PE25698A1 - Procedimientos e intermedios para preparar 1-bencil-4-((5,6-dimetoxi-1-indanon)-2-il)metilpiperidina - Google Patents
Procedimientos e intermedios para preparar 1-bencil-4-((5,6-dimetoxi-1-indanon)-2-il)metilpiperidinaInfo
- Publication number
- PE25698A1 PE25698A1 PE1996000883A PE00088396A PE25698A1 PE 25698 A1 PE25698 A1 PE 25698A1 PE 1996000883 A PE1996000883 A PE 1996000883A PE 00088396 A PE00088396 A PE 00088396A PE 25698 A1 PE25698 A1 PE 25698A1
- Authority
- PE
- Peru
- Prior art keywords
- compound
- react
- iii
- alkyl
- bencil
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIEREN A LOS COMPUESTOS INTERMEDIOS DE FORMULAS (I), (II) Y (III), EN DONDE: R1 ES R2O(CO) o R3(CO); R2 ES ALQUILO C1-C4; R3 ES ALQUILO C1-C4 O FENILO CON OPCIONALMENTE 1; 2 o 3 SUSTITUYENTES ALQUILO C1-C4, ALCOXI C1-C4, HALO o CF3. TAMBIEN SE REFIEREN A LOS PROCEDIMIENTOS DE PREPARACION QUE COMPRENDE: 1) HACER REACCIONAR UN COMPUESTO (IV) CON (V) EN PRESENCIA DE AlCl3 Y CLORURO DE METILENO, PARA FORMAR (III); 2) HACER REACCIONAR (III) CON UN AGENTE DE METENILACION, PARA FORMAR (II); 3) HACER REACCIONAR (II) CON H2SO4; 3) AISLAR MEDIANTE LA ADICION DE SOLUCION FUERTEMENTE ACIDA A HIELO/AGUA, SEGUIDA POR EXTRACCION CON UN DISOLVENTE ORGANICO Y ELIMINACION DEL DISOLVENTE ORGANICO ANTES DE QUE SE TRATE CON UNA BASE; 4) HACER REACCIONAR (I) CON HIDROXIDO, PARA FORMAR (VI) EN DONDE: (VI) ES EL COMPUESTO (I) EN EL QUE R1 ES H, Y HACER REACCIONAR DICHO COMPUESTO CON UN HALURO DE BENCILO, PARA FORMAR UN COMPUESTO FINAL ANTICOLINESTERASA DE FORMULA (VII), EN DONDE: (VII) ES (I) EN EL QUE R1 ES BENCILO. EL COMPUESTO OBTENIDO ES USADO PARA EL TRATAMIENTO DE LA DEMENCIA SENIL, PARTICULARMENTE DEL TIPO ALZHEIMER Y DE LA ENFERMEDAD CEREBROVASCULAR QUE ACOMPANA A LA APOPLEJIA CEREBRAL
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US875395P | 1995-12-15 | 1995-12-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE25698A1 true PE25698A1 (es) | 1998-05-21 |
Family
ID=21733469
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1996000883A PE25698A1 (es) | 1995-12-15 | 1996-12-09 | Procedimientos e intermedios para preparar 1-bencil-4-((5,6-dimetoxi-1-indanon)-2-il)metilpiperidina |
Country Status (33)
| Country | Link |
|---|---|
| EP (1) | EP0883607A1 (es) |
| JP (1) | JP3066083B2 (es) |
| KR (1) | KR20000064387A (es) |
| AP (1) | AP708A (es) |
| AR (1) | AR004368A1 (es) |
| AU (1) | AU716462B2 (es) |
| BG (1) | BG102525A (es) |
| BR (1) | BR9612018A (es) |
| CA (1) | CA2237647A1 (es) |
| CO (1) | CO4750831A1 (es) |
| CZ (1) | CZ180898A3 (es) |
| DZ (1) | DZ2141A1 (es) |
| GT (1) | GT199600092A (es) |
| HN (1) | HN1996000065A (es) |
| HR (1) | HRP960592A2 (es) |
| HU (1) | HUP9904275A3 (es) |
| IL (3) | IL136421A0 (es) |
| IS (1) | IS4752A (es) |
| MA (1) | MA24032A1 (es) |
| NO (1) | NO982712L (es) |
| NZ (1) | NZ318843A (es) |
| OA (1) | OA10694A (es) |
| PE (1) | PE25698A1 (es) |
| PL (1) | PL197306B1 (es) |
| RO (1) | RO121382B1 (es) |
| RU (1) | RU2160731C2 (es) |
| SK (1) | SK75498A3 (es) |
| TN (1) | TNSN96153A1 (es) |
| TW (1) | TW414787B (es) |
| UY (1) | UY24401A1 (es) |
| WO (1) | WO1997022584A1 (es) |
| YU (1) | YU49486B (es) |
| ZA (1) | ZA9610533B (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1047674B1 (en) | 1998-01-16 | 2005-03-30 | Eisai Co., Ltd. | Process for production of donepezil derivatives |
| IL125809A (en) | 1998-08-17 | 2005-08-31 | Finetech Lab Ltd | Process and intermediates for production of donepezil and related compounds |
| US7148354B2 (en) * | 2002-07-24 | 2006-12-12 | Dr. Reddy's Laboratories Limited | Process for preparation of donepezil |
| IL150982A (en) | 2002-07-30 | 2007-02-11 | Ori Lerman | Process for making Donafzil |
| IL151253A0 (en) * | 2002-08-14 | 2003-04-10 | Finetech Lab Ltd | Process for production of highly pure donepezil hydrochloride |
| US6953856B2 (en) | 2003-02-12 | 2005-10-11 | Usv, Limited | Process for the preparation of 1-benzyl-4-(5,6-dimethoxy-1-indanon)-2-yl) methyl piperidine hydrochloride (Donepezil HCI) |
| US6649765B1 (en) | 2003-02-12 | 2003-11-18 | Usv Limited, Bsd Marg. | Process for the preparation of 1-benzyl-4(5,6-dimethoxy-1-indanon)-2-yl) methyl piperidine hydrochloride (Donepezil HCL) |
| WO2004082685A1 (en) * | 2003-03-21 | 2004-09-30 | Ranbaxy Laboratories Limited | Process for the preparation of donepezil and derivatives thereof |
| WO2004099142A1 (en) * | 2003-05-05 | 2004-11-18 | Ranbaxy Laboratories Limited | Hydrobromide salt of benzyl-piperidylmethyl-indanone and its polymorphs |
| AU2003247158A1 (en) | 2003-07-01 | 2005-01-21 | Hetero Drugs Limited | Preparation of intermediates for acetyl cholinesterase inhibitors |
| CN1280273C (zh) * | 2003-11-05 | 2006-10-18 | 天津和美生物技术有限公司 | 合成多奈哌齐及其衍生物的方法 |
| CA2581926A1 (en) | 2004-09-29 | 2006-04-06 | Chemagis Ltd. | Use of purified donepezil maleate for preparing pharmaceutically pure amorphous donepezil hydrochloride |
| CN100436416C (zh) * | 2005-07-29 | 2008-11-26 | 西南合成制药股份有限公司 | 盐酸多奈哌齐合成工艺 |
| GB0515803D0 (en) * | 2005-07-30 | 2005-09-07 | Pliva Hrvatska D O O | Intermediate compounds |
| AR057910A1 (es) | 2005-11-18 | 2007-12-26 | Synthon Bv | Proceso para preparar donepezilo |
| EP1973878B1 (en) | 2006-01-04 | 2010-11-24 | Cipla Limited | Process and intermediate for preparation of donepezil |
| CN101626688A (zh) * | 2006-12-11 | 2010-01-13 | 雷维瓦药品公司 | 茚满酮基胆碱酯酶抑制剂的组合物、合成和使用方法 |
| WO2013078608A1 (en) | 2011-11-29 | 2013-06-06 | Ziqiang Gu | Donepezil pamoate and methods of making and using the same |
| EP3033082B1 (en) | 2013-08-16 | 2021-06-16 | Universiteit Maastricht | Treatment of cognitive impairment with pde4 inhibitor |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI95572C (fi) * | 1987-06-22 | 1996-02-26 | Eisai Co Ltd | Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi |
| FR2642069B1 (fr) * | 1989-01-20 | 1991-04-12 | Rhone Poulenc Sante | Nouveaux derives du benzopyranne, leur preparation et les compositions pharmaceutiques qui les contiennent |
| DE4439822A1 (de) * | 1994-11-08 | 1996-08-29 | Bayer Ag | Verfahren zur Herstellung von Benzyl-piperidylmethyl-indanonen |
-
1996
- 1996-10-11 NZ NZ318843A patent/NZ318843A/xx unknown
- 1996-10-11 EP EP96931937A patent/EP0883607A1/en not_active Withdrawn
- 1996-10-11 CZ CZ981808A patent/CZ180898A3/cs unknown
- 1996-10-11 HU HU9904275A patent/HUP9904275A3/hu unknown
- 1996-10-11 IL IL13642196A patent/IL136421A0/xx unknown
- 1996-10-11 RU RU98111204/04A patent/RU2160731C2/ru not_active IP Right Cessation
- 1996-10-11 IL IL12445296A patent/IL124452A0/xx unknown
- 1996-10-11 KR KR1019980704423A patent/KR20000064387A/ko not_active Application Discontinuation
- 1996-10-11 RO RO98-01070A patent/RO121382B1/ro unknown
- 1996-10-11 CA CA002237647A patent/CA2237647A1/en not_active Abandoned
- 1996-10-11 BR BR9612018A patent/BR9612018A/pt not_active Application Discontinuation
- 1996-10-11 SK SK754-98A patent/SK75498A3/sk unknown
- 1996-10-11 WO PCT/IB1996/001076 patent/WO1997022584A1/en not_active Application Discontinuation
- 1996-10-11 IL IL13642096A patent/IL136420A0/xx unknown
- 1996-10-11 JP JP9522607A patent/JP3066083B2/ja not_active Expired - Lifetime
- 1996-10-11 PL PL327512A patent/PL197306B1/pl not_active IP Right Cessation
- 1996-10-11 AU AU70925/96A patent/AU716462B2/en not_active Ceased
- 1996-10-14 TW TW085112515A patent/TW414787B/zh not_active IP Right Cessation
- 1996-10-15 HN HN1996000065A patent/HN1996000065A/es unknown
- 1996-11-18 GT GT199600092A patent/GT199600092A/es unknown
- 1996-12-09 PE PE1996000883A patent/PE25698A1/es not_active Application Discontinuation
- 1996-12-10 AR ARP960105577A patent/AR004368A1/es unknown
- 1996-12-11 TN TNTNSN96153A patent/TNSN96153A1/fr unknown
- 1996-12-11 DZ DZ960186A patent/DZ2141A1/fr active
- 1996-12-11 MA MA24424A patent/MA24032A1/fr unknown
- 1996-12-11 YU YU66096A patent/YU49486B/sh unknown
- 1996-12-12 AP APAP/P/1996/000892A patent/AP708A/en active
- 1996-12-12 CO CO96065334A patent/CO4750831A1/es unknown
- 1996-12-12 UY UY24401A patent/UY24401A1/es not_active IP Right Cessation
- 1996-12-13 ZA ZA9610533A patent/ZA9610533B/xx unknown
- 1996-12-13 HR HR60/008,753A patent/HRP960592A2/xx not_active Application Discontinuation
-
1998
- 1998-05-22 IS IS4752A patent/IS4752A/is unknown
- 1998-06-05 OA OA9800076A patent/OA10694A/en unknown
- 1998-06-09 BG BG102525A patent/BG102525A/xx unknown
- 1998-06-12 NO NO982712A patent/NO982712L/no not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |