CY1120660T1 - Καινοφανεις υποκαταστατες toy rig-i και μεθοδοι παραγωγης αυτων - Google Patents

Καινοφανεις υποκαταστατες toy rig-i και μεθοδοι παραγωγης αυτων

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Publication number
CY1120660T1
CY1120660T1 CY181100723T CY181100723T CY1120660T1 CY 1120660 T1 CY1120660 T1 CY 1120660T1 CY 181100723 T CY181100723 T CY 181100723T CY 181100723 T CY181100723 T CY 181100723T CY 1120660 T1 CY1120660 T1 CY 1120660T1
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CY
Cyprus
Prior art keywords
rig
substitutes
production
methods
new toy
Prior art date
Application number
CY181100723T
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English (en)
Inventor
Marion Goldeck
Den Boorn Jasper Van
JáNOS LUDWIG
Christine Schuberth-Wagner
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Univ Bonn Rheinische Friedrich Wilhelms
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Publication date
Application filed by Univ Bonn Rheinische Friedrich Wilhelms filed Critical Univ Bonn Rheinische Friedrich Wilhelms
Publication of CY1120660T1 publication Critical patent/CY1120660T1/el

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    • C07H1/00—Processes for the preparation of sugar derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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Abstract

Η παρούσα εφεύρεση σχετίζεται με νέα ολιγονουκλεοτίδια τροποποιημένης τριφωσφορικής ομάδας τα οποία μπορούν να δράσουν ως υποκατάστατες του RIG-I καθώς σχετίζεται και με μια νέα μέθοδο που επιτρέπει τη σύνθεση και τον καθαρισμό υπό μεγάλη απόδοση και καθαρότητα η οποία μέθοδος είναι κατάλληλη για φαρμακευτικές εφαρμογές.
CY181100723T 2012-09-27 2018-07-11 Καινοφανεις υποκαταστατες toy rig-i και μεθοδοι παραγωγης αυτων CY1120660T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12186444.1A EP2712870A1 (en) 2012-09-27 2012-09-27 Novel RIG-I ligands and methods for producing them
EP13774100.5A EP2903997B1 (en) 2012-09-27 2013-09-26 Novel rig-i ligands and methods for producing them
PCT/EP2013/070117 WO2014049079A1 (en) 2012-09-27 2013-09-26 Novel rig-i ligands and methods for producing them

Publications (1)

Publication Number Publication Date
CY1120660T1 true CY1120660T1 (el) 2019-12-11

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Family Applications (1)

Application Number Title Priority Date Filing Date
CY181100723T CY1120660T1 (el) 2012-09-27 2018-07-11 Καινοφανεις υποκαταστατες toy rig-i και μεθοδοι παραγωγης αυτων

Country Status (32)

Country Link
US (3) US10059943B2 (el)
EP (5) EP2712870A1 (el)
JP (1) JP6313768B2 (el)
KR (1) KR102182479B1 (el)
CN (2) CN106279300B (el)
AU (2) AU2013322620C1 (el)
BR (2) BR112015006874B1 (el)
CA (1) CA2885564C (el)
CL (1) CL2015000752A1 (el)
CY (1) CY1120660T1 (el)
DK (1) DK2903997T3 (el)
EA (2) EA028707B1 (el)
ES (1) ES2679373T3 (el)
HK (2) HK1209128A1 (el)
HR (1) HRP20181114T1 (el)
HU (1) HUE038811T2 (el)
IL (1) IL237794B (el)
LT (1) LT2903997T (el)
MX (1) MX2015003787A (el)
NZ (2) NZ706443A (el)
PH (1) PH12015500644B1 (el)
PL (1) PL2903997T3 (el)
PT (1) PT2903997T (el)
RS (1) RS57609B1 (el)
SA (2) SA517380700B1 (el)
SG (3) SG10201912308SA (el)
SI (1) SI2903997T1 (el)
TN (1) TN2015000104A1 (el)
TR (1) TR201810231T4 (el)
UA (1) UA117565C2 (el)
WO (1) WO2014049079A1 (el)
ZA (1) ZA201501718B (el)

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EP2712870A1 (en) 2012-09-27 2014-04-02 Rheinische Friedrich-Wilhelms-Universität Bonn Novel RIG-I ligands and methods for producing them
WO2014169049A1 (en) * 2013-04-09 2014-10-16 Duke University 2' fluoro-modified rnas as immunostimulators
DE102015008536A1 (de) 2015-07-02 2017-01-05 Rheinische Friedrich-Wilhelms-Universität Bonn Diskontinuierliche Oligonukleotid-Liganden
WO2018172546A1 (en) 2017-03-24 2018-09-27 Rigontec Gmbh Method for designing rig-i ligands
EP3607063A4 (en) 2017-04-03 2021-01-13 Duke University COMPOSITIONS AND METHODS FOR DIFFERENTIAL INDUCTION OF CELLULAR DEATH AND INTERFERON EXPRESSION
US10907161B2 (en) 2018-04-19 2021-02-02 Checkmate Pharmaceuticals, Inc. Synthetic RIG-I-like receptor agonists
US11542505B1 (en) 2018-04-20 2023-01-03 Merck Sharp & Dohme Llc Substituted RIG-I agonists: compositions and methods thereof
EP3790970A1 (en) 2018-05-07 2021-03-17 Alnylam Pharmaceuticals Inc. Extrahepatic delivery
KR102373488B1 (ko) * 2019-02-22 2022-03-14 주식회사 레모넥스 면역활성 또는 암의 예방 또는 치료용 의약 조성물
WO2020260547A1 (en) 2019-06-27 2020-12-30 Rigontec Gmbh Design method for optimized rig-i ligands
KR20240043747A (ko) 2021-07-02 2024-04-03 예일 유니버시티 암을 치료하기 위한 조성물 및 방법
WO2023034864A1 (en) 2021-08-31 2023-03-09 Yale University Compositions and methods for treating cancers
WO2023168352A1 (en) 2022-03-03 2023-09-07 Yale University Humanized 3e10 antibodies, variants, and antigen binding fragments thereof

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