DE69614841D1 - Verfahren zur Herstellung von Galanthaminderivate durch asymmetrische Reduktion - Google Patents

Verfahren zur Herstellung von Galanthaminderivate durch asymmetrische Reduktion

Info

Publication number
DE69614841D1
DE69614841D1 DE69614841T DE69614841T DE69614841D1 DE 69614841 D1 DE69614841 D1 DE 69614841D1 DE 69614841 T DE69614841 T DE 69614841T DE 69614841 T DE69614841 T DE 69614841T DE 69614841 D1 DE69614841 D1 DE 69614841D1
Authority
DE
Germany
Prior art keywords
pct
preparation
asymmetric reduction
sec
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69614841T
Other languages
English (en)
Other versions
DE69614841T2 (de
Inventor
Conrad Dyer
Marie Paul
Raymond Mccague
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9507100.7A external-priority patent/GB9507100D0/en
Priority claimed from GBGB9601227.3A external-priority patent/GB9601227D0/en
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of DE69614841D1 publication Critical patent/DE69614841D1/de
Application granted granted Critical
Publication of DE69614841T2 publication Critical patent/DE69614841T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69614841T 1995-04-06 1996-04-04 Verfahren zur Herstellung von Galanthaminderivate durch asymmetrische Reduktion Expired - Lifetime DE69614841T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9507100.7A GB9507100D0 (en) 1995-04-06 1995-04-06 Asymmetric reduction and products thereof
GBGB9601227.3A GB9601227D0 (en) 1996-01-22 1996-01-22 Reduction
PCT/GB1996/000843 WO1996031453A1 (en) 1995-04-06 1996-04-04 Process for preparing galanthamine derivatives by asymmetric reduction

Publications (2)

Publication Number Publication Date
DE69614841D1 true DE69614841D1 (de) 2001-10-04
DE69614841T2 DE69614841T2 (de) 2002-04-11

Family

ID=26306827

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69614841T Expired - Lifetime DE69614841T2 (de) 1995-04-06 1996-04-04 Verfahren zur Herstellung von Galanthaminderivate durch asymmetrische Reduktion

Country Status (12)

Country Link
US (1) US6018043A (de)
EP (1) EP0819108B1 (de)
AT (1) ATE204840T1 (de)
AU (1) AU709080B2 (de)
CA (1) CA2215518C (de)
CY (1) CY2257B1 (de)
DE (1) DE69614841T2 (de)
DK (1) DK0819108T3 (de)
ES (1) ES2162042T3 (de)
PT (1) PT819108E (de)
TW (1) TW448177B (de)
WO (1) WO1996031453A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9506843D0 (en) * 1995-04-03 1995-05-24 Chiroscience Ltd Oxidative process and products thereof
CN1875004B (zh) * 2003-09-26 2010-06-23 台湾神隆股份有限公司 那维啶酰胺衍生物的拆分
CA2552114A1 (en) * 2003-12-31 2005-07-21 Actavis Group Hf Solid dosage formulations of galantamine
US20050191349A1 (en) * 2003-12-31 2005-09-01 Garth Boehm Galantamine formulations
PL1895994T3 (pl) * 2005-05-13 2011-02-28 Alza Corp Wielowarstwowy system podawania leków z barierą zabezpieczającą przed wypływaniem materiału ze zbiornika
WO2007035941A2 (en) * 2005-09-23 2007-03-29 Alza Corporation Transdermal galantamine delivery system
CN100364995C (zh) * 2006-01-12 2008-01-30 兰州大学 加兰它敏制备方法
EP2009015B1 (de) 2007-06-18 2012-01-11 Aurobindo Pharma Limited Herstellungsprozess für Galantaminhydrobromid
AT507039A1 (de) * 2008-06-26 2010-01-15 Sanochemia Pharmazeutika Ag Verfahren zum herstellen von hochreinen benzazepinderivaten
CN102180886B (zh) * 2011-03-05 2015-01-21 兰州大学 加兰他敏不对称催化合成方法

Also Published As

Publication number Publication date
PT819108E (pt) 2002-02-28
AU709080B2 (en) 1999-08-19
AU5281996A (en) 1996-10-23
CY2257B1 (en) 2003-07-04
DK0819108T3 (da) 2001-11-26
ATE204840T1 (de) 2001-09-15
DE69614841T2 (de) 2002-04-11
ES2162042T3 (es) 2001-12-16
WO1996031453A1 (en) 1996-10-10
CA2215518A1 (en) 1996-10-10
CA2215518C (en) 2006-11-28
US6018043A (en) 2000-01-25
EP0819108A1 (de) 1998-01-21
TW448177B (en) 2001-08-01
EP0819108B1 (de) 2001-08-29

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition