CU23171A3 - Procedimiento para la preparacion de sal de calcio de zofenopril - Google Patents

Procedimiento para la preparacion de sal de calcio de zofenopril

Info

Publication number
CU23171A3
CU23171A3 CU20010032A CU20010032A CU23171A3 CU 23171 A3 CU23171 A3 CU 23171A3 CU 20010032 A CU20010032 A CU 20010032A CU 20010032 A CU20010032 A CU 20010032A CU 23171 A3 CU23171 A3 CU 23171A3
Authority
CU
Cuba
Prior art keywords
zofenopril
calcium salt
potassium salt
preparation
procedure
Prior art date
Application number
CU20010032A
Other languages
English (en)
Inventor
Anita Falezza
Carlo Manucci
Antonio Giachetti
Original Assignee
Menarini Int Operations Lu Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Menarini Int Operations Lu Sa filed Critical Menarini Int Operations Lu Sa
Publication of CU23171A3 publication Critical patent/CU23171A3/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C01INORGANIC CHEMISTRY
    • C01FCOMPOUNDS OF THE METALS BERYLLIUM, MAGNESIUM, ALUMINIUM, CALCIUM, STRONTIUM, BARIUM, RADIUM, THORIUM, OR OF THE RARE-EARTH METALS
    • C01F11/00Compounds of calcium, strontium, or barium
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Geology (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Se describe un procedimiento para la preparacion del polimorfo A de la sal de calcio de zofenopril en forma sustancialmente pura, el cual comprende: a) reaccion de cloruro de Acido S(-)-3-benzoiltio-2-metilpropanoico con cis-4-feniltio-L-prolina en agua a pH que varía de 9.0 a 9.5, y recuperacion de zofenopril en forma Acida; b)salificacion de zofenopril Acido con una sal de potasio en solucion alcoholica, y recuperacion de la sal de potasio resultante; c) conversion de la sal de potasio a sal de calcio mediante la adicion de una solucion acuosa de sal de potasio de zofenopril una solucion acuosa de CaCl2 a una temperatura de 70-90sC con sembrado simultAneo para promover la precipitacion del polimorfo A.
CU20010032A 1998-08-04 2001-02-01 Procedimiento para la preparacion de sal de calcio de zofenopril CU23171A3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1998MI001833A IT1301993B1 (it) 1998-08-04 1998-08-04 Processo per la preparazione di zofenopril sale di calcio.

Publications (1)

Publication Number Publication Date
CU23171A3 true CU23171A3 (es) 2006-09-22

Family

ID=11380611

Family Applications (1)

Application Number Title Priority Date Filing Date
CU20010032A CU23171A3 (es) 1998-08-04 2001-02-01 Procedimiento para la preparacion de sal de calcio de zofenopril

Country Status (32)

