ATE209908T1 - RADIKALFÄNGER (ßSPIN TRAPSß) ZUR BEHANDLUNG VON MIT OXIDATION VON LIPIDEN UND PROTEINEN VERBUNDENEN ERKRANKUNGEN - Google Patents

RADIKALFÄNGER (ßSPIN TRAPSß) ZUR BEHANDLUNG VON MIT OXIDATION VON LIPIDEN UND PROTEINEN VERBUNDENEN ERKRANKUNGEN

Info

Publication number
ATE209908T1
ATE209908T1 AT92914539T AT92914539T ATE209908T1 AT E209908 T1 ATE209908 T1 AT E209908T1 AT 92914539 T AT92914539 T AT 92914539T AT 92914539 T AT92914539 T AT 92914539T AT E209908 T1 ATE209908 T1 AT E209908T1
Authority
AT
Austria
Prior art keywords
disorders
derivatives
pbn
ischemia
spin
Prior art date
Application number
AT92914539T
Other languages
English (en)
Inventor
John M Carney
Robert A Floyd
Original Assignee
Oklahoma Med Res Found
Univ Kentucky Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oklahoma Med Res Found, Univ Kentucky Res Found filed Critical Oklahoma Med Res Found
Application granted granted Critical
Publication of ATE209908T1 publication Critical patent/ATE209908T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
AT92914539T 1991-06-18 1992-06-18 RADIKALFÄNGER (ßSPIN TRAPSß) ZUR BEHANDLUNG VON MIT OXIDATION VON LIPIDEN UND PROTEINEN VERBUNDENEN ERKRANKUNGEN ATE209908T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71695291A 1991-06-18 1991-06-18
PCT/US1992/005194 WO1992022290A1 (en) 1991-06-18 1992-06-18 Use of spin trapping for the treatment of diseases associated with oxidation of lipids and proteins

Publications (1)

Publication Number Publication Date
ATE209908T1 true ATE209908T1 (de) 2001-12-15

Family

ID=24880110

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92914539T ATE209908T1 (de) 1991-06-18 1992-06-18 RADIKALFÄNGER (ßSPIN TRAPSß) ZUR BEHANDLUNG VON MIT OXIDATION VON LIPIDEN UND PROTEINEN VERBUNDENEN ERKRANKUNGEN

Country Status (5)

