DE69707504T2 - Diphenylalkyl-tetrahydropyridine, verfahren zu ihren herstellung und diese enthaltende arzneimittel - Google Patents

Diphenylalkyl-tetrahydropyridine, verfahren zu ihren herstellung und diese enthaltende arzneimittel

Info

Publication number
DE69707504T2
DE69707504T2 DE69707504T DE69707504T DE69707504T2 DE 69707504 T2 DE69707504 T2 DE 69707504T2 DE 69707504 T DE69707504 T DE 69707504T DE 69707504 T DE69707504 T DE 69707504T DE 69707504 T2 DE69707504 T2 DE 69707504T2
Authority
DE
Germany
Prior art keywords
pct
diphenylalkyl
tetrahydropyridine
production
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69707504T
Other languages
English (en)
Other versions
DE69707504D1 (de
Inventor
Marco Baroni
Rosanna Cardamone
Jacqueline Fournier
Umberto Guzzi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo SA filed Critical Sanofi Synthelabo SA
Application granted granted Critical
Publication of DE69707504D1 publication Critical patent/DE69707504D1/de
Publication of DE69707504T2 publication Critical patent/DE69707504T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69707504T 1996-12-13 1997-12-12 Diphenylalkyl-tetrahydropyridine, verfahren zu ihren herstellung und diese enthaltende arzneimittel Expired - Fee Related DE69707504T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9615336A FR2757161B1 (fr) 1996-12-13 1996-12-13 Diphenylalkyl-tetrahydropyridines
PCT/FR1997/002289 WO1998025904A1 (fr) 1996-12-13 1997-12-12 Diphenylalkyl-tetrahydropyridines, procede pour leur preparation et composition pharmaceutique les contenant

Publications (2)

Publication Number Publication Date
DE69707504D1 DE69707504D1 (de) 2001-11-22
DE69707504T2 true DE69707504T2 (de) 2002-06-27

Family

ID=9498642

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69707504T Expired - Fee Related DE69707504T2 (de) 1996-12-13 1997-12-12 Diphenylalkyl-tetrahydropyridine, verfahren zu ihren herstellung und diese enthaltende arzneimittel

Country Status (31)

Country Link
US (1) US6124318A (de)
EP (1) EP0950049B1 (de)
JP (1) JP2001505903A (de)
KR (1) KR100549656B1 (de)
CN (1) CN1144784C (de)
AT (1) ATE207056T1 (de)
AU (1) AU730142B2 (de)
BR (1) BR9713926A (de)
CA (1) CA2274946C (de)
CY (1) CY2282B1 (de)
CZ (1) CZ290242B6 (de)
DE (1) DE69707504T2 (de)
DK (1) DK0950049T3 (de)
EE (1) EE03764B1 (de)
ES (1) ES2167805T3 (de)
FR (1) FR2757161B1 (de)
HK (1) HK1024001A1 (de)
HU (1) HUP0001437A3 (de)
IL (2) IL130001A0 (de)
IS (1) IS2001B (de)
NO (1) NO313282B1 (de)
NZ (1) NZ336032A (de)
PL (1) PL192926B1 (de)
PT (1) PT950049E (de)
RS (1) RS49672B (de)
RU (1) RU2198874C2 (de)
SI (1) SI0950049T1 (de)
SK (1) SK283332B6 (de)
TR (1) TR199901290T2 (de)
UA (1) UA52708C2 (de)
WO (1) WO1998025904A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2763847B1 (fr) * 1997-05-28 2003-06-06 Sanofi Sa Utilisation de tetrahydropyridines 4-substituees pour fabriquer des medicaments agissant sur le tgf-beta-1
WO2001078709A2 (en) * 2000-04-12 2001-10-25 Minerva Biotechnologies Corporation Treatment of neurodegenerative disease
AU2002314744A1 (en) 2001-04-17 2002-10-28 Sepracor, Inc. Thiazole and other heterocyclic ligands and use thereof
WO2005065661A2 (en) * 2003-12-31 2005-07-21 Actavis Group Hf Immediate, controlled and sustained release formulations of galanthamine

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1321701A (en) * 1969-10-01 1973-06-27 Continental Pharma Amino-alcohols their salts and process for prepairing the same
BE775611A (fr) * 1970-11-24 1972-03-16 Synthelabo Derives de la (diphenyl-3,3 propyl-1)-1 piperidine, leur preparation etles medicaments qui en contiennent
FR2650505B1 (fr) * 1989-08-07 1994-06-03 Midy Spa Utilisation de trifluoromethylphenyltetrahydropyridines pour la preparation de medicaments destines a combattre les troubles de la motricite intestinale
US5266573A (en) * 1989-08-07 1993-11-30 Elf Sanofi Trifluoromethylphenyltetrahydropyridines for the treatment and/or prophylaxis of intestinal motility disorders
FR2662355B1 (fr) * 1990-05-22 1994-11-10 Sanofi Sa Utilisation de la 1-[2-(2-naphtyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine pour la preparation de medicaments destines au traitement de troubles cerebraux et neuronaux.
US5512584A (en) * 1991-04-16 1996-04-30 Basf Aktiengesellschaft 1,3,4-trisubstituted piperidine derivatives, the preparation and use thereof
HU211019B (en) * 1991-12-02 1995-09-28 Richter Gedeon Vegyeszet Process for producing new 1,2,3,6-tetrahydropyridine and piperidine derivatives substituted with n-(hydroxylalkyl) group and compositions comprising such compounds
DK148392D0 (da) * 1992-12-09 1992-12-09 Lundbeck & Co As H Heterocykliske forbindelser

Also Published As

Publication number Publication date
NO992870D0 (no) 1999-06-11
CZ290242B6 (cs) 2002-06-12
HUP0001437A2 (hu) 2000-09-28
YU26399A (sh) 2000-03-21
SI0950049T1 (en) 2002-10-31
SK78799A3 (en) 1999-12-10
CN1240428A (zh) 2000-01-05
IL130001A0 (en) 2000-02-29
NO992870L (no) 1999-08-11
DK0950049T3 (da) 2002-01-28
JP2001505903A (ja) 2001-05-08
BR9713926A (pt) 2000-03-21
US6124318A (en) 2000-09-26
PL192926B1 (pl) 2006-12-29
FR2757161B1 (fr) 1999-03-12
ES2167805T3 (es) 2002-05-16
DE69707504D1 (de) 2001-11-22
ATE207056T1 (de) 2001-11-15
NO313282B1 (no) 2002-09-09
EE9900238A (et) 1999-12-15
UA52708C2 (uk) 2003-01-15
CA2274946A1 (en) 1998-06-18
CN1144784C (zh) 2004-04-07
EP0950049A1 (de) 1999-10-20
IS5074A (is) 1999-06-10
PL334073A1 (en) 2000-01-31
RS49672B (sr) 2007-11-15
KR100549656B1 (ko) 2006-02-08
WO1998025904A1 (fr) 1998-06-18
EP0950049B1 (de) 2001-10-17
PT950049E (pt) 2002-03-28
NZ336032A (en) 2000-12-22
IL130001A (en) 2006-04-10
CY2282B1 (en) 2003-07-04
TR199901290T2 (xx) 1999-08-23
KR20000069421A (ko) 2000-11-25
IS2001B (is) 2005-04-15
AU730142B2 (en) 2001-03-01
RU2198874C2 (ru) 2003-02-20
FR2757161A1 (fr) 1998-06-19
SK283332B6 (sk) 2003-06-03
HUP0001437A3 (en) 2001-12-28
EE03764B1 (et) 2002-06-17
HK1024001A1 (en) 2000-09-29
CA2274946C (en) 2005-09-20
AU5489598A (en) 1998-07-03
CZ211099A3 (cs) 1999-09-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: SANOFI-AVENTIS, PARIS, FR

8339 Ceased/non-payment of the annual fee