB00807139XA patent/CN1133635C/zh not_active Expired - Fee Related
- 2000-05-01 AT AT00932005T patent/ATE314365T1/de not_active IP Right Cessation
- 2000-05-01 DK DK00932005T patent/DK1173433T3/da active
- 2000-05-01 WO PCT/US2000/011844 patent/WO2000066581A1/en active IP Right Grant
- 2000-05-01 MX MXPA01011295A patent/MXPA01011295A/es active IP Right Grant
- 2000-05-01 AU AU49800/00A patent/AU4980000A/en not_active Abandoned
- 2000-05-01 CA CA002372560A patent/CA2372560C/en not_active Expired - Fee Related
- 2000-05-01 JP JP2000615611A patent/JP4836331B2/ja not_active Expired - Fee Related
- 2000-05-01 SI SI200030830T patent/SI1173433T1/sl unknown
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- 2002-06-28 HK HK02104856.3A patent/HK1043990B/zh not_active IP Right Cessation
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- 2003-01-15 US US10/342,719 patent/US6982261B2/en not_active Expired - Fee Related
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Also Published As
Publication number | Publication date |
---|---|
WO2000066581A1 (en) | 2000-11-09 |
DK1173433T3 (da) | 2006-05-15 |
ATE314365T1 (de) | 2006-01-15 |
US7846924B2 (en) | 2010-12-07 |
MXPA01011295A (es) | 2003-07-14 |
JP2011236225A (ja) | 2011-11-24 |
US6982261B2 (en) | 2006-01-03 |
DE60025189T2 (de) | 2006-09-07 |
CN1133635C (zh) | 2004-01-07 |
US6407101B1 (en) | 2002-06-18 |
US20050256110A1 (en) | 2005-11-17 |
CA2372560A1 (en) | 2000-11-09 |
AU4980000A (en) | 2000-11-17 |
US20030158182A1 (en) | 2003-08-21 |
CY1105688T1 (el) | 2010-12-22 |
EP1173433A1 (de) | 2002-01-23 |
US20020068735A1 (en) | 2002-06-06 |
EP1173433B1 (de) | 2005-12-28 |
US20110039839A1 (en) | 2011-02-17 |
CA2372560C (en) | 2009-09-15 |
JP4836331B2 (ja) | 2011-12-14 |
HK1043990B (zh) | 2006-05-04 |
JP2002543197A (ja) | 2002-12-17 |
WO2000066581A8 (en) | 2002-05-30 |
US8476262B2 (en) | 2013-07-02 |
US6562857B2 (en) | 2003-05-13 |
CN1349531A (zh) | 2002-05-15 |
HK1043990A1 (en) | 2002-10-04 |
ES2256008T3 (es) | 2006-07-16 |
SI1173433T1 (sl) | 2006-06-30 |
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Owner name: WYETH, MADISON, N.J., US |