DE69719974D1 - Chinolinderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel - Google Patents
Chinolinderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittelInfo
- Publication number
- DE69719974D1 DE69719974D1 DE69719974T DE69719974T DE69719974D1 DE 69719974 D1 DE69719974 D1 DE 69719974D1 DE 69719974 T DE69719974 T DE 69719974T DE 69719974 T DE69719974 T DE 69719974T DE 69719974 D1 DE69719974 D1 DE 69719974D1
- Authority
- DE
- Germany
- Prior art keywords
- lower alkyl
- pct
- production
- medicinal products
- chinoline derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/24—Oxygen atoms attached in position 8
- C07D215/26—Alcohols; Ethers thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AUPN9526A AUPN952696A0 (en) | 1996-04-29 | 1996-04-29 | New heterocyclic compounds |
PCT/JP1997/001415 WO1997041104A1 (en) | 1996-04-29 | 1997-04-24 | Quinoline derivatives, processes for their preparation, and their use as medicaments |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69719974D1 true DE69719974D1 (de) | 2003-04-24 |
DE69719974T2 DE69719974T2 (de) | 2003-08-28 |
Family
ID=3793840
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69719974T Expired - Lifetime DE69719974T2 (de) | 1996-04-29 | 1997-04-24 | Chinolinderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
Country Status (8)
Country | Link |
---|---|
US (1) | US6083959A (de) |
EP (1) | EP0900203B1 (de) |
JP (1) | JP2000509066A (de) |
AT (1) | ATE234818T1 (de) |
AU (1) | AUPN952696A0 (de) |
DE (1) | DE69719974T2 (de) |
ES (1) | ES2189956T3 (de) |
WO (1) | WO1997041104A1 (de) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2790260B1 (fr) * | 1999-02-26 | 2001-05-04 | Fournier Ind & Sante | Nouveaux composes de n-(benzenesulfonamide), procede de preparation et utilisation en therapeutique |
EP1914236A1 (de) | 2002-04-10 | 2008-04-23 | Ortho-McNeil Pharmaceutical, Inc. | Neue Heteroaryl-Alkylamid-Derivate als Bradykininrezeptormodulatoren |
EP2583678A3 (de) | 2004-06-24 | 2013-11-13 | Novartis Vaccines and Diagnostics, Inc. | Immunstimulatoren kleiner Moleküle und Assays für deren Nachweis |
TWI407960B (zh) * | 2007-03-23 | 2013-09-11 | Jerini Ag | 小分子緩激肽b2受體調節劑 |
US8883857B2 (en) | 2012-12-07 | 2014-11-11 | Baylor College Of Medicine | Small molecule xanthine oxidase inhibitors and methods of use |
AU2018371186B2 (en) * | 2017-11-24 | 2022-05-12 | Pharvaris Netherlands B.V. | Novel bradykinin B2 receptor antagonists |
UY38707A (es) | 2019-05-23 | 2020-12-31 | Pharvaris Gmbh | Nuevos antagonistas cíclicos del receptor b2 de bradiquinina |
UY38706A (es) * | 2019-05-23 | 2020-12-31 | Pharvaris Gmbh | Antagonistas cíclicos del receptor b2 de bradiquinina |
EP4203919B1 (de) | 2021-08-05 | 2024-01-31 | Pharvaris GmbH | Lipidbasierte zusammensetzung zur oralen verabreichung von bradykinin-b2-rezeptor-antagonisten |
WO2023180577A1 (en) | 2022-03-25 | 2023-09-28 | Pharvaris Gmbh | Therapeutic uses of bradykinin b2-receptor antagonists |
TW202345810A (zh) | 2022-03-25 | 2023-12-01 | 瑞士商帕法瑞斯有限責任公司 | 包含緩激肽b2受體拮抗劑之固態延長釋放組成物 |
WO2023180575A1 (en) | 2022-03-25 | 2023-09-28 | Pharvaris Gmbh | Solid composition comprising solubilised bradykinin b2-receptor antagonists |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3617183A1 (de) * | 1985-11-16 | 1987-05-27 | Bayer Ag | Substituierte benzylether |
DE3632329A1 (de) * | 1986-09-24 | 1988-03-31 | Bayer Ag | Substituierte phenylsulfonamide |
US5212182A (en) * | 1990-10-03 | 1993-05-18 | American Home Products Corpooration | Substituted quinolinyl- and naphthalenylbenzamides or benzylamines and related compounds useful as analgesics |
US5574042A (en) * | 1992-11-02 | 1996-11-12 | Fujisawa Pharmaceutical Co., Ltd | Imidazo [1,2-a] pyridines and their pharmaceutical use |
AU686115B2 (en) * | 1992-11-02 | 1998-02-05 | Fujisawa Pharmaceutical Co., Ltd. | Imidazo (I,2-a) pyridine derivatives as bradykinin antagonists, pharmaceuticals and processes for their preparation |
AU680870B2 (en) * | 1993-04-28 | 1997-08-14 | Astellas Pharma Inc. | New heterocyclic compounds |
ES2218554T3 (es) * | 1994-10-27 | 2004-11-16 | Fujisawa Pharmaceutical Co., Ltd. | Piridopirimidonas, quinolinas y n-heterociclos condensados que son antagonistas de bradiquinina. |
GB9519077D0 (en) * | 1995-09-18 | 1995-11-15 | Fujisawa Pharmaceutical Co | New heterocyclic compounds |
-
1996
- 1996-04-29 AU AUPN9526A patent/AUPN952696A0/en not_active Abandoned
-
1997
- 1997-04-24 ES ES97919665T patent/ES2189956T3/es not_active Expired - Lifetime
- 1997-04-24 JP JP9538734A patent/JP2000509066A/ja not_active Ceased
- 1997-04-24 US US09/147,193 patent/US6083959A/en not_active Expired - Fee Related
- 1997-04-24 EP EP97919665A patent/EP0900203B1/de not_active Expired - Lifetime
- 1997-04-24 WO PCT/JP1997/001415 patent/WO1997041104A1/en active IP Right Grant
- 1997-04-24 AT AT97919665T patent/ATE234818T1/de not_active IP Right Cessation
- 1997-04-24 DE DE69719974T patent/DE69719974T2/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ATE234818T1 (de) | 2003-04-15 |
US6083959A (en) | 2000-07-04 |
AUPN952696A0 (en) | 1996-05-23 |
EP0900203A1 (de) | 1999-03-10 |
JP2000509066A (ja) | 2000-07-18 |
DE69719974T2 (de) | 2003-08-28 |
ES2189956T3 (es) | 2003-07-16 |
EP0900203B1 (de) | 2003-03-19 |
WO1997041104A1 (en) | 1997-11-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR960701055A (ko) | 인터로이킨-1 및 종양 괴사 인자 억제 활성을 지닌 피라졸로트리아진 (pyrazol itriazines with interleukin-1 and tumour necrosis factor in-hibitory actvity) | |
DE69723869D1 (de) | Heterozyklische verbindungen, verfahren zu ihrer herstellung, pharmazeutische zusammensetzungen die diese enthalten und ihre anwendung in der behandlung von diabetis und verwandten krankheiten | |
ES2176204T3 (es) | Antidepresivos que contienen un derivado de xantina. | |
BR9610960A (pt) | Derivados de 8-azabiciclo [3.2.1] oct -2- eno sua preparação e uso | |
DE69607650T2 (de) | 2,3,5-trimethyl-hydroxyanilid-derivative, ihre herstellung und ihre theraoeutische verwendung | |
DE50011034D1 (de) | N-substituierte 4-aminopteridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel | |
DE69719974T2 (de) | Chinolinderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel | |
UY24802A1 (es) | Nuevos compuestos | |
DE69724098D1 (de) | Chinolin- und benzimidazolderivate als bradykinin agonisten | |
DE68905283T2 (de) | Alpha,Alpha disubstituierte N-Cycloalkylalkyl-Benzylamine, Verfahren zu ihrer Herstellung, ihre Anwendung als Arzneimittel und ihre Zwischenprodukte bei der Herstellung. | |
DE69719511T2 (de) | Antivirale 2,4-pyrimidindion-derivate und verfahren zu ihrer herstellung | |
ATE225335T1 (de) | Amide derivate als 5-ht1a liganden | |
ES2124413T3 (es) | Derivados de piridazinona con actividad farmaceutica. | |
ES2016017A6 (es) | Procedimiento para preparar derivados de acido 1,1-dioxocefem-4-carbotiolico. | |
ATE191465T1 (de) | Carbamoylcarbonsäureamide | |
DE69943259D1 (de) | Neue 2-Halogen-Derivate von 5-O-Desosaminylerythronolid A, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel | |
DE69707504D1 (de) | Diphenylalkyl-tetrahydropyridine, verfahren zu ihren herstellung und diese enthaltende arzneimittel | |
DE3481059D1 (de) | Neue 11-piperazinyl-5h-imidazo(2,1-c)(1,4)benzodiazepine, verfahren zu ihrer herstellung und zwischenprodukte und erstere enthaltende arzneimittel. | |
ZA941334B (en) | Amide derivative . | |
DE3762341D1 (de) | Chinolinderivate, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel und diese enthaltende zubereitungen. | |
DE59610387D1 (de) | Phenanthridinderivate, verfahren zu ihrer herstellung und arzneimittel, enthaltend phenanthridinderivate | |
ES2088320T3 (es) | Derivados de carboestirilo. | |
KR950011417A (ko) | 아미드기를 가지는 n-치환된 벤즈아미다졸 유도체 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8327 | Change in the person/name/address of the patent owner |
Owner name: ASTELLAS PHARMA INC., TOKIO/TOKYO, JP |