BR0309992A - Método para purificar albumina de soro humano recombinante (rhsa) de uma solução - Google Patents

Método para purificar albumina de soro humano recombinante (rhsa) de uma solução

Info

Publication number
BR0309992A
BR0309992A BR0309992-0A BR0309992A BR0309992A BR 0309992 A BR0309992 A BR 0309992A BR 0309992 A BR0309992 A BR 0309992A BR 0309992 A BR0309992 A BR 0309992A
Authority
BR
Brazil
Prior art keywords
rhsa
matrix
cation exchange
serum albumin
human serum
Prior art date
Application number
BR0309992-0A
Other languages
English (en)
Other versions
BRPI0309992B1 (pt
Inventor
Makonnen Belew
Mei Yan Li
Wei Zhang
Original Assignee
North China Pharmaceutical Group
Amersham Biosciences Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by North China Pharmaceutical Group, Amersham Biosciences Ab filed Critical North China Pharmaceutical Group
Publication of BR0309992A publication Critical patent/BR0309992A/pt
Publication of BRPI0309992B1 publication Critical patent/BRPI0309992B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"MéTODO PARA PURIFICAR ALBUMINA DE SORO HUMANO RECOMBINANTE (RHSA) DE UMA SOLUçãO". A presente invenção é um método de purificar albumina de soro humano recombinante (RHSA: recombinant human serum albumina) de uma matriz bimodal altamente tolerante a sal; cromatografia de interação hidrofóbica (HIC); e troca de ânions. A matriz bimodal de troca de cátions altamente tolerante a sal utilizada permite uma purificação de um sobrenadante de cultura de células diretamente, no sentido de que não é mais necessária diluição adicional do mesmo. Devido a sua alta capacidade de ligação, referida matriz bimodal de troca de cátions também permite o uso de uma quantidade menor de matriz em comparação com uma matriz de trocador de ânions convencional correspondente. Assim, a presente invenção permite economia substancial no que se refere a volumes e, conseq³entemente, a custos de operação.
BRPI0309992-0A 2002-05-15 2003-05-09 método para purificar albumina de soro humano recombinante (rhsa) de uma solução BRPI0309992B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0201518A SE526227C2 (sv) 2002-05-15 2002-05-15 Metod för rening av rekombinant humant serumalbumin
SE0201518-8 2002-05-15
PCT/SE2003/000766 WO2003097692A1 (en) 2002-05-15 2003-05-09 Method for albumin purification

Publications (2)

Publication Number Publication Date
BR0309992A true BR0309992A (pt) 2005-03-01
BRPI0309992B1 BRPI0309992B1 (pt) 2020-12-22

Family

ID=20287916

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0309992A BRPI0309992B8 (pt) 2002-05-15 2003-05-09 método para purificar albumina de soro humano recombinante (rhsa) de uma solução
BRPI0309992-0A BRPI0309992B1 (pt) 2002-05-15 2003-05-09 método para purificar albumina de soro humano recombinante (rhsa) de uma solução

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BRPI0309992A BRPI0309992B8 (pt) 2002-05-15 2003-05-09 método para purificar albumina de soro humano recombinante (rhsa) de uma solução

Country Status (13)

Country Link
US (2) US7423124B2 (pt)
EP (2) EP1504031B1 (pt)
JP (2) JP2006502098A (pt)
CN (1) CN100463921C (pt)
AT (1) ATE335006T1 (pt)
AU (2) AU2003228193B2 (pt)
BR (2) BRPI0309992B8 (pt)
CA (2) CA2483612A1 (pt)
DE (1) DE60307262T2 (pt)
ES (1) ES2268362T3 (pt)
IL (1) IL164844A (pt)
SE (1) SE526227C2 (pt)
WO (2) WO2003097692A1 (pt)

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PL209772B1 (pl) * 2003-01-28 2011-10-31 Du Pont Antraniloamidy, środek do zwalczania szkodnika będącego bezkręgowcem i sposób zwalczania szkodnika będącego bezkręgowcem
US20040217055A1 (en) * 2003-03-12 2004-11-04 Elmar Kraus Use of recombinant albumin in dialysis after liver failure
CN1956998B (zh) * 2004-04-23 2012-12-12 康久有限责任公司 用于纯化白蛋白结合物的方法
CN1854155B (zh) * 2005-04-29 2010-11-17 华北制药集团新药研究开发有限责任公司 一种纯化rHSA的方法
AR067536A1 (es) 2007-07-17 2009-10-14 Hoffmann La Roche Metodo para obtener una eritropoyetina mono-pegilada en una forma sustancialmente homogenea
CL2008002053A1 (es) 2007-07-17 2009-05-22 Hoffmann La Roche Metodo para la purificacion de una eritropoyetina monopeguilada (epompeg) que consiste en proporcionar una solucion que contiene eritropoyetina mono, poli y no peguilada y hacerla pasar por dos pasos de cromatografia de intercambio cationico y metodo para producir epo mpeg que incluye metodo de purificacion.
US8445213B2 (en) 2008-03-31 2013-05-21 Sekisui Medical Co., Ltd. Purified serum albumin, and immunological measurement method
US8753868B2 (en) * 2008-08-04 2014-06-17 General Electric Company Method and system for selective isolation of target biological molecules in a general purpose system
CN101768206B (zh) * 2008-12-31 2013-05-15 华北制药集团新药研究开发有限责任公司 一种重组人血清白蛋白的纯化方法及其应用
CA2752729A1 (en) 2009-02-20 2010-08-26 Ventria Bioscience Cell culture media containing combinations of proteins
NZ603648A (en) * 2010-05-25 2014-12-24 Genentech Inc Methods of purifying polypeptides
CN102127164B (zh) 2010-12-20 2013-01-30 武汉禾元生物科技有限公司 一种从水稻种子中提取重组人血清白蛋白的方法
CN102532254B (zh) * 2010-12-24 2015-06-24 武汉禾元生物科技股份有限公司 一种从水稻种子中分离纯化重组人血清白蛋白的方法
CN104812491B (zh) * 2012-03-08 2018-06-19 生物辐射实验室股份有限公司 阴离子交换-疏水性混合模式
CN103880947B (zh) 2012-12-21 2016-01-13 武汉禾元生物科技股份有限公司 一种分离纯化高纯度重组人血清白蛋白的层析方法
CN103923211A (zh) * 2014-05-08 2014-07-16 齐智 一种医药级重组人血清白蛋白的纯化方法
IL255884B2 (en) 2015-06-10 2024-05-01 Immunitybio Inc Modified NK-92 cells for cancer treatment
CN106146631A (zh) * 2015-12-09 2016-11-23 烟台大学 一种离心技术结合疏水层析介质制备藻红蛋白的方法
CN106117347A (zh) * 2015-12-09 2016-11-16 烟台大学 一种疏水层析制备高纯度藻红蛋白的方法
CN106117326A (zh) * 2015-12-09 2016-11-16 烟台大学 一种离心法结合阴离子交换层析介质制备藻红蛋白的方法
US11739166B2 (en) 2020-07-02 2023-08-29 Davol Inc. Reactive polysaccharide-based hemostatic agent
KR20230060524A (ko) 2020-12-08 2023-05-04 통화 안레이트 바이오파마슈티컬 컴퍼니 리미티드 재조합 단백질의 정제 방법
CN113461804A (zh) * 2021-08-09 2021-10-01 山东健通生物科技有限公司 减少重组人血白蛋白发酵过程中色素的方法
CN113880908B (zh) * 2021-08-25 2024-05-14 北京伟德杰生物科技有限公司 纯化重组人血清白蛋白的融合蛋白的方法
CN113735962B (zh) * 2021-08-27 2023-11-10 常熟纳微生物科技有限公司 一种从猪血中纯化重组人血清白蛋白的方法及应用

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CA2157219C (en) * 1994-08-31 2010-10-05 Munehiro Noda Process for purifying recombinant human serum albumin
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JP4798832B2 (ja) * 2000-10-24 2011-10-19 一般財団法人化学及血清療法研究所 ヒト血清アルブミン多量体の除去方法

Also Published As

Publication number Publication date
EP1504031B1 (en) 2006-08-02
CA2483612A1 (en) 2003-11-27
DE60307262T2 (de) 2007-06-28
IL164844A (en) 2009-09-01
IL164844A0 (en) 2005-12-18
BRPI0309992B8 (pt) 2023-03-21
WO2003097693A1 (en) 2003-11-27
AU2003228193B2 (en) 2009-05-07
AU2003228193A1 (en) 2003-12-02
EP1504032A1 (en) 2005-02-09
US7351801B2 (en) 2008-04-01
SE0201518D0 (sv) 2002-05-15
WO2003097692A1 (en) 2003-11-27
AU2003232704A1 (en) 2003-12-02
JP2006502098A (ja) 2006-01-19
US7423124B2 (en) 2008-09-09
ES2268362T3 (es) 2007-03-16
DE60307262D1 (de) 2006-09-14
BRPI0309992B1 (pt) 2020-12-22
US20050215765A1 (en) 2005-09-29
CA2483616A1 (en) 2003-11-27
US20050214902A1 (en) 2005-09-29
SE526227C2 (sv) 2005-08-02
ATE335006T1 (de) 2006-08-15
CN100463921C (zh) 2009-02-25
JP4559216B2 (ja) 2010-10-06
JP2006512283A (ja) 2006-04-13
CN1496993A (zh) 2004-05-19
EP1504031A1 (en) 2005-02-09

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 22/12/2020, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 09/05/2003 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B25D Requested change of name of applicant approved

Owner name: NORTH CHINA PHARMACEUTICAL GROUP CORPORATION (CN) ; CYTIVA SWEDEN AB (SE)