AR036018A1 - Proceso para aislar monohidrato de imipenem cristalino puro - Google Patents
Proceso para aislar monohidrato de imipenem cristalino puroInfo
- Publication number
- AR036018A1 AR036018A1 ARP020101854A ARP020101854A AR036018A1 AR 036018 A1 AR036018 A1 AR 036018A1 AR P020101854 A ARP020101854 A AR P020101854A AR P020101854 A ARP020101854 A AR P020101854A AR 036018 A1 AR036018 A1 AR 036018A1
- Authority
- AR
- Argentina
- Prior art keywords
- imipenem
- monohidrate
- pure crystal
- isolating pure
- isolating
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/02—Preparation
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
Abstract
El presente se relaciona con un proceso de efectividad en el costo industrialmente ventajoso para aislar imipenem de alta pureza de la fórmula (1), que comprende cristalizar a temperatura baja monohidrato de imipenem a partir de una solución del mismo que contiene un solvente orgánico miscible en agua, un solvente acuoso o una mezcla de los mismos, sin utilizar liofilización, secado por congelamiento ni técnicas cromatográficas.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN595DE2001 | 2001-05-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR036018A1 true AR036018A1 (es) | 2004-08-04 |
Family
ID=11097062
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP020101854A AR036018A1 (es) | 2001-05-18 | 2002-05-20 | Proceso para aislar monohidrato de imipenem cristalino puro |
Country Status (17)
Country | Link |
---|---|
US (1) | US7241885B2 (es) |
EP (1) | EP1395588A4 (es) |
JP (1) | JP2005514323A (es) |
KR (1) | KR20040010649A (es) |
CN (1) | CN1522255A (es) |
AR (1) | AR036018A1 (es) |
BR (1) | BR0209844A (es) |
CA (1) | CA2447673A1 (es) |
CZ (1) | CZ20033351A3 (es) |
HU (1) | HUP0501093A2 (es) |
MX (1) | MXPA03010548A (es) |
NO (1) | NO20035137D0 (es) |
OA (1) | OA12608A (es) |
PL (1) | PL373527A1 (es) |
SK (1) | SK15092003A3 (es) |
WO (1) | WO2002094773A2 (es) |
ZA (1) | ZA200309288B (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR0209842A (pt) * | 2001-05-18 | 2005-01-04 | Ranbaxy Lab Ltd | Processo para a preparação de imipenem |
EP1426376A4 (en) * | 2001-08-13 | 2004-12-22 | Eisai Co Ltd | PROCESS FOR THE PREPARATION OF CARBAPENEM-BASED ANTIBIOTICS |
BR0214209A (pt) * | 2001-11-16 | 2004-10-26 | Ranbaxy Lab Ltd | Processo para a preparação de imipenem cristalino e composto preparado pelo dito processo |
EP2209787A4 (en) * | 2007-10-08 | 2011-08-03 | Orchid Chemicals & Pharm Ltd | METHOD FOR PRODUCING A CARBAPENEM ANTIBIOTICS |
CN103524508B (zh) * | 2013-09-02 | 2016-03-30 | 上海龙翔生物医药开发有限公司 | 一种亚胺培南一水合物的结晶方法 |
CN108623598A (zh) * | 2018-05-21 | 2018-10-09 | 重庆天地药业有限责任公司 | 一种亚胺培南中间体及亚胺培南的制备方法 |
CN113135916A (zh) * | 2020-01-20 | 2021-07-20 | 鲁南制药集团股份有限公司 | 一种亚胺培南制备工艺的除钯方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4138433A (en) * | 1975-06-26 | 1979-02-06 | Hoechst Aktiengesellschaft | Process for preparing 1,2-oxa-phospholanes |
US4194047A (en) | 1975-11-21 | 1980-03-18 | Merck & Co., Inc. | Substituted N-methylene derivatives of thienamycin |
US4081455A (en) * | 1976-06-02 | 1978-03-28 | Pfizer Inc. | 6-Amino-2,2-dimethyl-3-cyanopenams |
US4260543A (en) | 1978-07-03 | 1981-04-07 | Merck & Co., Inc. | Crystalline N-formimidoyl thienamycin |
US4292436A (en) * | 1980-06-25 | 1981-09-29 | Merck & Co., Inc. | Process for the preparation of N-protected N-formimidoyl 2-aminoethanethiol |
US4374772A (en) | 1981-03-19 | 1983-02-22 | Merck & Co., Inc. | Process for the preparation of N-formimidoyl thienamycin and reagents therefor |
US4894450A (en) | 1987-05-11 | 1990-01-16 | Merck & Co., Inc. | Process for 2-(aminoalkylthio) carbapenems |
US5245069A (en) | 1992-10-27 | 1993-09-14 | Merck & Co., Inc. | Process for the preparation of bis(aryl)-phosphorohalidates |
IN191798B (es) * | 2000-11-03 | 2004-01-03 | Ranbaxy Lab Ltd | |
BR0214209A (pt) * | 2001-11-16 | 2004-10-26 | Ranbaxy Lab Ltd | Processo para a preparação de imipenem cristalino e composto preparado pelo dito processo |
-
2002
- 2002-05-20 PL PL02373527A patent/PL373527A1/xx not_active Application Discontinuation
- 2002-05-20 OA OA1200300302A patent/OA12608A/en unknown
- 2002-05-20 CZ CZ20033351A patent/CZ20033351A3/cs unknown
- 2002-05-20 CA CA002447673A patent/CA2447673A1/en not_active Abandoned
- 2002-05-20 CN CNA028131207A patent/CN1522255A/zh active Pending
- 2002-05-20 WO PCT/IB2002/001718 patent/WO2002094773A2/en not_active Application Discontinuation
- 2002-05-20 BR BR0209844-0A patent/BR0209844A/pt not_active IP Right Cessation
- 2002-05-20 HU HU0501093A patent/HUP0501093A2/hu unknown
- 2002-05-20 SK SK1509-2003A patent/SK15092003A3/sk not_active Application Discontinuation
- 2002-05-20 AR ARP020101854A patent/AR036018A1/es not_active Application Discontinuation
- 2002-05-20 US US10/478,624 patent/US7241885B2/en not_active Expired - Fee Related
- 2002-05-20 KR KR10-2003-7015043A patent/KR20040010649A/ko not_active Application Discontinuation
- 2002-05-20 MX MXPA03010548A patent/MXPA03010548A/es unknown
- 2002-05-20 EP EP02730574A patent/EP1395588A4/en active Pending
- 2002-05-20 JP JP2002591446A patent/JP2005514323A/ja not_active Withdrawn
-
2003
- 2003-11-18 NO NO20035137A patent/NO20035137D0/no not_active Application Discontinuation
- 2003-11-28 ZA ZA200309288A patent/ZA200309288B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
CZ20033351A3 (cs) | 2007-12-27 |
NO20035137D0 (no) | 2003-11-18 |
MXPA03010548A (es) | 2004-05-27 |
HUP0501093A2 (en) | 2006-03-28 |
BR0209844A (pt) | 2005-04-05 |
OA12608A (en) | 2006-06-08 |
EP1395588A2 (en) | 2004-03-10 |
PL373527A1 (en) | 2005-09-05 |
US20040242865A1 (en) | 2004-12-02 |
JP2005514323A (ja) | 2005-05-19 |
EP1395588A4 (en) | 2004-09-15 |
SK15092003A3 (sk) | 2004-09-08 |
CN1522255A (zh) | 2004-08-18 |
US7241885B2 (en) | 2007-07-10 |
WO2002094773A2 (en) | 2002-11-28 |
WO2002094773A3 (en) | 2003-10-16 |
CA2447673A1 (en) | 2002-11-28 |
ZA200309288B (en) | 2005-02-28 |
KR20040010649A (ko) | 2004-01-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |