DK480284A - Sporstofmaerkede konjugater af metallothionein og maalsoegende, biologisk aktive molekyler - Google Patents
Sporstofmaerkede konjugater af metallothionein og maalsoegende, biologisk aktive molekyler Download PDFInfo
- Publication number
- DK480284A DK480284A DK480284A DK480284A DK480284A DK 480284 A DK480284 A DK 480284A DK 480284 A DK480284 A DK 480284A DK 480284 A DK480284 A DK 480284A DK 480284 A DK480284 A DK 480284A
- Authority
- DK
- Denmark
- Prior art keywords
- metallothionein
- conjugates
- truckmarked
- targeting
- active molecules
- Prior art date
Links
- DIGQNXIGRZPYDK-WKSCXVIASA-N (2R)-6-amino-2-[[2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-[[(2R,3S)-2-[[2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S,3S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[2-[[2-[[2-[(2-amino-1-hydroxyethylidene)amino]-3-carboxy-1-hydroxypropylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxybutylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1,5-dihydroxy-5-iminopentylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxybutylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxyethylidene]amino]hexanoic acid Chemical compound C[C@@H]([C@@H](C(=N[C@@H](CS)C(=N[C@@H](C)C(=N[C@@H](CO)C(=NCC(=N[C@@H](CCC(=N)O)C(=NC(CS)C(=N[C@H]([C@H](C)O)C(=N[C@H](CS)C(=N[C@H](CO)C(=NCC(=N[C@H](CS)C(=NCC(=N[C@H](CCCCN)C(=O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)N=C([C@H](CS)N=C([C@H](CO)N=C([C@H](CO)N=C([C@H](C)N=C(CN=C([C@H](CO)N=C([C@H](CS)N=C(CN=C(C(CS)N=C(C(CC(=O)O)N=C(CN)O)O)O)O)O)O)O)O)O)O)O)O DIGQNXIGRZPYDK-WKSCXVIASA-N 0.000 title abstract 3
- 102000003792 Metallothionein Human genes 0.000 title abstract 3
- 108090000157 Metallothionein Proteins 0.000 title abstract 3
- 230000008685 targeting Effects 0.000 title 1
- 239000002184 metal Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6887—Antibody-chelate conjugates using chelates for therapeutic purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/804—Radioisotope, e.g. radioimmunoassay
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53973383 | 1983-10-06 | ||
| US06/539,733 US4732864A (en) | 1983-10-06 | 1983-10-06 | Trace-labeled conjugates of metallothionein and target-seeking biologically active molecules |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| DK480284D0 DK480284D0 (da) | 1984-10-05 |
| DK480284A true DK480284A (da) | 1985-04-07 |
| DK162105B DK162105B (da) | 1991-09-16 |
| DK162105C DK162105C (da) | 1992-02-17 |
Family
ID=24152436
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK480284A DK162105C (da) | 1983-10-06 | 1984-10-05 | Sporstofmaerkede konjugater af metallothionein eller et fragment deraf og et antistof eller et fragment deraf, fremgangsmaader til deres fremstilling og mellemprodukt til deres fremstilling |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4732864A (da) |
| EP (1) | EP0137457B1 (da) |
| JP (2) | JPS60166625A (da) |
| KR (1) | KR860001151B1 (da) |
| AT (1) | ATE32730T1 (da) |
| AU (1) | AU578428B2 (da) |
| CA (1) | CA1248090A (da) |
| DE (1) | DE3469536D1 (da) |
| DK (1) | DK162105C (da) |
| ES (1) | ES8605105A1 (da) |
| FI (1) | FI81263C (da) |
| GR (1) | GR80560B (da) |
| IE (1) | IE55709B1 (da) |
| IL (1) | IL73183A (da) |
| NO (1) | NO166267C (da) |
| NZ (1) | NZ209788A (da) |
| ZA (1) | ZA847797B (da) |
Families Citing this family (86)
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|---|---|---|---|---|
| US4707352A (en) * | 1984-01-30 | 1987-11-17 | Enzo Biochem, Inc. | Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group |
| US4880626A (en) * | 1985-01-18 | 1989-11-14 | Mcmichael John | Immunotherapeutic methods and compositions for the treatment of diseases of viral origin, including acquired immune deficiency syndrome |
| NO167124C (no) * | 1985-04-03 | 1991-10-09 | Du Pont Merck Pharma | Fremgangsmaate for fremstilling av et spormerket konjugat av metallthionein og biologisk aktivt molekyl. |
| US5776093A (en) * | 1985-07-05 | 1998-07-07 | Immunomedics, Inc. | Method for imaging and treating organs and tissues |
| JP2515357B2 (ja) * | 1986-01-16 | 1996-07-10 | ザ・ジェネラル・ホスピタル・コ−ポレ−ション | 炎症の診断方法および治療方法 |
| US6165729A (en) * | 1986-04-30 | 2000-12-26 | Hyperion Catalysis International, Inc. | Electrochemiluminescent reaction utilizing amine-derived reductant |
| US6451225B1 (en) | 1986-04-30 | 2002-09-17 | Igen International, Inc. | Electrochemiluminescent reaction utilizing amine-derived reductant |
| US5591581A (en) * | 1986-04-30 | 1997-01-07 | Igen, Inc. | Electrochemiluminescent rhenium moieties and methods for their use |
| US4877599A (en) * | 1986-11-10 | 1989-10-31 | New England Deaconess Hospital Corporation | Detection of vascular disease with labelled antibodies |
| US5672334A (en) * | 1991-01-16 | 1997-09-30 | Access Pharmaceuticals, Inc. | Invivo agents comprising cationic metal chelators with acidic saccharides and glycosaminoglycans |
| EP0339086B1 (en) * | 1987-11-04 | 1996-09-11 | Igen, Inc. | Electrochemiluminescent rhenium moieties and methods |
| US5202451A (en) * | 1988-02-17 | 1993-04-13 | Neorx Corporation | Anchimeric radiometal chelating compounds |
| USH735H (en) | 1988-03-30 | 1990-02-06 | The United States Of America As Represented By The United States Department Of Energy | Lead-203 as a label for radioimaging |
| US5061641A (en) * | 1988-04-01 | 1991-10-29 | Immunomedics, Inc. | Method for radiolabeling proteins |
| US5057301A (en) * | 1988-04-06 | 1991-10-15 | Neorx Corporation | Modified cellular substrates used as linkers for increased cell retention of diagnostic and therapeutic agents |
| US5059541A (en) * | 1988-04-29 | 1991-10-22 | Neorx Corporation | Minimal derivatization of proteins |
| US6702986B1 (en) | 1988-04-29 | 2004-03-09 | Igen International, Inc. | Electrochemiluminescent reaction utilizing amine-derived reductant |
| US5726153A (en) * | 1988-05-02 | 1998-03-10 | New England Deaconess Hospital Corporation | Synthetic peptides for arterial imaging |
| US5972890A (en) * | 1988-05-02 | 1999-10-26 | New England Deaconess Hospital Corporation | Synthetic peptides for arterial imaging |
| US5218128A (en) * | 1988-06-15 | 1993-06-08 | Centocor, Inc. | Bifunctional coupling agents and radionuclide labeled compositions prepared therefrom |
| WO1990006323A2 (en) * | 1988-11-29 | 1990-06-14 | Centocor, Inc. | Chimeric proteins incorporating a metal binding protein |
| US5985240A (en) * | 1989-08-09 | 1999-11-16 | Rhomed Incorporated | Peptide radiopharmaceutical applications |
| US5759515A (en) * | 1989-08-09 | 1998-06-02 | Rhomed Incorporated | Polyvalent peptide pharmaceutical applications |
| US5443816A (en) * | 1990-08-08 | 1995-08-22 | Rhomed Incorporated | Peptide-metal ion pharmaceutical preparation and method |
| US5700444A (en) * | 1992-02-20 | 1997-12-23 | Rhomed Incorporated | Chemotactic peptide pharmaceutical applications |
| US5078985A (en) * | 1989-08-09 | 1992-01-07 | Rhomed, Incorporated | Radiolabeling antibodies and other proteins with technetium or rhenium by regulated reduction |
| JP3070763B2 (ja) * | 1989-08-09 | 2000-07-31 | ロメッド インコーポレイティド | テクネチウムまたはレニウムでの抗体または他のタンパク質の直接放射能標識 |
| WO1991012328A1 (en) * | 1990-02-15 | 1991-08-22 | Fowlkes Dana M | Totally synthetic affinity reagents |
| US5747334A (en) * | 1990-02-15 | 1998-05-05 | The University Of North Carolina At Chapel Hill | Random peptide library |
| US5498538A (en) * | 1990-02-15 | 1996-03-12 | The University Of North Carolina At Chapel Hill | Totally synthetic affinity reagents |
| US6019958A (en) * | 1991-02-08 | 2000-02-01 | Diatide, Inc. | Technetium-99m labeled peptides for imaging inflammation |
| US5645815A (en) | 1991-02-08 | 1997-07-08 | Diatide, Inc. | Radiolabled compounds for thrombus imaging |
| EP0570493B1 (en) * | 1991-02-08 | 2000-01-05 | Diatide, Inc. | TECHNETIUM-99m LABELED POLYPEPTIDES FOR IMAGING |
| US7238340B1 (en) | 1991-11-27 | 2007-07-03 | Cis Bio International | Monoamine, diamide, thiol-containing metal chelating agents |
| US6403771B1 (en) | 1991-02-19 | 2002-06-11 | Actinium Pharmaceuticals, Limited | Method and means for site directed therapy |
| US6391590B1 (en) * | 1991-10-21 | 2002-05-21 | The Regents Of The University Of California | Recombinant streptavidin-metallothionein chimeric protein having biological recognition specificity |
| US5556609A (en) * | 1992-02-20 | 1996-09-17 | Rhomed Incorporated | YIGSR peptide radiopharmaceutical applications |
| US5738838A (en) * | 1992-02-20 | 1998-04-14 | Rhomed Incorporated | IKVAV peptide radiopharmaceutical applications |
| US5643549A (en) * | 1992-02-20 | 1997-07-01 | Rhomed Incorporated | Leukostimulatory agent for in vivo leukocyte tagging |
| US5326856A (en) * | 1992-04-09 | 1994-07-05 | Cytogen Corporation | Bifunctional isothiocyanate derived thiocarbonyls as ligands for metal binding |
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| WO1994026297A1 (en) * | 1993-05-17 | 1994-11-24 | Immunomedics, Inc. | Improved detection and therapy of lesions with biotin/avidin-metal chelating protein conjugates |
| DE69408145T2 (de) * | 1993-07-19 | 1998-09-03 | Resolution Pharm Inc | Hydrazine mit einer n3s konfiguration als radionukleide chelatoren |
| WO1995004753A1 (en) * | 1993-08-11 | 1995-02-16 | University Of New Mexico | Compositions of fusion proteins containing metallothionein and targeting-protein structural components |
| US5449761A (en) * | 1993-09-28 | 1995-09-12 | Cytogen Corporation | Metal-binding targeted polypeptide constructs |
| US5942210A (en) * | 1994-11-15 | 1999-08-24 | Cytogen Corporation | Methods for lyoprotecting a macromolecule using tricine |
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| US20030190740A1 (en) * | 1998-10-13 | 2003-10-09 | The University Of Georgia Research Foundation, Inc | Stabilized bioactive peptides and methods of identification, synthesis, and use |
| DE69926009D1 (de) * | 1998-10-13 | 2005-08-04 | Univ Georgia Res Found | Stabilisierte bioaktive peptide und methoden zu ihrer identifikation, synthese und verwendung |
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| AU2591800A (en) * | 1998-12-23 | 2000-07-31 | Bert L. Vallee | Synthetic and therapeutic methods for the alpha and beta domains of metallothionein |
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| ES2198171B1 (es) * | 2000-09-06 | 2005-04-16 | Provital, S.A. | Composicion cosmetica y/o farmaceutica conteniendo metalotioneina. |
| US7385025B2 (en) | 2000-12-19 | 2008-06-10 | Palatin Technologies, Inc. | Metallopeptide compounds |
| US20020117169A1 (en) * | 2001-02-27 | 2002-08-29 | Kurz Daniel R. | Cover and applicator for a portion of a mammalian body |
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| WO2003101495A1 (en) * | 2002-05-29 | 2003-12-11 | Immunomedics, Inc. | Methods and compositions for radioimmunotherapy of brain and cns tumors |
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| JP5395327B2 (ja) | 2003-09-17 | 2014-01-22 | ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム | 機構ベースの標的化した膵臓β細胞画像化および治療 |
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| US8357720B2 (en) * | 2005-03-23 | 2013-01-22 | Florida Atlantic University | Treatment or prevention of cancer and precancerous disorders |
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| KR20140001257A (ko) | 2008-05-13 | 2014-01-06 | 유니버시티 오브 캔사스 | 금속 추출 펩타이드(ｍａｐ) 태그 및 관련된 방법 |
| EP2456472B1 (en) | 2009-07-22 | 2024-03-27 | Actinium Pharmaceuticals, Inc. | Methods for generating radioimmunoconjugates |
| WO2011044186A1 (en) | 2009-10-06 | 2011-04-14 | The Board Of Trustees Of The University Of Illinois | Human single-chain t cell receptors |
| US9040464B2 (en) | 2010-08-16 | 2015-05-26 | Mount Sinai Hosptial | Markers of the male urogenital tract |
| WO2013181461A2 (en) | 2012-06-01 | 2013-12-05 | University Of Kansas | Metal abstraction peptide with superoxide dismutase activity |
| EP3409297A1 (en) | 2017-05-30 | 2018-12-05 | AlfaRim Medial Holding B.V. | The optimal 225actinium--213bismuth generator for alpha-particle radioimmunotherapy |
| US20200230266A1 (en) | 2017-09-20 | 2020-07-23 | Alfarim Medical Holding B.V. | The optimal 225actinium--213bismuth generator for alpha-particle radioimmunotherapy |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS56125317A (en) * | 1980-03-08 | 1981-10-01 | Nippon Mejifuijitsukusu Kk | Stable radioactive diagnosticum with radioactive metallic mark |
| FI82379C (fi) * | 1981-10-27 | 1991-03-11 | Univ California | Radioaktivt maerkta monoklonala antikroppar samt en komposition innehaollande dessa och anvaendbar som diagnostiskt radiofarmaseutiskt medel. |
| CA1222691A (en) * | 1981-12-29 | 1987-06-09 | Wilhelmus T. Goedemans | Method of preparing radionuclide-labelled proteins, in particular antibodies or antibody fragments |
| US4472509A (en) * | 1982-06-07 | 1984-09-18 | Gansow Otto A | Metal chelate conjugated monoclonal antibodies |
-
1983
- 1983-10-06 US US06/539,733 patent/US4732864A/en not_active Expired - Lifetime
-
1984
- 1984-09-28 AU AU33629/84A patent/AU578428B2/en not_active Ceased
- 1984-10-04 GR GR80560A patent/GR80560B/el unknown
- 1984-10-04 CA CA000464746A patent/CA1248090A/en not_active Expired
- 1984-10-04 DE DE8484111913T patent/DE3469536D1/de not_active Expired
- 1984-10-04 EP EP84111913A patent/EP0137457B1/en not_active Expired
- 1984-10-04 AT AT84111913T patent/ATE32730T1/de not_active IP Right Cessation
- 1984-10-04 ZA ZA847797A patent/ZA847797B/xx unknown
- 1984-10-05 DK DK480284A patent/DK162105C/da not_active IP Right Cessation
- 1984-10-05 ES ES536547A patent/ES8605105A1/es not_active Expired
- 1984-10-05 IE IE2539/84A patent/IE55709B1/en not_active IP Right Cessation
- 1984-10-05 NO NO844017A patent/NO166267C/no unknown
- 1984-10-05 NZ NZ209788A patent/NZ209788A/xx unknown
- 1984-10-05 JP JP59208413A patent/JPS60166625A/ja active Granted
- 1984-10-05 IL IL73183A patent/IL73183A/xx not_active IP Right Cessation
- 1984-10-05 FI FI843930A patent/FI81263C/fi not_active IP Right Cessation
- 1984-10-06 KR KR1019840006193A patent/KR860001151B1/ko not_active IP Right Cessation
-
1989
- 1989-04-04 JP JP1084174A patent/JPH01294700A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| GR80560B (en) | 1985-02-06 |
| IL73183A0 (en) | 1985-01-31 |
| KR850002961A (ko) | 1985-05-28 |
| EP0137457B1 (en) | 1988-03-02 |
| IE842539L (en) | 1985-04-06 |
| DK480284D0 (da) | 1984-10-05 |
| FI843930A0 (fi) | 1984-10-05 |
| DE3469536D1 (en) | 1988-04-07 |
| AU3362984A (en) | 1985-04-18 |
| AU578428B2 (en) | 1988-10-27 |
| US4732864A (en) | 1988-03-22 |
| CA1248090A (en) | 1989-01-03 |
| NZ209788A (en) | 1988-10-28 |
| JPH0470320B2 (da) | 1992-11-10 |
| ATE32730T1 (de) | 1988-03-15 |
| NO844017L (no) | 1985-04-09 |
| JPS60166625A (ja) | 1985-08-29 |
| DK162105C (da) | 1992-02-17 |
| IL73183A (en) | 1991-09-16 |
| IE55709B1 (en) | 1990-12-19 |
| ZA847797B (en) | 1986-05-28 |
| EP0137457A3 (en) | 1985-08-14 |
| NO166267C (no) | 1991-06-26 |
| JPH01294700A (ja) | 1989-11-28 |
| FI81263C (fi) | 1990-10-10 |
| ES536547A0 (es) | 1986-02-16 |
| EP0137457A2 (en) | 1985-04-17 |
| ES8605105A1 (es) | 1986-02-16 |
| NO166267B (no) | 1991-03-18 |
| FI843930L (fi) | 1985-04-07 |
| FI81263B (fi) | 1990-06-29 |
| KR860001151B1 (ko) | 1986-08-18 |
| DK162105B (da) | 1991-09-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PBP | Patent lapsed |