AR048876A1 - Un proceso para preparar montelukast y compuestos intermedios para el mismo - Google Patents

Un proceso para preparar montelukast y compuestos intermedios para el mismo

Info

Publication number
AR048876A1
AR048876A1 ARP050101620A ARP050101620A AR048876A1 AR 048876 A1 AR048876 A1 AR 048876A1 AR P050101620 A ARP050101620 A AR P050101620A AR P050101620 A ARP050101620 A AR P050101620A AR 048876 A1 AR048876 A1 AR 048876A1
Authority
AR
Argentina
Prior art keywords
same
intermediate compounds
formula
compound
prepare montelukast
Prior art date
Application number
ARP050101620A
Other languages
English (en)
Inventor
Arjanne Overeem
Reinerus Gieling
Zhu Jie
Thijs Lambertus
Original Assignee
Synthon Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthon Bv filed Critical Synthon Bv
Publication of AR048876A1 publication Critical patent/AR048876A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics

Abstract

Reivindicacion 1: Un compuesto caracterizado por la formula (1). Reivindicacion 2: Un proceso caracterizado porque comprende hacer reaccionar en la presencia de una base un compuesto de formula (1), con un compuesto de formula (3), donde R es hidrogeno o un grupo alquilo C1-4, y L es un grupo saliente seleccionado entre un halogeno o un grupo (alquil C1-4)- o (aril C6-8)-sulfoniloxi, para formar un compuesto de formula (2) o (2a), donde R es un grupo alquilo C1-4.
ARP050101620A 2004-04-30 2005-04-25 Un proceso para preparar montelukast y compuestos intermedios para el mismo AR048876A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US56660304P 2004-04-30 2004-04-30
US58467504P 2004-07-02 2004-07-02
US11/081,689 US7829716B2 (en) 2004-04-30 2005-03-17 Process for making montelukast and intermediates therefor

Publications (1)

Publication Number Publication Date
AR048876A1 true AR048876A1 (es) 2006-06-07

Family

ID=34965297

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050101620A AR048876A1 (es) 2004-04-30 2005-04-25 Un proceso para preparar montelukast y compuestos intermedios para el mismo

Country Status (6)

Country Link
US (1) US7829716B2 (es)
EP (1) EP1740545B1 (es)
AR (1) AR048876A1 (es)
AT (1) ATE461919T1 (es)
DE (1) DE602005020125D1 (es)
WO (1) WO2005105750A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE522507T1 (de) * 2003-10-10 2011-09-15 Synhton B V Montelukast in fester phase
US7501517B2 (en) * 2004-04-30 2009-03-10 Synthon Ip, Inc. Process for making montelukast and intermediates therefor
JP2008510840A (ja) 2005-07-05 2008-04-10 テバ ファーマシューティカル インダストリーズ リミティド モンテルカストの精製
CN101365683A (zh) * 2005-11-18 2009-02-11 斯索恩有限公司 制备孟鲁司特及其中间体的方法
AR057909A1 (es) * 2005-11-18 2007-12-26 Synthon Bv Proceso para preparar montelukast y compuestos relacionados, que utiliza un compuesto intermediario derivado de un ester sulfonico.
WO2007107297A1 (en) * 2006-03-17 2007-09-27 Synthon B.V. Montelukast amantadine salt
EP1886998A1 (en) 2006-08-09 2008-02-13 Esteve Quimica, S.A. Purification process of montelukast and its amine salts
CN101889081B (zh) 2007-09-28 2014-06-18 科德克希思公司 酮还原酶多肽及其用途
CN102046602A (zh) * 2008-04-25 2011-05-04 斯索恩有限公司 制备孟鲁司特中间体的方法
WO2011121091A1 (en) 2010-03-31 2011-10-06 Krka, D.D., Novo Mesto Efficient synthesis for the preparation of montelukast and novel crystalline form of intermediates therein
US8471030B2 (en) 2010-12-06 2013-06-25 Orochem Technologies Inc. Purification of montelukast using simulated moving bed
EP2502910A1 (en) 2011-03-15 2012-09-26 Laboratorios Lesvi, S.L. Camphorsulfonic salt of a key Montelukast intermediate
JP2021536467A (ja) 2018-09-06 2021-12-27 インノファーマスクリーン インコーポレイテッド 喘息またはパーキンソン病の処置のための方法および組成物

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5856322A (en) * 1990-10-12 1999-01-05 Merck Frosst Canada, Inc. Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists
DK0480717T3 (da) 1990-10-12 1999-02-08 Merck Frosst Canada Inc Umættede hydroxyalkylquinolinsyrer som leukotrienantagonister
US5266568A (en) * 1990-10-12 1993-11-30 Merck Frosst Canada, Inc. Hydroxyalkylquinoline ether acids as leukotriene antagonists
US5565473A (en) * 1990-10-12 1996-10-15 Merck Frosst Canada, Inc. Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists
US5270324A (en) * 1992-04-10 1993-12-14 Merck Frosst Canada, Inc. Fluorinated hydroxyalkylquinoline acids as leukotriene antagonists
TW416948B (en) * 1993-12-28 2001-01-01 Merck & Co Inc Process for the preparation of leukotriene antagonists
GB9423511D0 (en) * 1994-11-22 1995-01-11 Glaxo Wellcome Inc Compositions
US5585115A (en) 1995-01-09 1996-12-17 Edward H. Mendell Co., Inc. Pharmaceutical excipient having improved compressability
US5523477A (en) * 1995-01-23 1996-06-04 Merck & Co., Inc. Process for the preparation of 1-(thiomethyl)-cyclopropaneacetic acid
US5869673A (en) * 1997-02-28 1999-02-09 Merck & Co., Inc. Process for 3-(2-(7-chloro-2-quinolinyl)ethenyl) - benzaldehyde
US6585115B1 (en) * 2000-11-28 2003-07-01 Baker Hughes Incorporated Apparatus and method for transferring dry oil and gas well drill cuttings
CN1420113A (zh) * 2001-11-16 2003-05-28 北京上地新世纪生物医药研究所 孟鲁司特钠的制备方法及其制备中间体
CN1171873C (zh) * 2001-12-26 2004-10-20 北京上地新世纪生物医药研究所 一种孟鲁司特钠的制备方法及其制备中间体
US20040265375A1 (en) * 2003-04-16 2004-12-30 Platteeuw Johannes J. Orally disintegrating tablets
ATE522507T1 (de) * 2003-10-10 2011-09-15 Synhton B V Montelukast in fester phase
US7501517B2 (en) * 2004-04-30 2009-03-10 Synthon Ip, Inc. Process for making montelukast and intermediates therefor

Also Published As

Publication number Publication date
WO2005105750A1 (en) 2005-11-10
ATE461919T1 (de) 2010-04-15
DE602005020125D1 (de) 2010-05-06
US20050245568A1 (en) 2005-11-03
EP1740545B1 (en) 2010-03-24
EP1740545A1 (en) 2007-01-10
US7829716B2 (en) 2010-11-09

Similar Documents

Publication Publication Date Title
AR048876A1 (es) Un proceso para preparar montelukast y compuestos intermedios para el mismo
UY34969A (es) Síntesis de compuestos de ester y ácido bórico
AR048875A1 (es) Un proceso para preparar montelukast y compuestos intermedios para el mismo
EA200701176A1 (ru) Новые соединения нафталина, способ их получения и фармацевтические композиции, содержащие их
EA200801607A1 (ru) Производные бензимидазолонкарбоновой кислоты
AR052866A1 (es) Fenil-metanonas monociclicas sustituidas
ME01992B (me) Jedinjenje diarilhidantoina
AR053890A1 (es) Proceso para la sintesis de derivados de piridinil-pirimidinilo
CY1110064T1 (el) Παραγωγα φαινυλ-πιπεραζινης ως αναστολεις επαναπροσληψης σεροτονινης
DK1781683T3 (da) Fremgangsmåde til fremstilling af 17-vinyl-triflater som halvfabrikata
CY1109854T1 (el) Παραγωγα αζαδικυκλο(3.1.0)εξανιου χρησιμα ως ρυθμιστες υποδοχεων d3 ντοπαμινης
EA200702670A1 (ru) Препарат тиенопиридинового ингибитора агрегации тромбоцитов
MY148242A (en) Process for making trans-1-((1r,3s)-6-chloro-3-phenylindan-1-yl)-3,3-dimethylpiperazine
AR054533A1 (es) Proceso y reactivo magnetico para la separacion de impurezas de los minerales
EA200701470A1 (ru) Способы получения производных 4-(фенокси-5-метилпиримидин-4-илокси)пиперидин-1-карбоновой кислоты и родственных соединений
EA200801365A1 (ru) Замещенные 5-фенил-3,6-дигидро-2-оксо-6h-1,3,4-тиадиазины
RS52108B (en) 3-SUBSTITUTED [1,2,3] -BENZOTRIAZINONE UNIT TO INCREASE GLUTAMATERGIC SYNAPTIC ANSWERS
AR057909A1 (es) Proceso para preparar montelukast y compuestos relacionados, que utiliza un compuesto intermediario derivado de un ester sulfonico.
AR047810A1 (es) Proceso quimico
AR052917A1 (es) Proceso para preparar amidinas
SE0103710D0 (sv) Compounds
AR053989A1 (es) Compuestos espiro-hidantoina sustituidos con piridilo. composiciones farmaceuticas y procesos de obtencion.
EA200501530A1 (ru) Новые соединения бензотиадиазина, способ их получения и фармацевтические композиции, которые их содержат
AR052949A1 (es) Metabolitos derivados de piridina como antagonistas nk-1 para emesis
ATE466003T1 (de) Herstellung von 2-aminothiazol-5- carbonsäurederivaten

Legal Events

Date Code Title Description
FA Abandonment or withdrawal