KR880007466A - 콜린작동제로서의o-치환된테트라하이드로피리딘옥심 - Google Patents

콜린작동제로서의o-치환된테트라하이드로피리딘옥심

Info

Publication number
KR880007466A
KR880007466A KR1019870013971A KR870013971A KR880007466A KR 880007466 A KR880007466 A KR 880007466A KR 1019870013971 A KR1019870013971 A KR 1019870013971A KR 870013971 A KR870013971 A KR 870013971A KR 880007466 A KR880007466 A KR 880007466A
Authority
KR
South Korea
Prior art keywords
substituted tetrahydropyridine
choline agonist
tetrahydropyridine oxime
oxime
choline
Prior art date
Application number
KR1019870013971A
Other languages
English (en)
Other versions
KR960000072B1 (ko
Inventor
클라크 버그메이어 스테펜
알렉시스 도운스 데이비드
해밀톤 모스 월터
윈슬로우 모어랜드 데이비드
테클 헤일
Original Assignee
워너-람버트 컴퍼니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/939,507 external-priority patent/US4710508A/en
Application filed by 워너-람버트 컴퍼니 filed Critical 워너-람버트 컴퍼니
Publication of KR880007466A publication Critical patent/KR880007466A/ko
Application granted granted Critical
Publication of KR960000072B1 publication Critical patent/KR960000072B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1019870013971A 1986-12-08 1987-12-08 콜린작동제로서의o-치환된테트라하이드로피리딘옥심 KR960000072B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US939,507 1986-12-08
US06/939,507 US4710508A (en) 1986-12-08 1986-12-08 O-substituted tetrahydropyridine oxime cholinergic agents
US07/091,893 US4786648A (en) 1986-12-08 1987-09-04 O-substituted tetrahydropyridine oxime cholinergic agents
US091,893 1987-09-04

Publications (2)

Publication Number Publication Date
KR880007466A true KR880007466A (ko) 1988-08-27
KR960000072B1 KR960000072B1 (ko) 1996-01-03

Family

ID=26784455

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019870013971A KR960000072B1 (ko) 1986-12-08 1987-12-08 콜린작동제로서의o-치환된테트라하이드로피리딘옥심

Country Status (11)

Country Link
US (1) US4786648A (ko)
EP (1) EP0271798B1 (ko)
KR (1) KR960000072B1 (ko)
AU (1) AU607442B2 (ko)
DE (1) DE3785312T2 (ko)
DK (1) DK638487A (ko)
FI (1) FI85467C (ko)
NO (1) NO172045C (ko)
NZ (1) NZ222756A (ko)
PH (1) PH23404A (ko)
PT (1) PT86311B (ko)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL81610A (en) * 1986-02-27 1990-12-23 Roussel Uclaf Derivatives of 1,2,5,6-tetrahydropyridin-3-carboxaldehyde oxime,their preparation and pharmaceutical compositions containing them
IT1203971B (it) * 1987-04-24 1989-02-23 Roussel Maestretti Spa Derivati di 1,2,5,6-tetraidropiridina, loro procedimento di preparazione e loro applicazione come medicamenti
US5219873A (en) * 1987-04-24 1993-06-15 Roussel Uclaf Compounds of 1,2,5,6-tetrahydropyridine which are useful as cholinergic agents
US5231107A (en) * 1987-08-21 1993-07-27 Roussel Uclaf Derivatives of the oxime of 1,2,5,6-tetrahydropyridine 3-carboxaldehyde, the process for their preparation, their use as medicaments and the compositions containing them
IT1222526B (it) * 1987-08-21 1990-09-05 Roussel Maestretti Spa Derivati dell' ossima della 1,2,5,6-tetraidropiridin-3-carbossaldeide,loro procedimento di preparazione e loro impiego come sostanze medicinali
IE63906B1 (en) * 1987-11-13 1995-06-14 Novo Nordisk As Azabicyclic compounds and their preparation and use
DE68907982T2 (de) * 1988-04-15 1994-01-20 Beecham Group Plc Chemische Verbindungen.
US5278170A (en) * 1989-04-13 1994-01-11 Beecham Group P.L.C. Azabicylo oxime compounds
ATE269330T1 (de) * 1989-04-13 2004-07-15 Beecham Group Plc Chemische verbindungen
IT1240603B (it) * 1990-03-14 1993-12-17 Roussel Maestretti Spa Derivati della 1,2,5,6-tetraidropiridina 3- carbossaldeide ossima, loro procedimento di preparazione e loro impiego come sostanza medicinale
IT1241138B (it) * 1990-05-15 1993-12-29 Roussel Pharma Derivati dell'ossina della 1,2,5,6- tetraidropiridin-3-carbossaldeide,loro procedimento di preparazione e loro impiego come sostanze medicinali
IE912974A1 (en) * 1990-08-24 1992-02-26 Beecham Group Plc Novel compounds
GB9019095D0 (en) * 1990-09-01 1990-10-17 Beecham Group Plc Novel compounds
AU8645091A (en) * 1990-10-12 1992-05-20 Beecham Group Plc 1,2,5,6-tetrahydropyridine oxime derivatives
US5175166A (en) * 1991-08-27 1992-12-29 The University Of Toledo Muscarinic agonists
WO1993011767A1 (en) * 1991-12-18 1993-06-24 Warner-Lambert Company Transdermal delivery of (e)-1,2,5,6-tetrahydro-1-methyl-3-pyridine-carboxaldehyde-o-methyloxine hcl and related compounds in the treatment of cognitive disorders and for analgesia
ZA931109B (en) * 1992-03-04 1993-09-22 Akzo Nv Tetrahydropyrimidine derivatives.
US5208343A (en) * 1992-03-24 1993-05-04 Warner-Lambert Company Tetrahydropyridine oxime compounds
ZA937382B (en) * 1992-10-06 1994-04-29 Warner Lambert Co Novel composition for peroral therapy of cognitionimpairment and a process therefor
AU5297693A (en) * 1992-10-06 1994-04-26 Warner-Lambert Company Stabilized compositions containing 1,2,5,6-tetrahydro-1-methyl-3-pyridinecarboxyaldehyde-o-meth yl-oxime
AU5628194A (en) * 1992-11-27 1994-06-22 Akzo N.V. 1,3-diazacycloalkyl oxime derivatives
US5424301A (en) * 1993-02-01 1995-06-13 Warner-Lambert Company Starch stabilized o-substituted tetrahydropyridine oxime cholinergic agents
US5362860A (en) * 1993-02-01 1994-11-08 Warner-Lambert Company Neutral stabilization complex for CI-979 HCl, a cognition activator
US5618818A (en) * 1996-03-20 1997-04-08 The University Of Toledo Muscarinic agonist compounds
AU2002322720B2 (en) 2001-07-25 2008-11-13 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
US6912867B2 (en) * 2003-05-13 2005-07-05 Oasis Corporation Combined water cooler and refrigerator unit
WO2006116718A2 (en) 2005-04-28 2006-11-02 Proteus Biomedical, Inc. Pharma-informatics system
EP2258358A3 (en) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
CA2620333A1 (en) 2005-08-26 2007-03-01 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP1940389A2 (en) 2005-10-21 2008-07-09 Braincells, Inc. Modulation of neurogenesis by pde inhibition
WO2007053596A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
CN101374836A (zh) * 2005-12-27 2009-02-25 托莱多大学 毒蕈碱激动剂及其使用方法
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
EP2026813A2 (en) 2006-05-09 2009-02-25 Braincells, Inc. 5 ht receptor mediated neurogenesis
CA2651813A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
EP2068872A1 (en) 2006-09-08 2009-06-17 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
JP2010503710A (ja) 2006-09-18 2010-02-04 ラプトール ファーマシューティカル インコーポレイテッド 受容体関連タンパク質（ｒａｐ）結合体の投与による肝障害の処置
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
WO2009140483A1 (en) 2008-05-15 2009-11-19 University Of Toledo Muscarinic agonists as cognitive enhancers
ES2919563T3 (es) 2009-02-20 2022-07-27 Enhanx Biopharm Inc Sistema de administración de medicamentos a base de glutatión
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
EA024559B1 (ru) 2009-05-06 2016-09-30 Лаборэтори Скин Кэа, Инк. Композиции для нанесения на кератинизированную поверхность кожи млекопитающего и способ доставки
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
US9549928B2 (en) 2011-04-29 2017-01-24 The University Of Toledo Muscarinic agonists as enhancers of cognitive flexibility

