DK312986A - Isoxazol- eller furanforbindelse og fremgangsmaade til fremstillig deraf - Google Patents

Isoxazol- eller furanforbindelse og fremgangsmaade til fremstillig deraf Download PDF

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Publication number
DK312986A
DK312986A DK312986A DK312986A DK312986A DK 312986 A DK312986 A DK 312986A DK 312986 A DK312986 A DK 312986A DK 312986 A DK312986 A DK 312986A DK 312986 A DK312986 A DK 312986A
Authority
DK
Denmark
Prior art keywords
isoxazole
furan
procedures
relation
producing
Prior art date
Application number
DK312986A
Other languages
English (en)
Other versions
DK171275B1 (da
DK312986D0 (da
Inventor
Guy Dominic Diana
Philip Michael Carabateas
Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc
Publication of DK312986D0 publication Critical patent/DK312986D0/da
Publication of DK312986A publication Critical patent/DK312986A/da
Application granted granted Critical
Publication of DK171275B1 publication Critical patent/DK171275B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
DK312986A 1985-07-02 1986-07-01 Isoxazol- og furanderivater, fremgangsmåde til fremstilling heraf og antivirale præparater indeholdende disse. DK171275B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75134885A 1985-07-02 1985-07-02
US75134885 1985-07-02

Publications (3)

Publication Number Publication Date
DK312986D0 DK312986D0 (da) 1986-07-01
DK312986A true DK312986A (da) 1987-01-03
DK171275B1 DK171275B1 (da) 1996-08-19

Family

ID=25021592

Family Applications (2)

Application Number Title Priority Date Filing Date
DK198603130A DK173467B1 (da) 1985-07-02 1986-07-01 Phenoxyalkylisoxazol- eller -furanforbindelse, fremgangsmåde til fremstilling deraf og antivirale farmaceutiske præparater
DK312986A DK171275B1 (da) 1985-07-02 1986-07-01 Isoxazol- og furanderivater, fremgangsmåde til fremstilling heraf og antivirale præparater indeholdende disse.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK198603130A DK173467B1 (da) 1985-07-02 1986-07-01 Phenoxyalkylisoxazol- eller -furanforbindelse, fremgangsmåde til fremstilling deraf og antivirale farmaceutiske præparater

Country Status (21)

Country Link
EP (2) EP0207454B1 (da)
JP (2) JPH0819128B2 (da)
KR (2) KR900001314B1 (da)
AR (4) AR241705A1 (da)
AT (2) ATE80397T1 (da)
AU (2) AU589190B2 (da)
CA (2) CA1280753C (da)
DE (3) DE3686677T2 (da)
DK (2) DK173467B1 (da)
ES (5) ES8802517A1 (da)
FI (2) FI862795A (da)
GR (2) GR861695B (da)
IE (2) IE59755B1 (da)
IL (2) IL79309A (da)
MX (4) MX2954A (da)
MY (1) MY102908A (da)
NO (2) NO165023C (da)
NZ (1) NZ216678A (da)
PH (2) PH23197A (da)
PT (2) PT82891B (da)
ZA (2) ZA864873B (da)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1280753C (en) * 1985-07-02 1991-02-26 Philip Michael Carabateas Process for preparing heterocyclic substituted- phenoxyalkyl isoxazoles and-furans
IE59813B1 (en) * 1986-05-09 1994-04-06 Warner Lambert Co Styryl pyrazoles, isoxazoles and analogs thereof having activity as 5-lipoxy-genase inhibitors and pharmaceutical compositions containing them
US5051437A (en) * 1986-06-24 1991-09-24 Sterling Drug Inc. Thiazolylphenoxyalkylisoxazoles, related compounds, and their use as antiviral agents
GB8807275D0 (en) * 1988-03-26 1988-04-27 Synphar Lab Inc Chemical compounds
US6051231A (en) * 1988-09-01 2000-04-18 Bayer Corporation Antiviral methods and prepations
EP0362531B1 (en) 1988-09-01 1999-11-10 Bayer Corporation A human rhinovirus receptor protein that inhibits virus infectivity
ZA896668B (en) * 1988-09-01 1990-06-27 Molecular Therapeutics Inc A human rhinovirus receptor protein that inhibits virus infectivity
US6143298A (en) * 1988-09-01 2000-11-07 Bayer Corporation Soluble truncated forms of ICAM-1
US6514936B1 (en) 1988-09-01 2003-02-04 Bayer Corporation Antiviral methods using human rhinovirus receptor (ICAM-1)
US5070090A (en) * 1989-05-15 1991-12-03 Janssen Pharmaceutica N.V. Antipicorpaviral herterocyclic-substituted morpholinyl alkylphenol ethers
GB8911158D0 (en) * 1989-05-16 1989-07-05 Janssen Pharmaceutica Nv Antiviral pyridazinamines
US5175178A (en) * 1989-08-21 1992-12-29 Sterling Drug Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US4945164A (en) * 1989-08-18 1990-07-31 Sterling Drug Inc. 1,3,4-Oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents and intermediates thereof
US4942241A (en) * 1989-08-21 1990-07-17 Sterling Drug Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US5110821A (en) * 1989-08-18 1992-05-05 Sterling Drug Inc. 1,3,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
NZ234760A (en) * 1989-08-18 1991-09-25 Sterling Drug Inc Antiviral oxazole compounds and compositions
US5871733A (en) * 1990-07-20 1999-02-16 Bayer Corporation Multimeric forms of human rhinovirus receptor protein
US6107461A (en) * 1990-07-20 2000-08-22 Bayer Corporation Multimeric forms of human rhinovirus receptor and fragments thereof, and method of use
US5686581A (en) * 1990-07-20 1997-11-11 Bayer Corporation Multimeric form of human rhinovirus receptor protein
ES2134762T3 (es) * 1990-07-20 1999-10-16 Bayer Ag Formas multimericas de proteinas receptoras de rinovirus humanos.
IT1247509B (it) * 1991-04-19 1994-12-17 Univ Cagliari Composti di sintesi atti all'impiego nella terapia delle infezioni da rhinovirus
US5175177A (en) * 1991-07-17 1992-12-29 Sterling Drug Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US5349068A (en) * 1992-04-15 1994-09-20 Sterling Winthrop Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US5514781A (en) * 1994-04-11 1996-05-07 Bayer Corporation Use of azoles as virucidal agents in solutions of biologically active proteins
US5514679A (en) * 1994-05-13 1996-05-07 Sterling Winthrop Inc. Therapeutic phenoxyalklpyridazines and intermediates therefor
US5453433A (en) * 1994-05-13 1995-09-26 Sterling Winthrop Inc. Thiadiazoles and antipicornaviral compositions
KR100796093B1 (ko) 2003-07-02 2008-01-21 에프. 호프만-라 로슈 아게 티아졸 고리로 치환된 인돌릴 유도체 및 ｐｐａｒ조절제로서 그의 용도
EP1866293A1 (en) 2005-03-31 2007-12-19 UCB Pharma, S.A. Compounds comprising an oxazole or thiazole moiety, processes for making them, and their uses
US8993604B2 (en) 2009-06-30 2015-03-31 Siga Technologies, Inc. Treatment and prevention of dengue virus infections
EP2448410A4 (en) * 2009-06-30 2013-12-18 Siga Technologies Inc TREATMENT AND PREVENTION OF INFECTIONS WITH THE DENGUE VIRUS

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4451476A (en) * 1982-12-13 1984-05-29 Sterling Drug Inc. Isoxazoles as antiviral agents
NZ209209A (en) * 1983-08-29 1988-02-12 Sterling Drug Inc Substituted phenyl-aliphatic isoxazole derivatives and pharmaceutical compositions
CA1280753C (en) * 1985-07-02 1991-02-26 Philip Michael Carabateas Process for preparing heterocyclic substituted- phenoxyalkyl isoxazoles and-furans

Also Published As

Publication number Publication date
DE3689924T2 (de) 1995-01-19
JPH0768242B2 (ja) 1995-07-26
IL79308A0 (en) 1986-10-31
EP0207453A3 (en) 1988-11-23
EP0207453B1 (en) 1994-06-22
DE3689924T4 (de) 1995-05-11
NO164977B (no) 1990-08-27
IE59755B1 (en) 1994-03-23
IL79308A (en) 1991-01-31
ATE80397T1 (de) 1992-09-15
DK313086A (da) 1987-01-03
EP0207453A2 (en) 1987-01-07
ES8801651A1 (es) 1988-02-16
DK313086D0 (da) 1986-07-01
KR870001202A (ko) 1987-03-12
IE66234B1 (en) 1995-12-13
NO862650D0 (no) 1986-07-01
KR900001315B1 (ko) 1990-03-08
IE861723L (en) 1987-01-02
KR870001205A (ko) 1987-03-12
EP0207454B1 (en) 1992-09-09
MX9100033A (es) 1993-01-01
JPH0819128B2 (ja) 1996-02-28
ES8802518A1 (es) 1988-07-01
DE3686677D1 (de) 1992-10-15
FI85021C (fi) 1992-02-25
IL79309A0 (en) 1986-10-31
PT82892B (pt) 1994-09-30
CA1299176C (en) 1992-04-21
IE861724L (en) 1987-01-02
ES557780A0 (es) 1988-02-16
ES556811A0 (es) 1988-07-01
IL79309A (en) 1990-11-29
EP0207454A3 (en) 1988-08-10
AU589190B2 (en) 1989-10-05
ATE107645T1 (de) 1994-07-15
FI862794A (fi) 1987-01-03
AR241705A1 (es) 1992-11-30
AU587622B2 (en) 1989-08-24
ZA864873B (en) 1987-02-25
DK171275B1 (da) 1996-08-19
ES556812A0 (es) 1988-07-01
FI862795A (fi) 1987-01-03
MY102908A (en) 1993-03-31
ES557778A0 (es) 1988-04-01
DE3689924D1 (de) 1994-07-28
MX9100029A (es) 1993-01-01
JPS6216480A (ja) 1987-01-24
GR861695B (en) 1986-11-04
MX9100032A (es) 1993-01-01
AU5945786A (en) 1987-01-08
FI85021B (fi) 1991-11-15
GR861697B (en) 1986-11-04
PH23197A (en) 1989-05-29
PT82891B (pt) 1988-05-27
AR244686A1 (es) 1993-11-30
NO862650L (no) 1987-01-05
PT82891A (en) 1986-08-01
ES8802517A1 (es) 1988-07-01
NO862651D0 (no) 1986-07-01
PT82892A (pt) 1987-01-26
AU5945686A (en) 1987-01-08
NO165023B (no) 1990-09-03
DE3686677T2 (de) 1993-03-11
KR900001314B1 (ko) 1990-03-08
PH22321A (en) 1988-07-29
EP0207454A2 (en) 1987-01-07
NZ216678A (en) 1989-10-27
MX2954A (es) 1993-11-01
NO165023C (no) 1990-12-12
AR242573A1 (es) 1993-04-30
ES8801649A1 (es) 1988-02-16
ZA864872B (en) 1987-02-25
CA1280753C (en) 1991-02-26
NO164977C (no) 1990-12-05
AR242572A1 (es) 1993-04-30
DK312986D0 (da) 1986-07-01
FI862795A0 (fi) 1986-07-01
JPS6216479A (ja) 1987-01-24
ES8802153A1 (es) 1988-04-01
FI862794A0 (fi) 1986-07-01
DK173467B1 (da) 2000-12-04
NO862651L (no) 1987-01-05
ES557779A0 (es) 1988-02-16

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