DE3785312T2 - Substituierte tetrahydropyridinoxime und ihre verwendung als cholinergische heilmittel. - Google Patents
Substituierte tetrahydropyridinoxime und ihre verwendung als cholinergische heilmittel.Info
- Publication number
- DE3785312T2 DE3785312T2 DE8787118083T DE3785312T DE3785312T2 DE 3785312 T2 DE3785312 T2 DE 3785312T2 DE 8787118083 T DE8787118083 T DE 8787118083T DE 3785312 T DE3785312 T DE 3785312T DE 3785312 T2 DE3785312 T2 DE 3785312T2
- Authority
- DE
- Germany
- Prior art keywords
- tetrahydropyridinoxime
- cholinergic
- medicines
- substituted
- substituted tetrahydropyridinoxime
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/939,507 US4710508A (en) | 1986-12-08 | 1986-12-08 | O-substituted tetrahydropyridine oxime cholinergic agents |
US07/091,893 US4786648A (en) | 1986-12-08 | 1987-09-04 | O-substituted tetrahydropyridine oxime cholinergic agents |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3785312D1 DE3785312D1 (de) | 1993-05-13 |
DE3785312T2 true DE3785312T2 (de) | 1993-07-22 |
Family
ID=26784455
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8787118083T Expired - Fee Related DE3785312T2 (de) | 1986-12-08 | 1987-12-07 | Substituierte tetrahydropyridinoxime und ihre verwendung als cholinergische heilmittel. |
Country Status (11)
Country | Link |
---|---|
US (1) | US4786648A (de) |
EP (1) | EP0271798B1 (de) |
KR (1) | KR960000072B1 (de) |
AU (1) | AU607442B2 (de) |
DE (1) | DE3785312T2 (de) |
DK (1) | DK638487A (de) |
FI (1) | FI85467C (de) |
NO (1) | NO172045C (de) |
NZ (1) | NZ222756A (de) |
PH (1) | PH23404A (de) |
PT (1) | PT86311B (de) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL81610A (en) * | 1986-02-27 | 1990-12-23 | Roussel Uclaf | Derivatives of 1,2,5,6-tetrahydropyridin-3-carboxaldehyde oxime,their preparation and pharmaceutical compositions containing them |
US5219873A (en) * | 1987-04-24 | 1993-06-15 | Roussel Uclaf | Compounds of 1,2,5,6-tetrahydropyridine which are useful as cholinergic agents |
IT1203971B (it) * | 1987-04-24 | 1989-02-23 | Roussel Maestretti Spa | Derivati di 1,2,5,6-tetraidropiridina, loro procedimento di preparazione e loro applicazione come medicamenti |
US5231107A (en) * | 1987-08-21 | 1993-07-27 | Roussel Uclaf | Derivatives of the oxime of 1,2,5,6-tetrahydropyridine 3-carboxaldehyde, the process for their preparation, their use as medicaments and the compositions containing them |
IT1222526B (it) * | 1987-08-21 | 1990-09-05 | Roussel Maestretti Spa | Derivati dell' ossima della 1,2,5,6-tetraidropiridin-3-carbossaldeide,loro procedimento di preparazione e loro impiego come sostanze medicinali |
IL88156A (en) * | 1987-11-13 | 1997-02-18 | Novo Nordisk As | Azacyclic compounds their preparation and pharmaceutical compositions containing them |
DK177889A (da) * | 1988-04-15 | 1989-10-16 | Beecham Group Plc | Hidtil ukendte forbindelser |
US5278170A (en) * | 1989-04-13 | 1994-01-11 | Beecham Group P.L.C. | Azabicylo oxime compounds |
ATE269330T1 (de) * | 1989-04-13 | 2004-07-15 | Beecham Group Plc | Chemische verbindungen |
IT1240603B (it) * | 1990-03-14 | 1993-12-17 | Roussel Maestretti Spa | Derivati della 1,2,5,6-tetraidropiridina 3- carbossaldeide ossima, loro procedimento di preparazione e loro impiego come sostanza medicinale |
IT1241138B (it) * | 1990-05-15 | 1993-12-29 | Roussel Pharma | Derivati dell'ossina della 1,2,5,6- tetraidropiridin-3-carbossaldeide,loro procedimento di preparazione e loro impiego come sostanze medicinali |
IE912974A1 (en) * | 1990-08-24 | 1992-02-26 | Beecham Group Plc | Novel compounds |
GB9019095D0 (en) * | 1990-09-01 | 1990-10-17 | Beecham Group Plc | Novel compounds |
WO1992006959A1 (en) * | 1990-10-12 | 1992-04-30 | Beecham Group Plc | 1,2,5,6-tetrahydropyridine oxime derivatives |
US5175166A (en) * | 1991-08-27 | 1992-12-29 | The University Of Toledo | Muscarinic agonists |
AU3142793A (en) * | 1991-12-18 | 1993-07-19 | Warner-Lambert Company | Transdermal delivery of (E)-1,2,5,6-tetrahydro-1-methyl-3-pyridine-carboxaldehyde-O- methyloxine HCL and related compounds in the treatment of cognitive disorders and for analgesia |
ZA931109B (en) * | 1992-03-04 | 1993-09-22 | Akzo Nv | Tetrahydropyrimidine derivatives. |
US5208343A (en) * | 1992-03-24 | 1993-05-04 | Warner-Lambert Company | Tetrahydropyridine oxime compounds |
ZA937382B (en) * | 1992-10-06 | 1994-04-29 | Warner Lambert Co | Novel composition for peroral therapy of cognitionimpairment and a process therefor |
WO1994007493A1 (en) * | 1992-10-06 | 1994-04-14 | Warner-Lambert Company | Stabilized compositions containing 1,2,5,6-tetrahydro-1-methyl-3-pyridinecarboxyaldehyde-o-methyl-oxime |
AU5628194A (en) * | 1992-11-27 | 1994-06-22 | Akzo N.V. | 1,3-diazacycloalkyl oxime derivatives |
US5362860A (en) * | 1993-02-01 | 1994-11-08 | Warner-Lambert Company | Neutral stabilization complex for CI-979 HCl, a cognition activator |
US5424301A (en) * | 1993-02-01 | 1995-06-13 | Warner-Lambert Company | Starch stabilized o-substituted tetrahydropyridine oxime cholinergic agents |
US5618818A (en) * | 1996-03-20 | 1997-04-08 | The University Of Toledo | Muscarinic agonist compounds |
ATE445838T1 (de) | 2001-07-25 | 2009-10-15 | Raptor Pharmaceutical Inc | Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke |
WO2004101422A2 (en) * | 2003-05-13 | 2004-11-25 | Oasis Corporation | Combined water cooler and refrigerator unit |
DK1889198T3 (da) | 2005-04-28 | 2015-02-09 | Proteus Digital Health Inc | Farma-informatiksystem |
EP2258358A3 (de) | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenese mit Acetylcholinesterasehemmer |
CA2620333A1 (en) * | 2005-08-26 | 2007-03-01 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
EP1940389A2 (de) | 2005-10-21 | 2008-07-09 | Braincells, Inc. | Modulation von neurogenese durch pde-hemmung |
CA2625210A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
WO2007075297A2 (en) * | 2005-12-27 | 2007-07-05 | University Of Toledo | Muscarinic agonists and methods of use thereof |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
AU2007249399A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
MX2008014320A (es) | 2006-05-09 | 2009-03-25 | Braincells Inc | Neurogenesis mediada por el receptor de 5-hidroxitriptamina. |
MX2009002496A (es) | 2006-09-08 | 2009-07-10 | Braincells Inc | Combinaciones que contienen un derivado de 4-acilaminopiridina. |
WO2008036682A2 (en) | 2006-09-18 | 2008-03-27 | Raptor Pharmaceutical Inc. | Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
US20110294835A1 (en) | 2008-05-15 | 2011-12-01 | The Board Of Trustees Of The University Of Illinois | Muscarinic Agonists as Cognitive Enhancers |