Country Link
EP (1) EP0590072B1 (de)
AT (1) ATE209908T1 (de)
CA (1) CA2111836C (de)
DE (1) DE69232263T2 (de)
WO (1) WO1992022290A1 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5681845A (en) * 1989-10-17 1997-10-28 Oklahoma Medical Research Foundation DMPO spin trapping compositions and methods of use thereof
US5455272A (en) * 1993-10-22 1995-10-03 Oklahoma Medical Research Foundation Spin trap nitronyl hindered phenols
US5405967A (en) * 1993-10-22 1995-04-11 Oklahoma Medical Research Foundation Spin-trap molecules 2-trifluoromethyl- of 5,5-dimethyl-1-dyrroline-N-oxide
US5488145A (en) * 1993-12-23 1996-01-30 Oklahoma Medical Research Foundation 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps
DE9408805U1 (de) * 1994-05-30 1994-09-01 Baur Albert Lautsprecher, insbesondere in Säulenform
JPH0870889A (ja) * 1994-09-02 1996-03-19 Tokyo Jiyoshi Ika Univ 臓器障害誘導因子の検出方法
DE69634647T2 (de) * 1995-09-11 2006-03-02 Aventis Pharmaceuticals Inc. Cyclische Nitrone und pharmazeutische Mittel die sie enthalten
CN1219130A (zh) * 1996-04-23 1999-06-09 桑道药品有限会司 用于治疗眼部炎症的含硝酮化合物的组合物
US5900227A (en) * 1996-06-17 1999-05-04 Oklahoma Medical Research Foundation Multicyclic nitrone spin trapping compositions
NZ333705A (en) * 1996-07-19 2000-09-29 Centaur Pharmaceuticals Inc Furan nitrone derivatives and medicaments thereof
TW429241B (en) 1996-09-26 2001-04-11 Sumitomo Pharma Nitrone derivatives
US6096759A (en) 1997-09-19 2000-08-01 Georgetown University Method for treating essential hypertension
US6046232A (en) 1997-10-17 2000-04-04 Centaur Pharmaceuticals, Inc. α-aryl-N-alkylnitrones and pharmaceutical compositions containing the same
WO1999036415A1 (en) * 1998-01-16 1999-07-22 Centaur Pharmaceuticals, Inc. Thioether furan nitrone compounds
WO1999036420A1 (en) * 1998-01-16 1999-07-22 Centaur Pharmaceuticals, Inc. Thiophene nitrone compounds
US6255353B1 (en) * 1998-03-13 2001-07-03 Centaur Pharmaceuticals, Inc. Inhibition of angiogenesis
EP1077696A1 (de) * 1998-05-19 2001-02-28 Centaur Pharmaceuticals, Inc. Furan-nitrone therapeutische mittel zur behandlung von entzündlichen darmerkrankungen
US6194465B1 (en) 1998-05-19 2001-02-27 Centaur Pharmaceuticals, Inc. Benzamide therapeutics for the treatment of inflammatory bowel disease
PT1077694E (pt) * 1998-05-19 2004-12-31 Renovis Inc Produtos terapeuticos de arilnitrona para o tratamento da doenca inflamatoria dointestino
US6083989A (en) * 1999-05-18 2000-07-04 Centaur Pharmaceuticals, Inc. Aryl nitrone therapeutics for the treatment of inflammatory bowel disease
FR2780404B1 (fr) * 1998-06-26 2001-04-13 Adir Nouveaux derives de nitrone, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6197826B1 (en) 1998-07-17 2001-03-06 Centaur Pharmaceuticals, Inc. α-(2-hydroxyphenyl) nitrone compounds, pharmaceutical compositions containing the same and methods for treating inflammation
WO2001035951A2 (en) * 1999-11-18 2001-05-25 Centaur Pharmaceuticals, Inc. Aryl nitrone therapeutics and methods for treating inflammatory bowel disease
WO2002065993A2 (en) 2001-01-08 2002-08-29 Centaur Pharmaceuticals, Inc. Use of aryl nitrone compounds in methods for treating neuropathic pain
EP1677745A4 (de) * 2003-10-14 2008-10-22 Renovis Inc Nitron-verbindungs-prodrugs und pharmazeutische zusammensetzung daraus zur behandlung von menschlichen erkrankungen
KR101312422B1 (ko) * 2004-12-22 2013-09-30 시바 홀딩 인코포레이티드 항라디칼제
JP5191739B2 (ja) * 2004-12-22 2013-05-08 チバ ホールディング インコーポレーテッド 抗ラジカル剤
JP2009512723A (ja) * 2005-10-24 2009-03-26 チバ ホールディング インコーポレーテッド 易酸化性薬剤の保護
FR2902097A1 (fr) * 2006-06-13 2007-12-14 Univ Joseph Fourier Etablissem Nouveau procede de preparation de nitrones et de n-hydroxylamines comportant au moins un groupe hydroxyle, et produits tels qu'obtenus
US8420595B2 (en) 2006-07-25 2013-04-16 Oklahoma Medical Research Foundation Methods for treating acute acoustic trauma
AU2009214727B2 (en) 2008-02-12 2014-12-11 Tosk, Incorporated Doxorubicin adjuvants to reduce toxicity and methods for using the same
EP3114110A1 (de) 2014-03-07 2017-01-11 Dow Global Technologies LLC Stickstoffhaltige verbindungen und deren verwendung bei der körperpflege
JP2017515814A (ja) * 2014-05-12 2017-06-15 ダウ グローバル テクノロジーズ エルエルシー ニトロン化合物及びパーソナルケアにおけるその使用
US10064804B2 (en) 2014-06-30 2018-09-04 Dow Global Technologies Llc Polymeric nitrones and their use in personal care
US10137071B2 (en) 2015-03-20 2018-11-27 Dow Global Technologies Llc Nitrone inhibition of oxidation of unsaturated fats
BR112017018503B1 (pt) 2015-03-20 2021-08-24 Dow Global Technologies Llc Composição de cuidados pessoais

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3834073A (en) * 1971-05-03 1974-09-10 Scm Corp Phenyl nitrone derivatives useful as seed protectants
US4153722A (en) * 1977-10-06 1979-05-08 William H. Rorer, Inc. Method of treatment
WO1988005044A1 (en) * 1986-12-29 1988-07-14 Pharmacia Ab Nitroxide compounds for the preparation of a pharmaceutical composition intended for the prophylaxis and treatment of ischemic cell damage
WO1988005653A1 (en) * 1987-01-28 1988-08-11 Proctor Peter H Topical composition for stimulating hair growth with stable free radicals
KR960008230B1 (ko) * 1989-10-17 1996-06-21 윌리엄 쥐.씨먼 중추신경계의 산화적 손상에 관련된 질병들을 억제하기 위한 조성물들
US5036097A (en) * 1989-10-17 1991-07-30 Oklahoma Medical Research Foundation Phenylbutyl nitrone compositions and methods for prevention of gastric ulceration

