EA200100095A1 - Способ получения кальциевой соли зофеноприла - Google Patents

Способ получения кальциевой соли зофеноприла

Info

Publication number
EA200100095A1
EA200100095A1 EA200100095A EA200100095A EA200100095A1 EA 200100095 A1 EA200100095 A1 EA 200100095A1 EA 200100095 A EA200100095 A EA 200100095A EA 200100095 A EA200100095 A EA 200100095A EA 200100095 A1 EA200100095 A1 EA 200100095A1
Authority
EA
Eurasian Patent Office
Prior art keywords
zofenopril
salt
potassium salt
calcium salt
aqueous solution
Prior art date
Application number
EA200100095A
Other languages
English (en)
Other versions
EA003454B1 (ru
Inventor
Раффаэлло Джорджи
Антонио Джакетти
Карло Маннуччи
Анита Фалецца
Original Assignee
Менарини Ричерке С.П.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Менарини Ричерке С.П.А. filed Critical Менарини Ричерке С.П.А.
Publication of EA200100095A1 publication Critical patent/EA200100095A1/ru
Publication of EA003454B1 publication Critical patent/EA003454B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01F—COMPOUNDS OF THE METALS BERYLLIUM, MAGNESIUM, ALUMINIUM, CALCIUM, STRONTIUM, BARIUM, RADIUM, THORIUM, OR OF THE RARE-EARTH METALS
    • C01F11/00—Compounds of calcium, strontium, or barium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

Способ получения полиморфной модификации А кальциевой соли зофеноприла, по существу, в чистой форме, который включает: а) реакцию хлорида S(-)-3-бензоилтио-2-метилпропионовой кислоты с цис-4-фенилтио-L-пролином в воде при pH в интервале от 9,0 до 9,5 и выделение зофеноприла в кислотной форме; б) образование соли из кислого зофеноприла калиевой солью в спиртовом растворе и восстановление полученной калиевой соли; в) превращение калиевой соли в кальциевую соль добавлением водного раствора калиевой соли зофеноприла к водному раствору CaClпри температуре 70-90°C при одновременном затравливании для промотирования осаждения полиморфной модификации А.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200100095A 1998-08-04 1999-07-30 Способ получения кальциевой соли зофеноприла EA003454B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT1998MI001833A IT1301993B1 (it) 1998-08-04 1998-08-04 Processo per la preparazione di zofenopril sale di calcio.
PCT/EP1999/005461 WO2000007984A1 (en) 1998-08-04 1999-07-30 A process for the preparation of zofenopril calcium salt

Publications (2)

Publication Number Publication Date
EA200100095A1 true EA200100095A1 (ru) 2001-08-27
EA003454B1 EA003454B1 (ru) 2003-06-26

Family

ID=11380611

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200100095A EA003454B1 (ru) 1998-08-04 1999-07-30 Способ получения кальциевой соли зофеноприла

Country Status (32)

