DK2152667T3 - Fremgangsmåder til fremstilling af N-isobutyl-n-(2-hydroxy-3-amin-4-phenylbutyl)-p-nitrobenzenesulfonylamid-derivater - Google Patents
Fremgangsmåder til fremstilling af N-isobutyl-n-(2-hydroxy-3-amin-4-phenylbutyl)-p-nitrobenzenesulfonylamid-derivaterInfo
- Publication number
- DK2152667T3 DK2152667T3 DK08749718.6T DK08749718T DK2152667T3 DK 2152667 T3 DK2152667 T3 DK 2152667T3 DK 08749718 T DK08749718 T DK 08749718T DK 2152667 T3 DK2152667 T3 DK 2152667T3
- Authority
- DK
- Denmark
- Prior art keywords
- hydroxy
- phenylbutyl
- isobutyl
- preparation
- amine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
- C07C303/38—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reaction of ammonia or amines with sulfonic acids, or with esters, anhydrides, or halides thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07107177 | 2007-04-27 | ||
| PCT/EP2008/055042 WO2008132154A1 (en) | 2007-04-27 | 2008-04-25 | Methods for the preparation of n-isobutyl-n-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2152667T3 true DK2152667T3 (da) | 2011-05-16 |
Family
ID=38924830
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK08749718.6T DK2152667T3 (da) | 2007-04-27 | 2008-04-25 | Fremgangsmåder til fremstilling af N-isobutyl-n-(2-hydroxy-3-amin-4-phenylbutyl)-p-nitrobenzenesulfonylamid-derivater |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8076513B2 (da) |
| EP (1) | EP2152667B1 (da) |
| JP (1) | JP2010525029A (da) |
| CN (1) | CN101668734A (da) |
| AT (1) | ATE498606T1 (da) |
| AU (1) | AU2008244306A1 (da) |
| BR (1) | BRPI0810609A2 (da) |
| CA (1) | CA2682616A1 (da) |
| CY (1) | CY1111457T1 (da) |
| DE (1) | DE602008005012D1 (da) |
| DK (1) | DK2152667T3 (da) |
| ES (1) | ES2360654T3 (da) |
| HR (1) | HRP20110290T1 (da) |
| IL (1) | IL200811A0 (da) |
| MX (1) | MX2009011574A (da) |
| PL (1) | PL2152667T3 (da) |
| PT (1) | PT2152667E (da) |
| RU (1) | RU2009143867A (da) |
| SI (1) | SI2152667T1 (da) |
| WO (1) | WO2008132154A1 (da) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8921415B2 (en) | 2009-01-29 | 2014-12-30 | Mapi Pharma Ltd. | Polymorphs of darunavir |
| ES2516916T3 (es) | 2010-01-28 | 2014-10-31 | Mapi Pharma Limited | Procedimiento para la preparación de darunavir e intermedios de darunavir |
| WO2011158259A1 (en) * | 2010-06-18 | 2011-12-22 | Matrix Laboratories Ltd | Novel process for the preparation of (3s)-tetrahydrofuran-3-yl (is, 2r)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-(phosphonooxy) propylcarbamate and its pharmaceutically acceptable salts thereof |
| DK2643326T3 (da) | 2010-11-23 | 2017-01-09 | Mylan Laboratories Ltd | Fremgangsmåde til fremstilling af (3R, 3aS, 6aR)-hexahydrofuro[2,3-b]furan-3-ol |
| CN105315178B (zh) * | 2014-07-09 | 2018-07-06 | 浙江九洲药业股份有限公司 | 达芦那韦相关物质及其制备方法 |
| CN114685322B (zh) * | 2020-12-30 | 2023-08-25 | 上海飞腾医药科技有限公司 | 一种抗hiv类药物中间体晶体的生长方法和所得晶体及其应用 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3000377A1 (de) * | 1980-01-07 | 1981-07-09 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue sulfonamide, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel |
| JPH07110846B2 (ja) * | 1987-12-23 | 1995-11-29 | アグロカネショウ株式会社 | 置換ベンジルスルホアミド誘導体、その製法及び選択性除草剤 |
| ATE218541T1 (de) | 1992-08-25 | 2002-06-15 | Searle & Co | Hydroxyethylaminosulfonamide verwendbar als inhibitoren retroviraler proteasen |
| IS2334B (is) | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
| DK0715618T3 (da) | 1993-08-24 | 1999-08-23 | Searle & Co | Hydroxyethylaminosulfonamider til anvendelse som inhibitorer af retrovirale proteaser |
| US5929284A (en) | 1995-02-03 | 1999-07-27 | Kaneka Corporation | Processes for producing α-halo ketones, α-halohydrins and epoxides |
| US5753660A (en) | 1995-11-15 | 1998-05-19 | G. D. Searle & Co. | Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors |
| BR9912169A (pt) | 1998-06-19 | 2001-04-10 | Vertex Pharma | Inibidores de sulfonamida de protease de aspartil |
| DK1088098T4 (da) | 1998-06-23 | 2015-09-14 | Us Of America Represented By The Secretary Dept Of Health And Human Services | Fitnessassay og fremgangsmåder til reducering af HIV-resistens over for terapi |
| WO1999067254A2 (en) | 1998-06-23 | 1999-12-29 | The United States Of America Represented By The Secretary, Department Of Health And Human Services | Multi-drug resistant retroviral protease inhibitors and use thereof |
| US6278002B1 (en) | 1998-08-25 | 2001-08-21 | Kaneka Corporation | Process for the preparation of (2r,3s)-3-amino-1,2-oxirane |
| EP1067125B1 (en) | 1999-01-29 | 2006-07-26 | Kaneka Corporation | PROCESSES FOR THE PREPARATION OF threo-1,2-EPOXY-3-AMINO-4-PHENYLBUTANE DERIVATIVES |
| PT1159278E (pt) | 1999-02-12 | 2006-06-30 | Vertex Pharma | Inibidores de aspartil-protease |
| AR031520A1 (es) | 1999-06-11 | 2003-09-24 | Vertex Pharma | Un compuesto inhibidor de aspartilo proteasa, una composicion que lo comprende y un metodo para tratar un paciente con dicha composicion |
| KR100708221B1 (ko) | 1999-08-31 | 2007-04-17 | 아지노모토 가부시키가이샤 | 에폭사이드 결정의 제조방법 |
| ATE401298T1 (de) | 1999-12-23 | 2008-08-15 | Ampac Fine Chemicals Llc | Verbessertes verfahren zur herstellung von 2s,3s- n-isobutyl-n-(2-hydroxy-3-amino-4-phenylbutyl)- - nitrobenzenesulfonylamid hydrochlorid und anderen derivaten von 2-hydroxy-1,3-diamin |
| US6764545B2 (en) | 2000-12-12 | 2004-07-20 | Ajinomoto Co., Inc. | Production method of epoxide crystal |
| JP2002332270A (ja) * | 2001-03-07 | 2002-11-22 | Ajinomoto Co Inc | スルホンアミド誘導体の製造方法 |
| BRPI0212341B8 (pt) | 2001-09-10 | 2021-05-25 | Janssen R&D Ireland | compostos intermediários de inibidores de protease de hiv e processo para preparação dos mesmos |
| WO2004033462A2 (en) | 2002-10-09 | 2004-04-22 | The Board Of Trustees Of The University Of Illinois | METHOD OF PREPARING (3R, 3aS, 6aR) -3- HYDROXYHEXAHYDROFURO [2, 3-b] FURAN AND RELATED COMPOUNDS |