ES2728225T3 (es) | 2009-02-20 | 2019-10-23 | 2 Bbb Medicines B V | Sistema de administración de fármacos a base de glutatión |
US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
US8445002B2 (en) | 2009-05-06 | 2013-05-21 | Laboratory Skin Care, Inc. | Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same |
US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
WO2012149524A1 (en) | 2011-04-29 | 2012-11-01 | The University Of Toledo | Muscarinic agonists as enhancers of working memory and cognitive flexibility |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB889074A (en) * | 1959-02-12 | 1962-02-07 | Ciba Ltd | New pyridine derivatives and process for their manufacture |
FR1258847A (fr) * | 1960-02-12 | 1961-04-21 | Ciba Geigy | Procédé de préparation de nouveaux dérivés pyridiniques, entre autres de l'oxime de la l-méthyl-3 ou 4-acétyl-1, 2, 5, 6-tétrahydropyridine |
JPS511638A (ja) * | 1974-06-27 | 1976-01-08 | Fujisawa Pharmaceutical Co | Shokubutsuseichochoseizai |
US4297359A (en) * | 1978-07-25 | 1981-10-27 | Acf Chemiefarma Nv | Anti-ulcer compositions containing certain pyridyl oxime ethers |
IL81610A (en) * | 1986-02-27 | 1990-12-23 | Roussel Uclaf | Derivatives of 1,2,5,6-tetrahydropyridin-3-carboxaldehyde oxime,their preparation and pharmaceutical compositions containing them |
US4710508A (en) * | 1986-12-08 | 1987-12-01 | Warner-Lambert Company | O-substituted tetrahydropyridine oxime cholinergic agents |
IT1203971B (it) * | 1987-04-24 | 1989-02-23 | Roussel Maestretti Spa | Derivati di 1,2,5,6-tetraidropiridina, loro procedimento di preparazione e loro applicazione come medicamenti |
-
1987
- 1987-09-04 US US07/091,893 patent/US4786648A/en not_active Expired - Fee Related
- 1987-11-11 AU AU81102/87A patent/AU607442B2/en not_active Ceased
- 1987-11-30 NZ NZ222756A patent/NZ222756A/xx unknown
- 1987-12-04 DK DK638487A patent/DK638487A/da not_active Application Discontinuation
- 1987-12-04 FI FI875363A patent/FI85467C/fi not_active IP Right Cessation
- 1987-12-07 NO NO875082A patent/NO172045C/no unknown
- 1987-12-07 EP EP87118083A patent/EP0271798B1/de not_active Expired - Lifetime
- 1987-12-07 PH PH36177A patent/PH23404A/en unknown
- 1987-12-07 PT PT86311A patent/PT86311B/pt not_active IP Right Cessation
- 1987-12-07 DE DE8787118083T patent/DE3785312T2/de not_active Expired - Fee Related
- 1987-12-08 KR KR1019870013971A patent/KR960000072B1/ko not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
PH23404A (en) | 1989-07-26 |
DE3785312D1 (de) | 1993-05-13 |
FI85467C (fi) | 1992-04-27 |
NO172045C (no) | 1993-06-02 |
KR880007466A (ko) | 1988-08-27 |
NO172045B (no) | 1993-02-22 |
NO875082L (no) | 1988-06-09 |
PT86311B (pt) | 1990-11-07 |
FI875363A (fi) | 1988-06-09 |
AU607442B2 (en) | 1991-03-07 |
AU8110287A (en) | 1988-06-09 |
EP0271798B1 (de) | 1993-04-07 |
DK638487A (da) | 1988-06-09 |
NO875082D0 (no) | 1987-12-07 |
DK638487D0 (da) | 1987-12-04 |
NZ222756A (en) | 1989-10-27 |
EP0271798A3 (en) | 1989-01-18 |
EP0271798A2 (de) | 1988-06-22 |
PT86311A (en) | 1988-01-01 |
US4786648A (en) | 1988-11-22 |
FI875363A0 (fi) | 1987-12-04 |
FI85467B (fi) | 1992-01-15 |
KR960000072B1 (ko) | 1996-01-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |