MX2010001864A - Metodo para la preparacion de acido montelukast en un medio liquido ionico. - Google Patents

Metodo para la preparacion de acido montelukast en un medio liquido ionico.

Info

Publication number
MX2010001864A
MX2010001864A MX2010001864A MX2010001864A MX2010001864A MX 2010001864 A MX2010001864 A MX 2010001864A MX 2010001864 A MX2010001864 A MX 2010001864A MX 2010001864 A MX2010001864 A MX 2010001864A MX 2010001864 A MX2010001864 A MX 2010001864A
Authority
MX
Mexico
Prior art keywords
preparation
montelukast
ionic liquid
montelukast acid
liquid medium
Prior art date
Application number
MX2010001864A
Other languages
English (en)
Inventor
Chul-Hyun Park
Gwan Sun Lee
Young Kil Chang
Jaeheon Lee
Eun-Ju Park
Choong-Hahn Kim
Suk Man Jang
Eun Jung Lim
Original Assignee
Hanmi Pharm Ind Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40549354&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2010001864(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hanmi Pharm Ind Co Ltd filed Critical Hanmi Pharm Ind Co Ltd
Publication of MX2010001864A publication Critical patent/MX2010001864A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Quinoline Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención se refiere a un método para la preparación de un ácido Montelukast o su sal sádica mediante la reacción de un compuesto tiol con un intermedio Montelukast en presencia de una base, en un medio que comprende un compuesto líquido jónico. De conformidad con el método de la presente invención, se puede preparar fácilmente con rendimiento elevado ácido Montelukast de alta pureza o su sal sádica, que se utiliza de manera provechosa como materia prima en la preparación de Montelukast, un antagonista de leucotrienos.
MX2010001864A 2007-10-09 2008-10-01 Metodo para la preparacion de acido montelukast en un medio liquido ionico. MX2010001864A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020070101486A KR101072896B1 (ko) 2007-10-09 2007-10-09 이온성 액체 매개체를 이용한 몬테루카스트산의 제조 방법
PCT/KR2008/005794 WO2009048236A1 (en) 2007-10-09 2008-10-01 Method for the preparation of montelukast acid in ionic liquid medium

Publications (1)

Publication Number Publication Date
MX2010001864A true MX2010001864A (es) 2010-03-15

Family

ID=40549354

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010001864A MX2010001864A (es) 2007-10-09 2008-10-01 Metodo para la preparacion de acido montelukast en un medio liquido ionico.

Country Status (18)

Country Link
US (1) US8426599B2 (es)
EP (1) EP2195295B1 (es)
JP (1) JP5210389B2 (es)
KR (1) KR101072896B1 (es)
CN (1) CN101808998B (es)
AR (1) AR068755A1 (es)
CA (1) CA2701912C (es)
CL (1) CL2008002996A1 (es)
DK (1) DK2195295T3 (es)
ES (1) ES2398732T3 (es)
HR (1) HRP20130103T1 (es)
MX (1) MX2010001864A (es)
PE (2) PE20091369A1 (es)
PL (1) PL2195295T3 (es)
PT (1) PT2195295E (es)
RU (1) RU2436774C1 (es)
TW (1) TWI350284B (es)
WO (1) WO2009048236A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP1000425A2 (en) 2010-08-11 2012-03-28 Richter Gedeon Nyrt Process for the production of montelukast sodium
CN103570618A (zh) * 2013-09-30 2014-02-12 浙江车头制药股份有限公司 一种孟鲁司特钠盐的制备方法
CN105294556A (zh) * 2014-06-06 2016-02-03 上海迪赛诺化学制药有限公司 一种制备孟鲁司特酸的方法
EP3846792A4 (en) 2018-09-06 2022-10-12 Innopharmascreen Inc. METHODS AND COMPOSITIONS FOR TREATING ASTHMA OR PARKINSON'S DISEASE
KR102181155B1 (ko) * 2019-09-26 2020-11-20 대봉엘에스 주식회사 이온성 액체를 매개로 한 에피나코나졸의 신규 제조방법
CN111892535B (zh) * 2020-08-27 2023-04-11 鲁南制药集团股份有限公司 一种孟鲁司特钠的合成方法
CN111961083B (zh) * 2020-08-27 2022-11-25 鲁南制药集团股份有限公司 一种孟鲁司特钠中间体化合物

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0480717B1 (en) 1990-10-12 1998-04-15 Merck Frosst Canada Inc. Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists
TW416948B (en) 1993-12-28 2001-01-01 Merck & Co Inc Process for the preparation of leukotriene antagonists
US5523477A (en) * 1995-01-23 1996-06-04 Merck & Co., Inc. Process for the preparation of 1-(thiomethyl)-cyclopropaneacetic acid
EP1708708A1 (en) * 2004-01-30 2006-10-11 Teva Pharmaceutical Industries Ltd. Montelukast free acid polymorphs
MXPA06012220A (es) 2004-04-21 2007-07-18 Teva Pharma Procesos para preparar sodio de montelukast.
JP2006089463A (ja) * 2004-08-24 2006-04-06 Sumitomo Chemical Co Ltd アリールエーテル類の製造方法
WO2006064269A2 (en) 2004-12-17 2006-06-22 Cipla Limited Salts of leukotriene antagonist montelukast
GB0500029D0 (en) * 2005-01-04 2005-02-09 Univ Belfast Basic ionic liquids
US8232265B2 (en) * 2005-10-07 2012-07-31 Board Of Trustees Of The University Of Alabama Multi-functional ionic liquid compositions for overcoming polymorphism and imparting improved properties for active pharmaceutical, biological, nutritional, and energetic ingredients
EP1783117A1 (en) 2005-11-04 2007-05-09 Esteve Quimica, S.A. Process for the preparation of a leukotriene antagonist and intermediates thereof
WO2007069261A1 (en) 2005-12-13 2007-06-21 Msn Laboratories Limited An improved process for the preparation of montelukast and its pharmaceutically acceptable salts
WO2007072114A1 (en) * 2005-12-23 2007-06-28 Glade Organics Private Limited An improved process for the manufacture of montelukast sodium
US7528254B2 (en) * 2006-02-27 2009-05-05 Chemagis Ltd. Process for preparing montelukast and salts thereof
KR100774088B1 (ko) 2006-12-14 2007-11-06 한미약품 주식회사 몬테루카스트의 제조방법 및 이에 사용되는 중간체

Also Published As

Publication number Publication date
EP2195295B1 (en) 2013-01-23
CA2701912A1 (en) 2009-04-16
ES2398732T3 (es) 2013-03-21
CA2701912C (en) 2013-04-02
JP5210389B2 (ja) 2013-06-12
JP2011500555A (ja) 2011-01-06
US8426599B2 (en) 2013-04-23
TW200920737A (en) 2009-05-16
CN101808998B (zh) 2012-10-24
DK2195295T3 (da) 2013-05-06
EP2195295A1 (en) 2010-06-16
AR068755A1 (es) 2009-12-02
PE20091369A1 (es) 2009-10-01
WO2009048236A1 (en) 2009-04-16
TWI350284B (en) 2011-10-11
CL2008002996A1 (es) 2009-04-13
RU2436774C1 (ru) 2011-12-20
HRP20130103T1 (hr) 2013-02-28
PL2195295T3 (pl) 2013-06-28
EP2195295A4 (en) 2011-04-13
KR101072896B1 (ko) 2011-10-17
CN101808998A (zh) 2010-08-18
US20110105757A1 (en) 2011-05-05
PE20131219A1 (es) 2013-11-16
KR20090036349A (ko) 2009-04-14
PT2195295E (pt) 2013-02-28

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