DE69719511D1 - Antivirale 2,4-pyrimidindion-derivate und verfahren zu ihrer herstellung - Google Patents

Antivirale 2,4-pyrimidindion-derivate und verfahren zu ihrer herstellung

Info

Publication number
DE69719511D1
DE69719511D1 DE69719511T DE69719511T DE69719511D1 DE 69719511 D1 DE69719511 D1 DE 69719511D1 DE 69719511 T DE69719511 T DE 69719511T DE 69719511 T DE69719511 T DE 69719511T DE 69719511 D1 DE69719511 D1 DE 69719511D1
Authority
DE
Germany
Prior art keywords
pct
hydrogen
alkyl group
derivatives
date nov
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69719511T
Other languages
English (en)
Other versions
DE69719511T2 (de
Inventor
Chan Son
Young Lee
Sook Kim
Chel Kim
Hwan Cho
Gan Chung
Young Kim
Hwan Lee
Seok Kwon
Weung Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Korea Research Institute of Chemical Technology KRICT
Samjin Pharmaceutical Co Ltd
Original Assignee
Korea Research Institute of Chemical Technology KRICT
Samjin Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Korea Research Institute of Chemical Technology KRICT, Samjin Pharmaceutical Co Ltd filed Critical Korea Research Institute of Chemical Technology KRICT
Application granted granted Critical
Publication of DE69719511D1 publication Critical patent/DE69719511D1/de
Publication of DE69719511T2 publication Critical patent/DE69719511T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69719511T 1996-05-16 1997-05-15 Antivirale 2,4-pyrimidindion-derivate und verfahren zu ihrer herstellung Expired - Fee Related DE69719511T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR19960016413 1996-05-16
KR1019970013560A KR100219922B1 (ko) 1996-05-16 1997-04-14 신규한 항바이러스성 6-아릴옥시 및 6-아릴카르보닐 2,4-피리미딘디온 유도체 및 그의 제조 방법
PCT/KR1997/000084 WO1997043266A1 (en) 1996-05-16 1997-05-15 Antiviral 2,4-pyrimidinedione derivatives and process for the preparation thereof

Publications (2)

Publication Number Publication Date
DE69719511D1 true DE69719511D1 (de) 2003-04-10
DE69719511T2 DE69719511T2 (de) 2003-10-02

Family

ID=26631836

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69719511T Expired - Fee Related DE69719511T2 (de) 1996-05-16 1997-05-15 Antivirale 2,4-pyrimidindion-derivate und verfahren zu ihrer herstellung

Country Status (8)

Country Link
US (1) US6136815A (de)
EP (1) EP0912526B1 (de)
JP (1) JP3078333B2 (de)
KR (1) KR100219922B1 (de)
AT (1) ATE233741T1 (de)
AU (1) AU2713897A (de)
DE (1) DE69719511T2 (de)
WO (1) WO1997043266A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100390096B1 (ko) * 1998-03-10 2003-08-19 한국화학연구원 알파-치환된아릴메틸렌기로씨-6위치가치환된신규한항바이러스성2,4-피리미딘디온유도체및이의제조방법
KR100658489B1 (ko) * 1998-11-10 2006-12-18 얀센 파마슈티카 엔.브이. Ｈｉｖ 복제를 억제하는 피리미딘
US6713486B1 (en) * 1999-03-04 2004-03-30 Korea Research Institute Of Chemical Technology Antiviral 2,4-pyrimidinedione derivatives and process for the preparation thereof
KR100311949B1 (ko) * 1999-03-10 2001-11-02 최승주 1-[(사이클로펜트-3-엔-1-일)메틸]-5-에틸-6-(3,5-다이메틸벤조일)-2,4-피리미딘다이온의제조방법
KR20000065885A (ko) * 1999-04-10 2000-11-15 최승주 항바이러스성 피리미딘다이온 유도체 및 그 제조방법
US6545007B2 (en) 2000-11-17 2003-04-08 Idenix (Cayman) Limited Methods for inhibiting the transmission of HIV using topically applied substituted 6-benzyl-4-oxopyrimidines
EP2044037A2 (de) * 2006-07-24 2009-04-08 Gilead Sciences, Inc. Hemmer reverser hiv-transkriptase
AR067181A1 (es) * 2007-06-29 2009-09-30 Gilead Sciences Inc Inhibidores de transcriptasa inversa de hiv, composicion farmaceutica, uso del compuesto para preparar un medicamento, agente de combinacion farmaceutica y metodo de inhibicion de la replicacion de un retrovirus
US8354421B2 (en) * 2007-06-29 2013-01-15 Korea Research Insitute Of Chemical Technology HIV reverse transcriptase inhibitors
US8119800B2 (en) * 2007-12-21 2012-02-21 Korea Research Institute Of Chemical Technology Processes for preparing HIV reverse transcriptase inhibitors
CN104119283B (zh) * 2013-04-24 2016-06-22 北京大学 Hiv逆转录酶/整合酶双靶点抑制剂6-苯甲酰基取代尿嘧啶类化合物的制备及应用
US10117871B2 (en) 2015-03-03 2018-11-06 Regents Of The University Of Minnesota 3-hydroxypyrimidine-2,4-dione-5-carboxamides as potent inhibitors of HIV

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD283613A5 (de) * 1988-03-31 1990-10-17 ��@���������@�������k�� Verfahren zur herstellung von in 6-stellung substituierte acyclopyrimidin-nucleosid-derivaten
FR2652547B1 (fr) * 1989-09-29 1995-06-02 Valeo Timonerie de transmission de forces pour vehicules automobiles.
KR0155168B1 (ko) * 1989-09-29 1998-11-16 미우라 아끼라 6-치환된 아시클로피리미딘 뉴클레오시드 유도체 및 이를 활성성분으로 함유하는 항비루스제
EP0884319B1 (de) * 1992-03-12 2004-05-06 SmithKline Beecham plc N- (1-nButyl-4-piperidyl)methyl -3,4-dihydro-2H- 1,3 oxazino 3,2-a indol-10-carboxamid oder ein pharmazeutisch annehmbares Salz davon
KR0151811B1 (ko) * 1993-12-21 1998-10-15 강박광 신규한 항바이러스성 2,4-피리미딘디온 유도체 및 그의 제조방법

Also Published As

Publication number Publication date
DE69719511T2 (de) 2003-10-02
JP3078333B2 (ja) 2000-08-21
KR970074773A (ko) 1997-12-10
KR100219922B1 (ko) 1999-09-01
ATE233741T1 (de) 2003-03-15
US6136815A (en) 2000-10-24
WO1997043266A1 (en) 1997-11-20
AU2713897A (en) 1997-12-05
EP0912526A1 (de) 1999-05-06
EP0912526B1 (de) 2003-03-05
JPH11513996A (ja) 1999-11-30

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee