NO166267C - Konjugat av et maalsoekende biologisk aktivt molekyl og en forbindelse inneholdende spormerkende metall, samt diagnostisk preparat inneholdende konjugatet. - Google Patents
Konjugat av et maalsoekende biologisk aktivt molekyl og en forbindelse inneholdende spormerkende metall, samt diagnostisk preparat inneholdende konjugatet.Info
- Publication number
- NO166267C NO166267C NO844017A NO844017A NO166267C NO 166267 C NO166267 C NO 166267C NO 844017 A NO844017 A NO 844017A NO 844017 A NO844017 A NO 844017A NO 166267 C NO166267 C NO 166267C
- Authority
- NO
- Norway
- Prior art keywords
- conjugate
- metal
- biologically active
- targesting
- sporable
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- DIGQNXIGRZPYDK-WKSCXVIASA-N (2R)-6-amino-2-[[2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-[[(2R,3S)-2-[[2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S,3S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[2-[[2-[[2-[(2-amino-1-hydroxyethylidene)amino]-3-carboxy-1-hydroxypropylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxybutylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1,5-dihydroxy-5-iminopentylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxybutylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxyethylidene]amino]hexanoic acid Chemical compound C[C@@H]([C@@H](C(=N[C@@H](CS)C(=N[C@@H](C)C(=N[C@@H](CO)C(=NCC(=N[C@@H](CCC(=N)O)C(=NC(CS)C(=N[C@H]([C@H](C)O)C(=N[C@H](CS)C(=N[C@H](CO)C(=NCC(=N[C@H](CS)C(=NCC(=N[C@H](CCCCN)C(=O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)N=C([C@H](CS)N=C([C@H](CO)N=C([C@H](CO)N=C([C@H](C)N=C(CN=C([C@H](CO)N=C([C@H](CS)N=C(CN=C(C(CS)N=C(C(CC(=O)O)N=C(CN)O)O)O)O)O)O)O)O)O)O)O)O DIGQNXIGRZPYDK-WKSCXVIASA-N 0.000 abstract 2
- 102000003792 Metallothionein Human genes 0.000 abstract 2
- 108090000157 Metallothionein Proteins 0.000 abstract 2
- 239000002184 metal Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6887—Antibody-chelate conjugates using chelates for therapeutic purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/804—Radioisotope, e.g. radioimmunoassay
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Steroid Compounds (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NO884941A NO173874C (no) | 1983-10-06 | 1988-11-04 | Konjugat til bruk ved fremstilling av spormerkede konjugater, bestaaende av et maalsoekende, biologisk aktivt molekyl og en forbindelse inneholdende et ikke-radioaktivt metall |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/539,733 US4732864A (en) | 1983-10-06 | 1983-10-06 | Trace-labeled conjugates of metallothionein and target-seeking biologically active molecules |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO844017L NO844017L (no) | 1985-04-09 |
| NO166267B NO166267B (no) | 1991-03-18 |
| NO166267C true NO166267C (no) | 1991-06-26 |
Family
ID=24152436
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO844017A NO166267C (no) | 1983-10-06 | 1984-10-05 | Konjugat av et maalsoekende biologisk aktivt molekyl og en forbindelse inneholdende spormerkende metall, samt diagnostisk preparat inneholdende konjugatet. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4732864A (no) |
| EP (1) | EP0137457B1 (no) |
| JP (2) | JPS60166625A (no) |
| KR (1) | KR860001151B1 (no) |
| AT (1) | ATE32730T1 (no) |
| AU (1) | AU578428B2 (no) |
| CA (1) | CA1248090A (no) |
| DE (1) | DE3469536D1 (no) |
| DK (1) | DK162105C (no) |
| ES (1) | ES8605105A1 (no) |
| FI (1) | FI81263C (no) |
| GR (1) | GR80560B (no) |
| IE (1) | IE55709B1 (no) |
| IL (1) | IL73183A (no) |
| NO (1) | NO166267C (no) |
| NZ (1) | NZ209788A (no) |
| ZA (1) | ZA847797B (no) |
Families Citing this family (86)
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| NO167124C (no) * | 1985-04-03 | 1991-10-09 | Du Pont Merck Pharma | Fremgangsmaate for fremstilling av et spormerket konjugat av metallthionein og biologisk aktivt molekyl. |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS56125317A (en) * | 1980-03-08 | 1981-10-01 | Nippon Mejifuijitsukusu Kk | Stable radioactive diagnosticum with radioactive metallic mark |
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| US4472509A (en) * | 1982-06-07 | 1984-09-18 | Gansow Otto A | Metal chelate conjugated monoclonal antibodies |
-
1983
- 1983-10-06 US US06/539,733 patent/US4732864A/en not_active Expired - Lifetime
-
1984
- 1984-09-28 AU AU33629/84A patent/AU578428B2/en not_active Ceased
- 1984-10-04 ZA ZA847797A patent/ZA847797B/xx unknown
- 1984-10-04 AT AT84111913T patent/ATE32730T1/de not_active IP Right Cessation
- 1984-10-04 GR GR80560A patent/GR80560B/el unknown
- 1984-10-04 DE DE8484111913T patent/DE3469536D1/de not_active Expired
- 1984-10-04 CA CA000464746A patent/CA1248090A/en not_active Expired
- 1984-10-04 EP EP84111913A patent/EP0137457B1/en not_active Expired
- 1984-10-05 IE IE2539/84A patent/IE55709B1/en not_active IP Right Cessation
- 1984-10-05 IL IL73183A patent/IL73183A/xx not_active IP Right Cessation
- 1984-10-05 FI FI843930A patent/FI81263C/fi not_active IP Right Cessation
- 1984-10-05 JP JP59208413A patent/JPS60166625A/ja active Granted
- 1984-10-05 NO NO844017A patent/NO166267C/no unknown
- 1984-10-05 DK DK480284A patent/DK162105C/da not_active IP Right Cessation
- 1984-10-05 ES ES536547A patent/ES8605105A1/es not_active Expired
- 1984-10-05 NZ NZ209788A patent/NZ209788A/xx unknown
- 1984-10-06 KR KR1019840006193A patent/KR860001151B1/ko not_active IP Right Cessation
-
1989
- 1989-04-04 JP JP1084174A patent/JPH01294700A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ES536547A0 (es) | 1986-02-16 |
| AU578428B2 (en) | 1988-10-27 |
| EP0137457A3 (en) | 1985-08-14 |
| DK480284A (da) | 1985-04-07 |
| CA1248090A (en) | 1989-01-03 |
| EP0137457B1 (en) | 1988-03-02 |
| GR80560B (en) | 1985-02-06 |
| EP0137457A2 (en) | 1985-04-17 |
| NO844017L (no) | 1985-04-09 |
| FI843930A0 (fi) | 1984-10-05 |
| ZA847797B (en) | 1986-05-28 |
| IE842539L (en) | 1985-04-06 |
| JPH0470320B2 (no) | 1992-11-10 |
| ATE32730T1 (de) | 1988-03-15 |
| IL73183A0 (en) | 1985-01-31 |
| AU3362984A (en) | 1985-04-18 |
| US4732864A (en) | 1988-03-22 |
| JPH01294700A (ja) | 1989-11-28 |
| JPS60166625A (ja) | 1985-08-29 |
| IE55709B1 (en) | 1990-12-19 |
| ES8605105A1 (es) | 1986-02-16 |
| DE3469536D1 (en) | 1988-04-07 |
| KR850002961A (ko) | 1985-05-28 |
| FI843930L (fi) | 1985-04-07 |
| FI81263B (fi) | 1990-06-29 |
| DK162105C (da) | 1992-02-17 |
| IL73183A (en) | 1991-09-16 |
| NO166267B (no) | 1991-03-18 |
| FI81263C (fi) | 1990-10-10 |
| DK162105B (da) | 1991-09-16 |
| KR860001151B1 (ko) | 1986-08-18 |
| NZ209788A (en) | 1988-10-28 |
| DK480284D0 (da) | 1984-10-05 |
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