BR0008566A - Processo para cristalização de n-(4-trifluormetilfenil)-5-metil-isoxazol-4-carboxamida - Google Patents
Processo para cristalização de n-(4-trifluormetilfenil)-5-metil-isoxazol-4-carboxamidaInfo
- Publication number
- BR0008566A BR0008566A BR0008566-9A BR0008566A BR0008566A BR 0008566 A BR0008566 A BR 0008566A BR 0008566 A BR0008566 A BR 0008566A BR 0008566 A BR0008566 A BR 0008566A
- Authority
- BR
- Brazil
- Prior art keywords
- carboxamide
- isoxazol
- methyl
- trifluormethylphenyl
- crystallization
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 238000002425 crystallisation Methods 0.000 title abstract 2
- 230000008025 crystallization Effects 0.000 title abstract 2
- VHOGYURTWQBHIL-UHFFFAOYSA-N leflunomide Chemical compound O1N=CC(C(=O)NC=2C=CC(=CC=2)C(F)(F)F)=C1C VHOGYURTWQBHIL-UHFFFAOYSA-N 0.000 abstract 3
- 239000006227 byproduct Substances 0.000 abstract 2
- 239000003960 organic solvent Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 1
- 238000004445 quantitative analysis Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
Abstract
Patente de Invenção: "PROCESSO PARA CRISTALIZAçãO DE N-(4-TRI-FLUORMETILFENIL)-5-METIL-ISOXAZOL-4-CARBOXAMIDA". A invenção refere-se a um processo para obtenção de N-(4trifluormetilfenil)-5-metil-isoxazol-4-carboxamida na forma cristalina, que é essencialmente livre de subprodutos. Além disso N-(4-trifluormetilfenil)-5metil-isoxazola-4-carboxamida é levada a um solvente orgânico ou a misturas de solventes orgânicos e água, a quantidade de subprodutos na solução é determinada por análise quantitativa, e uma quantidade eq³imolar de uma base é adicionada. A partir da solução obtida separa-se por cristalização N-(4-trifluormetilfenil)-5-metil-isoxazol-4-carboxamida.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19908527A DE19908527C2 (de) | 1999-02-26 | 1999-02-26 | Verfahren zur Kristallisation von N-(4-Trifluormethylphenyl)-5-methyl-isoxazol-4-carboxamid |
PCT/EP2000/001151 WO2000050411A1 (de) | 1999-02-26 | 2000-02-12 | Verfahren zur kristallisation von n- (4-trifluormethylphenyl) -5-methyl- isoxazol- 4-carboxamid |
Publications (2)
Publication Number | Publication Date |
---|---|
BR0008566A true BR0008566A (pt) | 2002-01-22 |
BR0008566B1 BR0008566B1 (pt) | 2011-03-22 |
Family
ID=7899073
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0008566-9A BR0008566B1 (pt) | 1999-02-26 | 2000-02-12 | processo para cristalização de n-(4-trifluormetilfenil)-5-metil-isoxazol-4-carboxami da. |
Country Status (22)
Country | Link |
---|---|
US (1) | US6303792B1 (pt) |
EP (1) | EP1155004B1 (pt) |
JP (1) | JP4625187B2 (pt) |
KR (1) | KR100626110B1 (pt) |
CN (1) | CN1127491C (pt) |
AR (1) | AR022737A1 (pt) |
AT (1) | ATE257828T1 (pt) |
AU (1) | AU762394B2 (pt) |
BR (1) | BR0008566B1 (pt) |
CA (1) | CA2363875C (pt) |
DE (2) | DE19908527C2 (pt) |
DK (1) | DK1155004T3 (pt) |
ES (1) | ES2214259T3 (pt) |
HK (1) | HK1043787B (pt) |
HU (1) | HU228918B1 (pt) |
IL (2) | IL144867A0 (pt) |
NO (1) | NO319830B1 (pt) |
NZ (1) | NZ513777A (pt) |
PL (1) | PL199365B1 (pt) |
PT (1) | PT1155004E (pt) |
WO (1) | WO2000050411A1 (pt) |
ZA (1) | ZA200106973B (pt) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19610955A1 (de) * | 1996-03-20 | 1997-09-25 | Hoechst Ag | Kombinationspräparat, enthaltend 5-Methylisoxazol-4-carbonsäure-(4-trifluormethyl)- anilid und N-(4-Trifluormethylphenyl)-2-cyan-3- hydroxycrotonsäureamid |
DE59801792D1 (de) * | 1997-08-08 | 2001-11-22 | Aventis Pharma Gmbh | Kristallform von N-(4-Trifluormethylphenyl)-5-methylisoxazol-4-carbonsäureamid |
WO2001043742A1 (en) * | 1999-12-16 | 2001-06-21 | Teva Pharmaceuticals Industries Ltd. | Novel processes for making- and a new crystalline form of- leflunomide |
WO2001060363A1 (en) * | 2000-02-15 | 2001-08-23 | Teva Pharmaceutical Industries Ltd. | A method for synthesizing leflunomide |
CN107311954B (zh) * | 2017-05-17 | 2020-04-07 | 力赛生物医药科技(厦门)有限公司 | 来氟米特晶型化合物、制备方法及其应用 |
CN114436894A (zh) * | 2020-11-04 | 2022-05-06 | 欣凯医药化工中间体(上海)有限公司 | 泰瑞米特钠晶型及制备方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2854439A1 (de) * | 1978-12-16 | 1980-07-03 | Hoechst Ag | Ein isoxazolderivat, verfahren zu seiner herstellung, diese verbindung enthaltende mittel und verwendung |
DE3534440A1 (de) * | 1985-09-27 | 1987-04-02 | Hoechst Ag | Arzneimittel gegen chronische graft-versus-host-krankheiten sowie gegen autoimmunerkrankungen, insbesondere systemischen lupus erythematodes |
US5494911A (en) * | 1990-05-18 | 1996-02-27 | Hoechst Aktiengesellschaft | Isoxazole-4-carboxamides and hydroxyalkylidenecyanoacetamides, pharmaceuticals containing these compounds and their use |
DE4127737A1 (de) * | 1991-08-22 | 1993-02-25 | Hoechst Ag | Arzneimittel zur behandlung von abstossungsreaktionen bei organverpflanzungen |
US5519042A (en) * | 1994-01-13 | 1996-05-21 | Hoechst Aktiengesellschaft | Method of treating hyperproliferative vascular disease |
DE19734438A1 (de) * | 1997-08-08 | 1999-02-11 | Hoechst Marion Roussel De Gmbh | Kristallform von N-(4-Trifluormethylphenyl)-5-methyl-isoxazole-4-carboxamid |
DE59801792D1 (de) | 1997-08-08 | 2001-11-22 | Aventis Pharma Gmbh | Kristallform von N-(4-Trifluormethylphenyl)-5-methylisoxazol-4-carbonsäureamid |
-
1999
- 1999-02-26 DE DE19908527A patent/DE19908527C2/de not_active Expired - Lifetime
-
2000
- 2000-02-12 NZ NZ513777A patent/NZ513777A/xx not_active IP Right Cessation
- 2000-02-12 IL IL14486700A patent/IL144867A0/xx active IP Right Grant
- 2000-02-12 PL PL350422A patent/PL199365B1/pl unknown
- 2000-02-12 WO PCT/EP2000/001151 patent/WO2000050411A1/de active IP Right Grant
- 2000-02-12 PT PT00916829T patent/PT1155004E/pt unknown
- 2000-02-12 BR BRPI0008566-9A patent/BR0008566B1/pt not_active IP Right Cessation
- 2000-02-12 DK DK00916829T patent/DK1155004T3/da active
- 2000-02-12 AT AT00916829T patent/ATE257828T1/de active
- 2000-02-12 DE DE50005025T patent/DE50005025D1/de not_active Expired - Lifetime
- 2000-02-12 EP EP00916829A patent/EP1155004B1/de not_active Expired - Lifetime
- 2000-02-12 KR KR1020017010843A patent/KR100626110B1/ko active IP Right Grant
- 2000-02-12 CN CN00804234A patent/CN1127491C/zh not_active Expired - Lifetime
- 2000-02-12 ES ES00916829T patent/ES2214259T3/es not_active Expired - Lifetime
- 2000-02-12 JP JP2000600994A patent/JP4625187B2/ja not_active Expired - Lifetime
- 2000-02-12 HU HU0200058A patent/HU228918B1/hu unknown
- 2000-02-12 CA CA002363875A patent/CA2363875C/en not_active Expired - Fee Related
- 2000-02-12 AU AU38038/00A patent/AU762394B2/en not_active Expired
- 2000-02-22 US US09/510,157 patent/US6303792B1/en not_active Expired - Lifetime
- 2000-02-24 AR ARP000100788A patent/AR022737A1/es active IP Right Grant
-
2001
- 2001-08-13 IL IL144867A patent/IL144867A/en not_active IP Right Cessation
- 2001-08-22 NO NO20014077A patent/NO319830B1/no not_active IP Right Cessation
- 2001-08-23 ZA ZA200106973A patent/ZA200106973B/en unknown
-
2002
- 2002-05-31 HK HK02104056.1A patent/HK1043787B/zh not_active IP Right Cessation
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Legal Events
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B25D | Requested change of name of applicant approved |
Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) Free format text: ALTERADO DE: AVENTIS PHARMA DEUTSCHLAND GMBH |
|
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 22/03/2011, OBSERVADAS AS CONDICOES LEGAIS. |
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B21A | Patent or certificate of addition expired [chapter 21.1 patent gazette] |
Free format text: PATENTE EXTINTA EM 22.03.2021 |