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB889074A (en) * 1959-02-12 1962-02-07 Ciba Ltd New pyridine derivatives and process for their manufacture
FR1258847A (fr) * 1960-02-12 1961-04-21 Ciba Geigy Procédé de préparation de nouveaux dérivés pyridiniques, entre autres de l'oxime de la l-méthyl-3 ou 4-acétyl-1, 2, 5, 6-tétrahydropyridine
JPS511638A (ja) * 1974-06-27 1976-01-08 Fujisawa Pharmaceutical Co Shokubutsuseichochoseizai
US4297359A (en) * 1978-07-25 1981-10-27 Acf Chemiefarma Nv Anti-ulcer compositions containing certain pyridyl oxime ethers
IL81610A (en) * 1986-02-27 1990-12-23 Roussel Uclaf Derivatives of 1,2,5,6-tetrahydropyridin-3-carboxaldehyde oxime,their preparation and pharmaceutical compositions containing them
US4710508A (en) * 1986-12-08 1987-12-01 Warner-Lambert Company O-substituted tetrahydropyridine oxime cholinergic agents
IT1203971B (it) * 1987-04-24 1989-02-23 Roussel Maestretti Spa Derivati di 1,2,5,6-tetraidropiridina, loro procedimento di preparazione e loro applicazione come medicamenti

Also Published As

Publication number Publication date
KR960000072B1 (ko) 1996-01-03
DE3785312T2 (de) 1993-07-22
PT86311A (en) 1988-01-01
EP0271798A2 (en) 1988-06-22
NO875082D0 (no) 1987-12-07
US4786648A (en) 1988-11-22
NZ222756A (en) 1989-10-27
FI875363A (fi) 1988-06-09
NO875082L (no) 1988-06-09
DE3785312D1 (de) 1993-05-13
NO172045B (no) 1993-02-22
PT86311B (pt) 1990-11-07
FI85467B (fi) 1992-01-15
AU607442B2 (en) 1991-03-07
AU8110287A (en) 1988-06-09
FI875363A0 (fi) 1987-12-04
PH23404A (en) 1989-07-26
EP0271798B1 (en) 1993-04-07
DK638487A (da) 1988-06-09
NO172045C (no) 1993-06-02
EP0271798A3 (en) 1989-01-18
DK638487D0 (da) 1987-12-04
FI85467C (fi) 1992-04-27

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