EA201291235A1 - Новые способы - Google Patents
Новые способыInfo
- Publication number
- EA201291235A1 EA201291235A1 EA201291235A EA201291235A EA201291235A1 EA 201291235 A1 EA201291235 A1 EA 201291235A1 EA 201291235 A EA201291235 A EA 201291235A EA 201291235 A EA201291235 A EA 201291235A EA 201291235 A1 EA201291235 A1 EA 201291235A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- new ways
- formula
- atherosclerosis
- cardiovascular
- intermediates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
- C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
- C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
- C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
- C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C229/48—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms of the same non-condensed ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Изобретение относится к способам получения соединения формулы (I) и его промежуточным соединениям. Соединения формулы (I) полезны при лечении сердечно-сосудистых и воспалительных заболеваний, таких как атеросклероз.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US34522410P | 2010-05-17 | 2010-05-17 | |
PCT/US2011/036821 WO2011146494A1 (en) | 2010-05-17 | 2011-05-17 | Novel processes |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201291235A1 true EA201291235A1 (ru) | 2013-04-30 |
EA026569B1 EA026569B1 (ru) | 2017-04-28 |
Family
ID=44992024
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201291235A EA026569B1 (ru) | 2010-05-17 | 2011-05-17 | Способы получения определенных пиримидиновых соединений и их промежуточные соединения |
Country Status (24)
Country | Link |
---|---|
US (2) | US9447052B2 (ru) |
EP (1) | EP2571857B1 (ru) |
JP (1) | JP6027529B2 (ru) |
KR (1) | KR20130089157A (ru) |
CN (2) | CN105837520A (ru) |
AR (1) | AR081399A1 (ru) |
AU (1) | AU2011256270B2 (ru) |
BR (1) | BR112012030532A2 (ru) |
CA (1) | CA2799520C (ru) |
CL (1) | CL2012003206A1 (ru) |
CO (1) | CO6630197A2 (ru) |
CR (1) | CR20120630A (ru) |
DO (1) | DOP2012000289A (ru) |
EA (1) | EA026569B1 (ru) |
IL (1) | IL223068A0 (ru) |
MA (1) | MA34301B1 (ru) |
MX (1) | MX2012013387A (ru) |
NZ (1) | NZ603672A (ru) |
PE (1) | PE20130318A1 (ru) |
SG (1) | SG185559A1 (ru) |
TW (1) | TW201209043A (ru) |
UY (1) | UY33388A (ru) |
WO (1) | WO2011146494A1 (ru) |
ZA (1) | ZA201208631B (ru) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW201209043A (en) * | 2010-05-17 | 2012-03-01 | Glaxo Group Ltd | Novel processes |
WO2015087239A1 (en) | 2013-12-11 | 2015-06-18 | Ranbaxy Laboratories Limited | Processes for the preparation of darapladib and its intermediates |
WO2015092687A2 (en) | 2013-12-17 | 2015-06-25 | Ranbaxy Laboratories Limited | Process for the purification of darapladib |
US11583596B2 (en) | 2017-09-26 | 2023-02-21 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Radiolabeled Darapladib and analogs thereof and their use as imaging compounds |
US10866963B2 (en) * | 2017-12-28 | 2020-12-15 | Dropbox, Inc. | File system authentication |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1143516B (de) * | 1961-04-27 | 1963-02-14 | Bayer Ag | Verfahren zur Herstellung von Peptiden |
US4277465A (en) | 1978-08-26 | 1981-07-07 | Kyoto Yakuhin Kogyo Kabushiki Kaisha | Adjuvant for promoting absorption of therapeutically active substances through the digestive tract |
