ES2141076T3 - Proteina del receptor de rinovirus humano que inhibe la infectividad del virus. - Google Patents
Proteina del receptor de rinovirus humano que inhibe la infectividad del virus.Info
- Publication number
- ES2141076T3 ES2141076T3 ES89115358T ES89115358T ES2141076T3 ES 2141076 T3 ES2141076 T3 ES 2141076T3 ES 89115358 T ES89115358 T ES 89115358T ES 89115358 T ES89115358 T ES 89115358T ES 2141076 T3 ES2141076 T3 ES 2141076T3
- Authority
- ES
- Spain
- Prior art keywords
- receptor
- hrv
- human rhinovirus
- detergent
- receptor protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70525—ICAM molecules, e.g. CD50, CD54, CD102
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Otolaryngology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Detergent Compositions (AREA)
Abstract
UNA PREPARACION RECEPTORA DEL RINOVIRUS HUMANO SOLUBLE EN AGUA (HRV) COMPRENDE UNA GLICOPROTEINA DE DETERGENTE COMPLEJO AISLADA DE CELULAS ANIMALES, PREFERIBLEMENTE CELULAS DE MAMIFEROS, QUE EXPRESA EL RECEPTOR DE HRV Y QUE EXHIBE LA HABILIDAD DE UNIRSE AL HRV PARA REDUCIR SUSTANCIALMENTE LA EFECTIVIDAD DEL VIRUS. EL RECEPTOR SOLUBLE EN AGUA PURIFICADO SE OBTIENE MEDIANTE LA EXTRACCION DE CELULAS QUE EXPRESAN EL RECEPTOR CON DETERGENTE Y EL AISLAMIENTO DE LOS COMPLEJOS SOLUBILIZADOS DE GLICOPROTEINA - DETERGENTE MEDIANTE SU UNION A UN ANTICUERPO MONOCLONAL SELECTIVO PARA LA PROTEINA RECEPTORA DEL HRV.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23957188A | 1988-09-01 | 1988-09-01 | |
US26242888A | 1988-10-25 | 1988-10-25 | |
US39066289A | 1989-08-10 | 1989-08-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2141076T3 true ES2141076T3 (es) | 2000-03-16 |
Family
ID=27399251
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES89115358T Expired - Lifetime ES2141076T3 (es) | 1988-09-01 | 1989-08-19 | Proteina del receptor de rinovirus humano que inhibe la infectividad del virus. |
Country Status (15)
Country | Link |
---|---|
US (1) | US7132395B1 (es) |
EP (1) | EP0362531B1 (es) |
JP (1) | JP3253064B2 (es) |
AT (1) | ATE186552T1 (es) |
AU (1) | AU637324B2 (es) |
CA (1) | CA1339193C (es) |
DE (1) | DE68929096T2 (es) |
DK (1) | DK174095B1 (es) |
ES (1) | ES2141076T3 (es) |
FI (1) | FI894065A (es) |
GR (1) | GR3032456T3 (es) |
IL (1) | IL91454A (es) |
NO (1) | NO893373L (es) |
NZ (1) | NZ230474A (es) |
PT (1) | PT91570B (es) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH01502879A (ja) * | 1987-02-26 | 1989-10-05 | ダナ ファーバー キャンサー インスティテュート | Lfa―1のクローニング |
US5585264A (en) * | 1988-07-15 | 1996-12-17 | University Of Saskatchewan | Nucleotide sequences encoding recombinant bovine herpesvirus type-1 GI, GIII and GIV polypeptides |
US5151267A (en) * | 1988-07-15 | 1992-09-29 | University Of Saskatchewan | Bovine herpesvirus type 1 polypeptides and vaccines |
US6051231A (en) * | 1988-09-01 | 2000-04-18 | Bayer Corporation | Antiviral methods and prepations |
ZA896668B (en) * | 1988-09-01 | 1990-06-27 | Molecular Therapeutics Inc | A human rhinovirus receptor protein that inhibits virus infectivity |
ES2141076T3 (es) | 1988-09-01 | 2000-03-16 | Bayer Ag | Proteina del receptor de rinovirus humano que inhibe la infectividad del virus. |
US6143298A (en) * | 1988-09-01 | 2000-11-07 | Bayer Corporation | Soluble truncated forms of ICAM-1 |
US6514936B1 (en) | 1988-09-01 | 2003-02-04 | Bayer Corporation | Antiviral methods using human rhinovirus receptor (ICAM-1) |
NO900155L (no) * | 1989-01-24 | 1990-07-25 | Molecular Therapeutics Inc | Et opploeselig molekyl som er relatert til, men forskjellig fra icam-1. |
JPH04505009A (ja) * | 1989-03-09 | 1992-09-03 | ダナ・ファーバー・キャンサー・インスティチュート | クローニングlfa―1 |
DE69029528T2 (de) * | 1989-03-16 | 1997-06-26 | Blood Res Center | Verwendung von funkionellen Derivaten des Interzellulär-Adhäsions-Moleküls ICAM-1 in einer Antivirus-Therapie |
WO1991018010A1 (en) * | 1990-05-15 | 1991-11-28 | Swinburne Limited | Inhibition of viral infection using intercellular adhesion molecule-1-like peptides and/or analogues thereof |
DE69131564T2 (de) * | 1990-07-20 | 2000-01-13 | Bayer Ag | Multimere Formen des menschlichen Rhinovirus-Rezeptorproteins |
US5871733A (en) * | 1990-07-20 | 1999-02-16 | Bayer Corporation | Multimeric forms of human rhinovirus receptor protein |
US5674982A (en) * | 1990-07-20 | 1997-10-07 | Bayer Corporation | Multimeric form of human rhinovirus receptor protein |
US6130202A (en) * | 1990-07-20 | 2000-10-10 | Bayer Corporation | Antiviral methods |
US6107461A (en) * | 1990-07-20 | 2000-08-22 | Bayer Corporation | Multimeric forms of human rhinovirus receptor and fragments thereof, and method of use |
US5288854A (en) * | 1990-11-28 | 1994-02-22 | Center For Blood Research, Inc. | Functional derivatives of ICAM-1 which are substantially capable of binding to LFA-1 but are substantially incapable of binding to MAC-1 |
US5891841A (en) * | 1991-06-11 | 1999-04-06 | The Center For Blood Research, Inc. | Methods of using intercellular adhesion molecule-3 (ICAM-3), antibodies thereto, and soluble fragments thereof |
US6100383A (en) * | 1992-01-27 | 2000-08-08 | Icos Corporation | Fusion proteins comprising ICAM-R polypeptides and immunoglobulin constant regions |
US5811517A (en) * | 1992-01-27 | 1998-09-22 | Icos Corporation | ICAM-related protein variants |
US6818743B1 (en) | 1992-01-27 | 2004-11-16 | Icos Corporation | I-CAM related protein |
US6153395A (en) * | 1992-01-27 | 2000-11-28 | Icos Corporation | ICAM-related protein |
US5532127A (en) * | 1992-01-27 | 1996-07-02 | Icos Corporation | Assay for 1-CAM related protein expression |
EP0578819A4 (en) * | 1992-01-27 | 1994-10-12 | Icos Corp | Icam-related protein. |
US5989843A (en) * | 1992-01-27 | 1999-11-23 | Icos Corporation | Methods for identifying modulators of protein kinase C phosphorylation of ICAM-related protein |
US5837822A (en) * | 1992-01-27 | 1998-11-17 | Icos Corporation | Humanized antibodies specific for ICAM related protein |
US5525487A (en) * | 1992-01-27 | 1996-06-11 | Icos Corporation | DNA encoding I-CAM related protein |
AU710965B2 (en) * | 1992-06-22 | 1999-09-30 | Bayer Corporation | Multimeric forms of human rhinovirus receptor protein |
AU5466794A (en) * | 1992-11-18 | 1994-06-08 | Helsinki University Licensing Ltd Oy | Peptides from human icam-2 and from human icam-1 and their analogs for use in therapy and diagnosis |
GB9414966D0 (en) * | 1994-07-26 | 1994-09-14 | Danbiosyst Uk | Pharmaceutical compositions for the nasal administration of antiviral agents |
US5879712A (en) * | 1995-06-07 | 1999-03-09 | Sri International | Method for producing drug-loaded microparticles and an ICAM-1 dosage form so produced |
WO1997032596A1 (en) * | 1996-03-06 | 1997-09-12 | Boehringer Ingelheim Pharmaceuticals, Inc. | Intercellular adhesion molecule powder formulation |
US6391452B1 (en) | 1997-07-18 | 2002-05-21 | Bayer Corporation | Compositions for nasal drug delivery, methods of making same, and methods of removing residual solvent from pharmaceutical preparations |
PL1682537T3 (pl) | 2003-11-05 | 2012-09-28 | Sarcode Bioscience Inc | Modulatory adhezji komórkowej |
CA2609053C (en) | 2005-05-17 | 2017-04-25 | Sarcode Corporation | Compositions and methods for treatment of eye disorders |
EP3797775A1 (en) | 2007-10-19 | 2021-03-31 | Novartis AG | Compositions and methods for treatment of diabetic retinopathy |
US8080562B2 (en) | 2008-04-15 | 2011-12-20 | Sarcode Bioscience Inc. | Crystalline pharmaceutical and methods of preparation and use thereof |
US8378105B2 (en) | 2009-10-21 | 2013-02-19 | Sarcode Bioscience Inc. | Crystalline pharmaceutical and methods of preparation and use thereof |
CN104797574B (zh) | 2012-07-25 | 2019-11-22 | 原生质生物科学股份有限公司 | Lfa-1抑制剂及其多晶型物 |
CN117942405A (zh) | 2016-02-25 | 2024-04-30 | 应用生物实验室公司 | 保护空气传播的病原体和刺激物的组合物和方法 |
US20170360815A1 (en) | 2016-02-25 | 2017-12-21 | Applied Biological Laboratories, Inc. | Compositions and methods for protecting against airborne pathogens and irritants |
Family Cites Families (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4261928A (en) | 1977-08-05 | 1981-04-14 | Sterling Drug Inc. | 2-Benzoyl-8-(2-chloro-4-methoxyphenoxy)-1-phenyl-1-octanone |
US4171365A (en) | 1977-08-05 | 1979-10-16 | Sterling Drug Inc. | Antiviral aryloxyalkylpyrazoles |
US4209526A (en) | 1977-08-05 | 1980-06-24 | Sterling Drug Inc. | Antiviral arylenedioxyalkyl substituted pyrazoles |
FR2432170A1 (fr) | 1978-06-12 | 1980-02-22 | Corning Glass Works | Procede de mesure de recepteurs d'antigene sur des membranes de cellules |
US4232161A (en) | 1979-10-24 | 1980-11-04 | Sterling Drug Inc. | 4-[6-(2-Chloro-4-methoxyphenoxy)hexyl]-3,5-diethyl-1-(2-pyridinyl)-1H-pyrazole |
US4234725A (en) | 1979-10-24 | 1980-11-18 | Sterling Drug Inc. | 4-[6-(2-Chloro-4-methoxyphenoxy)hexyl]-3,5-diethyl-1-[4-(4-morpholinyl)-1-oxobutyl]-1H-pyrazole |
US5179017A (en) | 1980-02-25 | 1993-01-12 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
US4427653A (en) | 1981-01-26 | 1984-01-24 | President And Fellows Of Harvard College | Method of making monoclonal antibodies |
US4372976A (en) | 1981-08-07 | 1983-02-08 | Sterling Drug Inc. | Novel aryl-aliphatic ketone and its use as an antiviral agent |
US4451476A (en) | 1982-12-13 | 1984-05-29 | Sterling Drug Inc. | Isoxazoles as antiviral agents |
US4843087A (en) | 1983-08-29 | 1989-06-27 | Sterling Drug Inc. | Di-heterocyclic compounds and their use as antiviral agents |
EP0169146A3 (en) * | 1984-07-20 | 1988-07-20 | Merck & Co. Inc. | Monoclonal antibodies directed against the cellular receptor of human rhinovirus |
EP0169729A3 (en) | 1984-07-23 | 1988-08-03 | Becton Dickinson and Company | Recovery of cell receptors |
DE3505148A1 (de) | 1985-02-15 | 1986-10-30 | Boehringer Ingelheim International GmbH, 6507 Ingelheim | Polypeptide des rhinovirusstammes hrv2 sowie die hierfuer codierenden dna-molekuele |
CA1280753C (en) | 1985-07-02 | 1991-02-26 | Philip Michael Carabateas | Process for preparing heterocyclic substituted- phenoxyalkyl isoxazoles and-furans |
EP0227604A3 (en) | 1985-12-23 | 1989-01-18 | Sandoz Ag | Use of oligopeptides in the treatment of viral infections |
EP0261403A3 (de) | 1986-08-23 | 1988-04-13 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | Polypeptide des Rhinovirusstammes HRV89 sowie die hierfür codierenden DNA-Moleküle |
ATE98649T1 (de) | 1987-02-26 | 1994-01-15 | Dana Farber Cancer Inst Inc | Reinigung von lfa-3. |
DE3712678A1 (de) | 1987-04-14 | 1988-10-27 | Boehringer Ingelheim Int | Rezeptor der kleinen rhinovirus rezeptor gruppe |
US5603932A (en) | 1987-04-14 | 1997-02-18 | Boehringer Ingelheim International Gmbh | Receptor of the minor human rhinovirus receptor group |
US5304636A (en) | 1987-04-14 | 1994-04-19 | Boehringer Ingelheim International Gmbh | Receptor for the human rhinovirus minor group |
AU629189B2 (en) | 1987-05-04 | 1992-10-01 | Dana-Farber Cancer Institute | Intercellular adhesion molecules and their binding ligands |
US5284931A (en) | 1987-05-04 | 1994-02-08 | Dana Farber Cancer Institute | Intercellular adhesion molecules, and their binding ligands |
EP0289949B1 (en) | 1987-05-04 | 1995-10-04 | Dana Farber Cancer Institute | Intercellular adhesion molecules, and their binding ligands |
US5831036A (en) | 1987-05-04 | 1998-11-03 | Dana Farber Cancer Institute | Soluble fragments of human intercellular adhesion molecule-1 |
US4956281A (en) | 1987-06-03 | 1990-09-11 | Biogen, Inc. | DNA sequences, recombinant DNA molecules and processes for producing lymphocyte function associated antigen-3 |
US5109123A (en) | 1988-06-14 | 1992-04-28 | Dana Farber Cancer Institute | Alteration of ability of soluble CD4 fragments to bind HIV |
EP0314863B1 (en) | 1987-11-02 | 1994-12-07 | Baylor College Of Medicine | Use of ICAM-1 or its functional derivatives for the treatment of non-specific inflammation |
US5081228A (en) | 1988-02-25 | 1992-01-14 | Immunex Corporation | Interleukin-1 receptors |
CA1341055C (en) * | 1987-12-08 | 2000-07-18 | Alan Mcclelland | Transfectant cell lines which express the major human rhinovirus receptor |
US5395929A (en) | 1987-12-15 | 1995-03-07 | Dana Farber Cancer Institute | Isolated nucleic acid encoding the alpha subunit of the human leukocyte adhesion receptor |
DE68923048T2 (de) | 1988-08-23 | 1995-11-16 | Dana Farber Cancer Inst Inc | Alpha-Subeinheit des LFA-1-Leukocyt-Adhäsions-Rezeptors. |
US6051231A (en) | 1988-09-01 | 2000-04-18 | Bayer Corporation | Antiviral methods and prepations |
ZA896668B (en) * | 1988-09-01 | 1990-06-27 | Molecular Therapeutics Inc | A human rhinovirus receptor protein that inhibits virus infectivity |
ES2141076T3 (es) | 1988-09-01 | 2000-03-16 | Bayer Ag | Proteina del receptor de rinovirus humano que inhibe la infectividad del virus. |
US6143298A (en) | 1988-09-01 | 2000-11-07 | Bayer Corporation | Soluble truncated forms of ICAM-1 |
US6514936B1 (en) * | 1988-09-01 | 2003-02-04 | Bayer Corporation | Antiviral methods using human rhinovirus receptor (ICAM-1) |
ES2077572T3 (es) | 1988-09-28 | 1995-12-01 | Dana Farber Cancer Inst Inc | Moleculas de adhesion intercelular, y sus ligandos de fijacion. |
US5372933A (en) | 1988-10-03 | 1994-12-13 | The Scripps Research Institute | Polypeptides that mimic receptor-induced binding sites, and methods of using same |
NO900155L (no) | 1989-01-24 | 1990-07-25 | Molecular Therapeutics Inc | Et opploeselig molekyl som er relatert til, men forskjellig fra icam-1. |
CA2008368C (en) | 1989-01-24 | 2003-04-08 | Jeffrey Greve | Soluble molecule related to but distinct from icam-1 |
US5235049A (en) | 1989-01-24 | 1993-08-10 | Molecular Therapeutics, Inc. | Nucleic acid sequences encoding a soluble molecule (SICAM-1) related to but distinct from ICAM-1 |
PT92900A (pt) | 1989-01-24 | 1990-07-31 | Sistema de vectores de expressao para a producao de anticorpos monoclonais quimericos | |
EP0387701B1 (en) | 1989-03-09 | 1992-08-12 | Boehringer Ingelheim Pharmaceuticals Inc. | Use of intercellular adhesion molecules, and their binding ligands in the treatment of asthma |
HU217792B (hu) | 1989-03-16 | 2000-04-28 | Dana Farber Cancer Institute | Eljárás intercelluláris adhéziós molekula (ICAM-1) oldható származékai és ezeket tartalmazó gyógyszerkészítmények előállítására |
DE69029528T2 (de) * | 1989-03-16 | 1997-06-26 | Blood Res Center | Verwendung von funkionellen Derivaten des Interzellulär-Adhäsions-Moleküls ICAM-1 in einer Antivirus-Therapie |
US5324510A (en) | 1989-09-01 | 1994-06-28 | Boehringer Ingelheim Pharmaceuticals, Inc. | Use of antibodies to intercellular adhesion molecule-1 (ICAM-1) in the treatment of asthma |
EP0459577A3 (en) | 1990-06-01 | 1992-08-05 | Merck & Co. Inc. | Microbially expressed portions of a monoclonal antibody block rhinovirus attachment to cell receptors |
US5349053A (en) | 1990-06-01 | 1994-09-20 | Protein Design Labs, Inc. | Chimeric ligand/immunoglobulin molecules and their uses |
US5871733A (en) | 1990-07-20 | 1999-02-16 | Bayer Corporation | Multimeric forms of human rhinovirus receptor protein |
DE69131564T2 (de) | 1990-07-20 | 2000-01-13 | Bayer Ag | Multimere Formen des menschlichen Rhinovirus-Rezeptorproteins |
US6107461A (en) | 1990-07-20 | 2000-08-22 | Bayer Corporation | Multimeric forms of human rhinovirus receptor and fragments thereof, and method of use |
US6130202A (en) * | 1990-07-20 | 2000-10-10 | Bayer Corporation | Antiviral methods |
US5674982A (en) | 1990-07-20 | 1997-10-07 | Bayer Corporation | Multimeric form of human rhinovirus receptor protein |
CA2090427A1 (en) | 1990-08-27 | 1992-02-28 | Cetus Oncology Corporation | Cd18 peptide medicaments for the treatment of disease |
US5288854A (en) | 1990-11-28 | 1994-02-22 | Center For Blood Research, Inc. | Functional derivatives of ICAM-1 which are substantially capable of binding to LFA-1 but are substantially incapable of binding to MAC-1 |
DE69123241T2 (de) | 1990-12-14 | 1997-04-17 | Cell Genesys Inc | Chimärische ketten zur transduktion von rezeptorverbundenen signalwegen |
EP0510483A1 (en) | 1991-04-22 | 1992-10-28 | Boehringer Ingelheim Pharmaceuticals Inc. | Method for the detection of viruses |
US5223396A (en) | 1991-05-03 | 1993-06-29 | Boehringer Ingelheim Pharmaceuticals, Inc. | Method for detecting organ transplant rejection |
US5240694A (en) | 1991-09-23 | 1993-08-31 | University Of Virginia | Combined antiviral and antimediator treatment of common colds |
DE69229275T2 (de) | 1991-10-04 | 1999-12-30 | Us Health | Herstellung eines arzneimittels zur behandlung von augenentzündung durch blockierung von zelladhäsionsmolekulen |
US5532127A (en) | 1992-01-27 | 1996-07-02 | Icos Corporation | Assay for 1-CAM related protein expression |
US5525487A (en) | 1992-01-27 | 1996-06-11 | Icos Corporation | DNA encoding I-CAM related protein |
EP0578819A4 (en) | 1992-01-27 | 1994-10-12 | Icos Corp | Icam-related protein. |
ATE192499T1 (de) | 1992-03-13 | 2000-05-15 | Monsanto Co | Herstellung rekombinanter proteine unter verwendung von herpes-virus-promotoren und vp16- transaktivatoren |
EP0604624A4 (en) | 1992-06-22 | 1997-03-12 | Miles Inc | MULTIMER FORMS OF HUMAN RHINOVIRUS RECEPTOR PROTEIN. |
US5580969A (en) | 1992-07-24 | 1996-12-03 | The United States Of America As Represented By The Secretary Of The Navy | Antisense oligonucleotides directed against human ICAM-I RNA |
US5879712A (en) | 1995-06-07 | 1999-03-09 | Sri International | Method for producing drug-loaded microparticles and an ICAM-1 dosage form so produced |
-
1989
- 1989-08-19 ES ES89115358T patent/ES2141076T3/es not_active Expired - Lifetime
- 1989-08-19 AT AT89115358T patent/ATE186552T1/de not_active IP Right Cessation
- 1989-08-19 EP EP89115358A patent/EP0362531B1/en not_active Expired - Lifetime
- 1989-08-19 DE DE68929096T patent/DE68929096T2/de not_active Expired - Lifetime
- 1989-08-22 NO NO89893373A patent/NO893373L/no unknown
- 1989-08-25 AU AU40271/89A patent/AU637324B2/en not_active Ceased
- 1989-08-25 CA CA000609473A patent/CA1339193C/en not_active Expired - Fee Related
- 1989-08-28 IL IL9145489A patent/IL91454A/en not_active IP Right Cessation
- 1989-08-29 NZ NZ230474A patent/NZ230474A/xx unknown
- 1989-08-30 PT PT91570A patent/PT91570B/pt not_active IP Right Cessation
- 1989-08-30 FI FI894065A patent/FI894065A/fi not_active Application Discontinuation
- 1989-08-31 DK DK198904312A patent/DK174095B1/da not_active IP Right Cessation
- 1989-09-01 JP JP22730189A patent/JP3253064B2/ja not_active Expired - Lifetime
-
1994
- 1994-09-30 US US08/316,384 patent/US7132395B1/en not_active Expired - Fee Related
-
2000
- 2000-01-25 GR GR20000400150T patent/GR3032456T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
US7132395B1 (en) | 2006-11-07 |
IL91454A (en) | 1995-08-31 |
PT91570A (pt) | 1990-03-30 |
DE68929096D1 (de) | 1999-12-16 |
JPH02238892A (ja) | 1990-09-21 |
JP3253064B2 (ja) | 2002-02-04 |
ATE186552T1 (de) | 1999-11-15 |
DK174095B1 (da) | 2002-06-10 |
IL91454A0 (en) | 1990-04-29 |
FI894065A0 (fi) | 1989-08-30 |
GR3032456T3 (en) | 2000-05-31 |
CA1339193C (en) | 1997-08-05 |
NO893373D0 (no) | 1989-08-22 |
DK431289A (da) | 1990-03-02 |
PT91570B (pt) | 1995-05-31 |
DK431289D0 (da) | 1989-08-31 |
EP0362531B1 (en) | 1999-11-10 |
AU4027189A (en) | 1990-03-08 |
FI894065A (fi) | 1990-03-02 |
AU637324B2 (en) | 1993-05-27 |
EP0362531A1 (en) | 1990-04-11 |
NO893373L (no) | 1990-03-02 |
DE68929096T2 (de) | 2000-05-11 |
NZ230474A (en) | 1993-03-26 |
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