EA201391721A1 - Способ получения полиморфной формы i эторикоксиба - Google Patents

Способ получения полиморфной формы i эторикоксиба

Info

Publication number
EA201391721A1
EA201391721A1 EA201391721A EA201391721A EA201391721A1 EA 201391721 A1 EA201391721 A1 EA 201391721A1 EA 201391721 A EA201391721 A EA 201391721A EA 201391721 A EA201391721 A EA 201391721A EA 201391721 A1 EA201391721 A1 EA 201391721A1
Authority
EA
Eurasian Patent Office
Prior art keywords
polymorphic form
ethorikoxib
obtaining polymorphic
present
obtaining
Prior art date
Application number
EA201391721A
Other languages
English (en)
Other versions
EA023286B1 (ru
Inventor
Ален Кльяйиц
Силво Зупанциц
Миха Врбинц
Сабина Трост
Original Assignee
ФАРМА ДжРС, Д.О.О.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ФАРМА ДжРС, Д.О.О. filed Critical ФАРМА ДжРС, Д.О.О.
Publication of EA201391721A1 publication Critical patent/EA201391721A1/ru
Publication of EA023286B1 publication Critical patent/EA023286B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Настоящее изобретение относится к способу получения полиморфной формы I эторикоксиба и к содержащим ее фармацевтическим препаратам. Полиморфная форма эторикоксиба, полученная посредством способа по настоящему изобретению, характеризуется высокой полиморфной чистотой и высокой химической и физической стабильностью.
EA201391721A 2011-05-27 2012-05-25 Способ получения полиморфной формы i эторикоксиба EA023286B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SI201100190 2011-05-27
PCT/EP2012/059852 WO2012163839A1 (en) 2011-05-27 2012-05-25 A process for the preparation of polymorphic form i of etoricoxib

Publications (2)

Publication Number Publication Date
EA201391721A1 true EA201391721A1 (ru) 2014-03-31
EA023286B1 EA023286B1 (ru) 2016-05-31

Family

ID=46148892

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201391721A EA023286B1 (ru) 2011-05-27 2012-05-25 Способ получения полиморфной формы i эторикоксиба

Country Status (5)

Country Link
EP (1) EP2714676B1 (ru)
EA (1) EA023286B1 (ru)
PL (1) PL2714676T3 (ru)
SI (1) SI2714676T1 (ru)
WO (1) WO2012163839A1 (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013144977A2 (en) * 2012-03-30 2013-10-03 Mylan Laboratories Ltd. An improved process for the preparation of etoricoxib
WO2014041558A2 (en) * 2012-08-27 2014-03-20 Glenmark Pharmaceuticals Limited; Glenmark Generics Limited Process for preparation of crystalline etoricoxib
WO2014033526A1 (en) * 2012-08-27 2014-03-06 Cadila Healthcare Limited Pharmaceutical compositions of etoricoxib
EP3179987A1 (en) * 2014-07-31 2017-06-21 KRKA, d.d., Novo mesto Pharmaceutical composition of etoricoxib
CN105250231B (zh) * 2015-11-02 2020-05-12 北京泰德制药股份有限公司 一种含有依托考昔的药物组合物及其制备方法
CN111410629A (zh) * 2020-03-31 2020-07-14 天津大学 依托考昔溶剂化物及其制备方法
CN112321493A (zh) * 2020-10-28 2021-02-05 四川尚锐生物医药有限公司 一种依托考昔的纯化方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2260016C (en) 1996-07-18 2004-03-09 Merck Frosst Canada Inc. Substituted pyridines as selective cyclooxygenase-2 inhibitors
US5861419A (en) 1996-07-18 1999-01-19 Merck Frosst Canad, Inc. Substituted pyridines as selective cyclooxygenase-2 inhibitors
CA2329193C (en) 1998-04-24 2007-01-23 Merck & Co., Inc. Process for synthesizing cox-2 inhibitors
ATE320809T1 (de) 1999-11-29 2006-04-15 Merck Frosst Canada Inc Polymorphe, amorphe und hydratisierte formen von 5-chlor-3-(methansulfonylphenyl)-6'-methyl-2, 3')bipyridinyl
PH12001001175B1 (en) 2000-05-26 2006-08-10 Merck Sharp & Dohme 5-chloro-3-(4-methanesulfonylphenyl)-6'-methyl- (2,3')bipyridinyl in pure crystalline form and process for synthesis
US6521642B2 (en) * 2000-05-26 2003-02-18 Merck & Co., Inc. 5-chloro-3-(4-methanesulfonylphenyl)-6′-methyl-[2,3′]bipyridinyl in pure crystalline form and process for synthesis
WO2005085199A1 (en) 2004-01-14 2005-09-15 Cadila Healthcare Limited Novel polymorphs of etoricoxib
DK2401253T3 (en) * 2009-02-27 2016-04-18 Cadila Healthcare Ltd Method for producing etoricoxib

Also Published As

Publication number Publication date
WO2012163839A1 (en) 2012-12-06
EP2714676B1 (en) 2019-04-24
EP2714676A1 (en) 2014-04-09
PL2714676T3 (pl) 2019-10-31
SI2714676T1 (sl) 2019-06-28
EA023286B1 (ru) 2016-05-31

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM

PD4A Registration of transfer of a eurasian patent in accordance with the succession in title