AP2003002720A0 - Carboxamide compounds and their use as antagonists of a human 11 CBY receptor. - Google Patents
Carboxamide compounds and their use as antagonists of a human 11 CBY receptor.Info
- Publication number
- AP2003002720A0 AP2003002720A0 APAP/P/2003/002720A AP2003002720A AP2003002720A0 AP 2003002720 A0 AP2003002720 A0 AP 2003002720A0 AP 2003002720 A AP2003002720 A AP 2003002720A AP 2003002720 A0 AP2003002720 A0 AP 2003002720A0
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- cby
- antagonists
- receptor
- human
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- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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- C07C233/67—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/75—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
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- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Abstract
Compounds of formula (I) in which; each A is independently hydrogen, C1-6alkyl optionally substituted by hydroxyl, C1-6alkoxy, C1-6alkenyl or C1-6acyl group or a halogen atom or hydroxyl, CN or CF3 group, R3 is hydrogen, methyl or ethyl; R4 is an optionally substituted aromatic carbocyclic or heterocyclic ring; Z is an O or S atom, or an NH or Ch2 group, or a single bond, at the 3 or 4 position of R4 relative to the carbonyl group; R5 is an optinally substituted aromatic carbocyclic or heterocyclic ring, or unsaturated, carbocyclic or heterocyclic ring; and Q Is (a) Where X, Y, R1 and R2 are as defined in claim 1; are antagonists of a human 11 CBy receptor.
Applications Claiming Priority (3)
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GBGB0018758.3A GB0018758D0 (en) | 2000-07-31 | 2000-07-31 | Novel use and compunds |
GB0112544A GB0112544D0 (en) | 2001-05-23 | 2001-05-23 | Novel use and compounds |
PCT/EP2001/008637 WO2002010146A1 (en) | 2000-07-31 | 2001-07-26 | Carboxamide compounds and their use as antagonists of a human 11cby receptor |
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AP2003002720A0 true AP2003002720A0 (en) | 2003-06-30 |
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APAP/P/2003/002720A AP2003002720A0 (en) | 2000-07-31 | 2001-07-26 | Carboxamide compounds and their use as antagonists of a human 11 CBY receptor. |
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EP (1) | EP1305304A1 (en) |
JP (1) | JP2004505070A (en) |
KR (1) | KR20030059084A (en) |
CN (1) | CN1444573A (en) |
AP (1) | AP2003002720A0 (en) |
AU (1) | AU2001278508A1 (en) |
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BR (1) | BR0112856A (en) |
CA (1) | CA2417638A1 (en) |
CZ (1) | CZ2003297A3 (en) |
EA (1) | EA200300064A1 (en) |
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PL (1) | PL365183A1 (en) |
SK (1) | SK1142003A3 (en) |
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US7141561B2 (en) | 2002-07-25 | 2006-11-28 | Sanofi-Aventis Deutschland Gmbh | Substituted diaryl heterocycles, process for their preparation and their use as medicaments |
US7223788B2 (en) | 2003-02-14 | 2007-05-29 | Sanofi-Aventis Deutschland Gmbh | Substituted N-aryl heterocycles, process for their preparation and their use as medicaments |
DE10306250A1 (en) * | 2003-02-14 | 2004-09-09 | Aventis Pharma Deutschland Gmbh | Substituted N-aryl heterocycles, processes for their preparation and their use as pharmaceuticals |
PL1618092T3 (en) * | 2003-05-01 | 2011-02-28 | Bristol Myers Squibb Co | Aryl-substituted pyrazole-amide compounds useful as kinase inhibitors |
PL1651612T3 (en) | 2003-07-22 | 2012-09-28 | Astex Therapeutics Ltd | 3,4-disubstituted 1h-pyrazole compounds and their use as cyclin dependent kinases (cdk) and glycogen synthase kinase-3 (gsk-3) modulators |
US7037927B2 (en) * | 2003-10-16 | 2006-05-02 | Abbott Laboratories | Amides that inhibit vanilloid receptor subtype 1 (VR1) receptor |
US7319108B2 (en) | 2004-01-25 | 2008-01-15 | Sanofi-Aventis Deutschland Gmbh | Aryl-substituted heterocycles, process for their preparation and their use as medicaments |
US7241787B2 (en) | 2004-01-25 | 2007-07-10 | Sanofi-Aventis Deutschland Gmbh | Substituted N-cycloexylimidazolinones, process for their preparation and their use as medicaments |
US20070191363A1 (en) * | 2004-03-02 | 2007-08-16 | Neurogen Corporation | Heteroalkyl-substituted biphenyl-4-carboxylic acid arylamide analogues |
US7605176B2 (en) | 2004-03-06 | 2009-10-20 | Boehringer Ingelheim International Gmbh | β-ketoamide compounds with MCH antagonistic activity |
DE102004010893A1 (en) * | 2004-03-06 | 2005-09-22 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | New β-ketoamide compounds having MCH antagonist activity and medicaments containing these compounds |
TW200613272A (en) | 2004-08-13 | 2006-05-01 | Astrazeneca Ab | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators |
DE102004039789A1 (en) | 2004-08-16 | 2006-03-02 | Sanofi-Aventis Deutschland Gmbh | Aryl-substituted polycyclic amines, process for their preparation and their use as pharmaceuticals |
US8404718B2 (en) | 2005-01-21 | 2013-03-26 | Astex Therapeutics Limited | Combinations of pyrazole kinase inhibitors |
AR054425A1 (en) | 2005-01-21 | 2007-06-27 | Astex Therapeutics Ltd | PIPERIDIN ADDITION SALTS 4-IL-ACID AMID 4- (2,6-DICLORO-BENZOILAMINO) 1H-PIRAZOL-3-CARBOXILICO. |
US7807706B2 (en) | 2005-08-12 | 2010-10-05 | Astrazeneca Ab | Metabotropic glutamate-receptor-potentiating isoindolones |
US8618115B2 (en) | 2005-10-26 | 2013-12-31 | Bristol-Myers Squibb Company | Substituted thieno[3,2-d]pyrimidinones as MCHR1 antagonists and methods for using them |
US7553836B2 (en) | 2006-02-06 | 2009-06-30 | Bristol-Myers Squibb Company | Melanin concentrating hormone receptor-1 antagonists |
DE602007011897D1 (en) | 2006-02-15 | 2011-02-24 | Sanofi Aventis | NEW AMINO ALCOHOL SUBSTITUTED ARYL DIHYDROISOCHINOLINONE, METHOD OF MANUFACTURE AND ITS USE AS MEDICAMENTS |
GB0625523D0 (en) * | 2006-12-21 | 2007-01-31 | Ge Healthcare Ltd | In vivo imaging agents |
TWI417100B (en) | 2007-06-07 | 2013-12-01 | Astrazeneca Ab | Oxadiazole derivatives and their use as metabotropic glutamate receptor potentiators-842 |
EP2025674A1 (en) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituted tetra hydro naphthalines, method for their manufacture and their use as drugs |
PE20091928A1 (en) | 2008-05-29 | 2009-12-31 | Bristol Myers Squibb Co | HAVE HYDROXYSUSTITUTED PYRIMIDINES AS NON-BASIC MELANIN-CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS |
US7790760B2 (en) | 2008-06-06 | 2010-09-07 | Astrazeneca Ab | Metabotropic glutamate receptor isoxazole ligands and their use as potentiators 286 |
AR072297A1 (en) | 2008-06-27 | 2010-08-18 | Novartis Ag | DERIVATIVES OF INDOL-2-IL-PIRIDIN-3-ILO, PHARMACEUTICAL COMPOSITION THAT INCLUDES THEM AND ITS USE IN MEDICINES FOR THE TREATMENT OF DISEASES MEDIATED BY THE SYNTHESIS ALDOSTERONE. |
CA2739488A1 (en) | 2008-10-15 | 2010-04-22 | Boehringer Ingelheim International Gmbh | Fused heteroaryl diamide compounds useful as mmp-13 inhibitors |
US8785489B2 (en) | 2008-10-17 | 2014-07-22 | Boehringer Ingelheim International Gmbh | Heteroaryl substituted indole compounds useful as MMP-13 inhibitors |
TW201040154A (en) | 2009-02-13 | 2010-11-16 | Sanofi Aventis | Novel substituted indanes, process for preparation thereof and use thereof as a medicament |
AR075402A1 (en) | 2009-02-13 | 2011-03-30 | Sanofi Aventis | OXYGENATE AND / OR NITROGEN HETEROCICLIC DERIVATIVES OF TETRAHYDRONAFTALENE, DRUGS THAT CONTAIN THEM AND USE OF THE SAME IN THE TREATMENT OF METABOLIC DISORDERS, SUCH AS OBESITY, AMONG OTHERS. |
EP2819993B1 (en) * | 2012-03-01 | 2020-09-02 | University Of Cincinnati | Ros-activated compounds as selective anti-cancer therapeutics |
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ZA985542B (en) * | 1997-07-03 | 1999-04-07 | Smithkline Beecham Corp | Substituted benzanilides as CCR5 receptor ligands antiinflammatory agents and antiviral agents |
HUP0102752A3 (en) * | 1998-07-28 | 2002-11-28 | Smithkline Beecham Corp | Substituted anilide compounds |
AU2460600A (en) * | 1999-02-10 | 2000-08-29 | Mitsubishi Pharma Corporation | Amide compounds and medicinal use thereof |
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- 2001-07-26 WO PCT/EP2001/008637 patent/WO2002010146A1/en not_active Application Discontinuation
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- 2001-07-26 AP APAP/P/2003/002720A patent/AP2003002720A0/en unknown
- 2001-07-26 CN CN01813601A patent/CN1444573A/en active Pending
- 2001-07-26 AU AU2001278508A patent/AU2001278508A1/en not_active Abandoned
- 2001-07-26 EP EP01956562A patent/EP1305304A1/en not_active Withdrawn
- 2001-07-26 CA CA002417638A patent/CA2417638A1/en not_active Abandoned
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CN1444573A (en) | 2003-09-24 |
BG107510A (en) | 2003-09-30 |
NO20030471L (en) | 2003-03-28 |
IL153645A0 (en) | 2003-07-06 |
EA200300064A1 (en) | 2003-06-26 |
BR0112856A (en) | 2003-07-01 |
EP1305304A1 (en) | 2003-05-02 |
CZ2003297A3 (en) | 2003-05-14 |
NO20030471D0 (en) | 2003-01-30 |
HUP0302966A2 (en) | 2003-12-29 |
PL365183A1 (en) | 2004-12-27 |
MXPA03000923A (en) | 2003-06-09 |
KR20030059084A (en) | 2003-07-07 |
AU2001278508A1 (en) | 2002-02-13 |
SK1142003A3 (en) | 2003-06-03 |
JP2004505070A (en) | 2004-02-19 |
MA25829A1 (en) | 2003-07-01 |
CA2417638A1 (en) | 2002-02-07 |
WO2002010146A1 (en) | 2002-02-07 |
OA12346A (en) | 2004-04-13 |
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