EA201391554A1 - Способы получения макроциклических депсипептидов и новых промежуточных соединений - Google Patents

Способы получения макроциклических депсипептидов и новых промежуточных соединений

Info

Publication number
EA201391554A1
EA201391554A1 EA201391554A EA201391554A EA201391554A1 EA 201391554 A1 EA201391554 A1 EA 201391554A1 EA 201391554 A EA201391554 A EA 201391554A EA 201391554 A EA201391554 A EA 201391554A EA 201391554 A1 EA201391554 A1 EA 201391554A1
Authority
EA
Eurasian Patent Office
Prior art keywords
depypeptides
methods
intermediate compounds
new intermediate
making macrocyclic
Prior art date
Application number
EA201391554A
Other languages
English (en)
Other versions
EA025546B1 (ru
Inventor
Мурат Асемоглу
Хериберт Хелльштерн
Феликс Колльмер
Джон Лопес
Роберт Шрайбер
Кристиан Шпрехер
Ханс Штеттлер
Original Assignee
Новартис Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46317455&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201391554(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of EA201391554A1 publication Critical patent/EA201391554A1/ru
Publication of EA025546B1 publication Critical patent/EA025546B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cookers (AREA)
  • Cereal-Derived Products (AREA)

Abstract

Настоящее изобретение относится к способу химического получения депсипептидов формулы (I), где указанные символы имеют значения, определенные в описании, к новым промежуточным соединениям и их получению, также как к соответствующим вариантам изобретения.
EA201391554A 2011-04-20 2012-04-19 Способы получения макроциклических депсипептидов и новых промежуточных соединений EA025546B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161477319P 2011-04-20 2011-04-20
PCT/IB2012/051977 WO2012143888A1 (en) 2011-04-20 2012-04-19 Processes for the manufacture of macrocyclic depsipeptides and new intermediates

Publications (2)

Publication Number Publication Date
EA201391554A1 true EA201391554A1 (ru) 2014-11-28
EA025546B1 EA025546B1 (ru) 2017-01-30

Family

ID=46317455

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201391554A EA025546B1 (ru) 2011-04-20 2012-04-19 Способы получения макроциклических депсипептидов и новых промежуточных соединений
EA201500734A EA201500734A1 (ru) 2011-04-20 2012-04-19 Способы получения макроциклических депсипептидов и новых промежуточных соединений

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA201500734A EA201500734A1 (ru) 2011-04-20 2012-04-19 Способы получения макроциклических депсипептидов и новых промежуточных соединений

Country Status (21)

Country Link
US (2) US8614289B2 (ru)
EP (1) EP2699585A1 (ru)
JP (2) JP5951006B2 (ru)
KR (1) KR101580729B1 (ru)
CN (2) CN103476789B (ru)
AR (1) AR086168A1 (ru)
AU (1) AU2012245980B2 (ru)
BR (1) BR112013026660A2 (ru)
CA (1) CA2833109A1 (ru)
CL (2) CL2013003037A1 (ru)
CO (1) CO6801799A2 (ru)
EA (2) EA025546B1 (ru)
GT (1) GT201300256A (ru)
IL (1) IL228727A0 (ru)
MA (1) MA35034B1 (ru)
MX (1) MX337526B (ru)
PE (1) PE20141206A1 (ru)
SG (1) SG193918A1 (ru)
TN (1) TN2013000385A1 (ru)
TW (1) TW201249863A (ru)
WO (1) WO2012143888A1 (ru)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2183273T (pt) 2007-08-17 2017-05-22 Novartis Ag Depsipéptidos cíclicos
US8614289B2 (en) 2011-04-20 2013-12-24 Novartis Ag Processes for the manufacture of macrocyclic depsipeptides and new intermediates
US8680054B2 (en) 2011-04-20 2014-03-25 Novartis Ag Suspension type topical formulations comprising cyclic depsipeptide
US8987413B2 (en) 2012-10-09 2015-03-24 Novartis Ag Aldehyde acetal based processes for the manufacture of macrocyclic depsipeptides and new intermediates
US9067978B2 (en) 2012-10-09 2015-06-30 Novartis Ag Solution phase processes for the manufacture of macrocyclic depsipeptides and new intermediates
US20170022254A1 (en) 2014-04-08 2017-01-26 Novartis Ag Novel Aldehyde Acetal Based Processes for the Manufacture of Macrocyclic Depsipeptides and New Intermediates
SG10202103403SA (en) * 2015-05-20 2021-05-28 Boehringer Ingelheim Animal Health Usa Inc Anthelmintic depsipeptide compounds
JP2018530543A (ja) 2015-09-17 2018-10-18 マサチューセッツ インスティテュート オブ テクノロジー 固相ペプチド合成のための方法およびシステム
KR102031186B1 (ko) 2017-01-11 2019-11-08 주식회사 엘지생활건강 단백질 강도 강화용 조성물
WO2020018888A1 (en) 2018-07-20 2020-01-23 The Board Of Regents Of The University Of Oklahoma Antimicrobial peptides and methods of use

