DE68929096T2 - Menschliches Rhinovirusrezeptorprotein, das die Virusinfektionsanfälligkeit hemmt - Google Patents

Menschliches Rhinovirusrezeptorprotein, das die Virusinfektionsanfälligkeit hemmt

Info

Publication number
DE68929096T2
DE68929096T2 DE68929096T DE68929096T DE68929096T2 DE 68929096 T2 DE68929096 T2 DE 68929096T2 DE 68929096 T DE68929096 T DE 68929096T DE 68929096 T DE68929096 T DE 68929096T DE 68929096 T2 DE68929096 T2 DE 68929096T2
Authority
DE
Germany
Prior art keywords
receptor
hrv
human rhinovirus
detergent
receptor protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE68929096T
Other languages
English (en)
Other versions
DE68929096D1 (de
Inventor
Jeffrey Greve
Alan Mcclelland
Gary Davis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Bayer Corp
Original Assignee
Bayer AG
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG, Bayer Corp filed Critical Bayer AG
Application granted granted Critical
Publication of DE68929096D1 publication Critical patent/DE68929096D1/de
Publication of DE68929096T2 publication Critical patent/DE68929096T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70525—ICAM molecules, e.g. CD50, CD54, CD102
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DE68929096T 1988-09-01 1989-08-19 Menschliches Rhinovirusrezeptorprotein, das die Virusinfektionsanfälligkeit hemmt Expired - Lifetime DE68929096T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23957188A 1988-09-01 1988-09-01
US26242888A 1988-10-25 1988-10-25
US39066289A 1989-08-10 1989-08-10

Publications (2)

Publication Number Publication Date
DE68929096D1 DE68929096D1 (de) 1999-12-16
DE68929096T2 true DE68929096T2 (de) 2000-05-11

Family

ID=27399251

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68929096T Expired - Lifetime DE68929096T2 (de) 1988-09-01 1989-08-19 Menschliches Rhinovirusrezeptorprotein, das die Virusinfektionsanfälligkeit hemmt

Country Status (15)

Country Link
US (1) US7132395B1 (de)
EP (1) EP0362531B1 (de)
JP (1) JP3253064B2 (de)
AT (1) ATE186552T1 (de)
AU (1) AU637324B2 (de)
CA (1) CA1339193C (de)
DE (1) DE68929096T2 (de)
DK (1) DK174095B1 (de)
ES (1) ES2141076T3 (de)
FI (1) FI894065A (de)
GR (1) GR3032456T3 (de)
IL (1) IL91454A (de)
NO (1) NO893373L (de)
NZ (1) NZ230474A (de)
PT (1) PT91570B (de)

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US5151267A (en) * 1988-07-15 1992-09-29 University Of Saskatchewan Bovine herpesvirus type 1 polypeptides and vaccines
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US6143298A (en) * 1988-09-01 2000-11-07 Bayer Corporation Soluble truncated forms of ICAM-1
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DE69131564T2 (de) * 1990-07-20 2000-01-13 Bayer Ag Multimere Formen des menschlichen Rhinovirus-Rezeptorproteins
US6107461A (en) * 1990-07-20 2000-08-22 Bayer Corporation Multimeric forms of human rhinovirus receptor and fragments thereof, and method of use
US6130202A (en) * 1990-07-20 2000-10-10 Bayer Corporation Antiviral methods
US5686582A (en) * 1990-07-20 1997-11-11 Bayer Corporation Multimeric forms of human rhinovirus receptor protein
US5288854A (en) * 1990-11-28 1994-02-22 Center For Blood Research, Inc. Functional derivatives of ICAM-1 which are substantially capable of binding to LFA-1 but are substantially incapable of binding to MAC-1
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US5525487A (en) * 1992-01-27 1996-06-11 Icos Corporation DNA encoding I-CAM related protein
US5989843A (en) * 1992-01-27 1999-11-23 Icos Corporation Methods for identifying modulators of protein kinase C phosphorylation of ICAM-related protein
US6100383A (en) * 1992-01-27 2000-08-08 Icos Corporation Fusion proteins comprising ICAM-R polypeptides and immunoglobulin constant regions
US6153395A (en) * 1992-01-27 2000-11-28 Icos Corporation ICAM-related protein
US5532127A (en) * 1992-01-27 1996-07-02 Icos Corporation Assay for 1-CAM related protein expression
US5880268A (en) * 1992-01-27 1999-03-09 Icos Corporation Modulators of the interaction between ICAM-R and αd /CD18
US5837822A (en) * 1992-01-27 1998-11-17 Icos Corporation Humanized antibodies specific for ICAM related protein
CA2107097A1 (en) * 1992-01-27 1993-07-28 Michael W. Gallatin Icam-related protein
AU710965B2 (en) * 1992-06-22 1999-09-30 Bayer Corporation Multimeric forms of human rhinovirus receptor protein
AU5466794A (en) * 1992-11-18 1994-06-08 Helsinki University Licensing Ltd Oy Peptides from human icam-2 and from human icam-1 and their analogs for use in therapy and diagnosis
GB9414966D0 (en) * 1994-07-26 1994-09-14 Danbiosyst Uk Pharmaceutical compositions for the nasal administration of antiviral agents
US5879712A (en) * 1995-06-07 1999-03-09 Sri International Method for producing drug-loaded microparticles and an ICAM-1 dosage form so produced
JP2000507221A (ja) * 1996-03-06 2000-06-13 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド 細胞間接着分子粉末組成物
US6391452B1 (en) 1997-07-18 2002-05-21 Bayer Corporation Compositions for nasal drug delivery, methods of making same, and methods of removing residual solvent from pharmaceutical preparations
AU2004287875B2 (en) 2003-11-05 2011-06-02 Bausch + Lomb Ireland Limited Modulators of cellular adhesion
CN101175488B (zh) 2005-05-17 2012-04-18 萨可德公司 治疗眼病的组合物和方法
JP5808037B2 (ja) 2007-10-19 2015-11-10 サーコード バイオサイエンス インク． 糖尿病性網膜症の治療のための組成物及び方法
WO2009139817A2 (en) 2008-04-15 2009-11-19 Sarcode Corporation Crystalline pharmaceutical and methods of preparation and use thereof
US8378105B2 (en) 2009-10-21 2013-02-19 Sarcode Bioscience Inc. Crystalline pharmaceutical and methods of preparation and use thereof
CN110922393A (zh) 2012-07-25 2020-03-27 诺华股份有限公司 Lfa-1抑制剂及其多晶型物
AU2017224113B2 (en) 2016-02-25 2022-04-21 Applied Biological Laboratories, Inc. Compositions and methods for protecting against airborne pathogens and irritants
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ZA896668B (en) * 1988-09-01 1990-06-27 Molecular Therapeutics Inc A human rhinovirus receptor protein that inhibits virus infectivity
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Also Published As

Publication number Publication date
NZ230474A (en) 1993-03-26
EP0362531B1 (de) 1999-11-10
DK431289D0 (da) 1989-08-31
JPH02238892A (ja) 1990-09-21
FI894065A0 (fi) 1989-08-30
JP3253064B2 (ja) 2002-02-04
NO893373D0 (no) 1989-08-22
FI894065A (fi) 1990-03-02
PT91570B (pt) 1995-05-31
CA1339193C (en) 1997-08-05
AU4027189A (en) 1990-03-08
EP0362531A1 (de) 1990-04-11
PT91570A (pt) 1990-03-30
US7132395B1 (en) 2006-11-07
IL91454A (en) 1995-08-31
ATE186552T1 (de) 1999-11-15
AU637324B2 (en) 1993-05-27
GR3032456T3 (en) 2000-05-31
DK431289A (da) 1990-03-02
DE68929096D1 (de) 1999-12-16
DK174095B1 (da) 2002-06-10
IL91454A0 (en) 1990-04-29
ES2141076T3 (es) 2000-03-16
NO893373L (no) 1990-03-02

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