| EP1589018A4 (en) | 2002-12-27 | 2007-03-14 | Sumitomo Chemical Co | PROCESS FOR PRODUCING A DERIVATIVE OF HEXAHYDROFURANOL, INTERMEDIATE THEREOF AND PROCESS FOR PRODUCING THE SAME |
| UA79404C2 (en) * | 2003-10-02 | 2007-06-11 | Basf Ag | 2-cyanobenzenesulfonamide for controlling pests |
| DE602004021640D1 (de) | 2003-12-23 | 2009-07-30 | Tibotec Pharm Ltd | Verfahren zur herstellung von (1s,2r)-3-ää(4-aminophenyl)sulfonylü(isobutyl)aminoü-1-benzyl-2-hydroxypropylcarbamidsäure-(3r,3as,6ar)-hexahydrofuroä2,3-büfuran-3-ylester |
| TWI383975B (zh) | 2004-03-31 | 2013-02-01 | Tibotec Pharm Ltd | 製備（３Ｒ，３ａＳ，６ａＲ）六氫-呋喃并〔２，３-ｂ〕呋喃-３-醇之方法 |
-
2008
- 2008-04-25 PT PT08749718T patent/PT2152667E/pt unknown
- 2008-04-25 ES ES08749718T patent/ES2360654T3/es active Active
- 2008-04-25 CN CN200880013559A patent/CN101668734A/zh active Pending
- 2008-04-25 JP JP2010504703A patent/JP2010525029A/ja active Pending
- 2008-04-25 SI SI200830232T patent/SI2152667T1/sl unknown
- 2008-04-25 CA CA002682616A patent/CA2682616A1/en not_active Abandoned
- 2008-04-25 EP EP08749718A patent/EP2152667B1/en not_active Not-in-force
- 2008-04-25 PL PL08749718T patent/PL2152667T3/pl unknown
- 2008-04-25 MX MX2009011574A patent/MX2009011574A/es active IP Right Grant
- 2008-04-25 DE DE602008005012T patent/DE602008005012D1/de active Active
- 2008-04-25 AU AU2008244306A patent/AU2008244306A1/en not_active Abandoned
- 2008-04-25 US US12/597,088 patent/US8076513B2/en not_active Expired - Fee Related
- 2008-04-25 BR BRPI0810609-6A2A patent/BRPI0810609A2/pt not_active IP Right Cessation
- 2008-04-25 DK DK08749718.6T patent/DK2152667T3/da active
- 2008-04-25 WO PCT/EP2008/055042 patent/WO2008132154A1/en active Application Filing
- 2008-04-25 AT AT08749718T patent/ATE498606T1/de active
- 2008-04-25 RU RU2009143867/04A patent/RU2009143867A/ru not_active Application Discontinuation
-
2009
- 2009-09-08 IL IL200811A patent/IL200811A0/en unknown
-
2011
- 2011-04-19 HR HR20110290T patent/HRP20110290T1/hr unknown
- 2011-05-16 CY CY20111100463T patent/CY1111457T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL200811A0 (en) | 2010-05-17 |
| CN101668734A (zh) | 2010-03-10 |
| JP2010525029A (ja) | 2010-07-22 |
| PT2152667E (pt) | 2011-04-06 |
| BRPI0810609A2 (pt) | 2014-10-21 |
| PL2152667T3 (pl) | 2011-06-30 |
| CA2682616A1 (en) | 2008-11-06 |
| CY1111457T1 (el) | 2015-08-05 |
| AU2008244306A1 (en) | 2008-11-06 |
| US20100121094A1 (en) | 2010-05-13 |
| EP2152667A1 (en) | 2010-02-17 |
| HRP20110290T1 (hr) | 2011-05-31 |
| WO2008132154A1 (en) | 2008-11-06 |
| ATE498606T1 (de) | 2011-03-15 |
| ES2360654T3 (es) | 2011-06-08 |
| MX2009011574A (es) | 2009-11-09 |
| EP2152667B1 (en) | 2011-02-16 |
| RU2009143867A (ru) | 2011-06-10 |
| US8076513B2 (en) | 2011-12-13 |
| SI2152667T1 (sl) | 2011-06-30 |
| DE602008005012D1 (de) | 2011-03-31 |
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