AR048875A1 - Un proceso para preparar montelukast y compuestos intermedios para el mismo - Google Patents
Un proceso para preparar montelukast y compuestos intermedios para el mismoInfo
- Publication number
- AR048875A1 AR048875A1 ARP050101619A ARP050101619A AR048875A1 AR 048875 A1 AR048875 A1 AR 048875A1 AR P050101619 A ARP050101619 A AR P050101619A AR P050101619 A ARP050101619 A AR P050101619A AR 048875 A1 AR048875 A1 AR 048875A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- montelukast
- compound
- same
- intermediate compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
- C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/39—Preparation of carboxylic acid esters by oxidation of groups which are precursors for the acid moiety of the ester
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Un proceso para preparar montelukast y compuestos intermediarios. También se reivindica la obtencion de los intermediarios de formulas (1), (3) y (4). Reivindicacion 1: Un proceso para preparar montelukast o sus sales, caracterizado porque comprende convertir un compuesto de formula (1) en montelukast de formula (2) o una sal del mismo. Reivindicacion 2: El proceso de acuerdo con la reivindicacion 1, caracterizado porque dicha conversion comprende hacer reaccionar dicho compuesto de formula (1) con un compuesto de formula (3), donde R es hidrogeno o un grupo alquilo C1-4 y L es un grupo saliente. Reivindicacion 17: Un compuesto caracterizado por estar seleccionado del grupo formado por los compuestos de formula (1) y de formula (4).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US56660304P | 2004-04-30 | 2004-04-30 | |
US58467504P | 2004-07-02 | 2004-07-02 | |
US11/081,695 US7501517B2 (en) | 2004-04-30 | 2005-03-17 | Process for making montelukast and intermediates therefor |
Publications (1)
Publication Number | Publication Date |
---|---|
AR048875A1 true AR048875A1 (es) | 2006-06-07 |
Family
ID=34972158
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP050101619A AR048875A1 (es) | 2004-04-30 | 2005-04-25 | Un proceso para preparar montelukast y compuestos intermedios para el mismo |
Country Status (5)
Country | Link |
---|---|
US (1) | US7501517B2 (es) |
EP (2) | EP2181986B1 (es) |
AR (1) | AR048875A1 (es) |
AT (1) | ATE529408T1 (es) |
WO (1) | WO2005105749A2 (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2541994A1 (en) * | 2003-10-10 | 2005-05-06 | Arjanne Overeem | Solid-state montelukast |
US7829716B2 (en) * | 2004-04-30 | 2010-11-09 | Synthon Pharmaceuticals, Inc. | Process for making montelukast and intermediates therefor |
US7858793B2 (en) * | 2004-07-19 | 2010-12-28 | Chava Satyanarayana | Methyl 2-[(3S)-[3-[2E)-(7-chloro quinolin-2-yl) ethenyl] phenyl]-3-halopropyl] benzoates |
CA2608369A1 (en) | 2005-07-05 | 2007-01-11 | Teva Pharmaceutical Industries Ltd. | Purification of montelukast |
CN101356157B (zh) * | 2005-11-18 | 2011-07-06 | 斯索恩有限公司 | 制备孟鲁司特及其中间体的方法 |
AR056815A1 (es) * | 2005-11-18 | 2007-10-24 | Synthon Bv | PROCESO PARA PREPARAR MONTELUKAST, INTERMEDIARIOS DEL MISMO Y SUS SALES DE ADICIoN Y PROCEDIMIENTO DE PURIFICACIoN DE ÉSTOS Y DE MONTELUKAST |
EA021960B1 (ru) | 2005-12-30 | 2015-10-30 | Крка, Товарна Здравил, Д.Д., Ново Место | Таблетка, содержащая фармацевтически приемлемую соль монтелукаста в аморфной форме, и способ ее получения |
CN101432267A (zh) * | 2006-03-17 | 2009-05-13 | 斯索恩有限公司 | 孟鲁司特金刚烷胺盐 |
EP1886998A1 (en) | 2006-08-09 | 2008-02-13 | Esteve Quimica, S.A. | Purification process of montelukast and its amine salts |
WO2009042984A1 (en) | 2007-09-28 | 2009-04-02 | Codexis, Inc. | Ketoreductase polypeptides and uses thereof |
CN102046602A (zh) * | 2008-04-25 | 2011-05-04 | 斯索恩有限公司 | 制备孟鲁司特中间体的方法 |
US8207343B2 (en) | 2008-05-26 | 2012-06-26 | Laurus Labs Private Limited | Process for preparing montelukast and salts thereof |
EP2552892A1 (en) | 2010-03-31 | 2013-02-06 | KRKA, D.D., Novo Mesto | Efficient synthesis for the preparation of montelukast and novel crystalline form of intermediates therein |
HUP1000425A2 (en) | 2010-08-11 | 2012-03-28 | Richter Gedeon Nyrt | Process for the production of montelukast sodium |
US8471030B2 (en) | 2010-12-06 | 2013-06-25 | Orochem Technologies Inc. | Purification of montelukast using simulated moving bed |
CN103467276B (zh) * | 2013-09-13 | 2015-05-06 | 天津速研医药科技有限公司 | 一种孟鲁司特钠侧链关键中间体的合成方法 |
CN111072475A (zh) * | 2019-12-20 | 2020-04-28 | 牡丹江恒远药业股份有限公司 | 1-羟甲基环丙基乙酸的合成方法及应用 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5856322A (en) | 1990-10-12 | 1999-01-05 | Merck Frosst Canada, Inc. | Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists |
US5266568A (en) | 1990-10-12 | 1993-11-30 | Merck Frosst Canada, Inc. | Hydroxyalkylquinoline ether acids as leukotriene antagonists |
ES2114882T3 (es) | 1990-10-12 | 1998-06-16 | Merck Frosst Canada Inc | Acidos hidroxialquilquinolinos insaturados como antagonistas de leucotrienos. |
US5565473A (en) | 1990-10-12 | 1996-10-15 | Merck Frosst Canada, Inc. | Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists |
US5270324A (en) | 1992-04-10 | 1993-12-14 | Merck Frosst Canada, Inc. | Fluorinated hydroxyalkylquinoline acids as leukotriene antagonists |
TW448160B (en) | 1993-12-28 | 2001-08-01 | Merck & Co Inc | Novel dicyclohexylamine salt and process for the preparation of leukotriene antagonists |
GB9423511D0 (en) | 1994-11-22 | 1995-01-11 | Glaxo Wellcome Inc | Compositions |
US5585115A (en) | 1995-01-09 | 1996-12-17 | Edward H. Mendell Co., Inc. | Pharmaceutical excipient having improved compressability |
US5523477A (en) | 1995-01-23 | 1996-06-04 | Merck & Co., Inc. | Process for the preparation of 1-(thiomethyl)-cyclopropaneacetic acid |
US5869673A (en) | 1997-02-28 | 1999-02-09 | Merck & Co., Inc. | Process for 3-(2-(7-chloro-2-quinolinyl)ethenyl) - benzaldehyde |
CN1420113A (zh) * | 2001-11-16 | 2003-05-28 | 北京上地新世纪生物医药研究所 | 孟鲁司特钠的制备方法及其制备中间体 |
CN1171873C (zh) * | 2001-12-26 | 2004-10-20 | 北京上地新世纪生物医药研究所 | 一种孟鲁司特钠的制备方法及其制备中间体 |
US20040265375A1 (en) | 2003-04-16 | 2004-12-30 | Platteeuw Johannes J. | Orally disintegrating tablets |
CA2541994A1 (en) | 2003-10-10 | 2005-05-06 | Arjanne Overeem | Solid-state montelukast |
US7829716B2 (en) | 2004-04-30 | 2010-11-09 | Synthon Pharmaceuticals, Inc. | Process for making montelukast and intermediates therefor |
-
2005
- 2005-03-17 US US11/081,695 patent/US7501517B2/en not_active Expired - Fee Related
- 2005-04-14 EP EP10075051A patent/EP2181986B1/en not_active Not-in-force
- 2005-04-14 EP EP05759120A patent/EP1740546A2/en not_active Withdrawn
- 2005-04-14 AT AT10075051T patent/ATE529408T1/de not_active IP Right Cessation
- 2005-04-14 WO PCT/EP2005/004011 patent/WO2005105749A2/en not_active Application Discontinuation
- 2005-04-25 AR ARP050101619A patent/AR048875A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO2005105749A2 (en) | 2005-11-10 |
EP1740546A2 (en) | 2007-01-10 |
ATE529408T1 (de) | 2011-11-15 |
WO2005105749A3 (en) | 2006-03-02 |
US20050245569A1 (en) | 2005-11-03 |
US7501517B2 (en) | 2009-03-10 |
EP2181986B1 (en) | 2011-10-19 |
EP2181986A1 (en) | 2010-05-05 |
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Legal Events
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FA | Abandonment or withdrawal |