ATE232396T1 - Oxydiertes thymosin beta 4 - Google Patents

Oxydiertes thymosin beta 4

Info

Publication number
ATE232396T1
ATE232396T1 AT99913428T AT99913428T ATE232396T1 AT E232396 T1 ATE232396 T1 AT E232396T1 AT 99913428 T AT99913428 T AT 99913428T AT 99913428 T AT99913428 T AT 99913428T AT E232396 T1 ATE232396 T1 AT E232396T1
Authority
AT
Austria
Prior art keywords
oxidated
beta
thymosine beta
present
thymosine
Prior art date
Application number
AT99913428T
Other languages
English (en)
Inventor
Robert Duncan Stevenson
Anthony John Lawrence
John Young
Darryl John Cecil Pappin
Original Assignee
Univ Glasgow
Imp Cancer Res Technology Icrt
Robert Duncan Stevenson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Glasgow, Imp Cancer Res Technology Icrt, Robert Duncan Stevenson filed Critical Univ Glasgow
Application granted granted Critical
Publication of ATE232396T1 publication Critical patent/ATE232396T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57581—Thymosin; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
AT99913428T 1998-03-28 1999-03-29 Oxydiertes thymosin beta 4 ATE232396T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9806632.7A GB9806632D0 (en) 1998-03-28 1998-03-28 Peptide factor
PCT/GB1999/000833 WO1999049883A2 (en) 1998-03-28 1999-03-29 Oxidized thymosin beta 4

Publications (1)

Publication Number Publication Date
ATE232396T1 true ATE232396T1 (de) 2003-02-15

Family

ID=10829414

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99913428T ATE232396T1 (de) 1998-03-28 1999-03-29 Oxydiertes thymosin beta 4

Country Status (15)

Country Link
US (3) US6602519B1 (de)
EP (1) EP1094833B1 (de)
JP (1) JP2002509893A (de)
KR (1) KR20010074461A (de)
CN (2) CN1178695C (de)
AT (1) ATE232396T1 (de)
AU (1) AU766493B2 (de)
CA (1) CA2325984A1 (de)
DE (1) DE69905368T2 (de)
ES (1) ES2192839T3 (de)
GB (1) GB9806632D0 (de)
IL (1) IL138665A0 (de)
NZ (1) NZ507642A (de)
WO (1) WO1999049883A2 (de)
ZA (1) ZA200005196B (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9806632D0 (en) * 1998-03-28 1998-05-27 Stevenson Robert Peptide factor
US20040067227A1 (en) * 2001-11-02 2004-04-08 Goldstein Allan L. Inhibition or reversal of skin aging by actin-sequestering peptides
CA2338928A1 (en) * 1998-07-30 2000-02-10 Hynda K. Kleinman Thymosin .beta.4 promotes wound repair
US20070191275A1 (en) * 1998-07-30 2007-08-16 Regenerx Biopharmaceuticals, Inc. Method of treating, preventing, inhibiting or reducing damage to cardiac tissue with thymosin beta 4 fragments
WO2002036143A1 (en) 2000-11-02 2002-05-10 Regenerx Biopharmaceuticals, Inc. Inhibition or reversal of skin aging by actin-sequestering peptides
US20060100156A1 (en) * 2004-10-01 2006-05-11 Regenerx Biopharmaceuticals, Inc. Cell nucleus-entering compositions
US20070015698A1 (en) * 1998-07-30 2007-01-18 United States Of America As Represented By The Secretary Of Health Treatment of skin, and wound repair, with thymosin beta 4
OA12431A (en) * 2000-10-20 2006-04-19 Beate Kehrel Oxidized protein, their biological activity, and therapeutic and diagnostic measures, which are derived from the active mechanism, from the use of these proteins or from the inhibition thereof.
AU2002255736B2 (en) * 2001-03-15 2006-08-31 Regenerx, Biopharmaceuticals, Inc. Methods of treating disorders of the eye and surrounding tissue with thymosin beta4 (Tbeta4), analogues, isoforms and other derivatives
CN101549148A (zh) * 2001-08-29 2009-10-07 雷根内克斯生物制药有限公司 多肽在制备用于促进心内膜细胞向间质细胞转化的药物中的应用
AU2008201749B2 (en) * 2002-02-06 2010-05-13 Regenerx Biopharmaceuticals, Inc. Treatment of Infections and Other Disorders
EP2266595A3 (de) 2002-02-06 2011-07-06 Regenerx Biopharmaceuticals, Inc. Behandlung von Infektionen und anderen Erkrankungen
US20060264360A1 (en) * 2002-04-12 2006-11-23 Yale University Office Of Cooperstive Research Anti-inflammatory and wound healing effects of lymphoid thymosin beta-4
US6821524B2 (en) * 2002-06-03 2004-11-23 Jan Marini Skin Research, Inc. Cosmetic skin care compositions
EP1613369A4 (de) * 2003-03-31 2008-10-01 Regenerx Biopharmaceuticals Zusammensetzungen und verfahren zur abgabe von thymosin beta 4, analoga, isoformen und anderer derivate
WO2005027958A1 (en) * 2003-09-19 2005-03-31 Imperial College Innovations Ltd Thymosin-beta-sulphoxide as an immunosuppressive active agent
CN1897965A (zh) * 2003-12-22 2007-01-17 雷金纳克斯生物制药公司 反应性的化学剂、生物剂或毒素引起的生物反应或免疫反应的治疗方法或预防方法
JP2007537153A (ja) * 2004-03-05 2007-12-20 リジェナークス・バイオファーマスーティカルズ・インコーポレイテッド 細胞外基質蓄積の治療または防止
US20080248993A1 (en) * 2005-01-14 2008-10-09 Regenerx Biopharmaceuticals, Inc. Modified Beta Thymosin Peptides
KR20080033939A (ko) 2005-06-17 2008-04-17 리지너크스 바이오 파마소티컬스, 인코포레이티드 동결 건조된 형태이거나, 또는 동결 건조될 수 있는 형태인엘케이케이티이티 및/또는 엘케이케이티엔티 펩티드조성물들
AU2006269852A1 (en) * 2005-07-19 2007-01-25 Grannus Biosciences Truncated oxidized thymosin beta4 and derivatives thereof
ES2288118B1 (es) * 2006-05-10 2008-11-01 Bcn Peptides, S.A. Procedimiento para sintetizar timosinas.
CN101297965B (zh) * 2008-06-16 2011-01-05 浙江省中医药研究院 胸腺肽β4在制备防治支气管哮喘药物中的应用
US20100247693A1 (en) * 2009-03-24 2010-09-30 Marini Jan L Cosmetic formulation to treat rosacea telangiectasia
US20110160144A1 (en) * 2009-12-28 2011-06-30 Perricone Nicholas V Topical Acyl Glutathione Formulations
US8580742B2 (en) 2010-03-05 2013-11-12 N.V. Perricone Llc Topical glutathione formulations for menopausal skin
US8609604B2 (en) 2009-12-28 2013-12-17 N.V. Perricone Llc Methods of improving the appearance of aging skin
JP5847418B2 (ja) 2011-03-30 2016-01-20 富士フイルム株式会社 細胞接着性タンパク質
US9808654B2 (en) 2013-02-11 2017-11-07 Jan Marini Skin Research Post procedure skin care gel and methods of use thereof
CN110215513B (zh) * 2018-11-15 2022-02-22 北京诺思兰德生物技术股份有限公司 经修饰的胸腺素β4在治疗放射性肠炎方面的用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US388234A (en) * 1888-08-21 Car-brake
US3998798A (en) * 1972-12-22 1976-12-21 The Trustees Of The University Of Pennsylvania Monellin, a sweet polypeptide derived from fruit of dioscoreophyllum cumminsii
US4297276A (en) * 1979-03-23 1981-10-27 Hoffman-La Roche Inc. Thymosin beta 3 and beta 4
US4389343A (en) 1981-12-24 1983-06-21 Hoffmann-La Roche Inc. Immunopotentiating peptides from thymus
US4388234A (en) * 1981-12-28 1983-06-14 Hoffmann-La Roche Inc. Peptide isolation
US4572798A (en) * 1984-12-06 1986-02-25 Cetus Corporation Method for promoting disulfide bond formation in recombinant proteins
US5578570A (en) * 1993-10-07 1996-11-26 The George Washington University Medical Center Method of treating septic shock using thymosin β4
US5593964A (en) * 1993-10-07 1997-01-14 The George Washington University Medical Center Method of treating septic shock by preventing actin polymerization
US5468729A (en) * 1993-10-26 1995-11-21 Alpha 1 Biomedicals Method for treatment of autoimmune hepatitis
GB9806632D0 (en) * 1998-03-28 1998-05-27 Stevenson Robert Peptide factor

Also Published As

Publication number Publication date
JP2002509893A (ja) 2002-04-02
CN1308543A (zh) 2001-08-15
CN1178695C (zh) 2004-12-08
AU766493B2 (en) 2003-10-16
WO1999049883A3 (en) 2001-02-22
WO1999049883A2 (en) 1999-10-07
US6602519B1 (en) 2003-08-05
AU3155399A (en) 1999-10-18
NZ507642A (en) 2003-10-31
ZA200005196B (en) 2002-01-02
KR20010074461A (ko) 2001-08-04
DE69905368T2 (de) 2003-12-18
US20040213772A1 (en) 2004-10-28
EP1094833B1 (de) 2003-02-12
EP1094833A2 (de) 2001-05-02
GB9806632D0 (en) 1998-05-27
CA2325984A1 (en) 1999-10-07
US20060229234A1 (en) 2006-10-12
CN1644586A (zh) 2005-07-27
DE69905368D1 (en) 2003-03-20
IL138665A0 (en) 2001-10-31
ES2192839T3 (es) 2003-10-16

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