SE0400970D0 - Nicotinic acetylcholine receptor ligands - Google Patents

Nicotinic acetylcholine receptor ligands

Info

Publication number
SE0400970D0
SE0400970D0 SE0400970A SE0400970A SE0400970D0 SE 0400970 D0 SE0400970 D0 SE 0400970D0 SE 0400970 A SE0400970 A SE 0400970A SE 0400970 A SE0400970 A SE 0400970A SE 0400970 D0 SE0400970 D0 SE 0400970D0
Authority
SE
Sweden
Prior art keywords
acetylcholine receptor
nicotinic acetylcholine
receptor ligands
compounds
medicaments
Prior art date
Application number
SE0400970A
Other languages
English (en)
Inventor
Marc Chapdelaine
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Priority to SE0400970A priority Critical patent/SE0400970D0/sv
Publication of SE0400970D0 publication Critical patent/SE0400970D0/sv
Priority to AU2005233492A priority patent/AU2005233492B2/en
Priority to US10/599,839 priority patent/US7566727B2/en
Priority to CA002563010A priority patent/CA2563010A1/en
Priority to EP05722314A priority patent/EP1737854A1/en
Priority to CNA2005800194932A priority patent/CN1968951A/zh
Priority to PCT/SE2005/000500 priority patent/WO2005100351A1/en
Priority to BRPI0509777-0A priority patent/BRPI0509777A/pt
Priority to RU2006135481/04A priority patent/RU2372350C2/ru
Priority to JP2007508300A priority patent/JP2007532637A/ja
Priority to UAA200610315A priority patent/UA86617C2/ru
Priority to IL178241A priority patent/IL178241A0/en
Priority to ZA200608412A priority patent/ZA200608412B/xx
Priority to NO20065199A priority patent/NO20065199L/no
Priority to RU2009126341/04A priority patent/RU2009126341A/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
SE0400970A 2004-04-14 2004-04-14 Nicotinic acetylcholine receptor ligands SE0400970D0 (sv)

Priority Applications (15)