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3043252C2 (de) 1980-11-15 1982-12-02 Degussa Ag, 6000 Frankfurt Cyclische Acetale von N-Acylglutaminsäure -γ- semialdehyden, Verfahren zu deren Herstellung und ihre Verwendung
US5595756A (en) 1993-12-22 1997-01-21 Inex Pharmaceuticals Corporation Liposomal compositions for enhanced retention of bioactive agents
DE4421113A1 (de) 1994-06-16 1995-12-21 Biotechnolog Forschung Gmbh Chondramide, Gewinnungsverfahren, Mittel mit Chondramiden und Mischkultur zur Chondramid-Gewinnung
DE19828043A1 (de) 1998-06-24 1999-12-30 Bayer Ag Ektoparasitizide Mittel
JP2000154198A (ja) 1998-11-20 2000-06-06 Nisshin Flour Milling Co Ltd 環状デプシペプチドの固相合成方法及びその中間体
GB0108234D0 (en) * 2001-04-02 2001-05-23 Pharma Mar Sa Process for producing trunkamide A compounds
US20040110228A1 (en) 2002-04-01 2004-06-10 Mcalpine Shelli R. Combinatorial organic synthesis of unique biologically active compounds
CA2525383C (en) 2003-06-06 2012-03-06 Arexis Ab Use of heterocyclic compounds as scce inhibitors
GB0322140D0 (en) 2003-09-22 2003-10-22 Pfizer Ltd Combinations
EP1716248A1 (en) 2004-02-03 2006-11-02 Bayer HealthCare AG Diagnostics and therapeutics for diseases associated with kallikrein 7 (klk7)
WO2007101227A2 (en) 2006-02-27 2007-09-07 Arizona Board Of Regents For And On Behalf Of Arizona State University Identification and use of novopeptides for the treatment of cancer
GB0715750D0 (en) 2007-08-13 2007-09-19 Karus Therapeutics Ltd Chemical compounds
US8415305B2 (en) 2007-08-17 2013-04-09 Novartis Ag Use of cyclic depsipeptides to inhibit kallikrein 7
PT2183273T (pt) 2007-08-17 2017-05-22 Novartis Ag Depsipéptidos cíclicos
DE102007052391A1 (de) 2007-10-31 2009-05-07 Henkel Ag & Co. Kgaa Mattwachs
US20110112121A1 (en) 2009-07-06 2011-05-12 Joerg Berghausen Pharmaceutical Compositions and Solid Forms
KR101004362B1 (ko) 2010-03-19 2010-12-28 가톨릭대학교 산학협력단 자가 면역 질환 예방 및 치료용 ＴＮＦ－α와 ＴＷＥＡＫ 이중 길항제
US20120064136A1 (en) 2010-09-10 2012-03-15 Nanobio Corporation Anti-aging and wrinkle treatment methods using nanoemulsion compositions
WO2012035468A2 (en) 2010-09-14 2012-03-22 Trima - Israel Pharmaceutical Products Maabarot Ltd. Foamable topical composition
DK2667854T3 (en) 2011-01-24 2019-04-23 Anterios Inc NANO PARTICLE FORMATIONS
US20120328701A1 (en) 2011-01-24 2012-12-27 Anterios, Inc. Nanoparticle compositions, formulations thereof, and uses therefor
US8680054B2 (en) 2011-04-20 2014-03-25 Novartis Ag Suspension type topical formulations comprising cyclic depsipeptide
US8614289B2 (en) 2011-04-20 2013-12-24 Novartis Ag Processes for the manufacture of macrocyclic depsipeptides and new intermediates
US9067978B2 (en) 2012-10-09 2015-06-30 Novartis Ag Solution phase processes for the manufacture of macrocyclic depsipeptides and new intermediates
US8987413B2 (en) 2012-10-09 2015-03-24 Novartis Ag Aldehyde acetal based processes for the manufacture of macrocyclic depsipeptides and new intermediates
US20170022254A1 (en) 2014-04-08 2017-01-26 Novartis Ag Novel Aldehyde Acetal Based Processes for the Manufacture of Macrocyclic Depsipeptides and New Intermediates

Also Published As

Publication number Publication date
SG193918A1 (en) 2013-11-29
AR086168A1 (es) 2013-11-27
US20140080995A1 (en) 2014-03-20
CA2833109A1 (en) 2012-10-26
WO2012143888A1 (en) 2012-10-26
CN103476789B (zh) 2016-11-09
MA35034B1 (fr) 2014-04-03
EA201500734A1 (ru) 2015-11-30
AU2012245980A1 (en) 2013-10-03
BR112013026660A2 (pt) 2016-09-06
JP2014511899A (ja) 2014-05-19
US20120277406A1 (en) 2012-11-01
AU2012245980B2 (en) 2015-01-29
JP5951006B2 (ja) 2016-07-13
MX337526B (es) 2016-03-09
CL2015000688A1 (es) 2015-06-05
CO6801799A2 (es) 2013-11-29
KR20130140204A (ko) 2013-12-23
US9278997B2 (en) 2016-03-08
EA025546B1 (ru) 2017-01-30
JP2016164158A (ja) 2016-09-08
IL228727A0 (en) 2013-12-31
GT201300256A (es) 2015-02-19
CL2013003037A1 (es) 2014-10-03
MX2013012188A (es) 2013-11-04
CN103476789A (zh) 2013-12-25
CN104804072A (zh) 2015-07-29
KR101580729B1 (ko) 2015-12-28
TN2013000385A1 (en) 2015-01-20
PE20141206A1 (es) 2014-09-28
TW201249863A (en) 2012-12-16
EP2699585A1 (en) 2014-02-26
US8614289B2 (en) 2013-12-24

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU