EA200100184A1 - Новые гидратные формы алендроната натрия, способы их получения и фармацевтические композиции - Google Patents

Новые гидратные формы алендроната натрия, способы их получения и фармацевтические композиции

Info

Publication number
EA200100184A1
EA200100184A1 EA200100184A EA200100184A EA200100184A1 EA 200100184 A1 EA200100184 A1 EA 200100184A1 EA 200100184 A EA200100184 A EA 200100184A EA 200100184 A EA200100184 A EA 200100184A EA 200100184 A1 EA200100184 A1 EA 200100184A1
Authority
EA
Eurasian Patent Office
Prior art keywords
sodium
methods
pharmaceutical compositions
alandronate
reception
Prior art date
Application number
EA200100184A
Other languages
English (en)
Other versions
EA002739B1 (ru
Inventor
Джудит Аронхиме
Рами Лидор-Хадас
Нина Финкельштейн
Original Assignee
Тева Фармасьютикал Индастриес Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Тева Фармасьютикал Индастриес Лтд. filed Critical Тева Фармасьютикал Индастриес Лтд.
Publication of EA200100184A1 publication Critical patent/EA200100184A1/ru
Publication of EA002739B1 publication Critical patent/EA002739B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Описаны новые гидратные формы алендроната натрия с содержанием воды от 1 до 12% и способы их получения. Также описаны новые кристаллические формы алендроната натрия - B, D, E, F, G и H и способы их получения. Эти новые формы алендроната натрия пригодны для включения в фармацевтические композиции для лечения костной резорбции при костных заболеваниях.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200100184A 1998-08-27 1999-08-27 Новые гидратные формы алендроната натрия, способы их получения и фармацевтические композиции EA002739B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US9831398P 1998-08-27 1998-08-27
US12974399P 1999-04-16 1999-04-16
US14446199P 1999-07-19 1999-07-19
PCT/US1999/019838 WO2000012517A1 (en) 1998-08-27 1999-08-27 Novel hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof

Publications (2)

Publication Number Publication Date
EA200100184A1 true EA200100184A1 (ru) 2001-10-22
EA002739B1 EA002739B1 (ru) 2002-08-29

Family

ID=27378576

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200100184A EA002739B1 (ru) 1998-08-27 1999-08-27 Новые гидратные формы алендроната натрия, способы их получения и фармацевтические композиции

Country Status (30)

Country Link
US (2) US6281381B1 (ru)
EP (1) EP1107974B1 (ru)
JP (2) JP2002523514A (ru)
KR (2) KR20010079701A (ru)
AT (1) ATE334993T1 (ru)
AU (1) AU5698899A (ru)
BG (1) BG65329B1 (ru)
BR (1) BR9913472A (ru)
CA (1) CA2341459A1 (ru)
CZ (1) CZ2001629A3 (ru)
DE (1) DE69932620T2 (ru)
DK (1) DK1107974T3 (ru)
EA (1) EA002739B1 (ru)
EE (1) EE04552B1 (ru)
ES (1) ES2270613T3 (ru)
HR (1) HRP20010129A2 (ru)
HU (1) HUP0203078A3 (ru)
IL (1) IL141423A (ru)
IS (1) IS5864A (ru)
LT (1) LT4888B (ru)
LV (1) LV12720B (ru)
NO (1) NO20010957L (ru)
NZ (1) NZ510682A (ru)
PL (1) PL346347A1 (ru)
PT (1) PT1107974E (ru)
RO (1) RO122854B1 (ru)
SI (1) SI20581B (ru)
SK (1) SK2482001A3 (ru)
WO (1) WO2000012517A1 (ru)
YU (1) YU14701A (ru)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2451881A1 (fr) * 2001-07-16 2003-01-30 Universite Paris 13 Nouveaux derives de bisphosphonates, leurs preparations et utilisations
GB2383042A (en) 2001-10-18 2003-06-18 Cipla Ltd Amorphous alendronate sodium
US20040052843A1 (en) * 2001-12-24 2004-03-18 Lerner E. Itzhak Controlled release dosage forms
EP2172192A1 (en) * 2001-12-24 2010-04-07 Teva Pharmaceutical Industries Ltd. Dosage form with a core tablet of active ingredient sheathed in a compressed annular body of powder of granular material, and process and tooling for producing it
ITMI20020146A1 (it) * 2002-01-29 2003-07-29 Lyogen Ltd Alendronato monosodico amorfo e processo per la sua preparazione
JP2005531532A (ja) * 2002-04-05 2005-10-20 メルク　エンド　カムパニー　インコーポレーテッド アレンドロナートおよびビタミンｄ製剤を用いる骨吸収阻害法
US20080249068A1 (en) * 2002-09-05 2008-10-09 Deluca Hector F Method of Extending the Dose Range of Vitamin D Compounds
US20050113343A1 (en) * 2003-10-14 2005-05-26 Pliva - Research And Development Ltd. Solid-state form of alendronate sodium and preparation thereof
US20050181043A1 (en) * 2004-02-12 2005-08-18 Indranil Nandi Alendronate salt tablet compositions
US20050261250A1 (en) * 2004-05-19 2005-11-24 Merck & Co., Inc., Compositions and methods for inhibiting bone resorption
WO2005115331A2 (en) 2004-05-24 2005-12-08 The Procter & Gamble Company Enteric solid oral dosage form of bisphosphonate containing a chelating agent
CZ296937B6 (cs) * 2004-09-02 2006-07-12 Zentiva, A. S Trisodná sul kyseliny 4-amino-1-hydroxybutyliden-1,1-bisfosfonové
ATE440888T1 (de) * 2004-10-29 2009-09-15 Sandoz Ag Verfahren zur herstellung von glatiramer
US20060134190A1 (en) * 2004-12-16 2006-06-22 Banner Pharmacaps Inc. Formulations of bisphosphonate drugs with improved bioavailability
CZ297262B6 (cs) * 2004-12-28 2006-10-11 Zentiva, A. S. Trisodná sul kyseliny 4-amino-1-hydroxybutyliden-1,1-bisfosfonové
US8003820B2 (en) * 2005-10-20 2011-08-23 Dr. Reddy's Laboratories Limited Process for preparing bisphosphonic acids
AR058168A1 (es) * 2005-11-07 2008-01-23 Merck & Co Inc Sintesis del alendronato de sodio trihidratado
JP5523833B2 (ja) * 2006-10-27 2014-06-18 シグナル ファーマシューティカルズ，エルエルシー ４−［９−（テトラヒドロ−フラン−３−イル）−８−（２，４，６−トリフルオロ−フェニルアミノ）−９ｈ−プリン−２−イルアミノ］−シクロヘキサン−１−オールを含む固体形態、それらの組成物、及びそれらの使用
ES2392890T3 (es) * 2006-11-22 2012-12-14 Eisai R&D Management Co., Ltd. Sal sódica de un compuesto disacarídico, procedimiento para la producción de la misma y uso de la misma
US20090076144A1 (en) * 2007-09-17 2009-03-19 Protia, Llc Deuterium-enriched bazedoxifene
US20090118238A1 (en) * 2007-09-17 2009-05-07 Protia, Llc Deuterium-enriched alendronate
US20090170815A1 (en) * 2007-12-28 2009-07-02 Roxane Laboratories Incorporated. Alendronate oral liquid formulations
JP2013510097A (ja) * 2009-11-03 2013-03-21 リウ、リー タンシノンｉｉａスルホン酸ナトリウム水和物、並びにその調製方法及び使用
RU2021125455A (ru) 2013-11-15 2021-10-05 Экебиа Терапьютикс, Инк. Твердые формы { [5-(3-хлорфенил)-3-гидроксипиридин-2-карбонил]амино} уксусной кислоты, их композиции и применения

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3016289A1 (de) 1980-04-28 1981-10-29 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
IT1201087B (it) * 1982-04-15 1989-01-27 Gentili Ist Spa Bifosfonati farmacologicamente attivi,procedimento per la loro preparazione e relative composizioni farmaceutiche
US4639338A (en) * 1984-08-06 1987-01-27 Ciba-Geigy Corporation Preparation of crystalline disodium 3-amino-1-hydroxypropane-1,1-diphosphonate pentahydrate
DE3434667A1 (de) 1984-09-21 1986-04-03 Henkel KGaA, 4000 Düsseldorf 4-dimethylamino-1-hydroxybutan-1,1-diphosphonsaeure, deren wasserloesliche salze, verfahren zu ihrer herstellung sowie ihre verwendung
IT1196315B (it) * 1984-10-29 1988-11-16 Gentili Ist Spa Procedimento per la preparazione di acidi difosfonici
US4711800A (en) * 1985-06-06 1987-12-08 Divincenzo Maureen Needlecraft with metallic substrate
US4922007A (en) * 1989-06-09 1990-05-01 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
US5019651A (en) * 1990-06-20 1991-05-28 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof
US5039819A (en) 1990-09-18 1991-08-13 Merck & Co., Inc. Diphosphonate intermediate for preparing an antihypercalcemic agent
US5159108A (en) 1990-09-18 1992-10-27 Merck & Co., Inc. Process for preparing an antihypercalcemic agent
JPH11506757A (ja) * 1995-06-06 1999-06-15 メルク エンド カンパニー インコーポレーテッド 二ナトリウムアレンドロネート製剤
CA2221417C (en) * 1995-06-06 2002-04-30 Merck & Co., Inc. Anhydrous alendronate monosodium salt formulations

Also Published As

Publication number Publication date
EP1107974A1 (en) 2001-06-20
BR9913472A (pt) 2002-03-05
EE200100126A (et) 2002-06-17
US6281381B1 (en) 2001-08-28
PT1107974E (pt) 2006-10-31
EP1107974B1 (en) 2006-08-02
DE69932620D1 (de) 2006-09-14
SI20581B (sl) 2008-06-30
PL346347A1 (en) 2002-02-11
BG105292A (en) 2001-12-29
YU14701A (sh) 2003-01-31
JP2002523514A (ja) 2002-07-30
US20030065214A1 (en) 2003-04-03
ATE334993T1 (de) 2006-08-15
KR20070034132A (ko) 2007-03-27
CZ2001629A3 (cs) 2001-08-15
LV12720B (en) 2002-02-20
LT4888B (lt) 2002-02-25
LT2001016A (en) 2001-10-25
NO20010957D0 (no) 2001-02-26
US6696601B2 (en) 2004-02-24
LV12720A (lv) 2001-09-20
IS5864A (is) 2001-02-26
RO122854B1 (ro) 2010-03-30
SI20581A (sl) 2001-12-31
EE04552B1 (et) 2005-10-17
WO2000012517A1 (en) 2000-03-09
BG65329B1 (bg) 2008-02-29
NO20010957L (no) 2001-04-26
HUP0203078A2 (hu) 2003-01-28
AU5698899A (en) 2000-03-21
HUP0203078A3 (en) 2005-01-28
EA002739B1 (ru) 2002-08-29
KR20010079701A (ko) 2001-08-22
EP1107974A4 (en) 2001-09-26
CA2341459A1 (en) 2000-03-09
DE69932620T2 (de) 2006-12-14
NZ510682A (en) 2003-09-26
DK1107974T3 (da) 2006-10-30
WO2000012517A9 (en) 2000-07-13
ES2270613T3 (es) 2007-04-01
JP2009143955A (ja) 2009-07-02
SK2482001A3 (en) 2002-01-07
HRP20010129A2 (en) 2005-04-30
IL141423A0 (en) 2002-03-10
IL141423A (en) 2005-09-25

Similar Documents

Publication Publication Date Title
EA200100184A1 (ru) Новые гидратные формы алендроната натрия, способы их получения и фармацевтические композиции
EA199800563A1 (ru) Антагонисты гормона, высвобождающего гонадотропин
EA199900778A1 (ru) ГЕТЕРОЦИКЛИЧЕСКИЕ СОЕДИНЕНИЯ И ИХ ИСПОЛЬЗОВАНИЕ ДЛЯ ИНГИБИРОВАНИЯ β-АМИЛОИДНОГО ПЕПТИДА
EA200300293A1 (ru) Противовоспалительные конденсированные пирролокарбазолы
ME00520B (me) Levodop/karbidop/entakapon farmaceutski preparat
EA200100412A1 (ru) Замещенные 3-цианохинолины в качестве ингибиторов протеинтирозинкиназ
DE60025369D1 (de) Unterchlorige säure enthaltendes superoxidiertes wasser zur behandlung von wunden
EA200201214A1 (ru) Замещенные тиоацетамиды
CY1112139T1 (el) Μια φαρμακευτικη συνθεση περιλαμβανουσα κρυσταλλικη ριτοναβιρη μορφη ιι και ενα παρασκευασμα εξ αυτης
WO2001043732A3 (en) Use of retinoid receptor antagonists in the treatment of cartilage and bone pathologies
PT2009025E (pt) Método de inibição da actividade dos osteoclastos
TR199802394A2 (xx) Proteinleri stabilize etmek i�in geli�tirilmi� proses.
EA200300579A1 (ru) Соединение лактама
AU5548801A (en) Use of retinoid receptor antagonists or agonists in the treatment of cartilage and bone pathologies
GR3032950T3 (en) Substituted fused and bridged bicyclic compounds as therapeutic agents
TR199902117T2 (xx) (E)-4,6- Dikloro-3-(2-okso-1-fenilpirolidin-3-iliden metil)-1H-�ndol-2-karboksilik asidin kristalimsi hidratlanm�� sodyum tuzu.
ATE248218T1 (de) Humane hypertrophe chrondrozyten zelllinien
ATE248805T1 (de) Nicht-hygroskopische salze des l-karnitines und der alkanoyl-karnitine enthaltende feste zusammensetzungen zur oralen verabreichung
WO2001025264A3 (en) Substituted phosphinate based peptide derivatives
MXPA02011941A (es) Composiciones condroprotectoras acuosas que tiene limitaciones definidas de ph para admiistracion eficaz.
RU94013445A (ru) Новое соединение, лейстродуксин н, способ его получения и терапевтическая композиция
UA73024C2 (en) 10 % solution of calcium gluconate for injections
EP1702924A3 (en) Novel hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof
IT1303766B1 (it) Alesatore-rettificatore di cavita' chirurgiche ossee destinate adaccogliere impianti.
BR0314525A (pt) Composições e métodos para tratamento de disfunção sexual

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU