ATE172988T1 - Die mac-1-bindungsstelle von icam-1 - Google Patents
Die mac-1-bindungsstelle von icam-1Info
- Publication number
- ATE172988T1 ATE172988T1 AT91119894T AT91119894T ATE172988T1 AT E172988 T1 ATE172988 T1 AT E172988T1 AT 91119894 T AT91119894 T AT 91119894T AT 91119894 T AT91119894 T AT 91119894T AT E172988 T1 ATE172988 T1 AT E172988T1
- Authority
- AT
- Austria
- Prior art keywords
- icam
- mac
- binding site
- relates
- molecules
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70525—ICAM molecules, e.g. CD50, CD54, CD102
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2821—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against ICAM molecules, e.g. CD50, CD54, CD102
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2/00—Peptides of undefined number of amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/868—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, or immunotolerance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Ropes Or Cables (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Package Frames And Binding Bands (AREA)
- Hall/Mr Elements (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/618,286 US5288854A (en) | 1990-11-28 | 1990-11-28 | Functional derivatives of ICAM-1 which are substantially capable of binding to LFA-1 but are substantially incapable of binding to MAC-1 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE172988T1 true ATE172988T1 (de) | 1998-11-15 |
Family
ID=24477094
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT91119894T ATE172988T1 (de) | 1990-11-28 | 1991-11-21 | Die mac-1-bindungsstelle von icam-1 |
Country Status (8)
Country | Link |
---|---|
US (1) | US5288854A (de) |
EP (1) | EP0488061B1 (de) |
KR (1) | KR920009412A (de) |
AT (1) | ATE172988T1 (de) |
DE (1) | DE69130445T2 (de) |
DK (1) | DK0488061T3 (de) |
ES (1) | ES2122964T3 (de) |
NZ (2) | NZ240747A (de) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5284931A (en) * | 1987-05-04 | 1994-02-08 | Dana Farber Cancer Institute | Intercellular adhesion molecules, and their binding ligands |
US6143298A (en) * | 1988-09-01 | 2000-11-07 | Bayer Corporation | Soluble truncated forms of ICAM-1 |
EP0362531B1 (de) | 1988-09-01 | 1999-11-10 | Bayer Corporation | Menschliches Rhinovirusrezeptorprotein, das die Virusinfektionsanfälligkeit hemmt |
US6051231A (en) * | 1988-09-01 | 2000-04-18 | Bayer Corporation | Antiviral methods and prepations |
US6514936B1 (en) | 1988-09-01 | 2003-02-04 | Bayer Corporation | Antiviral methods using human rhinovirus receptor (ICAM-1) |
US6797270B1 (en) | 1989-03-16 | 2004-09-28 | Center For Blood Research, Inc. | Functional derivatives of the intercellular adhesion molecule ICAM-1 in anti-viral therapy |
US6130202A (en) * | 1990-07-20 | 2000-10-10 | Bayer Corporation | Antiviral methods |
US6107461A (en) * | 1990-07-20 | 2000-08-22 | Bayer Corporation | Multimeric forms of human rhinovirus receptor and fragments thereof, and method of use |
EP0468257B1 (de) * | 1990-07-20 | 1999-09-01 | Bayer Corporation | Multimere Formen des menschlichen Rhinovirus-Rezeptorproteins |
GB9115364D0 (en) * | 1991-07-16 | 1991-08-28 | Wellcome Found | Antibody |
US5869262A (en) * | 1992-01-27 | 1999-02-09 | Icos Corporation | Method for monitoring an inflammatory disease state by detecting circulating ICAM-R |
AU674556B2 (en) * | 1992-10-09 | 1997-01-02 | Center For Blood Research, Inc., The | A subpopulation of MAC-1 molecules which mediate neutrophil adhesion to ICAM-1 and fibrinogen |
US6001356A (en) * | 1995-09-29 | 1999-12-14 | Rush-Presbyterian-St. Luke's Medical Center | Method of inhibiting tissue destruction in autoimmune disease using anti-CD44 antibodies |
JP4451933B2 (ja) * | 1996-12-27 | 2010-04-14 | 住友化学株式会社 | 遺伝子操作による植物へのppo阻害性除草剤耐性付与法 |
ES2246567T3 (es) * | 1998-04-15 | 2006-02-16 | Brigham & Womens Hospital | Composiciones para receptores inhibidores de celulas t y usos de las mismas. |
US6331640B1 (en) | 1998-10-13 | 2001-12-18 | Hoffmann-La Roche Inc. | Diaminopropionic acid derivatives |
US6867203B2 (en) | 1998-12-29 | 2005-03-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds |
WO2002018583A2 (en) | 2000-09-01 | 2002-03-07 | The Center For Blood Research, Inc. | Modified polypeptides stabilized in a desired conformation and methods for producing same |
KR20030051882A (ko) * | 2000-11-28 | 2003-06-25 | 제넨테크, 인크. | Lfa-1 대항제 화합물 |
EP1682537B1 (de) | 2003-11-05 | 2012-03-28 | SARcode Bioscience Inc. | Modulatoren der zellulären adhäsion |
AU2005277547B2 (en) * | 2004-08-16 | 2011-08-25 | Immune Disease Institute, Inc. | Method of delivering RNA interference and uses thereof |
US20060233675A1 (en) * | 2005-04-13 | 2006-10-19 | Stein Israel M | Glass test tube having protective outer shield |
ES2614080T3 (es) | 2005-05-17 | 2017-05-29 | Sarcode Bioscience Inc. | Composiciones y métodos para el tratamiento de trastornos oculares |
AU2007243370A1 (en) * | 2006-04-24 | 2007-11-08 | The Cbr Institute For Biomedical Research, Inc. | Method of producing immunoliposomes and compositions thereof |
EP2018436A2 (de) * | 2006-04-25 | 2009-01-28 | Immune Disease Institute Inc. | Gezielte abgabe an leukozyten mit nicht-proteinträgern |
EP3797775A1 (de) | 2007-10-19 | 2021-03-31 | Novartis AG | Zusammensetzungen und verfahren zur behandlung von diabetischer retinopathie |
WO2009139817A2 (en) | 2008-04-15 | 2009-11-19 | Sarcode Corporation | Crystalline pharmaceutical and methods of preparation and use thereof |
EP2265124A4 (de) * | 2008-04-15 | 2011-12-28 | Sarcode Bioscience Inc | Aerosolisierte lfa-1-antagonisten zur verwendung bei der lokalen behandlung von immunerkrankungen |
JP2011516607A (ja) * | 2008-04-15 | 2011-05-26 | サーコード コーポレイション | 胃腸系へのlfa−1アンタゴニストの送達 |
CN102056485A (zh) * | 2008-04-15 | 2011-05-11 | 萨可德公司 | 用于局部治疗免疫相关疾病的局部lfa-1拮抗剂 |
WO2011050175A1 (en) | 2009-10-21 | 2011-04-28 | Sarcode Corporation | Crystalline pharmaceutical and methods of preparation and use thereof |
CN104797574B (zh) | 2012-07-25 | 2019-11-22 | 原生质生物科学股份有限公司 | Lfa-1抑制剂及其多晶型物 |
KR20210105890A (ko) | 2018-12-17 | 2021-08-27 | 레비토프 리미티드 | 트윈 면역 세포 인게이저 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3852374T2 (de) * | 1987-11-02 | 1995-05-04 | Baylor College Medicine | Verwendung von ICAM-1 oder ihre funktionelle Derivate zur Behandlung unspezifischer Entzündungen. |
EP0362531B1 (de) * | 1988-09-01 | 1999-11-10 | Bayer Corporation | Menschliches Rhinovirusrezeptorprotein, das die Virusinfektionsanfälligkeit hemmt |
ATE246245T1 (de) * | 1988-09-28 | 2003-08-15 | Dana Farber Cancer Inst Inc | Interzellulare adhäsions-moleküle und deren bindungsliganden |
-
1990
- 1990-11-28 US US07/618,286 patent/US5288854A/en not_active Expired - Lifetime
-
1991
- 1991-11-21 AT AT91119894T patent/ATE172988T1/de active
- 1991-11-21 DK DK91119894T patent/DK0488061T3/da active
- 1991-11-21 DE DE69130445T patent/DE69130445T2/de not_active Expired - Fee Related
- 1991-11-21 ES ES91119894T patent/ES2122964T3/es not_active Expired - Lifetime
- 1991-11-21 EP EP91119894A patent/EP0488061B1/de not_active Expired - Lifetime
- 1991-11-26 NZ NZ240747A patent/NZ240747A/en unknown
- 1991-11-26 NZ NZ260473A patent/NZ260473A/en unknown
- 1991-11-26 KR KR1019910021347A patent/KR920009412A/ko active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
DK0488061T3 (da) | 1999-07-19 |
EP0488061B1 (de) | 1998-11-04 |
ES2122964T3 (es) | 1999-01-01 |
NZ240747A (en) | 1996-05-28 |
DE69130445D1 (de) | 1998-12-10 |
EP0488061A3 (en) | 1992-08-26 |
KR920009412A (ko) | 1992-06-25 |
NZ260473A (en) | 1997-06-24 |
US5288854A (en) | 1994-02-22 |
EP0488061A2 (de) | 1992-06-03 |
DE69130445T2 (de) | 1999-07-08 |
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