Also Published As

Publication number Publication date
CA2111836C (en) 2006-08-29
CA2111836A1 (en) 1992-12-23
DE69232263D1 (de) 2002-01-17
AU2261492A (en) 1993-01-12
AU672364B2 (en) 1996-10-03
EP0590072A1 (de) 1994-04-06
WO1992022290A1 (en) 1992-12-23
DE69232263T2 (de) 2003-06-18
EP0590072B1 (de) 2001-12-05

Similar Documents

Publication Publication Date Title
ATE209908T1 (de) RADIKALFÄNGER (ßSPIN TRAPSß) ZUR BEHANDLUNG VON MIT OXIDATION VON LIPIDEN UND PROTEINEN VERBUNDENEN ERKRANKUNGEN
ATE142877T1 (de) Melatoninderivate zur behandlung von schlafstörungen und zur pre-anästhesie
ATE399553T1 (de) Pharmazeutische zusammensetzungen mit dextromethorphan und chinidin zur behandlung von neurologischen erkrankungen
PT740650E (pt) Co-farmacos como um metodo de administracao controlada de farmacos
BG101118A (en) Therapeutical compounds
DE69320646D1 (de) Verfahren zur behandlung von krebs durch kombinationstherapie mit 2&#39;-halomethylidenderivaten und einem s- oder m-phase spezifischen antineoplastischen wirkstoff
DE69426334T2 (de) Parenterales Busulfan zur Behandlung von malignen Krankheiten
BR9813318A (pt) Processo de tratamento de tumores e degeneração macular em paciente humano ou veterinário, composição farmacêutica para tratamento de tumores e degeneração macular em um paciente humano ou veterinário
ATE198550T1 (de) Verwendung von weihrauch zur behandlung der alzheimer-krankheit
DE58901002D1 (de) Mittel mit zerstoerender wirkung auf maligne tumore, verfahren zu dessen herstellung und praeparation zur anwendung in der therapie von krebskranken.
RU95101385A (ru) Продукты, содержащие g-csf и tnf связующие протеина
DE60031016D1 (de) Verwendung von Antiseptika zur Herstellung von Arzneimitteln zur Prophylaxe und Behandlung von Entzündungen im Korperinneren des Menschen
DE3787477D1 (de) Nasal applizierbares Arzneimittel, Verfahren zu seiner Herstellung und seine Verwendung.
RU94040886A (ru) Применение производных мелатонина для лечения нарушений сна, фармацевтическая композиция
DE58904722D1 (de) Arzneimittelzubereitung aus esterderivaten des hecogenins und dessen verwendung zur behandlung von benigner prostatahyperplasie.
DE69733169D1 (de) Verwendung von Alpha-1-Adrenorezeptor-Antagonisten zur Herstellung eines Medikaments für die Vorbeugung und die Behandlung von Krebs
DE69621786D1 (de) Aminotetralinderivat zur behandlung von herzkreislauferkrankung
ATE5256T1 (de) Phenylpiperazinderivate von 1,3,4oxadiazolylphenolen, ihre herstellung und diese enthaltende therapeutische mittel.
DE68901172D1 (de) (-)-2-pyrazolinverbindung, deren optischen aufspaltung und therapeutisches agens zur behandlung von zerebralen gefaesskrankheiten, diese verbindung als aktives ingredient enthaltend.
ATA67688A (de) Neue 3-(2-haloalkyl)-1,4-oxathiine und 2-(2-halo- alkyl)-1,4-dithiine sowie pharmazeutische zusammensetzungen mit diesen verbindungen zur behandlung von leukaemie und tumoren
DE69009765D1 (de) Kynurensäurederivate, deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
DE69325512D1 (de) Verwendung von remacemid zur behandlung des morbus parkinson
KR900017599A (ko) 종양 치료용 약학 조성물
ATE295731T1 (de) Olanzapine zur behandlung von drogenmissbrauch
ATE152911T1 (de) Verwendung von bilobalid und deren derivate zur behandlung von infektionen bei menschen und für eine solche anwendung geeignete pharmazeutische zusammensetzung

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties