FI875363A - O-substituerade tetrahydropyridinoximer saosom kolinergiska medel. - Google Patents

O-substituerade tetrahydropyridinoximer saosom kolinergiska medel. Download PDF

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Publication number
FI875363A
FI875363A FI875363A FI875363A FI875363A FI 875363 A FI875363 A FI 875363A FI 875363 A FI875363 A FI 875363A FI 875363 A FI875363 A FI 875363A FI 875363 A FI875363 A FI 875363A
Authority
FI
Finland
Prior art keywords
tetrahydropyridinoximer
kolinergiska
substituerade
saosom
medel
Prior art date
Application number
FI875363A
Other languages
English (en)
Other versions
FI85467C (fi
FI875363A0 (fi
FI85467B (fi
Inventor
Stephen Clark Bergmeier
David Alexix Downs
Walter Hamilton Moos
David Winslow Moreland
Haile Tecle
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/939,507 external-priority patent/US4710508A/en
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of FI875363A0 publication Critical patent/FI875363A0/fi
Publication of FI875363A publication Critical patent/FI875363A/fi
Application granted granted Critical
Publication of FI85467B publication Critical patent/FI85467B/fi
Publication of FI85467C publication Critical patent/FI85467C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
FI875363A 1986-12-08 1987-12-04 Foerfarande foer framstaellning av farmakologiskt vaerdefulla 4-substituerade tetrahydropyridiner. FI85467C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US06/939,507 US4710508A (en) 1986-12-08 1986-12-08 O-substituted tetrahydropyridine oxime cholinergic agents
US93950786 1986-12-08
US07/091,893 US4786648A (en) 1986-12-08 1987-09-04 O-substituted tetrahydropyridine oxime cholinergic agents
US9189387 1987-09-04

Publications (4)

Publication Number Publication Date
FI875363A0 FI875363A0 (fi) 1987-12-04
FI875363A true FI875363A (fi) 1988-06-09
FI85467B FI85467B (fi) 1992-01-15
FI85467C FI85467C (fi) 1992-04-27

Family

ID=26784455

Family Applications (1)

Application Number Title Priority Date Filing Date
FI875363A FI85467C (fi) 1986-12-08 1987-12-04 Foerfarande foer framstaellning av farmakologiskt vaerdefulla 4-substituerade tetrahydropyridiner.

Country Status (11)

Country Link
US (1) US4786648A (fi)
EP (1) EP0271798B1 (fi)
KR (1) KR960000072B1 (fi)
AU (1) AU607442B2 (fi)
DE (1) DE3785312T2 (fi)
DK (1) DK638487A (fi)
FI (1) FI85467C (fi)
NO (1) NO172045C (fi)
NZ (1) NZ222756A (fi)
PH (1) PH23404A (fi)
PT (1) PT86311B (fi)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL81610A (en) * 1986-02-27 1990-12-23 Roussel Uclaf Derivatives of 1,2,5,6-tetrahydropyridin-3-carboxaldehyde oxime,their preparation and pharmaceutical compositions containing them
US5219873A (en) * 1987-04-24 1993-06-15 Roussel Uclaf Compounds of 1,2,5,6-tetrahydropyridine which are useful as cholinergic agents
IT1203971B (it) * 1987-04-24 1989-02-23 Roussel Maestretti Spa Derivati di 1,2,5,6-tetraidropiridina, loro procedimento di preparazione e loro applicazione come medicamenti
IT1222526B (it) * 1987-08-21 1990-09-05 Roussel Maestretti Spa Derivati dell' ossima della 1,2,5,6-tetraidropiridin-3-carbossaldeide,loro procedimento di preparazione e loro impiego come sostanze medicinali
US5231107A (en) * 1987-08-21 1993-07-27 Roussel Uclaf Derivatives of the oxime of 1,2,5,6-tetrahydropyridine 3-carboxaldehyde, the process for their preparation, their use as medicaments and the compositions containing them
IE63906B1 (en) * 1987-11-13 1995-06-14 Novo Nordisk As Azabicyclic compounds and their preparation and use
US5110828A (en) * 1988-04-15 1992-05-05 Beecham Group P.L.C. Azabicyclo oxime derivatives
DK0392803T3 (da) * 1989-04-13 2004-10-18 Beecham Group Plc Hidtil ukendte forbindelser
US5278170A (en) * 1989-04-13 1994-01-11 Beecham Group P.L.C. Azabicylo oxime compounds
IT1240603B (it) * 1990-03-14 1993-12-17 Roussel Maestretti Spa Derivati della 1,2,5,6-tetraidropiridina 3- carbossaldeide ossima, loro procedimento di preparazione e loro impiego come sostanza medicinale
IT1241138B (it) * 1990-05-15 1993-12-29 Roussel Pharma Derivati dell'ossina della 1,2,5,6- tetraidropiridin-3-carbossaldeide,loro procedimento di preparazione e loro impiego come sostanze medicinali
EP0544773B1 (en) * 1990-08-24 1998-03-18 Beecham Group Plc Azabicyclic compounds, process and intermediates for their preparation and pharmaceutical compositions containing them
GB9019095D0 (en) * 1990-09-01 1990-10-17 Beecham Group Plc Novel compounds
JPH06501933A (ja) * 1990-10-12 1994-03-03 ビーチャム・グループ・パブリック・リミテッド・カンパニー １，２，５，６−テトラヒドロピリジン・オキシム誘導体
US5175166A (en) * 1991-08-27 1992-12-29 The University Of Toledo Muscarinic agonists
WO1993011767A1 (en) * 1991-12-18 1993-06-24 Warner-Lambert Company Transdermal delivery of (e)-1,2,5,6-tetrahydro-1-methyl-3-pyridine-carboxaldehyde-o-methyloxine hcl and related compounds in the treatment of cognitive disorders and for analgesia
ZA931109B (en) * 1992-03-04 1993-09-22 Akzo Nv Tetrahydropyrimidine derivatives.
US5208343A (en) * 1992-03-24 1993-05-04 Warner-Lambert Company Tetrahydropyridine oxime compounds
WO1994007493A1 (en) * 1992-10-06 1994-04-14 Warner-Lambert Company Stabilized compositions containing 1,2,5,6-tetrahydro-1-methyl-3-pyridinecarboxyaldehyde-o-methyl-oxime
ZA937382B (en) * 1992-10-06 1994-04-29 Warner Lambert Co Novel composition for peroral therapy of cognitionimpairment and a process therefor
WO1994012480A1 (en) * 1992-11-27 1994-06-09 Akzo Nobel N.V. 1,3-diazacycloalkyl oxime derivatives
US5424301A (en) * 1993-02-01 1995-06-13 Warner-Lambert Company Starch stabilized o-substituted tetrahydropyridine oxime cholinergic agents
US5362860A (en) * 1993-02-01 1994-11-08 Warner-Lambert Company Neutral stabilization complex for CI-979 HCl, a cognition activator
US5618818A (en) * 1996-03-20 1997-04-08 The University Of Toledo Muscarinic agonist compounds
ATE445838T1 (de) 2001-07-25 2009-10-15 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
WO2004101422A2 (en) * 2003-05-13 2004-11-25 Oasis Corporation Combined water cooler and refrigerator unit
EP2671508B1 (en) 2005-04-28 2020-09-16 Proteus Digital Health, Inc. Pharma-informatics system
EP2275095A3 (en) * 2005-08-26 2011-08-17 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
EP2377530A3 (en) 2005-10-21 2012-06-20 Braincells, Inc. Modulation of neurogenesis by PDE inhibition
EP2314289A1 (en) 2005-10-31 2011-04-27 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
WO2007075297A2 (en) * 2005-12-27 2007-07-05 University Of Toledo Muscarinic agonists and methods of use thereof
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
WO2007134077A2 (en) 2006-05-09 2007-11-22 Braincells, Inc. 5 ht receptor mediated neurogenesis
CA2651813A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
AU2007292848A1 (en) 2006-09-08 2008-03-13 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
CA2663377A1 (en) 2006-09-18 2008-03-27 Raptor Pharmaceutical Inc. Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
WO2009140483A1 (en) 2008-05-15 2009-11-19 University Of Toledo Muscarinic agonists as cognitive enhancers
HUE059078T2 (hu) 2009-02-20 2022-10-28 Enhanx Biopharm Inc Glutation-alapú hatóanyagszállító rendszer
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
JP2012526144A (ja) 2009-05-06 2012-10-25 ラボラトリー スキン ケア インコーポレイテッド 活性物質−リン酸カルシウム粒子複合体を含む経皮送達組成物およびその使用方法
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
WO2012149524A1 (en) 2011-04-29 2012-11-01 The University Of Toledo Muscarinic agonists as enhancers of working memory and cognitive flexibility

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB889074A (en) * 1959-02-12 1962-02-07 Ciba Ltd New pyridine derivatives and process for their manufacture
FR1258847A (fr) * 1960-02-12 1961-04-21 Ciba Geigy Procédé de préparation de nouveaux dérivés pyridiniques, entre autres de l'oxime de la l-méthyl-3 ou 4-acétyl-1, 2, 5, 6-tétrahydropyridine
JPS511638A (ja) * 1974-06-27 1976-01-08 Fujisawa Pharmaceutical Co Shokubutsuseichochoseizai
US4297359A (en) * 1978-07-25 1981-10-27 Acf Chemiefarma Nv Anti-ulcer compositions containing certain pyridyl oxime ethers
IL81610A (en) * 1986-02-27 1990-12-23 Roussel Uclaf Derivatives of 1,2,5,6-tetrahydropyridin-3-carboxaldehyde oxime,their preparation and pharmaceutical compositions containing them
US4710508A (en) * 1986-12-08 1987-12-01 Warner-Lambert Company O-substituted tetrahydropyridine oxime cholinergic agents
IT1203971B (it) * 1987-04-24 1989-02-23 Roussel Maestretti Spa Derivati di 1,2,5,6-tetraidropiridina, loro procedimento di preparazione e loro applicazione come medicamenti

Also Published As

Publication number Publication date
PT86311A (en) 1988-01-01
NZ222756A (en) 1989-10-27
KR880007466A (ko) 1988-08-27
EP0271798A2 (en) 1988-06-22
EP0271798B1 (en) 1993-04-07
US4786648A (en) 1988-11-22
FI85467C (fi) 1992-04-27
PH23404A (en) 1989-07-26
NO875082L (no) 1988-06-09
KR960000072B1 (ko) 1996-01-03
DE3785312T2 (de) 1993-07-22
FI875363A0 (fi) 1987-12-04
DK638487D0 (da) 1987-12-04
DK638487A (da) 1988-06-09
NO172045C (no) 1993-06-02
NO875082D0 (no) 1987-12-07
NO172045B (no) 1993-02-22
AU607442B2 (en) 1991-03-07
AU8110287A (en) 1988-06-09
EP0271798A3 (en) 1989-01-18
DE3785312D1 (de) 1993-05-13
PT86311B (pt) 1990-11-07
FI85467B (fi) 1992-01-15

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Legal Events

Date Code Title Description
MM Patent lapsed

Owner name: WARNER-LAMBERT COMPANY