Application Number Priority Date Filing Date Title
SE0400970A SE0400970D0 (sv) 2004-04-14 2004-04-14 Nicotinic acetylcholine receptor ligands
JP2007508300A JP2007532637A (ja) 2004-04-14 2005-04-06 α７ニコチン性アセチルコリン受容体に対する新規な２−（１−アザ−ビシクロ［２．２．２］オクタ−３−イル）−２，３−ジヒドロイソインドール−１−オン／５，６−ジヒドロ−フロ［２，３−ｃ］ピロール−４−オン誘導体リガンド
PCT/SE2005/000500 WO2005100351A1 (en) 2004-04-14 2005-04-06 NOVEL 2-(1-AZA-BICYCLO[2.2.2]OCT-3-yl)-2,3-DIHYDROISOINDOL-l-ONE/5,6-DIHYDRO-FURO[2,3-c]PYRROL-4ONE DERIVATIVES LIGANDS FOR ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR
RU2006135481/04A RU2372350C2 (ru) 2004-04-14 2005-04-06 НОВЫЕ ПРОИЗВОДНЫЕ 2-(1-АЗА-БИЦИКЛО[2.2.2]ОКТ-3-ИЛ)-2,3-ДИГИДРОИЗОИНДОЛ-1-ОНА/5,6-ДИГИДРО-ФУРО[2,3-c]ПИРРОЛ-4-ОНА В КАЧЕСТВЕ ЛИГАНДОВ К АЛЬФА 7 НИКОТИНОВОМУ АЦЕТИЛХОЛИНОВОМУ РЕЦЕПТОРУ
CA002563010A CA2563010A1 (en) 2004-04-14 2005-04-06 Novel 2-(1-aza-bicyclo[2.2.2]oct-3-yl)-2,3-dihydroisoindol-1-one/5,6-dihydro-furo[2,3-c]pyrrol-4one derivatives ligands for alpha 7 nicotinic acetylcholine receptor
EP05722314A EP1737854A1 (en) 2004-04-14 2005-04-06 NOVEL 2-(1-AZA-BICYCLO[2.2.2]OCT-3-yl)-2,3-DIHYDROISOINDOL-l-ONE/5,6-DIHYDRO-FURO[2,3-c]PYRROL-4ONE DERIVATIVES LIGANDS FOR ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR
CNA2005800194932A CN1968951A (zh) 2004-04-14 2005-04-06 α 7烟碱乙酰胆碱受体的新颖 2 －( 1 －氮杂 －二环 [ 2 . 2 . 2 ]辛－ 3 －基 ) － 2 , 3 －二氢 －异吲哚 － 1 －酮 / 5 , 6 －二氢－呋喃并 [ 2 , 3 － C ]吡咯 －4 －酮衍生物配体
AU2005233492A AU2005233492B2 (en) 2004-04-14 2005-04-06 Novel 2-(1-aza-bicyclo[2.2.2]oct-3-yl)-2,3-dihydroisoindol-l-one/5,6-dihydro-furo[2,3-c]pyrrol-4one derivatives ligands for alpha 7 nicotinic acetylcholine receptor
BRPI0509777-0A BRPI0509777A (pt) 2004-04-14 2005-04-06 composto, métodos de tratamento ou profilaxia de doenças ou condições e de distúrbios, método para induzir o parar de fumar, composição farmacêutica, e, uso de um composto,um enantiÈmero do mesmo ou um sal farmaceuticamente aceitável do mesmo
US10/599,839 US7566727B2 (en) 2004-04-14 2005-04-06 2-(1-aza-bicyclo[2.2.2]oct-3-yl)-2,3-dihydro-isoindole-1-one/5,6-dihydro-furo[2,3-c] pyrrol-4-one derivative ligands for alpha 7 nicotinic acetylcholine receptor
UAA200610315A UA86617C2 (en) 2004-04-14 2005-06-04 2-(1-AZA-BICYCLO[2.2.2]OCT-3-YL)-2,3-DIHYDROISOINDOL-l-ONE/5,6-DIHYDRO-FURO[2,3-c]PYRROL-4-ONE DERIVATIVES AS LIGANDS FOR ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR
IL178241A IL178241A0 (en) 2004-04-14 2006-09-21 NOVEL 2 - (1 - AZA - BICYCLO [2.2.2] OCT - 3 - YL) - 2, 3 - DIHYDROISOINDOL - 1 - ONE /5, 6 - DIHYDRO - FURO [2, 3 - c] PYRROL - 4 - ONE DERIVATIVES LIGANDS FOR ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR
ZA200608412A ZA200608412B (en) 2004-04-14 2006-10-09 Novel 2-[1-aza-bicyclo (2.2.2)oct-3-yl)-2,3-dihydroisoindol-1-one/5/6-dihydro-furo[2,3-c]pyrrol-4one derivatives ligands for alpha 7 nicotinic acetylcholine receptor
NO20065199A NO20065199L (no) 2004-04-14 2006-11-13 Nye 2-(1-aza-bicyklo[2.2.2]okt-3-yl)-2,3-dihydroisoindol-1-on/5,6-dihydro-furo[2,3-c]pyrrol-4-on derivater ligander for alfa 7 nikotinacetylcholin reseptor
RU2009126341/04A RU2009126341A (ru) 2004-04-14 2009-07-10 НОВЫЕ ПРОИЗВОДНЫЕ 2-(1-АЗА-БИЦИКЛО[2.2.2.]ОКТ-3-ИЛ)-2,3-ДИГИДРОИЗОИНДОЛ-1-ОНА/5,6-ДИГИДРО-ФУРО[2,3-c]ПИРРОЛ-4-ОНА В КАЧЕСТВЕ ЛИГАНДОВ К АЛЬФА 7 НИКОТИНОВОМУ АЦЕТИЛХОЛИНОВОМУ РЕЦЕПТОРУ

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0400970A SE0400970D0 (sv) 2004-04-14 2004-04-14 Nicotinic acetylcholine receptor ligands

Publications (1)

Publication Number Publication Date
SE0400970D0 true SE0400970D0 (sv) 2004-04-14

Family

ID=32294312

Family Applications (1)

Application Number Title Priority Date Filing Date
SE0400970A SE0400970D0 (sv) 2004-04-14 2004-04-14 Nicotinic acetylcholine receptor ligands

Country Status (14)

Country Link
US (1) US7566727B2 (sv)
EP (1) EP1737854A1 (sv)
JP (1) JP2007532637A (sv)
CN (1) CN1968951A (sv)
AU (1) AU2005233492B2 (sv)
BR (1) BRPI0509777A (sv)
CA (1) CA2563010A1 (sv)
IL (1) IL178241A0 (sv)
NO (1) NO20065199L (sv)
RU (2) RU2372350C2 (sv)
SE (1) SE0400970D0 (sv)
UA (1) UA86617C2 (sv)
WO (1) WO2005100351A1 (sv)
ZA (1) ZA200608412B (sv)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7807706B2 (en) 2005-08-12 2010-10-05 Astrazeneca Ab Metabotropic glutamate-receptor-potentiating isoindolones
TW200804281A (en) 2006-02-16 2008-01-16 Astrazeneca Ab New metabotropic glutamate receptor-potentiating isoindolones
TWI417100B (zh) 2007-06-07 2013-12-01 Astrazeneca Ab 二唑衍生物及其作為代謝型麩胺酸受體增效劑-８４２之用途
AU2008304231A1 (en) * 2007-09-27 2009-04-02 Albany Molecular Research, Inc. Isoindoline compounds for the treatment of spinal muscular atrophy and other uses
US7790760B2 (en) 2008-06-06 2010-09-07 Astrazeneca Ab Metabotropic glutamate receptor isoxazole ligands and their use as potentiators 286
EP2470183B1 (en) * 2009-08-26 2015-09-16 Merck Sharp & Dohme Corp. Heterocyclic amide compounds as protein kinase inhibitors
NZ600954A (en) * 2009-12-22 2013-11-29 Isoindolinone inhibitors of phosphatidylinositol 3-kinase
JP2013516402A (ja) 2009-12-31 2013-05-13 ピラマル エンタープライジーズ リミテッド ジアシルグリセロールアシルトランスフェラーゼの抑制剤
JO3383B1 (ar) * 2013-03-14 2019-03-13 Lilly Co Eli مثبطات cdc7
WO2017107089A1 (en) 2015-12-23 2017-06-29 Merck Sharp & Dohme Corp. 3- (1h-pyrazol-4-yl) pyridineallosteric modulators of the m4 muscarinic acetylcholine receptor
TW201726675A (zh) * 2015-12-23 2017-08-01 默沙東藥廠 M4毒蕈鹼乙醯膽鹼受體之異位調節劑6,7-二氫-5h-吡咯并[3,4-b]吡啶-5-酮
EP3559005A1 (en) 2016-12-21 2019-10-30 Biotheryx Inc. Thienopyrrole derivatives for use in targeting proteins, compositions, methods, and uses thereof
WO2018112842A1 (en) 2016-12-22 2018-06-28 Merck Sharp & Dohme Corp. 6,6-fused heteroaryl piperidine ether allosteric modulators of m4 muscarinic acetylcholine receptor
WO2018112843A1 (en) 2016-12-22 2018-06-28 Merck Sharp & Dohme Corp. Heteroaryl piperidine ether allosteric modulators of the m4 muscarinic acetylcholine receptor
WO2018210229A1 (zh) * 2017-05-18 2018-11-22 南京明德新药研发股份有限公司 α-7尼古丁乙酰胆碱受体激动剂及应用
CN107188900B (zh) * 2017-05-27 2019-09-06 北京师范大学 α7烟碱型乙酰胆碱受体的配体化合物及其应用
EP3634408B1 (en) * 2017-06-09 2022-12-28 Merck Sharp & Dohme LLC Azabicyclo[4.1.0]heptane allosteric modulators of the m4 muscarinic acetylcholine receptor
WO2019000237A1 (en) 2017-06-27 2019-01-03 Merck Sharp & Dohme Corp. ALLOSTERIC MODULATORS OF 3- (1H-PYRAZOL-4-YL) PYRIDINE FROM THE M4 ACETYLCHOLINE MUSCARINIC RECEPTOR
WO2019000236A1 (en) 2017-06-27 2019-01-03 Merck Sharp & Dohme Corp. ALLOSTERIC MODULATORS OF 3- (1H-PYRAZOL-4-YL) PYRIDINE FROM THE M4 ACETYLCHOLINE MUSCARINIC RECEPTOR
WO2019000238A1 (en) 2017-06-27 2019-01-03 Merck Sharp & Dohme Corp. 5- (PYRIDIN-3-YL) OXAZOLE ALLOSTERIC MODULATORS OF M4 ACETYLCHOLINE MUSCARINIC RECEPTOR
NL2021185B1 (en) 2018-06-26 2020-01-06 Stichting Het Nederlands Kanker Inst Antoni Van Leeuwenhoek Ziekenhuis Combination Therapy and Use Thereof for Treating Cancer

Family Cites Families (8)

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Publication number Priority date Publication date Assignee Title
US5491148A (en) * 1991-04-26 1996-02-13 Syntex (U.S.A.) Inc. Isoquinolinone and dihydroisoquinolinone 5-HT3 receptor antagonists
SE9201478D0 (sv) * 1992-05-11 1992-05-11 Kabi Pharmacia Ab Heteroaromatic quinuclidinenes, their use and preparation
IT1303123B1 (it) * 1998-10-13 2000-10-30 Rotta Research Lab Derivati basici di benz(e)isoindol-1-oni e pirrolo(3,4-c)chinolin-1-oni ad attivita' 5ht3 antagonista, loro preparazione ed
DE10045112A1 (de) * 2000-09-11 2002-03-21 Merck Patent Gmbh Verwendung von Indolderivaten zur Behandlung von Erkrankungen des zentralen Nervensystems
AU2002220517A1 (en) * 2000-12-01 2002-06-11 Neurosearch A/S 3-substituted quinuclidines and their use as nicotinic agonists
DE10118551A1 (de) * 2001-04-14 2002-10-17 Merck Patent Gmbh Nikotinische Acetylcholinrezeptor Liganden
ATE341548T1 (de) * 2001-07-06 2006-10-15 Neurosearch As Neue verbindungen, deren herstellung und verwendung
WO2004016608A1 (en) * 2002-08-14 2004-02-26 Neurosearch A/S Novel quinuclidine derivatives and their use

Also Published As

Publication number Publication date
CN1968951A (zh) 2007-05-23
AU2005233492A1 (en) 2005-10-27
RU2009126341A (ru) 2011-01-20
WO2005100351A1 (en) 2005-10-27
US7566727B2 (en) 2009-07-28
CA2563010A1 (en) 2005-10-27
EP1737854A1 (en) 2007-01-03
NO20065199L (no) 2006-11-13
AU2005233492B2 (en) 2009-06-11
US20070213342A1 (en) 2007-09-13
RU2006135481A (ru) 2008-05-20
RU2372350C2 (ru) 2009-11-10
JP2007532637A (ja) 2007-11-15
UA86617C2 (en) 2009-05-12
ZA200608412B (en) 2008-09-25
BRPI0509777A (pt) 2007-10-23
IL178241A0 (en) 2006-12-31

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