DE69719511T2 - Antivirale 2,4-pyrimidindion-derivate und verfahren zu ihrer herstellung - Google Patents
Antivirale 2,4-pyrimidindion-derivate und verfahren zu ihrer herstellungInfo
- Publication number
- DE69719511T2 DE69719511T2 DE69719511T DE69719511T DE69719511T2 DE 69719511 T2 DE69719511 T2 DE 69719511T2 DE 69719511 T DE69719511 T DE 69719511T DE 69719511 T DE69719511 T DE 69719511T DE 69719511 T2 DE69719511 T2 DE 69719511T2
- Authority
- DE
- Germany
- Prior art keywords
- pct
- hydrogen
- alkyl group
- derivatives
- date nov
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR19960016413 | 1996-05-16 | ||
KR1019970013560A KR100219922B1 (ko) | 1996-05-16 | 1997-04-14 | 신규한 항바이러스성 6-아릴옥시 및 6-아릴카르보닐 2,4-피리미딘디온 유도체 및 그의 제조 방법 |
PCT/KR1997/000084 WO1997043266A1 (en) | 1996-05-16 | 1997-05-15 | Antiviral 2,4-pyrimidinedione derivatives and process for the preparation thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69719511D1 DE69719511D1 (de) | 2003-04-10 |
DE69719511T2 true DE69719511T2 (de) | 2003-10-02 |
Family
ID=26631836
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69719511T Expired - Fee Related DE69719511T2 (de) | 1996-05-16 | 1997-05-15 | Antivirale 2,4-pyrimidindion-derivate und verfahren zu ihrer herstellung |
Country Status (8)
Country | Link |
---|---|
US (1) | US6136815A (de) |
EP (1) | EP0912526B1 (de) |
JP (1) | JP3078333B2 (de) |
KR (1) | KR100219922B1 (de) |
AT (1) | ATE233741T1 (de) |
AU (1) | AU2713897A (de) |
DE (1) | DE69719511T2 (de) |
WO (1) | WO1997043266A1 (de) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100390096B1 (ko) * | 1998-03-10 | 2003-08-19 | 한국화학연구원 | 알파-치환된아릴메틸렌기로씨-6위치가치환된신규한항바이러스성2,4-피리미딘디온유도체및이의제조방법 |
NZ511116A (en) * | 1998-11-10 | 2003-08-29 | Janssen Pharmaceutica Nv | HIV replication inhibiting pyrimidines |
EP1159271B1 (de) * | 1999-03-04 | 2004-08-25 | Korea Research Institute of Chemical Technology | Anivirale 2,4-pyrimidindion-derivate und ein verfahren zu ihrer herstellung |
KR100311949B1 (ko) * | 1999-03-10 | 2001-11-02 | 최승주 | 1-[(사이클로펜트-3-엔-1-일)메틸]-5-에틸-6-(3,5-다이메틸벤조일)-2,4-피리미딘다이온의제조방법 |
KR20000065885A (ko) * | 1999-04-10 | 2000-11-15 | 최승주 | 항바이러스성 피리미딘다이온 유도체 및 그 제조방법 |
US6545007B2 (en) | 2000-11-17 | 2003-04-08 | Idenix (Cayman) Limited | Methods for inhibiting the transmission of HIV using topically applied substituted 6-benzyl-4-oxopyrimidines |
WO2008016522A2 (en) * | 2006-07-24 | 2008-02-07 | Gilead Sciences, Inc. | Hiv reverse transcriptase inhibitors |
US8354421B2 (en) * | 2007-06-29 | 2013-01-15 | Korea Research Insitute Of Chemical Technology | HIV reverse transcriptase inhibitors |
MX2009013804A (es) * | 2007-06-29 | 2010-02-03 | Korea Res Inst Chem Tech | Inhibidores novedosos de transcriptasa inversa de vih. |
WO2009085797A1 (en) * | 2007-12-21 | 2009-07-09 | Gilead Sciences, Inc. | Processes for preparing hiv reverse transcriptase inhibitors |
CN104119283B (zh) * | 2013-04-24 | 2016-06-22 | 北京大学 | Hiv逆转录酶/整合酶双靶点抑制剂6-苯甲酰基取代尿嘧啶类化合物的制备及应用 |
US10117871B2 (en) | 2015-03-03 | 2018-11-06 | Regents Of The University Of Minnesota | 3-hydroxypyrimidine-2,4-dione-5-carboxamides as potent inhibitors of HIV |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA892407B (en) * | 1988-03-31 | 1989-11-29 | Mitsubishi Chem Ind | 6-substituted acyclopyrimidine nucleoside derivative and antiviral agent containing the same as active ingredient thereof |
KR0155168B1 (ko) * | 1989-09-29 | 1998-11-16 | 미우라 아끼라 | 6-치환된 아시클로피리미딘 뉴클레오시드 유도체 및 이를 활성성분으로 함유하는 항비루스제 |
FR2652547B1 (fr) * | 1989-09-29 | 1995-06-02 | Valeo | Timonerie de transmission de forces pour vehicules automobiles. |
ATE180785T1 (de) * | 1992-03-12 | 1999-06-15 | Smithkline Beecham Plc | Kondensierte indol-derivate als 5-ht4-rezeptor- antagonisten |
KR0151811B1 (ko) * | 1993-12-21 | 1998-10-15 | 강박광 | 신규한 항바이러스성 2,4-피리미딘디온 유도체 및 그의 제조방법 |
-
1997
- 1997-04-14 KR KR1019970013560A patent/KR100219922B1/ko not_active IP Right Cessation
- 1997-05-15 WO PCT/KR1997/000084 patent/WO1997043266A1/en active IP Right Grant
- 1997-05-15 DE DE69719511T patent/DE69719511T2/de not_active Expired - Fee Related
- 1997-05-15 AU AU27138/97A patent/AU2713897A/en not_active Abandoned
- 1997-05-15 EP EP97920976A patent/EP0912526B1/de not_active Expired - Lifetime
- 1997-05-15 JP JP09540756A patent/JP3078333B2/ja not_active Expired - Fee Related
- 1997-05-15 AT AT97920976T patent/ATE233741T1/de not_active IP Right Cessation
- 1997-05-15 US US09/180,490 patent/US6136815A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JPH11513996A (ja) | 1999-11-30 |
DE69719511D1 (de) | 2003-04-10 |
EP0912526B1 (de) | 2003-03-05 |
ATE233741T1 (de) | 2003-03-15 |
US6136815A (en) | 2000-10-24 |
EP0912526A1 (de) | 1999-05-06 |
JP3078333B2 (ja) | 2000-08-21 |
KR970074773A (ko) | 1997-12-10 |
AU2713897A (en) | 1997-12-05 |
WO1997043266A1 (en) | 1997-11-20 |
KR100219922B1 (ko) | 1999-09-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |