AR058168A1 - Sintesis del alendronato de sodio trihidratado - Google Patents

Sintesis del alendronato de sodio trihidratado

Info

Publication number
AR058168A1
AR058168A1 ARP060104748A AR058168A1 AR 058168 A1 AR058168 A1 AR 058168A1 AR P060104748 A ARP060104748 A AR P060104748A AR 058168 A1 AR058168 A1 AR 058168A1
Authority
AR
Argentina
Prior art keywords
synthesis
sodium alendronate
trihydrated
trihydrated sodium
water
Prior art date
Application number
Other languages
English (en)
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of AR058168A1 publication Critical patent/AR058168A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Reivindicacion 1: Un procedimiento para preparar un compuesto de formula (1) que comprende las etapas: a) hacer reaccionar ácido alendronico con una base fuerte en agua; b) ajustar el pH entre 4,3 y 4,4; c) concentrar la solucion; d) cristalizar la sal en agua.
ARP060104748 2005-11-07 2006-10-30 Sintesis del alendronato de sodio trihidratado AR058168A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73417905P 2005-11-07 2005-11-07

Publications (1)

Publication Number Publication Date
AR058168A1 true AR058168A1 (es) 2008-01-23

Family

ID=37944596

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060104748 AR058168A1 (es) 2005-11-07 2006-10-30 Sintesis del alendronato de sodio trihidratado

Country Status (3)

Country Link
AR (1) AR058168A1 (es)
TW (1) TW200736268A (es)
WO (1) WO2007056417A2 (es)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5510517A (en) * 1993-08-25 1996-04-23 Merck & Co., Inc. Process for producing N-amino-1-hydroxy-alkylidene-1,1-bisphosphonic acids
CA2197267C (en) * 1997-02-11 2000-02-08 Yong Tao Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
RO122854B1 (ro) * 1998-08-27 2010-03-30 Teva Pharmaceutical Industries Ltd. Alendronat de sodiu hidrat, procedeu de obţinere şi compoziţie farmaceutică

Also Published As

Publication number Publication date
WO2007056417A2 (en) 2007-05-18
WO2007056417A3 (en) 2007-07-05
TW200736268A (en) 2007-10-01

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal