KR880007518A - 비사이클릭 아미노카복실산 유도체, 그의 제조방법 및 중간생성물 및 그의 용도 - Google Patents

비사이클릭 아미노카복실산 유도체, 그의 제조방법 및 중간생성물 및 그의 용도 Download PDF

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KR880007518A
KR880007518A KR870013757A KR870013757A KR880007518A KR 880007518 A KR880007518 A KR 880007518A KR 870013757 A KR870013757 A KR 870013757A KR 870013757 A KR870013757 A KR 870013757A KR 880007518 A KR880007518 A KR 880007518A
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compound
formula
hydrogen
intermediates
acid derivatives
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KR870013757A
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KR960000851B1 (ko
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바르톤 데렉
뽀띠에 삐에르
에르베 욜랑드
띠예리 조지안느
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하인리히 베커, 베른하르트 베크
훽스트 아크티엔 게젤샤프트
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyridine Compounds (AREA)

Abstract

내용 없음.

Description

비사이클릭 아미노카복실산 유도체, 그의 제조방법 및 중간생성물 및 그의 용도
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (6)

  1. 일반식(Ⅰ)의 화합물
    상기식에서 N은 1,2 또는 3을 나타내고, R은 (C1-C17)-아실을 나타내며, R1은 (C1-C8)-알킬, (C3-C7)-사이클로알킬, (C7-C11)-아르알킬 또는 다른 카복실-보호그룹을 나타낸다.
  2. 제1항에 있어서, 브리지헤드(bridge head)탄소원자 3a 및 (5+n)상의 수소원자가 시스 배열을 갖는 일반식(Ⅰ)의 화합물.
  3. 제1항 또는 제2항에 있어서, 2위치에 있는 탄소원자가 S배열을 갖는 일반식(Ⅰ)의 화합물.
  4. 일반식(Ⅱ)의 화합물을 자유-라디칼 탈카복실화 시킴을 특징으로하여 제1항에 따른 일반식(Ⅰ)화합물을 제조하는 방법.
    상기식에서 N,R 및 R1은 제1항에서 정의한 바와 같다.
  5. 일반식(Ⅲ)의 화합물.
    상기식에서, N,R 및 R1은 제1항에서 정의한 바와 같으며, R2는 2-티옥소-2H-[1]피리딜 또는 (C1-C6)-알콕시카보닐을 나타낸다.
  6. 일반식(Ⅰ)의 화합물을 적절한 용매중에서 라니니켈로 처리한후, 필요한 경우, 산 및/또는 염기 첨가하 및/또는 가수소분해 반응시켜 수소를 나타내지 않는 R3및/또는 R4라디칼중 1개 또는 2개를 수소로 대체시키고, 필요한 경우, 일반식(Ⅳ)의 화합물을 에스테르화 반응 또는 에스테르 교환반응시켜 R4가 R에서 정의한 바와 같은 일반식(Ⅳ)의 에스테르로 전환시킴으로써 하기 일반식(Ⅳ)의 화합물을 제조하는 방법에 사용하기 위한, 제1항 내지 3항중 어느한 항에 따른 일반식(Ⅰ)화합물의 용도.
    상기식에서, R3는 수소이거나, 제1항에서 R로서 정의한 바와 같으며, R4는 수소이거나, 제1항에서 R1으로서 정의한 바와 같다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019870013757A 1986-12-04 1987-12-03 비사이클릭 아미노 카복실산 유도체, 그의 제조 방법 및 중간 생성물, 및 그의 용도 KR960000851B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19863641451 DE3641451A1 (de) 1986-12-04 1986-12-04 Derivate bicyclischer aminocarbonsaeuren, verfahren und zwischenprodukte zu deren herstellung sowie deren verwendung
DEP3641451.4 1986-12-04

Publications (2)

Publication Number Publication Date
KR880007518A true KR880007518A (ko) 1988-08-27
KR960000851B1 KR960000851B1 (ko) 1996-01-13

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KR1019870013757A KR960000851B1 (ko) 1986-12-04 1987-12-03 비사이클릭 아미노 카복실산 유도체, 그의 제조 방법 및 중간 생성물, 및 그의 용도

Country Status (23)

Country Link
US (1) US4868307A (ko)
EP (1) EP0270982B1 (ko)
JP (2) JP2550369B2 (ko)
KR (1) KR960000851B1 (ko)
AR (1) AR243882A1 (ko)
AT (1) ATE104295T1 (ko)
AU (1) AU641498B2 (ko)
CA (1) CA1317960C (ko)
DE (2) DE3641451A1 (ko)
DK (1) DK173877B1 (ko)
EG (1) EG18416A (ko)
ES (1) ES2053511T3 (ko)
FI (1) FI90773C (ko)
IE (1) IE63322B1 (ko)
IL (1) IL84678A (ko)
MA (1) MA21122A1 (ko)
MX (1) MX172782B (ko)
NO (1) NO170933C (ko)
NZ (1) NZ222771A (ko)
PH (1) PH26415A (ko)
PT (1) PT86281B (ko)
TN (1) TNSN87135A1 (ko)
ZA (1) ZA879079B (ko)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3333455A1 (de) * 1983-09-16 1985-04-11 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung n-alkylierter dipeptide und deren estern
DE3413710A1 (de) * 1984-04-12 1985-10-24 Hoechst Ag, 6230 Frankfurt Verfahren zur behandlung der herzinsuffizienz
US5684016A (en) * 1984-04-12 1997-11-04 Hoechst Aktiengesellschaft Method of treating cardiac insufficiency
DE3431541A1 (de) * 1984-08-28 1986-03-06 Hoechst Ag, 6230 Frankfurt Cis,endo-2-azabicycloalkan-3-carbonsaeure-derivate, verfahren zu deren herstellung, deren verwendung sowie zwischenprodukte bei deren herstellung
US5231080A (en) * 1985-10-15 1993-07-27 Hoechst Aktiengesellschaft Method for the treatment of atherosclerosis, thrombosis, and peripheral vessel disease
US5231084A (en) * 1986-03-27 1993-07-27 Hoechst Aktiengesellschaft Compounds having a cognition adjuvant action, agents containing them, and the use thereof for the treatment and prophylaxis of cognitive dysfuncitons
DE3639879A1 (de) * 1986-11-21 1988-06-01 Hoechst Ag Verfahren zur herstellung von mono-, bi- und tricyclischen aminosaeuren, zwischenprodukte dieses verfahrens sowie ein verfahren zu deren herstellung
DE3731085A1 (de) * 1987-09-16 1989-04-06 Hoechst Ag Neue aminosaeureester, verfahren zu ihrer herstellung, sie enthaltende arzneimittel und deren verwendung
EP0331609A3 (de) * 1988-01-27 1992-07-01 Hoechst Aktiengesellschaft Angiotensin-Converting-Enzym-Hemmstoffe mit psychotroper Wirkung
HU904967D0 (en) * 1988-04-22 1991-01-28 Hoechst Ag Process for producing new azabicyclo(3.3.o)octane-3-carboxylic acid-octylesther derivatives
JP2005519098A (ja) * 2002-03-01 2005-06-30 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー 変形性関節症の治療方法
EP1615885A1 (en) * 2003-04-15 2006-01-18 Warner-Lambert Company LLC B -fused bicyclic proline derivatives and their use for treating arthritic conditions
CA2521364A1 (en) * 2003-04-15 2004-10-28 Warner-Lambert Company Llc [c]-fused bicyclic proline derivatives and their use for treating arthritic conditions
EP1536017B1 (en) * 2003-10-30 2007-04-18 Sumitomo Chemical Company, Limited Process for producing optically active octahydro-1H-indole-2-carboxylic acid

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE52663B1 (en) * 1980-04-02 1988-01-20 Warner Lambert Co Substituted acyl derivatives of octahydro-1h-indole-2-carboxylic acids
US4350704A (en) * 1980-10-06 1982-09-21 Warner-Lambert Company Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids
DE3174844D1 (en) * 1980-10-23 1986-07-24 Schering Corp Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them
ZA817261B (en) * 1980-10-23 1982-09-29 Schering Corp Carboxyalkyl dipeptides,processes for their production and pharmaceutical compositions containing them
FR2510112A1 (fr) * 1981-07-24 1983-01-28 Roussel Uclaf Nouveaux derives du 2-oxo-pyrid-3-yl ou piperidin-3-yl indole, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant
DE3226768A1 (de) * 1981-11-05 1983-05-26 Hoechst Ag, 6230 Frankfurt Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
IE55867B1 (en) * 1981-12-29 1991-02-14 Hoechst Ag New derivatives of bicyclic aminoacids,processes for their preparation,agents containing these compounds and their use,and new bicyclic aminoacids as intermediates and processes for their preparation
DE3246503A1 (de) * 1982-12-16 1984-06-20 Hoechst Ag, 6230 Frankfurt Derivate der cis, endo-2-azabicyclo-(5.3.0)-decan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung

Also Published As

Publication number Publication date
JP2550369B2 (ja) 1996-11-06
JP2675992B2 (ja) 1997-11-12
PH26415A (en) 1992-07-15
DE3641451A1 (de) 1988-06-16
JPH08283240A (ja) 1996-10-29
NO170933C (no) 1992-12-30
DK635887D0 (da) 1987-12-03
CA1317960C (en) 1993-05-18
JPS63145278A (ja) 1988-06-17
PT86281A (de) 1988-01-01
AU7621091A (en) 1991-08-01
DK635887A (da) 1988-06-05
MX172782B (es) 1994-01-13
ATE104295T1 (de) 1994-04-15
MA21122A1 (fr) 1988-07-01
FI90773C (fi) 1994-03-25
EG18416A (en) 1992-12-30
AR243882A1 (es) 1993-09-30
US4868307A (en) 1989-09-19
AU8209487A (en) 1988-06-09
PT86281B (pt) 1990-11-07
AU609754B2 (en) 1991-05-09
NO875051L (no) 1988-06-06
ZA879079B (en) 1988-06-01
AU641498B2 (en) 1993-09-23
NO170933B (no) 1992-09-21
EP0270982A2 (de) 1988-06-15
EP0270982B1 (de) 1994-04-13
FI875319A (fi) 1988-06-05
MX9606A (es) 1993-07-01
IL84678A (en) 1993-03-15
KR960000851B1 (ko) 1996-01-13
TNSN87135A1 (fr) 1990-01-01
NZ222771A (en) 1991-01-29
EP0270982A3 (en) 1989-08-09
IL84678A0 (en) 1988-05-31
NO875051D0 (no) 1987-12-03
DE3789609D1 (de) 1994-05-19
IE63322B1 (en) 1995-04-05
IE873288L (en) 1988-06-04
FI875319A0 (fi) 1987-12-02
DK173877B1 (da) 2002-01-21
FI90773B (fi) 1993-12-15
ES2053511T3 (es) 1994-08-01

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