BR112012019620A2 - Processo para preparar voriconazol usando novos intermediários - Google Patents

Processo para preparar voriconazol usando novos intermediários

Info

Publication number
BR112012019620A2
BR112012019620A2 BR112012019620A BR112012019620A BR112012019620A2 BR 112012019620 A2 BR112012019620 A2 BR 112012019620A2 BR 112012019620 A BR112012019620 A BR 112012019620A BR 112012019620 A BR112012019620 A BR 112012019620A BR 112012019620 A2 BR112012019620 A2 BR 112012019620A2
Authority
BR
Brazil
Prior art keywords
voriconazole
chemical formula
new intermediates
prepare
preparing
Prior art date
Application number
BR112012019620A
Other languages
English (en)
Inventor
Chul Kwon Hyuk
Hoi Cha Kyung
Dong Rho Man
Original Assignee
Dong Kook Pharm Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42645839&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112012019620(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Dong Kook Pharm Co Ltd filed Critical Dong Kook Pharm Co Ltd
Publication of BR112012019620A2 publication Critical patent/BR112012019620A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

processo para preparar voriconazol usando novos intermediários. é provido um processo para a preparação de voriconazol representado pela fórmula química 1. mais especificamente, o processo para a preparação de voriconazol de fórmula química 1 inclui: realizar a reação de acoplamento tipo reformatsky entre um derivado de cetona de fórmula química 4 e um derivado de pirimidina de fórmula qímica 5 para obter um composto de fórmula química 3; reagir os substituintes halogênios e oxissulfonila com um doador de hidrogênio para ogter voriconazol racêmico pela adição de um ácido opticamente ativo adequado para obter voriconazol tendo alta pureza óptica com alta rentabilidade e alto rendimento.
BR112012019620A 2010-02-04 2011-02-01 Processo para preparar voriconazol usando novos intermediários BR112012019620A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020100010467A KR100971371B1 (ko) 2010-02-04 2010-02-04 신규한 중간체를 이용한 보리코나졸의 제조방법
PCT/KR2011/000689 WO2011096697A2 (en) 2010-02-04 2011-02-01 Process for preparing voriconazole by using new intermediates

Publications (1)

Publication Number Publication Date
BR112012019620A2 true BR112012019620A2 (pt) 2022-05-10

Family

ID=42645839

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012019620A BR112012019620A2 (pt) 2010-02-04 2011-02-01 Processo para preparar voriconazol usando novos intermediários

Country Status (9)

Country Link
US (1) US8575344B2 (pt)
EP (1) EP2531499B1 (pt)
JP (1) JP5553911B2 (pt)
KR (1) KR100971371B1 (pt)
BR (1) BR112012019620A2 (pt)
ES (1) ES2518892T3 (pt)
MX (1) MX2012008152A (pt)
PE (1) PE20130043A1 (pt)
WO (1) WO2011096697A2 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101435741B1 (ko) * 2013-01-17 2014-08-29 (주) 에프엔지리서치 신규한 보리코나졸 중간체 및 이를 이용한 보리코나졸의 제조 방법
KR101709543B1 (ko) * 2014-12-09 2017-02-23 (주) 에프엔지리서치 신규한 보리코나졸 중간체 및 이를 이용한 보리코나졸의 제조 방법
WO2021127965A1 (zh) * 2019-12-24 2021-07-01 刘杰 一种伏立康唑对映异构体的回收方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0069442B1 (en) 1981-06-06 1985-02-20 Pfizer Limited Antifungal agents, processes for their preparation, and pharmaceutical compositions containing them
GB9002375D0 (en) 1990-02-02 1990-04-04 Pfizer Ltd Triazole antifungal agents
GB9516121D0 (en) 1995-08-05 1995-10-04 Pfizer Ltd Organometallic addition to ketones
WO2007013096A1 (en) 2005-06-30 2007-02-01 Msn Laboratories Limited Improved process for the preparation of 2r, 3s-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1h-1,2,4-triazol-1-yl) butan-2-ol (voriconazole)
CA2640922A1 (en) * 2006-02-01 2007-11-22 Medichem, S.A. Process for preparing voriconazole, new polymorphic form of intermediate thereof, and uses thereof
KR100889937B1 (ko) * 2007-08-06 2009-03-20 한미약품 주식회사 보리코나졸의 제조방법
GB2452049A (en) 2007-08-21 2009-02-25 Alpharma Aps Process for the preparation of voriconazole
WO2009084029A2 (en) 2007-12-03 2009-07-09 Neuland Laboratories Ltd Improved process for the preparation of (2r,3s)-2-(2,4- difluqrophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1h-1,2,4-triazol-1-yl) butan-2-ol

Also Published As

Publication number Publication date
EP2531499A4 (en) 2013-06-26
MX2012008152A (es) 2012-08-23
US20130005973A1 (en) 2013-01-03
PE20130043A1 (es) 2013-02-04
ES2518892T3 (es) 2014-11-05
WO2011096697A3 (en) 2011-12-15
JP2013518876A (ja) 2013-05-23
WO2011096697A2 (en) 2011-08-11
EP2531499B1 (en) 2014-07-23
US8575344B2 (en) 2013-11-05
KR100971371B1 (ko) 2010-07-20
EP2531499A2 (en) 2012-12-12
JP5553911B2 (ja) 2014-07-23

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Legal Events

Date Code Title Description
B15K Others concerning applications: alteration of classification

Free format text: AS CLASSIFICACOES ANTERIORES ERAM: C07D 403/02 , C07D 403/08

Ipc: C07D 403/02 (2006.01), C07D 403/08 (2006.01), A61P

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements