PT86311B - Processo para a preparacao de agentes colinergicos de tetra-hidro-piridina-oxima 0 substituida e de composicoes farmaceuticas que os contem - Google Patents
Processo para a preparacao de agentes colinergicos de tetra-hidro-piridina-oxima 0 substituida e de composicoes farmaceuticas que os contem Download PDFInfo
- Publication number
- PT86311B PT86311B PT86311A PT8631187A PT86311B PT 86311 B PT86311 B PT 86311B PT 86311 A PT86311 A PT 86311A PT 8631187 A PT8631187 A PT 8631187A PT 86311 B PT86311 B PT 86311B
- Authority
- PT
- Portugal
- Prior art keywords
- carbon atoms
- pyridine
- tetrahydro
- carboxaldehyde
- methyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/939,507 US4710508A (en) | 1986-12-08 | 1986-12-08 | O-substituted tetrahydropyridine oxime cholinergic agents |
US07/091,893 US4786648A (en) | 1986-12-08 | 1987-09-04 | O-substituted tetrahydropyridine oxime cholinergic agents |
Publications (2)
Publication Number | Publication Date |
---|---|
PT86311A PT86311A (en) | 1988-01-01 |
PT86311B true PT86311B (pt) | 1990-11-07 |
Family
ID=26784455
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT86311A PT86311B (pt) | 1986-12-08 | 1987-12-07 | Processo para a preparacao de agentes colinergicos de tetra-hidro-piridina-oxima 0 substituida e de composicoes farmaceuticas que os contem |
Country Status (11)
Country | Link |
---|---|
US (1) | US4786648A (da) |
EP (1) | EP0271798B1 (da) |
KR (1) | KR960000072B1 (da) |
AU (1) | AU607442B2 (da) |
DE (1) | DE3785312T2 (da) |
DK (1) | DK638487A (da) |
FI (1) | FI85467C (da) |
NO (1) | NO172045C (da) |
NZ (1) | NZ222756A (da) |
PH (1) | PH23404A (da) |
PT (1) | PT86311B (da) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL81610A (en) * | 1986-02-27 | 1990-12-23 | Roussel Uclaf | Derivatives of 1,2,5,6-tetrahydropyridin-3-carboxaldehyde oxime,their preparation and pharmaceutical compositions containing them |
US5219873A (en) * | 1987-04-24 | 1993-06-15 | Roussel Uclaf | Compounds of 1,2,5,6-tetrahydropyridine which are useful as cholinergic agents |
IT1203971B (it) * | 1987-04-24 | 1989-02-23 | Roussel Maestretti Spa | Derivati di 1,2,5,6-tetraidropiridina, loro procedimento di preparazione e loro applicazione come medicamenti |
US5231107A (en) * | 1987-08-21 | 1993-07-27 | Roussel Uclaf | Derivatives of the oxime of 1,2,5,6-tetrahydropyridine 3-carboxaldehyde, the process for their preparation, their use as medicaments and the compositions containing them |
IT1222526B (it) * | 1987-08-21 | 1990-09-05 | Roussel Maestretti Spa | Derivati dell' ossima della 1,2,5,6-tetraidropiridin-3-carbossaldeide,loro procedimento di preparazione e loro impiego come sostanze medicinali |
IE63906B1 (en) * | 1987-11-13 | 1995-06-14 | Novo Nordisk As | Azabicyclic compounds and their preparation and use |
PT90266B (pt) * | 1988-04-15 | 1994-07-29 | Beecham Group Plc | Processo para a preparacao de compostos azabiciclicos |
ES2219636T3 (es) * | 1989-04-13 | 2004-12-01 | Beecham Group P.L.C. | Nuevos compuestos. |
US5278170A (en) * | 1989-04-13 | 1994-01-11 | Beecham Group P.L.C. | Azabicylo oxime compounds |
IT1240603B (it) * | 1990-03-14 | 1993-12-17 | Roussel Maestretti Spa | Derivati della 1,2,5,6-tetraidropiridina 3- carbossaldeide ossima, loro procedimento di preparazione e loro impiego come sostanza medicinale |
IT1241138B (it) * | 1990-05-15 | 1993-12-29 | Roussel Pharma | Derivati dell'ossina della 1,2,5,6- tetraidropiridin-3-carbossaldeide,loro procedimento di preparazione e loro impiego come sostanze medicinali |
WO1992003435A1 (en) * | 1990-08-24 | 1992-03-05 | Beecham Group Plc | Azabicyclic compounds, process and intermediates for their preparation and pharmaceutical compositions containing them |
GB9019095D0 (en) * | 1990-09-01 | 1990-10-17 | Beecham Group Plc | Novel compounds |
WO1992006959A1 (en) * | 1990-10-12 | 1992-04-30 | Beecham Group Plc | 1,2,5,6-tetrahydropyridine oxime derivatives |
US5175166A (en) * | 1991-08-27 | 1992-12-29 | The University Of Toledo | Muscarinic agonists |
WO1993011767A1 (en) * | 1991-12-18 | 1993-06-24 | Warner-Lambert Company | Transdermal delivery of (e)-1,2,5,6-tetrahydro-1-methyl-3-pyridine-carboxaldehyde-o-methyloxine hcl and related compounds in the treatment of cognitive disorders and for analgesia |
ZA931109B (en) * | 1992-03-04 | 1993-09-22 | Akzo Nv | Tetrahydropyrimidine derivatives. |
US5208343A (en) * | 1992-03-24 | 1993-05-04 | Warner-Lambert Company | Tetrahydropyridine oxime compounds |
AU5297693A (en) * | 1992-10-06 | 1994-04-26 | Warner-Lambert Company | Stabilized compositions containing 1,2,5,6-tetrahydro-1-methyl-3-pyridinecarboxyaldehyde-o-meth yl-oxime |
ZA937382B (en) * | 1992-10-06 | 1994-04-29 | Warner Lambert Co | Novel composition for peroral therapy of cognitionimpairment and a process therefor |
WO1994012480A1 (en) * | 1992-11-27 | 1994-06-09 | Akzo Nobel N.V. | 1,3-diazacycloalkyl oxime derivatives |
US5424301A (en) * | 1993-02-01 | 1995-06-13 | Warner-Lambert Company | Starch stabilized o-substituted tetrahydropyridine oxime cholinergic agents |
US5362860A (en) * | 1993-02-01 | 1994-11-08 | Warner-Lambert Company | Neutral stabilization complex for CI-979 HCl, a cognition activator |
US5618818A (en) * | 1996-03-20 | 1997-04-08 | The University Of Toledo | Muscarinic agonist compounds |
DE60234057D1 (de) | 2001-07-25 | 2009-11-26 | Raptor Pharmaceutical Inc | Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke |
WO2004101422A2 (en) * | 2003-05-13 | 2004-11-25 | Oasis Corporation | Combined water cooler and refrigerator unit |
CA2789262C (en) | 2005-04-28 | 2016-10-04 | Proteus Digital Health, Inc. | Pharma-informatics system |
JP2009506069A (ja) * | 2005-08-26 | 2009-02-12 | ブレインセルス,インコーポレイティド | ムスカリン性受容体調節による神経発生 |
EP2258357A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
AU2006304787A1 (en) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation of neurogenesis by PDE inhibition |
US20070112017A1 (en) | 2005-10-31 | 2007-05-17 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
JP2009521531A (ja) * | 2005-12-27 | 2009-06-04 | ザ・ユニバーシティ・オブ・トレド | ムスカリンアゴニスト及びその使用方法 |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
EP2026813A2 (en) | 2006-05-09 | 2009-02-25 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
EP2021000A2 (en) | 2006-05-09 | 2009-02-11 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
JP2010502722A (ja) | 2006-09-08 | 2010-01-28 | ブレインセルス,インコーポレイティド | 4−アシルアミノピリジン誘導体を含む組み合わせ |
EP2063905B1 (en) | 2006-09-18 | 2014-07-30 | Raptor Pharmaceutical Inc | Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
JP2011520905A (ja) | 2008-05-15 | 2011-07-21 | ザ・ユニバーシティ・オブ・トレド | 向知性剤としてのムスカリンアゴニスト |
PL2398500T3 (pl) | 2009-02-20 | 2019-09-30 | 2-Bbb Medicines B.V. | System dostarczania leków na bazie glutationu |
US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
KR101741629B1 (ko) | 2009-05-06 | 2017-05-31 | 라보라토리 스킨 케어, 인크. | 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법 |
US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
US9549928B2 (en) | 2011-04-29 | 2017-01-24 | The University Of Toledo | Muscarinic agonists as enhancers of cognitive flexibility |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB889074A (en) * | 1959-02-12 | 1962-02-07 | Ciba Ltd | New pyridine derivatives and process for their manufacture |
FR1258847A (fr) * | 1960-02-12 | 1961-04-21 | Ciba Geigy | Procédé de préparation de nouveaux dérivés pyridiniques, entre autres de l'oxime de la l-méthyl-3 ou 4-acétyl-1, 2, 5, 6-tétrahydropyridine |
JPS511638A (ja) * | 1974-06-27 | 1976-01-08 | Fujisawa Pharmaceutical Co | Shokubutsuseichochoseizai |
US4297359A (en) * | 1978-07-25 | 1981-10-27 | Acf Chemiefarma Nv | Anti-ulcer compositions containing certain pyridyl oxime ethers |
IL81610A (en) * | 1986-02-27 | 1990-12-23 | Roussel Uclaf | Derivatives of 1,2,5,6-tetrahydropyridin-3-carboxaldehyde oxime,their preparation and pharmaceutical compositions containing them |
US4710508A (en) * | 1986-12-08 | 1987-12-01 | Warner-Lambert Company | O-substituted tetrahydropyridine oxime cholinergic agents |
IT1203971B (it) * | 1987-04-24 | 1989-02-23 | Roussel Maestretti Spa | Derivati di 1,2,5,6-tetraidropiridina, loro procedimento di preparazione e loro applicazione come medicamenti |
-
1987
- 1987-09-04 US US07/091,893 patent/US4786648A/en not_active Expired - Fee Related
- 1987-11-11 AU AU81102/87A patent/AU607442B2/en not_active Ceased
- 1987-11-30 NZ NZ222756A patent/NZ222756A/xx unknown
- 1987-12-04 FI FI875363A patent/FI85467C/fi not_active IP Right Cessation
- 1987-12-04 DK DK638487A patent/DK638487A/da not_active Application Discontinuation
- 1987-12-07 NO NO875082A patent/NO172045C/no unknown
- 1987-12-07 PH PH36177A patent/PH23404A/en unknown
- 1987-12-07 PT PT86311A patent/PT86311B/pt not_active IP Right Cessation
- 1987-12-07 EP EP87118083A patent/EP0271798B1/en not_active Expired - Lifetime
- 1987-12-07 DE DE8787118083T patent/DE3785312T2/de not_active Expired - Fee Related
- 1987-12-08 KR KR1019870013971A patent/KR960000072B1/ko not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
NO172045C (no) | 1993-06-02 |
PH23404A (en) | 1989-07-26 |
KR880007466A (ko) | 1988-08-27 |
FI85467B (fi) | 1992-01-15 |
EP0271798B1 (en) | 1993-04-07 |
EP0271798A2 (en) | 1988-06-22 |
AU607442B2 (en) | 1991-03-07 |
AU8110287A (en) | 1988-06-09 |
KR960000072B1 (ko) | 1996-01-03 |
PT86311A (en) | 1988-01-01 |
FI875363A (fi) | 1988-06-09 |
NO875082D0 (no) | 1987-12-07 |
DE3785312D1 (de) | 1993-05-13 |
FI875363A0 (fi) | 1987-12-04 |
NZ222756A (en) | 1989-10-27 |
NO875082L (no) | 1988-06-09 |
NO172045B (no) | 1993-02-22 |
DE3785312T2 (de) | 1993-07-22 |
US4786648A (en) | 1988-11-22 |
DK638487A (da) | 1988-06-09 |
FI85467C (fi) | 1992-04-27 |
EP0271798A3 (en) | 1989-01-18 |
DK638487D0 (da) | 1987-12-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 19940930 |