Country Link
US (2) US6521760B1 (ru)
EP (1) EP1102745B1 (ru)
JP (1) JP2002522417A (ru)
KR (1) KR100593428B1 (ru)
CN (1) CN1146538C (ru)
AT (1) ATE266635T1 (ru)
AU (1) AU5372299A (ru)
BG (1) BG65022B1 (ru)
BR (1) BR9912842A (ru)
CA (1) CA2339283C (ru)
CU (1) CU23171A3 (ru)
CZ (1) CZ301908B6 (ru)
DE (1) DE69917282T2 (ru)
DK (1) DK1102745T3 (ru)
EA (1) EA003454B1 (ru)
EE (1) EE04798B1 (ru)
ES (1) ES2221417T3 (ru)
HK (1) HK1039616B (ru)
HR (1) HRP20010083B1 (ru)
HU (1) HU227557B1 (ru)
IL (1) IL141222A0 (ru)
IT (1) IT1301993B1 (ru)
NO (1) NO319773B1 (ru)
PL (1) PL193828B1 (ru)
PT (1) PT1102745E (ru)
RS (1) RS49768B (ru)
SI (1) SI1102745T1 (ru)
SK (1) SK285527B6 (ru)
TR (1) TR200100272T2 (ru)
UA (1) UA65628C2 (ru)
WO (1) WO2000007984A1 (ru)
ZA (1) ZA200100907B (ru)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1899297B1 (en) 2005-07-01 2015-12-09 Generics [UK] Limited Zofenopril calcium in polymorph form c
EA012845B1 (ru) * 2005-12-09 2009-12-30 Менарини Интернэшнл Оперейшнс Люксембург С. А. Фармацевтическая композиция, содержащая зофеноприл и hctz, для лечения гипертензии
AU2007266837A1 (en) * 2006-05-26 2007-12-06 Generics [Uk] Limited Zofenopril calcium
GB0715626D0 (en) * 2007-08-10 2007-09-19 Generics Uk Ltd Crystalline form of zofenopril calcium
CN101981004B (zh) * 2008-02-27 2014-09-17 基因里克斯(英国)有限公司 晶体形式
US8853421B2 (en) 2008-02-27 2014-10-07 Generics [Uk] Limited Crystalline forms of zofenopril calcium
WO2010084515A2 (en) * 2009-01-23 2010-07-29 Glenmark Generics Limited A process for the preparation of zofenopril and its pharmaceutically acceptable salts thereof
SI23949A (sl) 2011-12-19 2013-06-28 Silverstone Pharma Nove kristalne soli zofenoprila, postopek za njihovo dobivanje in njihova uporaba v terapiji
CN104138359B (zh) * 2013-05-06 2016-03-02 扬子江药业集团上海海尼药业有限公司 佐芬普利钙片的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4105776A (en) * 1976-06-21 1978-08-08 E. R. Squibb & Sons, Inc. Proline derivatives and related compounds
US4154935A (en) * 1978-02-21 1979-05-15 E. R. Squibb & Sons, Inc. Halogen substituted mercaptoacylamino acids
US4316906A (en) 1978-08-11 1982-02-23 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of substituted prolines

Also Published As

Publication number Publication date
CN1316992A (zh) 2001-10-10
HRP20010083A2 (en) 2002-02-28
BG65022B1 (bg) 2006-12-29
NO319773B1 (no) 2005-09-12
DE69917282D1 (de) 2004-06-17
PL345814A1 (en) 2002-01-14
ITMI981833A0 (it) 1998-08-04
IL141222A0 (en) 2002-03-10
HUP0103826A2 (hu) 2002-02-28
DK1102745T3 (da) 2004-08-02
EP1102745A1 (en) 2001-05-30
HK1039616A1 (en) 2002-05-03
AU5372299A (en) 2000-02-28
PT1102745E (pt) 2004-08-31
HRP20010083B1 (en) 2005-02-28
WO2000007984A1 (en) 2000-02-17
IT1301993B1 (it) 2000-07-20
ITMI981833A1 (it) 2000-02-04
NO20010552L (no) 2001-02-01
EE04798B1 (et) 2007-04-16
SI1102745T1 (en) 2004-10-31
EE200100065A (et) 2002-06-17
YU7501A (sh) 2005-06-10
EA003454B1 (ru) 2003-06-26
US20020156293A1 (en) 2002-10-24
UA65628C2 (ru) 2004-04-15
CA2339283A1 (en) 2000-02-17
NO20010552D0 (no) 2001-02-01
BR9912842A (pt) 2001-10-16
BG105176A (en) 2001-11-30
ZA200100907B (en) 2001-10-04
EP1102745B1 (en) 2004-05-12
HU227557B1 (en) 2011-08-29
KR20010072171A (ko) 2001-07-31
US6515012B2 (en) 2003-02-04
ES2221417T3 (es) 2004-12-16
CU23171A3 (es) 2006-09-22
HK1039616B (zh) 2004-10-08
ATE266635T1 (de) 2004-05-15
HUP0103826A3 (en) 2002-03-28
RS49768B (sr) 2008-06-05
PL193828B1 (pl) 2007-03-30
SK1632001A3 (en) 2001-09-11
JP2002522417A (ja) 2002-07-23
DE69917282T2 (de) 2005-05-25
CZ2001408A3 (cs) 2001-07-11
CN1146538C (zh) 2004-04-21
US6521760B1 (en) 2003-02-18
KR100593428B1 (ko) 2006-06-28
TR200100272T2 (tr) 2001-05-21
SK285527B6 (sk) 2007-03-01
CZ301908B6 (cs) 2010-07-28
CA2339283C (en) 2009-03-17

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KG MD TJ TM

PC4A Registration of transfer of a eurasian patent by assignment
MK4A Patent expired

Designated state(s): BY KZ RU