Country Link
US (2) US6521760B1 (es)
EP (1) EP1102745B1 (es)
JP (1) JP2002522417A (es)
KR (1) KR100593428B1 (es)
CN (1) CN1146538C (es)
AT (1) ATE266635T1 (es)
AU (1) AU5372299A (es)
BG (1) BG65022B1 (es)
BR (1) BR9912842A (es)
CA (1) CA2339283C (es)
CU (1) CU23171A3 (es)
CZ (1) CZ301908B6 (es)
DE (1) DE69917282T2 (es)
DK (1) DK1102745T3 (es)
EA (1) EA003454B1 (es)
EE (1) EE04798B1 (es)
ES (1) ES2221417T3 (es)
HK (1) HK1039616B (es)
HR (1) HRP20010083B1 (es)
HU (1) HU227557B1 (es)
IL (1) IL141222A0 (es)
IT (1) IT1301993B1 (es)
NO (1) NO319773B1 (es)
PL (1) PL193828B1 (es)
PT (1) PT1102745E (es)
RS (1) RS49768B (es)
SI (1) SI1102745T1 (es)
SK (1) SK285527B6 (es)
TR (1) TR200100272T2 (es)
UA (1) UA65628C2 (es)
WO (1) WO2000007984A1 (es)
ZA (1) ZA200100907B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006264650B2 (en) * 2005-07-01 2012-08-23 Generics [Uk] Limited Zofenopril calcium in polymorph form C
EA012845B1 (ru) * 2005-12-09 2009-12-30 Менарини Интернэшнл Оперейшнс Люксембург С. А. Фармацевтическая композиция, содержащая зофеноприл и hctz, для лечения гипертензии
WO2007138352A1 (en) * 2006-05-26 2007-12-06 Generics (Uk) Limited Zofenopril calcium
GB0715626D0 (en) 2007-08-10 2007-09-19 Generics Uk Ltd Crystalline form of zofenopril calcium
NZ622549A (en) * 2008-02-27 2015-10-30 Generics Uk Ltd Novel crystalline form of zofenopril calcium
US8853421B2 (en) 2008-02-27 2014-10-07 Generics [Uk] Limited Crystalline forms of zofenopril calcium
WO2010084515A2 (en) * 2009-01-23 2010-07-29 Glenmark Generics Limited A process for the preparation of zofenopril and its pharmaceutically acceptable salts thereof
SI23949A (sl) 2011-12-19 2013-06-28 Silverstone Pharma Nove kristalne soli zofenoprila, postopek za njihovo dobivanje in njihova uporaba v terapiji
CN104138359B (zh) * 2013-05-06 2016-03-02 扬子江药业集团上海海尼药业有限公司 佐芬普利钙片的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4105776A (en) * 1976-06-21 1978-08-08 E. R. Squibb & Sons, Inc. Proline derivatives and related compounds
US4154935A (en) * 1978-02-21 1979-05-15 E. R. Squibb & Sons, Inc. Halogen substituted mercaptoacylamino acids
US4316906A (en) 1978-08-11 1982-02-23 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of substituted prolines

Also Published As

Publication number Publication date
NO319773B1 (no) 2005-09-12
DK1102745T3 (da) 2004-08-02
CN1316992A (zh) 2001-10-10
NO20010552L (no) 2001-02-01
HK1039616A1 (en) 2002-05-03
NO20010552D0 (no) 2001-02-01
KR20010072171A (ko) 2001-07-31
KR100593428B1 (ko) 2006-06-28
IT1301993B1 (it) 2000-07-20
EA003454B1 (ru) 2003-06-26
CZ301908B6 (cs) 2010-07-28
SK285527B6 (sk) 2007-03-01
US20020156293A1 (en) 2002-10-24
SK1632001A3 (en) 2001-09-11
ATE266635T1 (de) 2004-05-15
DE69917282T2 (de) 2005-05-25
EP1102745A1 (en) 2001-05-30
TR200100272T2 (tr) 2001-05-21
EE04798B1 (et) 2007-04-16
HU227557B1 (en) 2011-08-29
BG65022B1 (bg) 2006-12-29
WO2000007984A1 (en) 2000-02-17
US6515012B2 (en) 2003-02-04
DE69917282D1 (de) 2004-06-17
ITMI981833A1 (it) 2000-02-04
RS49768B (sr) 2008-06-05
CZ2001408A3 (cs) 2001-07-11
CA2339283C (en) 2009-03-17
JP2002522417A (ja) 2002-07-23
BR9912842A (pt) 2001-10-16
EE200100065A (et) 2002-06-17
HUP0103826A3 (en) 2002-03-28
UA65628C2 (uk) 2004-04-15
HUP0103826A2 (hu) 2002-02-28
HRP20010083A2 (en) 2002-02-28
ZA200100907B (en) 2001-10-04
CA2339283A1 (en) 2000-02-17
ES2221417T3 (es) 2004-12-16
SI1102745T1 (en) 2004-10-31
HRP20010083B1 (en) 2005-02-28
BG105176A (en) 2001-11-30
HK1039616B (zh) 2004-10-08
US6521760B1 (en) 2003-02-18
IL141222A0 (en) 2002-03-10
PT1102745E (pt) 2004-08-31
EP1102745B1 (en) 2004-05-12
CN1146538C (zh) 2004-04-21
PL345814A1 (en) 2002-01-14
ITMI981833A0 (it) 1998-08-04
YU7501A (sh) 2005-06-10
PL193828B1 (pl) 2007-03-30
AU5372299A (en) 2000-02-28
EA200100095A1 (ru) 2001-08-27

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