DE68923675D1 - Interzellulare Adhäsions-Moleküle und deren Bindungsliganden. - Google Patents

Interzellulare Adhäsions-Moleküle und deren Bindungsliganden.

Info

Publication number
DE68923675D1
DE68923675D1 DE68923675T DE68923675T DE68923675D1 DE 68923675 D1 DE68923675 D1 DE 68923675D1 DE 68923675 T DE68923675 T DE 68923675T DE 68923675 T DE68923675 T DE 68923675T DE 68923675 D1 DE68923675 D1 DE 68923675D1
Authority
DE
Germany
Prior art keywords
molecules
adhesion molecules
intercellular adhesion
binding ligands
binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE68923675T
Other languages
English (en)
Other versions
DE68923675T2 (de
Inventor
Timothy Alan Springer
Robert Rothlein
Steven Dean Marlin
Michael Loran Dustin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dana Farber Cancer Institute Inc
Original Assignee
Dana Farber Cancer Institute Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dana Farber Cancer Institute Inc filed Critical Dana Farber Cancer Institute Inc
Publication of DE68923675D1 publication Critical patent/DE68923675D1/de
Application granted granted Critical
Publication of DE68923675T2 publication Critical patent/DE68923675T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2845—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta2-subunit-containing molecules, e.g. CD11, CD18
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70525—ICAM molecules, e.g. CD50, CD54, CD102
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2821—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against ICAM molecules, e.g. CD50, CD54, CD102
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE68923675T 1988-09-28 1989-09-23 Interzellulare Adhäsions-Moleküle und deren Bindungsliganden. Expired - Lifetime DE68923675T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25044688A 1988-09-28 1988-09-28
US32448189A 1989-03-16 1989-03-16
US37388289A 1989-06-30 1989-06-30

Publications (2)

Publication Number Publication Date
DE68923675D1 true DE68923675D1 (de) 1995-09-07
DE68923675T2 DE68923675T2 (de) 1996-02-15

Family

ID=27400322

Family Applications (2)

Application Number Title Priority Date Filing Date
DE68929477T Expired - Lifetime DE68929477T2 (de) 1988-09-28 1989-09-23 Interzellulare Adhäsions-Moleküle und deren Bindungsliganden
DE68923675T Expired - Lifetime DE68923675T2 (de) 1988-09-28 1989-09-23 Interzellulare Adhäsions-Moleküle und deren Bindungsliganden.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE68929477T Expired - Lifetime DE68929477T2 (de) 1988-09-28 1989-09-23 Interzellulare Adhäsions-Moleküle und deren Bindungsliganden

Country Status (11)

Country Link
EP (2) EP0365837B1 (de)
AT (2) ATE246245T1 (de)
CA (1) CA1341185C (de)
DE (2) DE68929477T2 (de)
ES (2) ES2201052T3 (de)
GR (1) GR3017959T3 (de)
HK (1) HK1003105A1 (de)
IE (1) IE69975B1 (de)
MX (1) MX9203212A (de)
NZ (1) NZ230775A (de)
PT (2) PT91834B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE68929096T2 (de) 1988-09-01 2000-05-11 Bayer Ag Menschliches Rhinovirusrezeptorprotein, das die Virusinfektionsanfälligkeit hemmt
US6051231A (en) * 1988-09-01 2000-04-18 Bayer Corporation Antiviral methods and prepations
US6143298A (en) * 1988-09-01 2000-11-07 Bayer Corporation Soluble truncated forms of ICAM-1
ZA896668B (en) * 1988-09-01 1990-06-27 Molecular Therapeutics Inc A human rhinovirus receptor protein that inhibits virus infectivity
US6514936B1 (en) 1988-09-01 2003-02-04 Bayer Corporation Antiviral methods using human rhinovirus receptor (ICAM-1)
CA2008368C (en) * 1989-01-24 2003-04-08 Jeffrey Greve Soluble molecule related to but distinct from icam-1
US5776775A (en) * 1989-02-21 1998-07-07 Dana-Farber Cancer Institute Anti-LAM 1-3 antibody and hybridoma
WO1990015076A2 (en) 1989-06-02 1990-12-13 The Johns Hopkins University School Of Medicine MONOCLONAL ANTIBODIES AGAINST LEUKOCYTE ADHESION RECEPTOR β-CHAIN, METHODS OF PRODUCING THESE ANTIBODIES AND USE THEREFORE
US6107461A (en) * 1990-07-20 2000-08-22 Bayer Corporation Multimeric forms of human rhinovirus receptor and fragments thereof, and method of use
US5871733A (en) * 1990-07-20 1999-02-16 Bayer Corporation Multimeric forms of human rhinovirus receptor protein
US5674982A (en) * 1990-07-20 1997-10-07 Bayer Corporation Multimeric form of human rhinovirus receptor protein
ES2134762T3 (es) * 1990-07-20 1999-10-16 Bayer Ag Formas multimericas de proteinas receptoras de rinovirus humanos.
US5288854A (en) * 1990-11-28 1994-02-22 Center For Blood Research, Inc. Functional derivatives of ICAM-1 which are substantially capable of binding to LFA-1 but are substantially incapable of binding to MAC-1
US5709859A (en) * 1991-01-24 1998-01-20 Bristol-Myers Squibb Company Mixed specificity fusion proteins
WO1993006864A1 (en) * 1991-10-01 1993-04-15 The General Hospital Corporation Preventing allograft rejection with antibodies to adhesion molecules
US5861151A (en) * 1991-12-20 1999-01-19 Bristol-Myers Squibb Co Soluble fusion molecules with binding specificity for cell adhesion molecules
AU675441B2 (en) * 1992-06-22 1997-02-06 Bayer Corporation Multimeric forms of human rhinovirus receptor protein
FR2756735B1 (fr) * 1996-12-11 1999-02-26 Thorel Jean Noel Agent d'inhibition de l'expression de la proteine d'adherence icam-1 et compositions cosmetiques et pharmaceutiques le contenant
WO1999022765A1 (en) * 1997-10-30 1999-05-14 Brigham And Women's Hospital Control of lymphocyte localization by leep-cam activity
US20030035798A1 (en) 2000-08-16 2003-02-20 Fang Fang Humanized antibodies
CH694344A5 (de) 2000-09-29 2004-11-30 Pesola Praez Swaagen Ag Federwaage.
AU2002365196C1 (en) 2001-07-19 2009-08-13 Perlan Therapeutics, Inc. Multimeric proteins and methods of making and using same

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2080044T3 (es) * 1987-05-04 1996-02-01 Dana Farber Cancer Inst Inc Moleculas de adhesion intercelular y sus ligandos de fijacion.
CA1341055C (en) * 1987-12-08 2000-07-18 Alan Mcclelland Transfectant cell lines which express the major human rhinovirus receptor

Also Published As

Publication number Publication date
ES2201052T3 (es) 2004-03-16
PT101731A (pt) 1996-04-30
ATE125708T1 (de) 1995-08-15
EP0365837A2 (de) 1990-05-02
EP0365837B1 (de) 1995-08-02
EP0606518A1 (de) 1994-07-20
ATE246245T1 (de) 2003-08-15
DE68923675T2 (de) 1996-02-15
IE69975B1 (en) 1996-10-16
GR3017959T3 (en) 1996-02-29
DE68929477D1 (de) 2003-09-04
EP0606518B1 (de) 2003-07-30
ES2077572T3 (es) 1995-12-01
EP0365837A3 (de) 1991-01-09
PT91834B (pt) 1996-08-30
HK1003105A1 (en) 1998-10-09
NZ230775A (en) 1995-03-28
DE68929477T2 (de) 2004-06-03
PT101731B (pt) 1997-04-30
CA1341185C (en) 2001-02-20
PT91834A (pt) 1990-03-30
MX9203212A (es) 1992-07-01
IE893089L (en) 1990-03-28

Similar Documents

Publication Publication Date Title
DE3854536T2 (de) Interzellulare Adhäsions-Moleküle und deren Bindungsliganden.
DE68929477D1 (de) Interzellulare Adhäsions-Moleküle und deren Bindungsliganden
NO901093L (no) Intercellulaert adhesjonsmolekyl 2 og dets bindingsligander
DK412589D0 (da) Alfa-underenheden af lfa-1-leukocytadhaesionsreceptoren

Legal Events

Date Code Title Description
8364 No opposition during term of opposition