DK638487A - 0-substituerede tetrahydropyridin-oximer, fremgangsmaade til deres fremstilling og deres anvendelse - Google Patents

0-substituerede tetrahydropyridin-oximer, fremgangsmaade til deres fremstilling og deres anvendelse

Info

Publication number
DK638487A
DK638487A DK638487A DK638487A DK638487A DK 638487 A DK638487 A DK 638487A DK 638487 A DK638487 A DK 638487A DK 638487 A DK638487 A DK 638487A DK 638487 A DK638487 A DK 638487A
Authority
DK
Denmark
Prior art keywords
oximes
procedures
preparation
substituted tetrahydropyridine
tetrahydropyridine
Prior art date
Application number
DK638487A
Other languages
English (en)
Other versions
DK638487D0 (da
Inventor
Stephen Clark Bergmeier
David Alexis Downs
Walter Hamilton Moos
David Winslow Moreland
Haile Tecle
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/939,507 external-priority patent/US4710508A/en
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of DK638487D0 publication Critical patent/DK638487D0/da
Publication of DK638487A publication Critical patent/DK638487A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
DK638487A 1986-12-08 1987-12-04 0-substituerede tetrahydropyridin-oximer, fremgangsmaade til deres fremstilling og deres anvendelse DK638487A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/939,507 US4710508A (en) 1986-12-08 1986-12-08 O-substituted tetrahydropyridine oxime cholinergic agents
US07/091,893 US4786648A (en) 1986-12-08 1987-09-04 O-substituted tetrahydropyridine oxime cholinergic agents

Publications (2)

Publication Number Publication Date
DK638487D0 DK638487D0 (da) 1987-12-04
DK638487A true DK638487A (da) 1988-06-09

Family

ID=26784455

Family Applications (1)

Application Number Title Priority Date Filing Date
DK638487A DK638487A (da) 1986-12-08 1987-12-04 0-substituerede tetrahydropyridin-oximer, fremgangsmaade til deres fremstilling og deres anvendelse

Country Status (11)

Country Link
US (1) US4786648A (da)
EP (1) EP0271798B1 (da)
KR (1) KR960000072B1 (da)
AU (1) AU607442B2 (da)
DE (1) DE3785312T2 (da)
DK (1) DK638487A (da)
FI (1) FI85467C (da)
NO (1) NO172045C (da)
NZ (1) NZ222756A (da)
PH (1) PH23404A (da)
PT (1) PT86311B (da)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL81610A (en) * 1986-02-27 1990-12-23 Roussel Uclaf Derivatives of 1,2,5,6-tetrahydropyridin-3-carboxaldehyde oxime,their preparation and pharmaceutical compositions containing them
US5219873A (en) * 1987-04-24 1993-06-15 Roussel Uclaf Compounds of 1,2,5,6-tetrahydropyridine which are useful as cholinergic agents
IT1203971B (it) * 1987-04-24 1989-02-23 Roussel Maestretti Spa Derivati di 1,2,5,6-tetraidropiridina, loro procedimento di preparazione e loro applicazione come medicamenti
US5231107A (en) * 1987-08-21 1993-07-27 Roussel Uclaf Derivatives of the oxime of 1,2,5,6-tetrahydropyridine 3-carboxaldehyde, the process for their preparation, their use as medicaments and the compositions containing them
IT1222526B (it) * 1987-08-21 1990-09-05 Roussel Maestretti Spa Derivati dell' ossima della 1,2,5,6-tetraidropiridin-3-carbossaldeide,loro procedimento di preparazione e loro impiego come sostanze medicinali
IE63906B1 (en) * 1987-11-13 1995-06-14 Novo Nordisk As Azabicyclic compounds and their preparation and use
DK177889A (da) * 1988-04-15 1989-10-16 Beecham Group Plc Hidtil ukendte forbindelser
US5278170A (en) * 1989-04-13 1994-01-11 Beecham Group P.L.C. Azabicylo oxime compounds
EP0392803B1 (en) * 1989-04-13 2004-06-16 Beecham Group p.l.c. Novel compounds
IT1240603B (it) * 1990-03-14 1993-12-17 Roussel Maestretti Spa Derivati della 1,2,5,6-tetraidropiridina 3- carbossaldeide ossima, loro procedimento di preparazione e loro impiego come sostanza medicinale
IT1241138B (it) * 1990-05-15 1993-12-29 Roussel Pharma Derivati dell'ossina della 1,2,5,6- tetraidropiridin-3-carbossaldeide,loro procedimento di preparazione e loro impiego come sostanze medicinali
JPH06500550A (ja) * 1990-08-24 1994-01-20 ビーチャム・グループ・パブリック・リミテッド・カンパニー アザ二環式化合物、その製造方法および製造用中間体ならびにその化合物含有の医薬組成物
GB9019095D0 (en) * 1990-09-01 1990-10-17 Beecham Group Plc Novel compounds
JPH06501933A (ja) * 1990-10-12 1994-03-03 ビーチャム・グループ・パブリック・リミテッド・カンパニー １，２，５，６−テトラヒドロピリジン・オキシム誘導体
US5175166A (en) * 1991-08-27 1992-12-29 The University Of Toledo Muscarinic agonists
WO1993011767A1 (en) * 1991-12-18 1993-06-24 Warner-Lambert Company Transdermal delivery of (e)-1,2,5,6-tetrahydro-1-methyl-3-pyridine-carboxaldehyde-o-methyloxine hcl and related compounds in the treatment of cognitive disorders and for analgesia
ZA931109B (en) * 1992-03-04 1993-09-22 Akzo Nv Tetrahydropyrimidine derivatives.
US5208343A (en) * 1992-03-24 1993-05-04 Warner-Lambert Company Tetrahydropyridine oxime compounds
ZA937382B (en) * 1992-10-06 1994-04-29 Warner Lambert Co Novel composition for peroral therapy of cognitionimpairment and a process therefor
WO1994007493A1 (en) * 1992-10-06 1994-04-14 Warner-Lambert Company Stabilized compositions containing 1,2,5,6-tetrahydro-1-methyl-3-pyridinecarboxyaldehyde-o-methyl-oxime
AU5628194A (en) * 1992-11-27 1994-06-22 Akzo N.V. 1,3-diazacycloalkyl oxime derivatives
US5362860A (en) * 1993-02-01 1994-11-08 Warner-Lambert Company Neutral stabilization complex for CI-979 HCl, a cognition activator
US5424301A (en) * 1993-02-01 1995-06-13 Warner-Lambert Company Starch stabilized o-substituted tetrahydropyridine oxime cholinergic agents
US5618818A (en) * 1996-03-20 1997-04-08 The University Of Toledo Muscarinic agonist compounds
DE60234057D1 (de) 2001-07-25 2009-11-26 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
WO2004101422A2 (en) * 2003-05-13 2004-11-25 Oasis Corporation Combined water cooler and refrigerator unit
CN103259027A (zh) 2005-04-28 2013-08-21 普罗透斯数字保健公司 药物信息系统
JP2009506069A (ja) 2005-08-26 2009-02-12 ブレインセルス，インコーポレイティド ムスカリン性受容体調節による神経発生
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
AU2006304787A1 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by PDE inhibition
CA2625210A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
JP2009521531A (ja) * 2005-12-27 2009-06-04 ザ・ユニバーシティ・オブ・トレド ムスカリンアゴニスト及びその使用方法
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
US7678808B2 (en) 2006-05-09 2010-03-16 Braincells, Inc. 5 HT receptor mediated neurogenesis
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
EP2068872A1 (en) 2006-09-08 2009-06-17 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
KR20090071598A (ko) 2006-09-18 2009-07-01 랩터 파마슈티컬 인코포레이티드 수용체 결합 단백질(ｒａｐ)-접합체 투여에 의한 간 질환의 치료
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
EP2296471A4 (en) 2008-05-15 2012-03-14 Univ Toledo MUSCARIC ACID AGONISTS AS COGNITIVE ENHANCERS
PT2398500T (pt) 2009-02-20 2019-06-14 2 Bbb Medicines B V Sistema de entrega de medicamentos à base de glutationas
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
TWI556839B (zh) 2009-05-06 2016-11-11 研究室護膚股份有限公司 包含活性劑－磷酸鈣粒子複合物之皮膚遞送組成物及其使用方法
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
WO2012149524A1 (en) 2011-04-29 2012-11-01 The University Of Toledo Muscarinic agonists as enhancers of working memory and cognitive flexibility

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB889074A (en) * 1959-02-12 1962-02-07 Ciba Ltd New pyridine derivatives and process for their manufacture
FR1258847A (fr) * 1960-02-12 1961-04-21 Ciba Geigy Procédé de préparation de nouveaux dérivés pyridiniques, entre autres de l'oxime de la l-méthyl-3 ou 4-acétyl-1, 2, 5, 6-tétrahydropyridine
JPS511638A (ja) * 1974-06-27 1976-01-08 Fujisawa Pharmaceutical Co Shokubutsuseichochoseizai
US4297359A (en) * 1978-07-25 1981-10-27 Acf Chemiefarma Nv Anti-ulcer compositions containing certain pyridyl oxime ethers
IL81610A (en) * 1986-02-27 1990-12-23 Roussel Uclaf Derivatives of 1,2,5,6-tetrahydropyridin-3-carboxaldehyde oxime,their preparation and pharmaceutical compositions containing them
US4710508A (en) * 1986-12-08 1987-12-01 Warner-Lambert Company O-substituted tetrahydropyridine oxime cholinergic agents
IT1203971B (it) * 1987-04-24 1989-02-23 Roussel Maestretti Spa Derivati di 1,2,5,6-tetraidropiridina, loro procedimento di preparazione e loro applicazione come medicamenti

Also Published As

Publication number Publication date
NO172045B (no) 1993-02-22
EP0271798A3 (en) 1989-01-18
DK638487D0 (da) 1987-12-04
DE3785312D1 (de) 1993-05-13
NO875082D0 (no) 1987-12-07
FI85467B (fi) 1992-01-15
FI875363A (fi) 1988-06-09
NZ222756A (en) 1989-10-27
PH23404A (en) 1989-07-26
KR960000072B1 (ko) 1996-01-03
NO172045C (no) 1993-06-02
PT86311A (en) 1988-01-01
US4786648A (en) 1988-11-22
EP0271798B1 (en) 1993-04-07
DE3785312T2 (de) 1993-07-22
NO875082L (no) 1988-06-09
AU607442B2 (en) 1991-03-07
AU8110287A (en) 1988-06-09
FI875363A0 (fi) 1987-12-04
EP0271798A2 (en) 1988-06-22
PT86311B (pt) 1990-11-07
FI85467C (fi) 1992-04-27
KR880007466A (ko) 1988-08-27

Similar Documents

Publication Publication Date Title
DK638487A (da) 0-substituerede tetrahydropyridin-oximer, fremgangsmaade til deres fremstilling og deres anvendelse
NO881660D0 (no) Hepariner og femgangsmaate for deres fremstilling.
DK166084C (da) Imidazoquinolinyletherderivater og fremgangsmaade til deres fremstilling
NO873640D0 (no) Nye cefemforbindelser og fremgangsmaate til deres fremstilling.
NO875358D0 (no) 6-benzoksazinyl- og 6-benzotiazinyl-2,3,4,5-tetrahydropyridazin-3-oner og fremgangsmaate for deres fremstilling.
DK373787D0 (da) Substituerede hydrazoner, fremgangsmaade til deres fremstilling og deres anvendelse som skadedyrsbekaempelsesmiddel
NO870512D0 (no) 1,4-benzoksazinderivater og fremgangsmaate for deres fremstilling.
NO871526L (no) Tiolaktam-n-eddiksyrederivater og fremgangsmaate for deres fremstilling.
NO862975D0 (no) Kvaternaere oksalkylerte polykondensater, fremgangsmaate til deres fremstilling, og deres anvendelse.
DK354687D0 (da) 7-acyloxy-6-aminoacyloxypolyoxylabdaner, deres fremstilling og anvendelse
DK631587D0 (da) Imidazolderivater og fremgangsmaade til deres fremstilling
NO862976L (no) Oksalkylerte polyesteraminer, fremgangsmaate til deres fremstilling, og deres anvendelse.
NO883114D0 (no) 1h-pyrazol-1-alkanamider og fremgangsmaate for deres fremstilling.
NO871634D0 (no) Plantevernmidler og fremgangsmaate for deres fremstilling.
DK289287D0 (da) 1-phenylalkylimidazol-4- og/eller -5-carboxamider samt deres fremstiling og anvendelse
DK540887A (da) Iminooxazolidiner, fremgangsmaade til deres fremstilling samt anvendelse deraf
DK380787D0 (da) Decahydro-2-naphthylalkylaminer, fremgangsmaade til deres fremstilling samt deres anvendelse
DK625287A (da) 1-aryloxy-3-amino-2-propanoler, deres fremstilling og anvendelse
DK675687D0 (da) Substituerede n-methylisoxazolidiner, deres fremstilling og anvendelse
DK126987A (da) Pyrimidoindoler, deres fremstilling og anvendelse
NO872885L (no) 1,3,5-tritianderivater og fremgangsmŸte for deres fremstilling.
DK367887A (da) Arylethanolhydroxylaminer, deres fremstilling og anvendelse samt mellemprodukter til fremstilling ogdisses fremstilling
DK390287D0 (da) Cephalosporiner og derivater deraf samt fremgangsmaader til deres fremstilling
DK447687D0 (da) Urdamycin g og derivater deraf samt deres fremstilling og anvendelse
DK354688D0 (da) Benzooe5,6aacycloheptapyridiner, kompositioner og fremgangsmaader til deres anvendelse

Legal Events

Date Code Title Description
AHS Application shelved for other reasons than non-payment