KR920009412A - ICAM-1의 Mac-1 결합 부위 - Google Patents
ICAM-1의 Mac-1 결합 부위 Download PDFInfo
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- KR920009412A KR920009412A KR1019910021347A KR910021347A KR920009412A KR 920009412 A KR920009412 A KR 920009412A KR 1019910021347 A KR1019910021347 A KR 1019910021347A KR 910021347 A KR910021347 A KR 910021347A KR 920009412 A KR920009412 A KR 920009412A
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- icam
- functional derivative
- mac
- response
- lfa
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70525—ICAM molecules, e.g. CD50, CD54, CD102
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2821—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against ICAM molecules, e.g. CD50, CD54, CD102
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2/00—Peptides of undefined number of amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/868—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, or immunotolerance
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Ropes Or Cables (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Package Frames And Binding Bands (AREA)
- Hall/Mr Elements (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 정제된 ICAM-1에 대한 LFA-1 및 Mac-1 COS 세포 변형체의 유착을 나타내는 그래프,
제2도는 정제된 Mac-1에 대한 ICAM-1+L세포 유착의 용량 반응곡선을 나타내는 그래프,
제3도는 정제된 Mac-1 및 LFA←1에 대한 ICAM-1+L세포의 결합력을 비교하는 그래프.
Claims (24)
- Mac-1에는 실질적으로 결합할 수 없지만 LFA-1에는 실질적으로 결합할 수 있는 ICAM-1 작용성 유도체.
- 제1항에 있어서, 가용성 ICAM-1 작용성 유도체인 ICAM-1 작용성 유도체.
- 제2항에 있어서, ICAM-1의 도메인 1,2,3,4 및 5를 포함하며 가용성인 ICAM-1 작용성 유도체.
- 제3항에 있어서, ICAM-1의 도메인 3에 돌연변이를 포함하는 ICAM-1 작용성 유도체.
- 제4항에 있어서, 돌연변이가 ICAM-1의 잔기 229-231 및 잔기 254-256의 그룹중에서 선택된 잔기내에서 일어난 ICAM-1 작용성 유도체.
- LFA-1에는 실질적으로 결합할 수 없지만 Mac-1에는 실질적으로 결합할 수 있는 ICAM-1 작용성 유도체.
- 제6항에 있어서, 가용성 ICAM-1 작용성 유도체인 ICAM-1 작용성 유도체.
- 제7항에 있어서, ICAM-1의 도메인 1,2,3,4 및 5를 포함하며 가용성인 ICAM-1 작용성 유도체.
- 제8항에 있어서, ICAM-1의 도메인 1에 돌연변이를 포함하는 ICAM-1 작용성 유도체.
- 제9항에 있어서, 돌연변이가 ICAM-1의 E34, Q58ED 및 Q73의 그룹중에서 선택된 잔기내에서 일어난 ICAM-1 작용성 유도체.
- 제8항에 있어서, ICAM-1의 도메인 2에 돌연변이를 포함하는 ICAM-1 작용성 유도체.
- 제7항에 있어서, ICAM-1의 도메인 3과 4를 포함하며 가용성인 ICAM-1 작용성 유도체.
- Mac-1과 LFA-1에는 실질적으로 결합할 수 없지만 인간 리노바이러스를 실질적으로 결합시킬 수 있는 ICAM-1 작용성 유도체.
- Mac-1에 대한 결합 능력을 증대시킬 수 있는, 글리코실화 부위가 결여된 ICAM-1 작용성 유도체.
- 제14항에 있어서, 글리코실화 부위가 ICAM-1의 N269, N240 및 N358로 이루어진 그룹중에서 선택된 ICAM-1 작용성 유도체.
- 비-특이적 방어계의 반응에 의해 유발된 염증은 치료할 수 있지만 특이적 방어계의 반응에 의해 유발된 염증은 실질적으로 억제할 수 없음을 특징으로 하는 소염제.
- 제16항에 있어서, LFA-1에는 실질적으로 결합할 수 없지만 Mac-1에는 실질적으로 결합할 수 있는 ICAM-1 작용성 유도체인 소염제.
- 제17항에 있어서, 가용성 ICAM-1 작용성 유도체인 소염제.
- 특이적 방어계의 반응에 의해 유발된 염증은 치료할 수 있지만 비-특이적 방어계의 반응에 의해 유발된 염증은 실질적으로 억제할 수 없음을 특징으로 하는 소염제.
- 제19항에 있어서, Mac-1에는 실질적으로 결합할 수 없지만 LFA-1에는 실질적으로 결합할 수 있는 ICAM-1 작용성 유도체인 소염제.
- 제20항에 있어서, 가용성 ICAM-1 작용성 유도체인 소염제.
- 비-특이적 방어계의 반응에 의해 유발된 염증은 실질적으로 억제하지 않으면서 특이적 방어계의 반응에 의해 유발된 염증을 치료하기 위한 약제학적 제제를 제조하는데 있어서의 제1내지 5항중 어느 하나에 따른 화합물, 또는 LFA-1 또는 LFA-1 작용성 유도체, 안티-LFA-1 항체 또는 안티-ICAM-1 항체의 용도.
- 특이적 방어계의 반응에 의해 유발된 염증은 실질적으로 억제하지 않으면서 비-특이적 방어계의 반응에 의해 유발된 염증을 치료하기 위한 약제학적 제제제를 제조하는데 있어서의 제6내지 12, 14 및 15항중 어느 하나에 따른 화합물, 또는 Mac-1, Mac-1 작용성 유도체, 안티-Mac-1 항체 또는 안티-ICAM-1 항체의 용도.
- 특이적 또는 비-특이적 방어계의 반응에 의해 유발된 염증은 실질적으로 억제하지 않으면서 리노바이러스 감염을 치료 또는 예방하기 위한 약제학적 제제를 제조하는데 있어서의 제13항에 따른 화합물의 용도.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/618,286 US5288854A (en) | 1990-11-28 | 1990-11-28 | Functional derivatives of ICAM-1 which are substantially capable of binding to LFA-1 but are substantially incapable of binding to MAC-1 |
US618,286 | 1990-11-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR920009412A true KR920009412A (ko) | 1992-06-25 |
Family
ID=24477094
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019910021347A KR920009412A (ko) | 1990-11-28 | 1991-11-26 | ICAM-1의 Mac-1 결합 부위 |
Country Status (8)
Country | Link |
---|---|
US (1) | US5288854A (ko) |
EP (1) | EP0488061B1 (ko) |
KR (1) | KR920009412A (ko) |
AT (1) | ATE172988T1 (ko) |
DE (1) | DE69130445T2 (ko) |
DK (1) | DK0488061T3 (ko) |
ES (1) | ES2122964T3 (ko) |
NZ (2) | NZ260473A (ko) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5284931A (en) * | 1987-05-04 | 1994-02-08 | Dana Farber Cancer Institute | Intercellular adhesion molecules, and their binding ligands |
US6051231A (en) * | 1988-09-01 | 2000-04-18 | Bayer Corporation | Antiviral methods and prepations |
US6514936B1 (en) | 1988-09-01 | 2003-02-04 | Bayer Corporation | Antiviral methods using human rhinovirus receptor (ICAM-1) |
ES2141076T3 (es) | 1988-09-01 | 2000-03-16 | Bayer Ag | Proteina del receptor de rinovirus humano que inhibe la infectividad del virus. |
US6143298A (en) * | 1988-09-01 | 2000-11-07 | Bayer Corporation | Soluble truncated forms of ICAM-1 |
US6797270B1 (en) | 1989-03-16 | 2004-09-28 | Center For Blood Research, Inc. | Functional derivatives of the intercellular adhesion molecule ICAM-1 in anti-viral therapy |
US6130202A (en) * | 1990-07-20 | 2000-10-10 | Bayer Corporation | Antiviral methods |
US6107461A (en) * | 1990-07-20 | 2000-08-22 | Bayer Corporation | Multimeric forms of human rhinovirus receptor and fragments thereof, and method of use |
DE69131564T2 (de) * | 1990-07-20 | 2000-01-13 | Bayer Ag | Multimere Formen des menschlichen Rhinovirus-Rezeptorproteins |
GB9115364D0 (en) * | 1991-07-16 | 1991-08-28 | Wellcome Found | Antibody |
US5811517A (en) * | 1992-01-27 | 1998-09-22 | Icos Corporation | ICAM-related protein variants |
CA2144738A1 (en) * | 1992-10-09 | 1994-04-28 | Michael Diamond | A subpopulation of mac-1 (cd11b/cd18) molecules which mediate neutrophil adhesion to icam-1 and fibrinogen |
US6001356A (en) * | 1995-09-29 | 1999-12-14 | Rush-Presbyterian-St. Luke's Medical Center | Method of inhibiting tissue destruction in autoimmune disease using anti-CD44 antibodies |
JP4451933B2 (ja) * | 1996-12-27 | 2010-04-14 | 住友化学株式会社 | 遺伝子操作による植物へのppo阻害性除草剤耐性付与法 |
ATE298248T1 (de) * | 1998-04-15 | 2005-07-15 | Brigham & Womens Hospital | T-zell inhibierende rezeptorzusammensetzungen sowie deren verwendung |
US6331640B1 (en) * | 1998-10-13 | 2001-12-18 | Hoffmann-La Roche Inc. | Diaminopropionic acid derivatives |
US6867203B2 (en) | 1998-12-29 | 2005-03-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds |
DE60140457D1 (de) * | 2000-09-01 | 2009-12-24 | Blood Res Center | Veränderte, in gewünschter konformation stabilisierte polypeptide und verfahren zu deren herstellung |
HUP0402305A2 (hu) * | 2000-11-28 | 2005-02-28 | Genentech, Inc. | LFA-1-antagonista vegyületek, az ezeket tartalmazó gyógyászati készítmények és alkalmazásuk |
PL1682537T3 (pl) * | 2003-11-05 | 2012-09-28 | Sarcode Bioscience Inc | Modulatory adhezji komórkowej |
AU2005277547B2 (en) | 2004-08-16 | 2011-08-25 | Immune Disease Institute, Inc. | Method of delivering RNA interference and uses thereof |
US20060233675A1 (en) * | 2005-04-13 | 2006-10-19 | Stein Israel M | Glass test tube having protective outer shield |
CA2609053C (en) * | 2005-05-17 | 2017-04-25 | Sarcode Corporation | Compositions and methods for treatment of eye disorders |
WO2007127272A2 (en) * | 2006-04-24 | 2007-11-08 | The Cbr Institute For Biomedical Research | Method of producing immunoliposomes and compositions thereof |
US20100008937A1 (en) * | 2006-04-25 | 2010-01-14 | Immune Disease Institute, Inc. | Targeted delivery to leukocytes using non-protein carriers |
EP3797775A1 (en) | 2007-10-19 | 2021-03-31 | Novartis AG | Compositions and methods for treatment of diabetic retinopathy |
JP2011518155A (ja) * | 2008-04-15 | 2011-06-23 | サーコード コーポレイション | 免疫関連障害の局所治療に使用するためのエアゾール化lfa−1アンタゴニスト |
US8080562B2 (en) | 2008-04-15 | 2011-12-20 | Sarcode Bioscience Inc. | Crystalline pharmaceutical and methods of preparation and use thereof |
WO2009128932A1 (en) * | 2008-04-15 | 2009-10-22 | Sarcode Corporation | Delivery of lfa-1 antagonists to the gastrointestinal system |
EP3632444A3 (en) * | 2008-04-15 | 2020-08-26 | SARcode Bioscience Inc. | Topical lfa-1 antagonists for use in localized treatment of immune related disorders |
US8378105B2 (en) | 2009-10-21 | 2013-02-19 | Sarcode Bioscience Inc. | Crystalline pharmaceutical and methods of preparation and use thereof |
CN104797574B (zh) | 2012-07-25 | 2019-11-22 | 原生质生物科学股份有限公司 | Lfa-1抑制剂及其多晶型物 |
EP3897851A2 (en) | 2018-12-17 | 2021-10-27 | Revitope Limited | Twin immune cell engager |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0314863B1 (en) * | 1987-11-02 | 1994-12-07 | Baylor College Of Medicine | Use of ICAM-1 or its functional derivatives for the treatment of non-specific inflammation |
ES2141076T3 (es) * | 1988-09-01 | 2000-03-16 | Bayer Ag | Proteina del receptor de rinovirus humano que inhibe la infectividad del virus. |
ES2077572T3 (es) * | 1988-09-28 | 1995-12-01 | Dana Farber Cancer Inst Inc | Moleculas de adhesion intercelular, y sus ligandos de fijacion. |
-
1990
- 1990-11-28 US US07/618,286 patent/US5288854A/en not_active Expired - Lifetime
-
1991
- 1991-11-21 DE DE69130445T patent/DE69130445T2/de not_active Expired - Fee Related
- 1991-11-21 EP EP91119894A patent/EP0488061B1/en not_active Expired - Lifetime
- 1991-11-21 DK DK91119894T patent/DK0488061T3/da active
- 1991-11-21 AT AT91119894T patent/ATE172988T1/de active
- 1991-11-21 ES ES91119894T patent/ES2122964T3/es not_active Expired - Lifetime
- 1991-11-26 NZ NZ260473A patent/NZ260473A/en unknown
- 1991-11-26 KR KR1019910021347A patent/KR920009412A/ko active IP Right Grant
- 1991-11-26 NZ NZ240747A patent/NZ240747A/en unknown
Also Published As
Publication number | Publication date |
---|---|
NZ260473A (en) | 1997-06-24 |
DK0488061T3 (da) | 1999-07-19 |
US5288854A (en) | 1994-02-22 |
EP0488061A2 (en) | 1992-06-03 |
NZ240747A (en) | 1996-05-28 |
EP0488061A3 (en) | 1992-08-26 |
EP0488061B1 (en) | 1998-11-04 |
DE69130445T2 (de) | 1999-07-08 |
ES2122964T3 (es) | 1999-01-01 |
DE69130445D1 (de) | 1998-12-10 |
ATE172988T1 (de) | 1998-11-15 |
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