US4235776A (en) * | 1979-03-15 | 1980-11-25 | Eli Lilly And Company | Tetrahydro-2H-benzo[c]pyrroles |
DE2941597A1 (de) * | 1979-10-13 | 1981-04-23 | Basf Ag, 6700 Ludwigshafen | Piperidinderivate von 4,5-dialkyl-3-hydroxy-pyrrol-2-carbonsaeureestern, ihre herstellung und diese enthaltende pharmazeutische zubereitungen |
US4619941A (en) * | 1984-11-19 | 1986-10-28 | American Cyanamid Company | N-[(1H-imidazol-1-yl)alkyl]-1H-indolecarboxamides useful as thromboxane synthetase inhibitors and antihypertensive agents |
WO1999024420A1 (en) | 1997-11-06 | 1999-05-20 | Smithkline Beecham Plc | Pyrimidinone compounds and pharmaceutical compositions containing them |
US6750228B1 (en) * | 1997-11-14 | 2004-06-15 | Pharmacia Corporation | Aromatic sulfone hydroxamic acid metalloprotease inhibitor |
US6503745B1 (en) | 1998-11-05 | 2003-01-07 | Biocryst Pharmaceuticals, Inc. | Cyclopentane and cyclopentene compounds and use for detecting influenza virus |
AU766003B2 (en) * | 1999-05-01 | 2003-10-09 | Smithkline Beecham Plc | Pyrimidinone compounds |
BRPI0108396B1 (pt) * | 2000-02-16 | 2015-05-19 | Smithkline Beecham Plc | Derivados de pirimidina-4-ona como inibidores de ldl-pla2 |
GB0119795D0 (en) * | 2001-08-14 | 2001-10-03 | Smithkline Beecham Plc | Novel process |
TW201209043A (en) * | 2010-05-17 | 2012-03-01 | Glaxo Group Ltd | Novel processes |
-
2011
- 2011-05-16 TW TW100117029A patent/TW201209043A/zh unknown
- 2011-05-16 AR ARP110101679 patent/AR081399A1/es unknown
- 2011-05-16 UY UY33388A patent/UY33388A/es not_active Application Discontinuation
- 2011-05-17 AU AU2011256270A patent/AU2011256270B2/en not_active Ceased
- 2011-05-17 JP JP2013511295A patent/JP6027529B2/ja not_active Expired - Fee Related
- 2011-05-17 BR BR112012030532A patent/BR112012030532A2/pt not_active IP Right Cessation
- 2011-05-17 PE PE2012002160A patent/PE20130318A1/es not_active Application Discontinuation
- 2011-05-17 KR KR20127032795A patent/KR20130089157A/ko active IP Right Grant
- 2011-05-17 EA EA201291235A patent/EA026569B1/ru not_active IP Right Cessation
- 2011-05-17 WO PCT/US2011/036821 patent/WO2011146494A1/en active Application Filing
- 2011-05-17 NZ NZ60367211A patent/NZ603672A/en not_active IP Right Cessation
- 2011-05-17 MX MX2012013387A patent/MX2012013387A/es unknown
- 2011-05-17 CA CA2799520A patent/CA2799520C/en not_active Expired - Fee Related
- 2011-05-17 EP EP11784095.9A patent/EP2571857B1/en active Active
- 2011-05-17 SG SG2012083648A patent/SG185559A1/en unknown
- 2011-05-17 CN CN201610182606.0A patent/CN105837520A/zh active Pending
- 2011-05-17 MA MA35441A patent/MA34301B1/fr unknown
- 2011-05-17 CN CN201180035126.7A patent/CN103003249B/zh not_active Expired - Fee Related
- 2011-05-17 US US13/698,102 patent/US9447052B2/en not_active Expired - Fee Related
-
2012
- 2012-11-15 DO DO2012000289A patent/DOP2012000289A/es unknown
- 2012-11-15 IL IL223068A patent/IL223068A0/en unknown
- 2012-11-16 ZA ZA2012/08631A patent/ZA201208631B/en unknown
- 2012-11-16 CO CO12208170A patent/CO6630197A2/es unknown
- 2012-11-16 CL CL2012003206A patent/CL2012003206A1/es unknown
- 2012-12-12 CR CR20120630A patent/CR20120630A/es unknown
-
2016
- 2016-08-12 US US15/235,468 patent/US9725420B2/en not_active Expired - Fee Related
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |