ATE32730T1 - Indikatormarkierte konjugate von metallothionein und zielsuchenden, biologisch aktiven molekuelen. - Google Patents
Indikatormarkierte konjugate von metallothionein und zielsuchenden, biologisch aktiven molekuelen.Info
- Publication number
- ATE32730T1 ATE32730T1 AT84111913T AT84111913T ATE32730T1 AT E32730 T1 ATE32730 T1 AT E32730T1 AT 84111913 T AT84111913 T AT 84111913T AT 84111913 T AT84111913 T AT 84111913T AT E32730 T1 ATE32730 T1 AT E32730T1
- Authority
- AT
- Austria
- Prior art keywords
- metallothionein
- conjugates
- target
- biologically active
- marked
- Prior art date
Links
- DIGQNXIGRZPYDK-WKSCXVIASA-N (2R)-6-amino-2-[[2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-[[(2R,3S)-2-[[2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S,3S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[2-[[2-[[2-[(2-amino-1-hydroxyethylidene)amino]-3-carboxy-1-hydroxypropylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxybutylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1,5-dihydroxy-5-iminopentylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxybutylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxyethylidene]amino]hexanoic acid Chemical compound C[C@@H]([C@@H](C(=N[C@@H](CS)C(=N[C@@H](C)C(=N[C@@H](CO)C(=NCC(=N[C@@H](CCC(=N)O)C(=NC(CS)C(=N[C@H]([C@H](C)O)C(=N[C@H](CS)C(=N[C@H](CO)C(=NCC(=N[C@H](CS)C(=NCC(=N[C@H](CCCCN)C(=O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)N=C([C@H](CS)N=C([C@H](CO)N=C([C@H](CO)N=C([C@H](C)N=C(CN=C([C@H](CO)N=C([C@H](CS)N=C(CN=C(C(CS)N=C(C(CC(=O)O)N=C(CN)O)O)O)O)O)O)O)O)O)O)O)O DIGQNXIGRZPYDK-WKSCXVIASA-N 0.000 title abstract 3
- 102000003792 Metallothionein Human genes 0.000 title abstract 3
- 108090000157 Metallothionein Proteins 0.000 title abstract 3
- 239000002184 metal Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6887—Antibody-chelate conjugates using chelates for therapeutic purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/804—Radioisotope, e.g. radioimmunoassay
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Steroid Compounds (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/539,733 US4732864A (en) | 1983-10-06 | 1983-10-06 | Trace-labeled conjugates of metallothionein and target-seeking biologically active molecules |
| EP84111913A EP0137457B1 (de) | 1983-10-06 | 1984-10-04 | Indikatormarkierte Konjugate von Metallothionein und zielsuchenden, biologisch aktiven Molekülen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE32730T1 true ATE32730T1 (de) | 1988-03-15 |
Family
ID=24152436
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT84111913T ATE32730T1 (de) | 1983-10-06 | 1984-10-04 | Indikatormarkierte konjugate von metallothionein und zielsuchenden, biologisch aktiven molekuelen. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4732864A (de) |
| EP (1) | EP0137457B1 (de) |
| JP (2) | JPS60166625A (de) |
| KR (1) | KR860001151B1 (de) |
| AT (1) | ATE32730T1 (de) |
| AU (1) | AU578428B2 (de) |
| CA (1) | CA1248090A (de) |
| DE (1) | DE3469536D1 (de) |
| DK (1) | DK162105C (de) |
| ES (1) | ES8605105A1 (de) |
| FI (1) | FI81263C (de) |
| GR (1) | GR80560B (de) |
| IE (1) | IE55709B1 (de) |
| IL (1) | IL73183A (de) |
| NO (1) | NO166267C (de) |
| NZ (1) | NZ209788A (de) |
| ZA (1) | ZA847797B (de) |
Families Citing this family (88)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4707352A (en) * | 1984-01-30 | 1987-11-17 | Enzo Biochem, Inc. | Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group |
| US4880626A (en) * | 1985-01-18 | 1989-11-14 | Mcmichael John | Immunotherapeutic methods and compositions for the treatment of diseases of viral origin, including acquired immune deficiency syndrome |
| NO167124C (no) * | 1985-04-03 | 1991-10-09 | Du Pont Merck Pharma | Fremgangsmaate for fremstilling av et spormerket konjugat av metallthionein og biologisk aktivt molekyl. |
| US5776093A (en) | 1985-07-05 | 1998-07-07 | Immunomedics, Inc. | Method for imaging and treating organs and tissues |
| WO1987004351A1 (en) * | 1986-01-16 | 1987-07-30 | The General Hospital Corporation | Method for the diagnosis and treatment of inflammation |
| US6451225B1 (en) | 1986-04-30 | 2002-09-17 | Igen International, Inc. | Electrochemiluminescent reaction utilizing amine-derived reductant |
| US6165729A (en) * | 1986-04-30 | 2000-12-26 | Hyperion Catalysis International, Inc. | Electrochemiluminescent reaction utilizing amine-derived reductant |
| US5591581A (en) | 1986-04-30 | 1997-01-07 | Igen, Inc. | Electrochemiluminescent rhenium moieties and methods for their use |
| US4877599A (en) * | 1986-11-10 | 1989-10-31 | New England Deaconess Hospital Corporation | Detection of vascular disease with labelled antibodies |
| US5672334A (en) * | 1991-01-16 | 1997-09-30 | Access Pharmaceuticals, Inc. | Invivo agents comprising cationic metal chelators with acidic saccharides and glycosaminoglycans |
| DE3856567T2 (de) * | 1987-11-04 | 2004-12-16 | Igen International, Inc. | Lumineszente Rhenium-Komplexe und Verfahren zur Herstellung |
| US5202451A (en) * | 1988-02-17 | 1993-04-13 | Neorx Corporation | Anchimeric radiometal chelating compounds |
| USH735H (en) | 1988-03-30 | 1990-02-06 | The United States Of America As Represented By The United States Department Of Energy | Lead-203 as a label for radioimaging |
| US5061641A (en) * | 1988-04-01 | 1991-10-29 | Immunomedics, Inc. | Method for radiolabeling proteins |
| US5057301A (en) * | 1988-04-06 | 1991-10-15 | Neorx Corporation | Modified cellular substrates used as linkers for increased cell retention of diagnostic and therapeutic agents |
| US5059541A (en) * | 1988-04-29 | 1991-10-22 | Neorx Corporation | Minimal derivatization of proteins |
| US6702986B1 (en) | 1988-04-29 | 2004-03-09 | Igen International, Inc. | Electrochemiluminescent reaction utilizing amine-derived reductant |
| US5972890A (en) * | 1988-05-02 | 1999-10-26 | New England Deaconess Hospital Corporation | Synthetic peptides for arterial imaging |
| US5726153A (en) * | 1988-05-02 | 1998-03-10 | New England Deaconess Hospital Corporation | Synthetic peptides for arterial imaging |
| US5218128A (en) * | 1988-06-15 | 1993-06-08 | Centocor, Inc. | Bifunctional coupling agents and radionuclide labeled compositions prepared therefrom |
| WO1990006323A2 (en) * | 1988-11-29 | 1990-06-14 | Centocor, Inc. | Chimeric proteins incorporating a metal binding protein |
| US5078985A (en) * | 1989-08-09 | 1992-01-07 | Rhomed, Incorporated | Radiolabeling antibodies and other proteins with technetium or rhenium by regulated reduction |
| ATE172879T1 (de) * | 1989-08-09 | 1998-11-15 | Rhomed Inc | Direkte radioetikettierung von antikörpern und sonstigen proteinen mittels technetium oder rhenium |
| US5985240A (en) * | 1989-08-09 | 1999-11-16 | Rhomed Incorporated | Peptide radiopharmaceutical applications |
| US5700444A (en) * | 1992-02-20 | 1997-12-23 | Rhomed Incorporated | Chemotactic peptide pharmaceutical applications |
| US5759515A (en) * | 1989-08-09 | 1998-06-02 | Rhomed Incorporated | Polyvalent peptide pharmaceutical applications |
| US5443816A (en) * | 1990-08-08 | 1995-08-22 | Rhomed Incorporated | Peptide-metal ion pharmaceutical preparation and method |
| US5747334A (en) * | 1990-02-15 | 1998-05-05 | The University Of North Carolina At Chapel Hill | Random peptide library |
| US5498538A (en) * | 1990-02-15 | 1996-03-12 | The University Of North Carolina At Chapel Hill | Totally synthetic affinity reagents |
| JP3043407B2 (ja) * | 1990-02-15 | 2000-05-22 | ザ ユニバーシティー オブ ノースカロライナ アット チャペル ヒル | 完全合成アフィニティ試薬 |
| US6019958A (en) * | 1991-02-08 | 2000-02-01 | Diatide, Inc. | Technetium-99m labeled peptides for imaging inflammation |
| US7238340B1 (en) | 1991-11-27 | 2007-07-03 | Cis Bio International | Monoamine, diamide, thiol-containing metal chelating agents |
| ATE188387T1 (de) * | 1991-02-08 | 2000-01-15 | Diatide Inc | Technetium-99m markierte polypeptide zur bildformung |
| US5645815A (en) | 1991-02-08 | 1997-07-08 | Diatide, Inc. | Radiolabled compounds for thrombus imaging |
| US6403771B1 (en) | 1991-02-19 | 2002-06-11 | Actinium Pharmaceuticals, Limited | Method and means for site directed therapy |
| US6391590B1 (en) * | 1991-10-21 | 2002-05-21 | The Regents Of The University Of California | Recombinant streptavidin-metallothionein chimeric protein having biological recognition specificity |
| US5738838A (en) * | 1992-02-20 | 1998-04-14 | Rhomed Incorporated | IKVAV peptide radiopharmaceutical applications |
| US5556609A (en) * | 1992-02-20 | 1996-09-17 | Rhomed Incorporated | YIGSR peptide radiopharmaceutical applications |
| US5643549A (en) * | 1992-02-20 | 1997-07-01 | Rhomed Incorporated | Leukostimulatory agent for in vivo leukocyte tagging |
| US5326856A (en) * | 1992-04-09 | 1994-07-05 | Cytogen Corporation | Bifunctional isothiocyanate derived thiocarbonyls as ligands for metal binding |
| US5338686A (en) * | 1992-04-29 | 1994-08-16 | Hellerstein Marc K | Method for measuring in vivo synthesis of biopolymers |
| CA2100709C (en) * | 1992-07-27 | 2004-03-16 | Maurits W. Geerlings | Method and means for site directed therapy |
| US6203775B1 (en) * | 1993-03-19 | 2001-03-20 | The General Hospital Corporation | Chelating polymers for labeling of proteins |
| WO1994026297A1 (en) * | 1993-05-17 | 1994-11-24 | Immunomedics, Inc. | Improved detection and therapy of lesions with biotin/avidin-metal chelating protein conjugates |
| US6120768A (en) * | 1993-05-17 | 2000-09-19 | Immunomedics, Inc. | Dota-biotin derivatives |
| JPH09500140A (ja) * | 1993-07-19 | 1997-01-07 | レゾリューション・ファーマスーティカルズ・インコーポレーテッド | Ｎ▲下３▼ｓ立体配置を有するヒドラジノ型放射性核種キレート形成剤 |
| WO1995004753A1 (en) * | 1993-08-11 | 1995-02-16 | University Of New Mexico | Compositions of fusion proteins containing metallothionein and targeting-protein structural components |
| US5449761A (en) * | 1993-09-28 | 1995-09-12 | Cytogen Corporation | Metal-binding targeted polypeptide constructs |
| US5942210A (en) * | 1994-11-15 | 1999-08-24 | Cytogen Corporation | Methods for lyoprotecting a macromolecule using tricine |
| US5891418A (en) * | 1995-06-07 | 1999-04-06 | Rhomed Incorporated | Peptide-metal ion pharmaceutical constructs and applications |
| US6331285B1 (en) | 1996-06-05 | 2001-12-18 | Palatin Technologies, Inc. | Structurally determined cyclic metallo-constructs and applications |
| US7070921B2 (en) | 2000-04-28 | 2006-07-04 | Molecular Devices Corporation | Molecular modification assays |
| US7745142B2 (en) | 1997-09-15 | 2010-06-29 | Molecular Devices Corporation | Molecular modification assays |
| US7632651B2 (en) | 1997-09-15 | 2009-12-15 | Mds Analytical Technologies (Us) Inc. | Molecular modification assays |
| WO2000006243A2 (en) | 1998-07-28 | 2000-02-10 | Innerdyne, Inc. | Absorbable brachytherapy and chemotherapy delivery devices and methods |
| WO2000022112A1 (en) * | 1998-10-13 | 2000-04-20 | The University Of Georgia Research Foundation, Inc. | Stabilized bioactive peptides and methods of identification, synthesis and use |
| US20030190740A1 (en) | 1998-10-13 | 2003-10-09 | The University Of Georgia Research Foundation, Inc | Stabilized bioactive peptides and methods of identification, synthesis, and use |
| US7666609B1 (en) | 1998-12-01 | 2010-02-23 | Shanghai Cp Guojian Pharmaceutical Co. Ltd. | Method and composition for diagnosis of melanocytic lesions |
| AU2591800A (en) * | 1998-12-23 | 2000-07-31 | Bert L. Vallee | Synthetic and therapeutic methods for the alpha and beta domains of metallothionein |
| DE60017083T2 (de) * | 1999-01-22 | 2005-12-22 | Martek Biosciences Corp. | Einfaches verfahren zur herstellung von markierten konjugaten |
| ES2198171B1 (es) * | 2000-09-06 | 2005-04-16 | Provital, S.A. | Composicion cosmetica y/o farmaceutica conteniendo metalotioneina. |
| US7385025B2 (en) * | 2000-12-19 | 2008-06-10 | Palatin Technologies, Inc. | Metallopeptide compounds |
| US20020117169A1 (en) | 2001-02-27 | 2002-08-29 | Kurz Daniel R. | Cover and applicator for a portion of a mammalian body |
| US20030003051A1 (en) * | 2001-06-11 | 2003-01-02 | Inverardi Luca A. | Methods of achieving transplantation tolerance through radioablation of hemolymphopoietic cell populations |
| WO2003101495A1 (en) * | 2002-05-29 | 2003-12-11 | Immunomedics, Inc. | Methods and compositions for radioimmunotherapy of brain and cns tumors |
| JP2006502390A (ja) * | 2002-10-11 | 2006-01-19 | センティナ バイオテクノロジー インコーポレイテッド | 胸部癌の検出のための方法 |
| CN1279056C (zh) * | 2003-06-06 | 2006-10-11 | 马菁 | 肿瘤相关抗原sm5－1的特异性抗体及其应用 |
| US20050232926A1 (en) * | 2003-06-06 | 2005-10-20 | Oncomax Acquisition Corp. | Antibodies specific for cancer associated antigen SM5-1 and uses thereof |
| EP2474328A3 (de) | 2003-09-17 | 2012-07-18 | Board Of Regents, The University Of Texas System | Mechanismusbasierte gezielte pankreatische Betazellenabbildung und Behandlung |
| ATE476525T1 (de) | 2003-12-23 | 2010-08-15 | Mount Sinai Hospital Corp | Verfahren zum nachweis von mit endometrialer krankheit oder phase assoziierten markern |
| US7833731B2 (en) | 2004-03-31 | 2010-11-16 | Canon Kabushiki Kaisha | Gold-binding protein and use thereof |
| WO2006118615A2 (en) * | 2004-12-16 | 2006-11-09 | Brandeis University | Clonable tag for purification and electron microscopy labeling |
| US8357720B2 (en) * | 2005-03-23 | 2013-01-22 | Florida Atlantic University | Treatment or prevention of cancer and precancerous disorders |
| US8765808B2 (en) * | 2005-03-23 | 2014-07-01 | Chs Pharma, Inc. | Treatment or prevention of cancer and precancerous disorders |
| EP1865972B1 (de) * | 2005-03-23 | 2013-11-06 | CHS Pharma, Inc. | Behandlung oder vorbeugung von krebs und präkanzerösen erkrankungen |
| US20090312238A1 (en) * | 2006-05-03 | 2009-12-17 | Florida Atlantic University | Protection Against Oxidative Damage in Cells |
| GB0621894D0 (en) * | 2006-11-02 | 2006-12-13 | Iti Scotland Ltd | Magnetic recognition system |
| US20080269065A1 (en) * | 2007-04-30 | 2008-10-30 | Syntrix Biosystems, Inc. | Conformationally Constrained Analytical Probes |
| WO2008141318A1 (en) * | 2007-05-14 | 2008-11-20 | Dr. Susan Love Research Foundation | Device for determining risk of developing breast cancer and method thereof |
| CA2618163A1 (en) | 2008-02-07 | 2009-08-07 | K. W. Michael Siu | Head and neck cancer biomarkers |
| GB0808086D0 (en) * | 2008-05-02 | 2008-06-11 | Iti Scotland Ltd | Magnetic proteins for in vivo imaging |
| CA2727803C (en) | 2008-05-13 | 2013-03-12 | University Of Kansas | Metal abstraction peptide (map) tag and associated methods |
| IN2012DN00551A (de) | 2009-07-22 | 2015-06-12 | Actinium Pharmaceuticals Inc | |
| CA2777053A1 (en) | 2009-10-06 | 2011-04-14 | The Board Of Trustees Of The University Of Illinois | Human single-chain t cell receptors |
| EP2606165B1 (de) | 2010-08-16 | 2016-10-12 | Sinai Health System | Marker für den männlichen urogenitaltrakt |
| WO2013181461A2 (en) | 2012-06-01 | 2013-12-05 | University Of Kansas | Metal abstraction peptide with superoxide dismutase activity |
| EP3409297A1 (de) | 2017-05-30 | 2018-12-05 | AlfaRim Medial Holding B.V. | Optimaler 225actinium-213bismut-generator für alpha-partikelradioimmunotherapie |
| WO2019057598A1 (en) | 2017-09-20 | 2019-03-28 | Alfarim Medical Holding B.V. | OPTIMAL 225ACTINIUM - 213BISMUTH GENERATOR FOR ALPHA PARTICLE RADIO IMMUNOTHERAPY |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS56125317A (en) * | 1980-03-08 | 1981-10-01 | Nippon Mejifuijitsukusu Kk | Stable radioactive diagnosticum with radioactive metallic mark |
| GB2109407B (en) * | 1981-10-27 | 1985-12-18 | Hybritech Inc | Tumour imaging with radiolabelled monoclonal antibodies |
| CA1222691A (en) * | 1981-12-29 | 1987-06-09 | Wilhelmus T. Goedemans | Method of preparing radionuclide-labelled proteins, in particular antibodies or antibody fragments |
| US4472509A (en) * | 1982-06-07 | 1984-09-18 | Gansow Otto A | Metal chelate conjugated monoclonal antibodies |
-
1983
- 1983-10-06 US US06/539,733 patent/US4732864A/en not_active Expired - Lifetime
-
1984
- 1984-09-28 AU AU33629/84A patent/AU578428B2/en not_active Ceased
- 1984-10-04 GR GR80560A patent/GR80560B/el unknown
- 1984-10-04 CA CA000464746A patent/CA1248090A/en not_active Expired
- 1984-10-04 EP EP84111913A patent/EP0137457B1/de not_active Expired
- 1984-10-04 ZA ZA847797A patent/ZA847797B/xx unknown
- 1984-10-04 DE DE8484111913T patent/DE3469536D1/de not_active Expired
- 1984-10-04 AT AT84111913T patent/ATE32730T1/de not_active IP Right Cessation
- 1984-10-05 NZ NZ209788A patent/NZ209788A/xx unknown
- 1984-10-05 DK DK480284A patent/DK162105C/da not_active IP Right Cessation
- 1984-10-05 ES ES536547A patent/ES8605105A1/es not_active Expired
- 1984-10-05 JP JP59208413A patent/JPS60166625A/ja active Granted
- 1984-10-05 FI FI843930A patent/FI81263C/fi not_active IP Right Cessation
- 1984-10-05 IL IL73183A patent/IL73183A/xx not_active IP Right Cessation
- 1984-10-05 IE IE2539/84A patent/IE55709B1/en not_active IP Right Cessation
- 1984-10-05 NO NO844017A patent/NO166267C/no unknown
- 1984-10-06 KR KR1019840006193A patent/KR860001151B1/ko not_active Expired
-
1989
- 1989-04-04 JP JP1084174A patent/JPH01294700A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DK162105B (da) | 1991-09-16 |
| ES536547A0 (es) | 1986-02-16 |
| EP0137457A3 (en) | 1985-08-14 |
| AU578428B2 (en) | 1988-10-27 |
| NO844017L (no) | 1985-04-09 |
| KR860001151B1 (ko) | 1986-08-18 |
| FI81263C (fi) | 1990-10-10 |
| NO166267B (no) | 1991-03-18 |
| ES8605105A1 (es) | 1986-02-16 |
| FI81263B (fi) | 1990-06-29 |
| IL73183A0 (en) | 1985-01-31 |
| IL73183A (en) | 1991-09-16 |
| GR80560B (en) | 1985-02-06 |
| NZ209788A (en) | 1988-10-28 |
| DK162105C (da) | 1992-02-17 |
| JPH01294700A (ja) | 1989-11-28 |
| EP0137457B1 (de) | 1988-03-02 |
| CA1248090A (en) | 1989-01-03 |
| JPH0470320B2 (de) | 1992-11-10 |
| DE3469536D1 (en) | 1988-04-07 |
| DK480284A (da) | 1985-04-07 |
| EP0137457A2 (de) | 1985-04-17 |
| JPS60166625A (ja) | 1985-08-29 |
| KR850002961A (ko) | 1985-05-28 |
| AU3362984A (en) | 1985-04-18 |
| FI843930L (fi) | 1985-04-07 |
| US4732864A (en) | 1988-03-22 |
| IE842539L (en) | 1985-04-06 |
| FI843930A0 (fi) | 1984-10-05 |
| ZA847797B (en) | 1986-05-28 |
| NO166267C (no) | 1991-06-26 |
| DK480284D0 (da) | 1984-10-05 |
| IE55709B1 (en) | 1990-12-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EEIH | Change in the person of patent owner | ||
| REN | Ceased due to non-payment of the annual fee |