ATE246245T1 - Interzellulare adhäsions-moleküle und deren bindungsliganden - Google Patents

Interzellulare adhäsions-moleküle und deren bindungsliganden

Info

Publication number
ATE246245T1
ATE246245T1 AT93104664T AT93104664T ATE246245T1 AT E246245 T1 ATE246245 T1 AT E246245T1 AT 93104664 T AT93104664 T AT 93104664T AT 93104664 T AT93104664 T AT 93104664T AT E246245 T1 ATE246245 T1 AT E246245T1
Authority
AT
Austria
Prior art keywords
molecules
adhesion molecules
intercellular adhesion
binding ligands
binding
Prior art date
Application number
AT93104664T
Other languages
English (en)
Inventor
Timothy Alan Springer
Robert Rothlein
Steven Dean Marlin
Michael Loran Dustin
Original Assignee
Dana Farber Cancer Inst Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dana Farber Cancer Inst Inc filed Critical Dana Farber Cancer Inst Inc
Application granted granted Critical
Publication of ATE246245T1 publication Critical patent/ATE246245T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2845—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta2-subunit-containing molecules, e.g. CD11, CD18
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70525—ICAM molecules, e.g. CD50, CD54, CD102
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2821—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against ICAM molecules, e.g. CD50, CD54, CD102
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
AT93104664T 1988-09-28 1989-09-23 Interzellulare adhäsions-moleküle und deren bindungsliganden ATE246245T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25044688A 1988-09-28 1988-09-28
US32448189A 1989-03-16 1989-03-16
US37388289A 1989-06-30 1989-06-30

Publications (1)

Publication Number Publication Date
ATE246245T1 true ATE246245T1 (de) 2003-08-15

Family

ID=27400322

Family Applications (2)

Application Number Title Priority Date Filing Date
AT89117620T ATE125708T1 (de) 1988-09-28 1989-09-23 Interzellulare adhäsions-moleküle und deren bindungsliganden.
AT93104664T ATE246245T1 (de) 1988-09-28 1989-09-23 Interzellulare adhäsions-moleküle und deren bindungsliganden

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT89117620T ATE125708T1 (de) 1988-09-28 1989-09-23 Interzellulare adhäsions-moleküle und deren bindungsliganden.

Country Status (11)

Country Link
EP (2) EP0365837B1 (de)
AT (2) ATE125708T1 (de)
CA (1) CA1341185C (de)
DE (2) DE68923675T2 (de)
ES (2) ES2201052T3 (de)
GR (1) GR3017959T3 (de)
HK (1) HK1003105A1 (de)
IE (1) IE69975B1 (de)
MX (1) MX9203212A (de)
NZ (1) NZ230775A (de)
PT (2) PT91834B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE186552T1 (de) 1988-09-01 1999-11-15 Bayer Ag Menschliches rhinovirusrezeptorprotein, das die virusinfektionsanfälligkeit hemmt
US6143298A (en) * 1988-09-01 2000-11-07 Bayer Corporation Soluble truncated forms of ICAM-1
ZA896668B (en) * 1988-09-01 1990-06-27 Molecular Therapeutics Inc A human rhinovirus receptor protein that inhibits virus infectivity
US6514936B1 (en) 1988-09-01 2003-02-04 Bayer Corporation Antiviral methods using human rhinovirus receptor (ICAM-1)
US6051231A (en) * 1988-09-01 2000-04-18 Bayer Corporation Antiviral methods and prepations
CA2008368C (en) * 1989-01-24 2003-04-08 Jeffrey Greve Soluble molecule related to but distinct from icam-1
US5776775A (en) * 1989-02-21 1998-07-07 Dana-Farber Cancer Institute Anti-LAM 1-3 antibody and hybridoma
CA2033347C (en) 1989-06-02 2000-02-29 James E. Hildreth Monoclonal antibodies against leukocyte adhesion receptor beta-chain, methods of producing these antibodies and use therefore
ATE184049T1 (de) * 1990-07-20 1999-09-15 Bayer Ag Multimere formen des menschlichen rhinovirus- rezeptorproteins
US5871733A (en) * 1990-07-20 1999-02-16 Bayer Corporation Multimeric forms of human rhinovirus receptor protein
US5674982A (en) * 1990-07-20 1997-10-07 Bayer Corporation Multimeric form of human rhinovirus receptor protein
US6107461A (en) * 1990-07-20 2000-08-22 Bayer Corporation Multimeric forms of human rhinovirus receptor and fragments thereof, and method of use
US5288854A (en) * 1990-11-28 1994-02-22 Center For Blood Research, Inc. Functional derivatives of ICAM-1 which are substantially capable of binding to LFA-1 but are substantially incapable of binding to MAC-1
US5709859A (en) * 1991-01-24 1998-01-20 Bristol-Myers Squibb Company Mixed specificity fusion proteins
HUT69725A (en) * 1991-10-01 1995-09-28 Gen Hospital Corp Process for producing compositions for preventing allograft rejection
US5861151A (en) * 1991-12-20 1999-01-19 Bristol-Myers Squibb Co Soluble fusion molecules with binding specificity for cell adhesion molecules
AU675441B2 (en) * 1992-06-22 1997-02-06 Bayer Corporation Multimeric forms of human rhinovirus receptor protein
FR2756735B1 (fr) * 1996-12-11 1999-02-26 Thorel Jean Noel Agent d'inhibition de l'expression de la proteine d'adherence icam-1 et compositions cosmetiques et pharmaceutiques le contenant
AU1207999A (en) * 1997-10-30 1999-05-24 Brigham And Women's Hospital Control of lymphocyte localization by leep-cam activity
US20030035798A1 (en) 2000-08-16 2003-02-20 Fang Fang Humanized antibodies
CH694344A5 (de) 2000-09-29 2004-11-30 Pesola Praez Swaagen Ag Federwaage.
US20030138440A1 (en) 2001-07-19 2003-07-24 Fang Fang Multimeric proteins and methods of making and using same

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2080044T3 (es) * 1987-05-04 1996-02-01 Dana Farber Cancer Inst Inc Moleculas de adhesion intercelular y sus ligandos de fijacion.
CA1341055C (en) * 1987-12-08 2000-07-18 Alan Mcclelland Transfectant cell lines which express the major human rhinovirus receptor

Also Published As

Publication number Publication date
HK1003105A1 (en) 1998-10-09
ES2077572T3 (es) 1995-12-01
PT91834A (pt) 1990-03-30
DE68923675D1 (de) 1995-09-07
ES2201052T3 (es) 2004-03-16
GR3017959T3 (en) 1996-02-29
EP0365837A3 (de) 1991-01-09
PT91834B (pt) 1996-08-30
MX9203212A (es) 1992-07-01
CA1341185C (en) 2001-02-20
IE69975B1 (en) 1996-10-16
EP0365837A2 (de) 1990-05-02
PT101731A (pt) 1996-04-30
NZ230775A (en) 1995-03-28
EP0365837B1 (de) 1995-08-02
DE68929477T2 (de) 2004-06-03
DE68923675T2 (de) 1996-02-15
IE893089L (en) 1990-03-28
EP0606518A1 (de) 1994-07-20
DE68929477D1 (de) 2003-09-04
EP0606518B1 (de) 2003-07-30
PT101731B (pt) 1997-04-30
ATE125708T1 (de) 1995-08-15

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NO901093L (no) Intercellulaert adhesjonsmolekyl 2 og dets bindingsligander
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